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| 1 | 肽酰基精氨酸脱亚氨酶4和中性粒细胞胞外诱捕网形成在实验性动脉粥样硬化和动脉损伤中的作用:浅表糜烂的影响显示文摘中性粒细胞可能促进人类动脉粥样硬化的血栓并发症的发生。特别是中性粒细胞胞外诱捕网(neutrophil extracellular traps,NETs)可加剧局部炎症,并放大和加剧动脉内膜损伤和血栓形成。肽酰基精氨酸脱亚氨酶4(peptidyl arginine deiminase 4,PAD4)参与NET的形成,但对该酶在动脉粥样硬化血栓形成中的作用的认识仍然不足。 | 刘青 叶鹏 Franck G Mawson TL Folco EJ Molinaro R Ruvkun V Engelbertsen D Liu X Tesmenitsky Y Shvartz F Sukhova GK Michel JB Nicoletti A Lichtman AH Wagner DD Croce KJ Libby P | 2018 | 中华高血压杂志2018，26，5： | 13 |
| 2 | Banxia Xiexin Decoction(半夏泻心汤)Treats Diabetic Gastroparesis through PLC-IP3-Ca^2+/NO-cGMP-PKG Signal Pathway显示文摘Objective To test the effect of Banxia Xiexin Decoction(半夏泻心汤,BXD)on the contraction and relaxation of gastric smooth muscle(SM)in diabetic gastroparesis(DGP)model rats,and to explore the mechanism of BXD in the prevention and treatment of DGP through experiments of signal pathway both in vivo and in vitro.Methods Sixty Sprague-Dawley rats were divided into 6 groups according to a random number table:control group,model group,high-,medium-and low-dose BXD groups(9.2,4.6 and 1.8 g/(kg·d),respectively),and domperidone group(10 mg/(kg·d)),10 rats per group.DGP model was established initially by a single intraperitoneal injection of streptozotocin(STZ),and was confirmed by recording gastric emptying,intestinal transport velocity and gastric myoelectric activity of rats after 2 months.Each group was treated with a corresponding drug for 4 weeks.The mRNA and protein expressions of phospholipase C(PLC),inositol triphosphate(IP3),neuronal nitric oxide synthase(nNOS),and cyclic guanosine monophosphate(cGMP)dependent protein kinase G(PKG)were detected by reverse transcription-polymerase chain reaction and Western blot,respectively,while nitric oxide(NO)and cGMP expressions were detected by enzyme-linked immunosorbent assay.Gastric tissues were obtained from rats for primary cell culture preparation.Gastric SM cells were treated with 0.8µmol/L of STZ or STZ plus 1,000,500 and 200µg/mL of BXD or STZ plus 2.5µmol/mL of domperidone for 24,48,72 or 96 h,respectively.The length of gastric SM cells and intracellular Ca^2+concentration([Ca^2+]i)before and after BXD treatment was measured.Results Compared with the model group,high-and medium-dose BXD and domperidone significantly increased the expressions of PLC,IP3,NO,nNOS,cGMP and PKG in rat’s gastric tissue(P<0.01).Gastric SM cells treated with BXD showed a time-and dose-dependent increase in cell viability(P<0.01).The treatment with high-and medium-dose BXD and domperidone inhibited the increase in gastric SM cells length and increased[Ca^2+]i compared with the model cells(P<0.01).Conclusions Treatment with high-and medium-dose BXD significantly attenuated STZ-induced experimental DGP in rats.The therapeutic effect of BXD on DGP rats might be associated with the PLC-IP3-Ca^2+/NO-cGMP-PKG signal pathway. | WANG Bin ZENG Ke-wu HONG Zi-fu Tl Gui-xiang WANG Li-yun LU Pin LIU Zhen | 2020 | Chinese Journal of Integrative Medicine2020，26，11： | 8 |
| 3 | Cloning of the human sodium iodide symporter显示文摘 | Smanik PA Liu Q Furminger TL | 1996 | Biochem Biophys Res Commun1996，226，： | 2 |
| 4 | The red-cell immune system显示文摘 | Siegel I Liu TL GieicherN | 1981 | Lancet1981，12，2： | 1 |
| 5 | Comparison Between F-18-FDG Positron Emission Tomography and Histology for the Assessment of Tumor Necrosis Rates in Primary Osteosareoma 显示文摘 | HUANG TL LIU R S CHEN TH | 2006 | J Chin Med Assoc2006，69，8： | 1 |
| 6 | Study of solubility of steroids in hydrofluoroalkane propellants显示文摘 | Williams RO 3rd Rogers TL Liu J | | 0，，12： | 1 |
| 7 | Cytotoxic effects of free fatty acid on ascites tumor cell 显示文摘 | Siegel I Liu TL Yaghoubzadeh E | 1987 | J Natl Cancer Inst1987，78，2： | 1 |
| 8 | Cloning of the human sodium iodide symporter显示文摘 | Smanik PA Liu Q Furminger TL et al | 1996 | Biochem Res Commun1996，226，： | 1 |
| 9 | The red cell immune system显示文摘 | Siegel I Liu TL Gleicherk N | 1981 | Lancet1981，2，8246： | 1 |
| 10 | Molecular analysis of the diversity ofvaginal microbiota associated with bacterial vaginosis显示文摘 | Ling TL Kong J Liu F | 2010 | BMCGenomics2010，11，1： | 1 |
| 11 | Reduced potassium-chloride co- transporter expression in spinal cord dorsal horn neurons contributes to inflammatory pain hypersensitivity in rats 显示文摘 | Zhang W Liu LY Xu TL | 2008 | Neuroscience2008，152，2： | 1 |
| 12 | Differential effects of IL-21 during initiation and progression of autoimmunity against neuroantigen显示文摘 | Vollmer TL Liu R Price M | 2005 | J Immunol2005，174，5： | 1 |
| 13 | Effects of long-term chemical fertilization and organic amendments on dynamics of soil organic C and total N in paddy soil derived from barren land in subtropical China显示文摘 | Li ZP Liu M Wu XC Han FX Zhang TL | 2010 | Soil and Tillage Research2010，106，2： | 1 |
| 14 | Beginning a molecular analysis of the eukaryal community in activated sludge显示文摘 | Marsh TL Liu WT Forney L J | 1998 | Water Science and Technology1998，37，45： | 1 |
| 15 | Stability of hydrous phases in sub- ducting oceanic crust显示文摘 | Liu J Bohlen S tL Ernst W G | 1996 | Earth and Planetary Science Letters1996，143，： | 1 |
| 16 | Reconstitution of caspase - 3 sensi- tizes MCF - 7 breast cancer ceils to doxorubicin and etoposide - in- duced apoptosis显示文摘 | Yang XH Sladek TL Liu X | 2001 | Cancer Res2001，61，1： | 1 |
| 17 | Activity of camptothecin,harringtonin,cantharidin and curcumae in the human tumor stem cell assay显示文摘 | Jiang TL Salmon SE Liu RM | 1983 | Eur J Cancer Clin Oncol1983，19，2： | 1 |
| 18 | The red-cell immune system显示文摘 | Siegel I Liu TL Gleicher N | 1981 | Lancet1981，2，8246： | 1 |
| 19 | TSPY potentiates cell proliferation and tumorigenesis by promoting cell cycle progression in HeLa and NIH3 T3 cells 显示文摘 | Oram SW Liu XX Lee TL | 2006 | BMC Cancer2006，6，1： | 1 |
| 20 | Microcalorimetric study of the effects of long-term fertilization on soil microbial activity in a wheat field on the Loess Plateau 显示文摘 | Zhang Q Liu XM Ma XJ Fang J Fan TL Wu FS An LZ Feng HY | 2014 | Ecotoxicology2014，1315，： | 1 |
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