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| 1 | Proton pump inhibitors in cirrhosis:Tradition or evidence based practice?显示文摘Proton Pump Inhibitors (PPI) are very effective in inhibiting acid secretion and are extensively used in many acid related diseases. They are also often used in patients with cirrhosis sometimes in the absence of a specific acid related disease, with the aim of preventing peptic complications in patients with variceal or hypertensive gastropathic bleeding receiving multidrug treatment. Contradicting reports support their use in cirrhosis and evidence of their efficacy in this condition is poor. Moreover there are convincing papers suggesting that acid secretion is reduced in patients with liver cirrhosis. With regard to Helicobacter pylori (H pylori) infection, its prevalence in patients with cirrhosis is largely variable among different studies, and it seems that H pylori eradication does not prevent gastro-duodenal ulcer formation and bleeding. With regard to the prevention and treatment of oesophageal complications after banding or sclerotherapy of oesophageal varices, there is little evidence for a protective role of PPI. Moreover, due to liver metabolism of PPI, the dose of most available PPIs should be reduced in cirrhotics. In conclusion, the use of this class of drugs seems more habit related than evidence- based eventually leading to an increase in health costs. | Francesca Lodato Francesco Azzaroli Maria Di Girolamo Valentina Feletti Paolo Cecinato Andrea Lisotti Davide Festi Enrico Roda Giuseppe Mazzella | 2008 | World Journal of Gastroenterology2008，14，19： | 10 |
| 2 | Hepatocellular carcinoma prevention:A worldwide emergence between the opulence of developed countries and the economic constraints of developing nations显示文摘Hepatocellular carcinoma (HCC) is the fifth most common neoplasm, the major cause of death in patients with liver cirrhosis, and the third most common cause of cancer-related death in the world. The geographic distribution of HCC varies significantly and 80% of cases occur in developing countries (Far East and South Asia) where the prevalence of viral hepatitis is higher. The treatment of HCC is difficult because most patients are diagnosed when the tumour is in an advanced stage and is not amenable to potential curative therapy, thus prevention is the key to reducing HCC and its related morbidity and mortality. HCC is unique among cancers, occurring mostly in patients with a known risk factor. Ninety percent of HCCs develop in the context of chronic liver diseases and mainly in patients with cirrhosis. Viral hepatitis is the most common cause of HCC worldwide, followed by alcoholic liver disease (ALD) and other causes such as non-alcoholic fatty liver disease (NAFLD), genetic haemocromatosis (GH) and primary biliary cirrhosis in an advanced stage (Ⅲ- Ⅴ). In certain areas of the People’s Republic of China, exposure to aflatoxin and HBV infection are thought to be responsible for the extraordinary high risk of HCC. Substantial progresses in the prevention of virusl-related hepatitis (screening of blood units, use of disposable sanitary tools, HBV vaccination) have been achieved in developed countries, but in the same areas, alcohol- and dysmetabolism-related HCCs are emerging problems which require specific interventions in terms of public health measures. In developing countries, economic constraints limit the development of any program for the prevention of viral hepatitis transmission (including health education campaigns, healthcare politics, primary prevention and the improvement of hygienic and sanitary conditions). When viral liver disease is established, only a minority of patients are treated worldwide and benefit a possible preventive effect of medical treatment onHCC development. Thus the real contribution of medical treatment to HCC prevention in patients with chronic viral hepatitis is small. Great efforts are needed to identify more effective medical measures for primary and secondary prevention of HCC. | Francesca Lodato Giuseppe Mazzella Davide Festi Francesco Azzaroli Antonio Colecchia Enrico Roda | 2006 | World Journal of Gastroenterology2006，12，45： | 9 |
| 3 | Systemic lupus erythematosus following virological response to peginterferon alfa-2b in a transplanted patient with chronic hepatitis C recurrence显示文摘自体免疫的表明在丙肝病毒长期地感染的病人,并且在为非自体免疫的疾病移植的病人是普通的。在干扰素之间的关联基于治疗和自体免疫的疾病或自身抗体的发展很好在非移植的病人被建立,但是很少数据关于移植病人是可得到的。干扰素是否可以增加尖锐细胞的拒绝的发生,是不清楚的,在肝以后的移植干扰素或 pegylated 干扰素治疗期间在不正常的自体免疫的表明的发展有很少报告。我们与长期的丙肝的复发在一个移植病人与 pegylated 干扰素 alfa-2b 描述全身性红斑狼疮追随者治疗的一个案例。我们的经验建议那 pegylated 干扰素可以在免疫导致自体免疫的疾病压制的主人,与为到在干扰素期间,在肝的基于的治疗移植了的可能的自体免疫的混乱开发的大注意的尖锐细胞的拒绝和电话不同病人。 | Francesca Lodato Maria Rosa Tamé Antonio Colecchia Chiara Racchini Francesco Azzaroli Antonia D'Errico Silvia Casanova Antonio Pinna Enrico Roda Giuseppe Mazzella | 2006 | World Journal of Gastroenterology2006，12，26： | 2 |
| 4 | 羊膜细胞可保护和修复缺血再灌注损伤小鼠脑组织细胞显示文摘背景:羊膜细胞主要由羊膜上皮细胞和羊膜间充质细胞组成,均具有多分化潜能,可转化为神经元,且还有合成、释放生物活性物质和神经营养因子的功能。作者前期研究证实羊膜细胞移植入脑内后,能明显促进脑内神经元的再生。目的:探索羊膜细胞对小鼠缺血再灌注损伤脑细胞的作用。方法:将Balb/C小鼠通过夹闭双侧颈总动脉方法建立脑缺血再灌注损伤模型后,分离小鼠脑细胞。取孕鼠新鲜胎盘,分离羊膜细胞。将与羊膜细胞共培养的小鼠脑细胞作为实验组,以PBS培养的小鼠脑细胞作为对照组。结果与结论:实验组小鼠脑细胞活性较对照组明显增加(P<0.05)。培养24,72 h后实验组小鼠脑细胞坏死率较对照组差异无显著性意义(P>0.05),而培养48 h后实验组小鼠脑细胞坏死率较对照组明显降低(P<0.05)。实验组小鼠脑细胞中S期细胞数量增加,而对照组小鼠脑细胞中G1期细胞数量增加,S期细胞数量减少,但2组小鼠脑细胞中G2期细胞数量不变。说明羊膜细胞具有保护缺血再灌注损伤Balb/C小鼠脑细胞的作用,且能抑制其坏死和凋亡并促进其再生。 | 郑彦涛 刘斌 Robert Lodato 李奇林 蓝迪慧 洪小英 鲜华 | 2014 | 中国组织工程研究2014，18，37： | 2 |
| 5 | Prevalence and risk factors of diabetic retinopathy in adult and elderly subjects: the Casteldaccia Eye Study 显示文摘 | Giuffre G Lodato G Dardanoni G | 2004 | Graefes Arch Clin Exp Ophthalmol2004，242，7： | 1 |
| 6 | Expression of the carotenoid biosynthesis genes in XanthophyIlomyces dendrorhous显示文摘 | Lodato P Alcaino J Barahona S | 2007 | Biological Research2007，40，1： | 1 |
| 7 | Efficient construction of sequence-specific TAL effectors for modulating mammali an transcription显示文摘 | Zhang F Cong L Lodato S | 2011 | Nat Biotechnol2011，29，2： | 1 |
| 8 | Viability and thermal stability of a strain of Saccharomyces cerevisiae freeze-dried in different sugar and polymer matrices显示文摘 | LODATO P de HUERGO M S BUERA M P | 1999 | Appl Microbiol Biotechnol1999，52，： | 1 |
| 9 | Alternative splicing of transcripts from crtI and crtYB genes of Xanthophyllomyces dendrorhous显示文摘 | Alcaino J Barahona S | 2003 | Appl Environ Micobiol2003，69，： | 1 |
| 10 | Efficient construction of sequence-specific TAL effectors for modulating mamma- lian transcription 显示文摘 | Zhang F Cong L Lodato S | 2011 | Nature Biotechnology2011，29，2： | 1 |
| 11 | Roles of IL-land TNF in the decreased ileal muscle contractility induced by lipoplysaccharide显示文摘 | Lodato RF Khan AR Zembowicz MJ | 1999 | Am J Physiol1999，276，： | 1 |
| 12 | Atternuuve splicing of transcripts from crtI and crtYB genes of Xanthophyllomyces dendrorhous显示文摘 | Lodato P Alcaino J Baralaona S et at | 2003 | Applied and Environmental Microbiology2003，69，8： | 1 |
| 13 | Expression of the carotenoid biosynthesis genes in Xanthophyllomyces dendrorhous显示文摘 | Lodato P Alcaíno J Barahona S | 2007 | Biological Research2007，40，1： | 1 |
| 14 | Post-transcriptional processing of the LEE4 operon in enterohaemorrhagic Escherichia eoli 显示文摘 | Lodato PB Kaper JB | 2009 | Mol Microbiol2009，71，2： | 1 |
| 15 | Combined assessment of coronary anatomy and myocardial perfusion using muhidelector computed tomography for the evaluation of coronary artery disease显示文摘 | Kachenonra N Gnspar T Lodato JA | 2009 | Am J Cardiol2009，103，： | 1 |
| 16 | The role of cytoreduetivesur- gery in advanced-stage ovarian cancer: a systematicreview 显示文摘 | Vitale SG Marilli I Lodato M | 2013 | Up- dates Surg2013，65，4： | 1 |
| 17 | Feasibility of real-time three-dimensional transesophageal echocardiography forguidance of percutaneous atrial septal defect closure显示文摘 | Lodato JA Cao QL Weinert L | 2009 | Eur JEchocardiogr2009，10，4： | 1 |
| 18 | Alternative Splicing of Transcripts from crtI and crtYB Genes of Xanthophyllomyces dendrorhous 显示文摘 | Lodato P Alcaino J Barahona S | 2003 | Appl Environ Microbiol2003，69，8： | 1 |
| 19 | Use of 3-dimensional color Doppler echocardiography to measure stroke volume in human beings:comparison with thermodilution显示文摘 | Lodato JA Weinert L Baumann R | | 0，，02： | 1 |
| 20 | Combined as- sessment of coronary anatomy and myocardial perfusion us- ing multidetector computed tomography for the evaluation of coronary artery disease显示文摘 | Kachenoura N Gaspar T Lodato JA | 2009 | Am J Cardiol2009，103，11： | 1 |
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