5篇
您的检索式：作者名="Liu Jingqun"
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| 1 | Intensified cleaning of organic-fouled reverse osmosis membranes by thermo- responsive polymer (TRP) 显示文摘 | Sanehuan Yu Zhihai Chen Jingqun Liu | 2012 | Journal of Membrane Science2012，37，3： | 1 |
| 2 | Intensified cleaning of organic-fouled reverse osmosis membranes by thermo-responsive polymer (TRP) 显示文摘 | Yu Sanchuan Chen Zhihai Liu Jingqun | 2012 | Joumal of Membrane Science2012，392，2： | 1 |
| 3 | Expression analysis of immune-relevant genes in the spleen of large yellow croaker ( Pseudosciaena crocea ) stimulated with poly I:C显示文摘 | Wenbiao Zheng Guozhu Liu Jingqun Ao Xinhua Chen | 2006 | Fish and Shellfish Immunology2006，，4： | 1 |
| 4 | Ethyl Acetate Fraction in Hedyotis Diffusa Willd Inhibits T Cell Proliferation to Improve the Pathogenesis of Systemic Lupus Erythematosus显示文摘Background:Abnormal proliferation of T cells plays an essential role in the pathogenesis of Systemic lupus erythematosus(SLE).The pharmaceutical effect of Hedyotis Diffusa Willd(HDW)on SLE has been investigated previously.Nevertheless,the biomedical mechanism is still left unclear.Objective:This study has been arranged to evaluate the therapeutic effect of the ethyl acetate fraction of HDW(EAHDW)on lupus mice and explore the potential therapeutic mechanism.Methods:EAHDW was prepared with 80%ethanol reflex extraction followed by successive extraction,and ana-lyzed with HPLC and UPLC-Q/TOP-MS.The potential targets and STAT3 affinity regulators were predicted with network pharmacology.The pharmaceutic effect of EAHDW was studied with MRL/lpr mice.Cytokines and au-toantibodies were quantified with ELISA assays.The pathological damage of glomerulus and STAT3 expression in the kidney was detected with histochemical and immunohistochemical techniques.The cell cycle properties in cell proliferation were identified with the flow cytometry.The western blot and dual-Luciferase reporter assay were applied to evaluate translational and transcriptional activity of STAT3,respectively.Results:In this study,the extraction ratio of EAHDW was 2.7±1%,in which 19 ingredients were identified.Network pharmacological analysis showed that the target genes of EAHDW were highly focused on influencing the abnormal T cell proliferation in SLE.EAHDW showed the beneficial effects on pathological changes and STAT3 expression in the glomerulus of lupus mice,and the levels of cytokines and autoantibodies in serum.In cytological study,EAHDW treatment attenuated the transcription and phosphorylation of STAT3,which inhibited T cell proliferation by prolonged S-phase of the cell cycle.A total of 5 compounds in EAHDW exhibited high docking affinity to the DNA-binding site of STAT3.Conclusion:EAHDW could reduce the inflammatory response and inhibit the proliferation of T cells by interfering with the STAT3 signaling pathway,thereby playing a therapeutic effect on SLE. | Yahui Lai JinJun Ji Ying Li Jingqun Liu Xinhui Lan Weihong Ge Li Xu Yongsheng Fan Bin Ding | 2021 | Clinical Complementary Medicine and Pharmacology2021，1，1： | 0 |
| 5 | Properties and Cytocompatibility of Anti-Washout Calcium Phosphate Cement by Introducing Locust Bean Gum显示文摘The washout resistance of injectable calcium phosphate cement(CPC) is highly requisite for more widely clinical applications. In this work, locust bean gum(LBG) was used as the anti-washout agent to improve the washout resistance of CPC. The results indicated that the washout resistance was greatly improved,and meanwhile the injectability, setting time and compressive strength slightly decreased when the content of LBG was no more than 1.0%. Additionally, the CPC with 1.0% LBG exhibited good cell compatibility of the mouse bone mesenchymal stem cells(mBMSCs). Therefore, the 1.0% LBG content was proposed to serve as a useful additive in CPC as a result of its ability to promote washout resistance, which may play an important role in clinical applications. | Jingqun Liu Jiyan Li Jiandong Ye | 2016 | Journal of Materials Science & Technology2016，32，10： | 0 |
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