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| 1 | A comparative study between Embosphere~ and conventional transcatheter arterial chemoembolization for treatment of unresectable liver metastasis from GIST显示文摘Objective:Transcatheter arterial chemoembolization(TACE) is a standard treatment for hepatocellular carcinoma(HCC) and/or some unresectable liver metastasis tumors.Hypervascular liver metastatic lesions such as metastasis from gastrointestinal stromal tumor(GIST) are an indication for transcatheter arterial embolization(TAE).The purpose of this study was to evaluate the efficacy and safety of Embosphere~-TAE(Embo-TAE) in comparison with conventional TACE(cTACE) for the treatment of liver metastasis from GIST.Methods:A total of 45 patients who underwent TACE between Aug 2008 and Feb 2013 were enrolled.Patients with GIST who underwent TAE with Embosphere~(n=19) were compared with controls who received cTACE(n=26).The primary end points were treatment response and treatment-related adverse events.The secondary end points were progression-free survival(PFS) and overall survival(OS).Results:The treatment response of Embo-TAE group was significantly higher than that of the cTACE group(P<0.001).The PFS was significantly better in the Embosphere~-group than in the cTACE group(56.6 and 42.1 weeks,respectively;P=0.003).However,there was no statistically significant difference in liver toxicity between the two groups(P>0.05).The median OS in the Embo-TAE group was longer than that in the cTACE group(74.0 weeks,95% CI:68.2-79.8 vs.61.7 weeks,95% CI:56.2-67.2 weeks)(unadjusted P=0.045).The use of Embo-TAE significantly reduced the risk of death in patients with GIST with liver metastases according to the Cox proportional hazards regression model [hazard ratio(HR):0.149;95% CI:0.064-0.475].Conclusions:TAE with Embosphere~ showed better treatment response and delayed tumor progression compared with cTACE.There was no significant difference in treatment-related hepatic toxicities.EmboTAE thus appears to be a feasible and promising approach in the treatment of liver metastasis from GIST. | Guang Cao Xu Zhu Jian Li Lin Shen Renjie Yang Hui Chen Xiaodong Wang Song Gao Haifeng Xu Linzhong Zhu Peng Liu Jianhai Guo | 2014 | Chinese Journal of Cancer Research2014，26，1： | 18 |
| 2 | Progress and Prospects of Salt Lake Research in China显示文摘China has unique salt lake resources, and they are distributed in the east of Eurasian salt lake subzone of the Northern Hemisphere Salt Lake Zone, mainly concentrated in the regions with modern mean annual precipitation lower than 500 mm. This paper preliminarily reviews the progress made in salt lake research in China for the past 60 years. In the research of Paleoclimate and paleoenvironment from salt lake sediments, a series of salts have been proposed to be indicators of paleoclimate, and have been well accepted by scholars. The chloride-sulfate depositional regions of the west Qaidam and the east Tarim have been revealed to be the drought center of China since the Quaternary, and more than 6 spreading stages of arid climate(salt forming) have been identified. Five pan-lake periods with highstands have been proved to exist during the late Quaternary on the Tibetan Plateau. In mineral resource prospecting and theories of the forming of salt deposits: the atlas(1:2500000) of hydrochemical zoning of salt lakes on the Tibetan Plateau has been compiled for the first time, revealing the zonal distribution and transition from carbonate type to chloride type from south to north and presenting corresponding mineral assemblages for different type of salt lakes; several large continental salt deposits have been discovered and the theory of continental potash deposition has been developed, including the salt deposition in deep basins surrounded by high mountains, the mineral deposition from multistage evolution through chains of moderate or shallow lakes with multilevels, the origin of potassium rich brines in gravel layers, and the forming of potassium deposits through the inheriting from ancient salt deposits, thus establishing the framework of 'Continental Potash Deposition Theory'; several new types of Mg-borate deposits have been discovered, including the ulexite and pinnoite bed in Da Qaidam Lake, Qinghai, the pinnoite and kurnakovite bed in Chagcam Caka, Tibet, the kurnakovite bed in Lake Nyer, and the corresponding model of borate deposition from the cooling and dissolution of boron rich brines was proposed based on principles of geology, physics and chemistry. The anti-floatation-cold crystallization method developed independently has improved the capacity of KCl production to 3 million tons per year for the Qarham, serving the famous brand of potash fertilizer products. One 1.2 million ton K-sulfate production line, the biggest in the world, has been built in Lop Nor, and K-sulfate of about 1.6 million tons was produced in 2015. Supported by the new technology, i.e. brine preparation in winter-cooling-solarization-isolation-lithium deposition from salt gradient solar pond' the highest lithium production base at Zabuye Lake(4421 m), Tibet, has been established, which is the first lithium production base in China that reaches the year production of 5000 tons of lithium carbonate. The concept of Salt lake agriculture(Salt land agriculture) has been established based on the mass growth of Dunaliella and other bacillus-algae and the occurrence of various halophytes in saltmarsh and salt saline-alkali lands, finding a new way to increase arable lands and develop related green industry in salt rich environments. Finally this paper presents some new thoughts for the further research and development on salt science, and the further progress in salt science and technology will facilitate the maturing of the interdisciplinary science 'Salinology'. | ZHENG Mianping ZHANG Yongsheng LIU Xifang NIE Zhen KONG Fanjing QI Wen Jia Qingxian PU Linzhong HOU Xianhua WANG Hailei ZHANG Zhen KONG Weigang LIN Yongjie | 2016 | Acta Geologica Sinica(English Edition)2016，90，4： | 15 |
| 3 | Adjacent strong edge coloring of graphs显示文摘 | Zhang Zhongfu Liu Linzhong Wang Jianfang | 2002 | Applied Mathematics Letter2002，，15： | 1 |
| 4 | Adjacent Strong Edge Coloring of Graphs 显示文摘 | Zhang Zhongfu Liu Linzhong Wang Jianfang | 2002 | Applied Mathematics Letter2002，，5： | 1 |
| 5 | Adjacent strong edge coloring of graphs显示文摘 | Zhang Zhongfu Liu Linzhong Wang Jianfang | 2002 | Applied Mathematics Letters2002，，15： | 1 |
| 6 | Adjacent strong edge coloring of graphs显示文摘 | Zhang Zhongfu Liu Linzhong Wang Jianfang | 2002 | Applied Mathematics Letters2002，15，： | 1 |
| 7 | Adjacentstrong edge coloring of graphs 显示文摘 | ZhangZhongfu Liu Linzhong Wang Jianfang | 2002 | Applied Mathematica Let-ters2002，15，： | 1 |
| 8 | Adjacent Strong Edge Coloring of Graphs显示文摘 | Zhang Zhongfu Liu Linzhong Wang Jianfang | | 0，，： | 1 |
| 9 | On the adjacent strong edge-coloring of Graphs 显示文摘 | ZHANG Zhongfu LIU Linzhong WANG Jianfang | 2002 | Applied Math Letters2002，，15： | 1 |
| 10 | Adjacent strong edge coloring of graphs显示文摘 | Zhang Zhonffu Liu Linzhong Wang Jianfang | 2002 | Appl Math Lett2002，15，5： | 1 |
| 11 | Adjacent strong edge coloring of graphs显示文摘 | Zhang Zhongfu Liu Linzhong Wang Jianfang | 2002 | Applied Mathematics Letters2002，15，： | 1 |
| 12 | Adjacent strong edge coloring of graphs显示文摘 | ZHANG Zhongfu LIU Linzhong WANG Jianfang | 2002 | AML2002，15，5： | 1 |
| 13 | Adjacent strong edge coloring of graphs显示文摘 | Zhang Zhongfu Liu Linzhong Wang Jianfang | 2002 | Applied Mathematics Letters2002，15，： | 1 |
| 14 | Adjacent strong edge coloring of graphs 显示文摘 | ZHANG Zhongfu LIU Linzhong WANG Jianfang | 2002 | Applied Mathematics Let- ters2002，15，： | 1 |
| 15 | Adjacent strong edge cloring of graph 显示文摘 | Zhang Zhongfu Liu Linzhong Wangjianfang | 2002 | Applied Mathematics Letters2002，15，5： | 1 |
| 16 | Adjacent strong edge coloring of graphs显示文摘 | Zhang Zhongfu Liu Linzhong Wang Jianfang | 2002 | Applied Mathematics Letters2002，15，： | 1 |
| 17 | A note on the lower bounds of signed domination number of a graph显示文摘 | Zhongfu Zhang Baogen Xu Yinzhen Li Linzhong Liu | 1999 | Discrete Mathematics1999，，1： | 1 |
| 18 | Genome-wide profiling of histone H3 lysine 27 trimethylation and its modification in response to chilling stress in grapevine leaves显示文摘Histone H3 lysine 27 trimethylation(H3K27me3) is a histone modification associated with transcriptional repression. However, insights into the genome-wide pattern of H3K27me3 in grapevines are limited. Here, anti-H3K27 chromatin immunoprecipitation(ChIP), high-throughput sequencing, and transcriptome analysis were performed using leaves of Vitis amurensis. The leaves were treated at 4°C for 2 h and 24 h and used to investigate changes in H3K27me3 under chilling treatment. The results show that H3K27me3 is well-distributed both in gene regions(-50%) and in the intergenic region(-50%) in the grapevine genome(Vitis vinifera ‘Pinot Noir PN40024'). H3K27me3 was found to be localized in8 368 annotated gene regions in all detected samples(leaves at normal temperature and under chilling treatments) and mainly enriched in gene bodies with the adjacent promoter and downstream areas. The short-term chilling treatments(4°C for 2 h) induced 2 793 gains and 305losses in H3K27me3 modification. Subsequently, 97.3% of the alterations were restored to original levels after 24 h treatment. The ChIP-qPCR for five differential peaks showed similar results to the data for ChIP-seq, indicating that the chilling-induced H3K27me3 modification is reliable.Integrative analysis of transcriptome and ChIP-seq results showed that the expression of H3K27me3 target genes was significantly lower than those of non-target genes, indicating transcriptional repression of H3K27me3 in grapevine leaves. Furthermore, histone methylation alterations were detected in 82 genes and were related to either repression or activation of their expression during chilling stress. The findings provide the genome-wide H3K27me3 patterns in grapevines and shed light on uncovering its regulation in chilling stress responses. | Zhenfei Zhu Qingyun Li Duncan Kiragu Gichuki Yujun Hou Yuanshuang Liu Huimin Zhou Chen Xu Linchuan Fang Linzhong Gong Beibei Zheng Wei Duan Peige Fan Qingfeng Wang Haiping Xin | 2023 | Horticultural Plant Journal2023，9，3： | 1 |
| 19 | Adjacent strong edge coloring of graphs显示文摘 | Zhang Zhongfu Liu Linzhong Wang Jianfang | 2002 | Applied Mathematics Letters2002，，15： | 1 |
| 20 | Adjacent strong edge coloring of graphs显示文摘 | Zhang Zhongfu Liu Linzhong Wang Jianfang | 2002 | Applied Mathematics Letters2002，15，： | 1 |
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