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| 1 | Tectonic dynamics and correlation of major earthquake sequences of the Xiaojiang and Qujiang-Shiping fault systems, Yunnan, China显示文摘The N-S trending Xiaojiang fault zone and the NW-SE trending Qujiang-Shiping fault zone are adjacent active fault systems and seismogenic zones associated with strong and major earthquakes in Yunnan, China. To understand the interaction of the two fault systems, and its probable influence on earthquake occurrences, this paper conducts a synthetic study based on data of active tectonics, historical earthquakes, relocated small earthquakes, GPS station velocities and focal mechanism resolutions. The study makes several conclusions. (1) The active southward motion of the western side of the Xiaojiang fault zone (i.e. the side of the Sichuan-Yunnan block) has a persistent and intensive effect on the Qujiang-Shiping fault zone. The later fault zone has absorbed and transformed the southward motion of the western side of the former fault zone through dextral strike-slip/shearing as well as transverse shortening/thrusting. (2) Along the Xiaojiang fault zone, the present sinistral strike-slip/shearing rate decreases from 10 and 8 mm/a on the northern, central and central-southern segments to 4 mm/a on the southern segment. The decreased rate has been adjusted in the area along and surrounding the Qujiang-Shiping fault zone through reverse-dextral faulting and distributed shearing and shortening. (3) The tectonic-dynamic relation between the Xiaojiang fault zone and the Qujiang-Shiping fault zone is also manifested by a close correlation of earthquake occurrences on the two fault zones. From 1500 to 1850 a sequence of strong and major earthquakes occurred along the Xiaojiang fault zone and its northern neighbor, the Zemuhe fault zone, which was characterized by gradually accelerating strain release, gradually shortening intervals between M≥7 events, and major releases occurring in the mid to later stages of the sequence. As a response to this sequence, after an 88-year delay, another sequence of 383 years (from 1588 to 1970) of strong and major earthquakes occurred on the Qujiang-Shiping fault zone, and had the same features in accelerating strain release and its temporal course. (4) Since there has been no M≥7 event for 177 years on the Xiaojiang fault zone, the potential risk of a strong or major earthquake occurring on this fault zone in the future should be noticed and studied further. | WEN XueZe DU Fang LONG Feng FAN Jun ZHU Hang | 2011 | Science China Earth Sciences2011，54，10： | 22 |
| 2 | GPER agonist G1 suppresses neuronal apoptosis mediated by endoplasmic reticulum stress after cerebral ischemia/reperfusion injury显示文摘Studies have confirmed a strong association between activation of the endoplasmic reticulum stress pathway and cerebral ischemia/reperfusion(I/R) injury.In this study,three key proteins in the endoplasmic reticulum stress pathway(glucose-regulated protein 78,caspase-12,and C/EBP homologous protein) were selected to examine the potential mechanism of endoplasmic reticulum stress in the neuroprotective effect of G protein-coupled estrogen receptor.Female Sprague-Dawley rats received ovariectomy(OVX),and then cerebral I/R rat models(OVX+ I/R) were established by middle cerebral artery occlusion.Immediately after I/R,rat models were injected with 100 μg/kg E2(OVX + I/R +E2),or 100 μg/kg G protein-coupled estrogen receptor agonist G1(OVX + I/R + G1) in the lateral ventricle.Longa scoring was used to detect neurobehavioral changes in each group.Infarct volumes were measured by 2,3,5-triphenyltetrazolium chloride staining.Morphological changes in neurons were observed by Nissl staining.Terminal dexynucleotidyl transferase-mediated nick end-labeling staining revealed that compared with the OVX + I/R group,neurological function was remarkably improved,infarct volume was reduced,number of normal Nissl bodies was dramatically increased,and number of apoptotic neurons in the hippocampus was decreased after E2 and G1 intervention.To detect the expression and distribution of endoplasmic reticulum stress-related proteins in the endoplasmic reticulum,caspase-12 distribution and expression were detected by immunofluorescence,and mRNA and protein levels of glucose-regulated protein 78,caspase-12,and C/EBP homologous protein were determined by polymerase chain reaction and western blot assay.The results showed that compared with the OVX+ I/R group,E2 and G1 treatment obviously decreased mRNA and protein expression levels of glucose-regulated protein 78,C/EBP homologous protein,and caspase-12.However,the G protein-coupled estrogen receptor antagonist G15(OVX + I/R + E2 + G15) could eliminate the effect of E2 on cerebral I/R injury.These results confirm that E2 and G protein-coupled estrogen receptor can inhibit the expression of endoplasmic reticulum stress-related proteins and neuronal apoptosis in the hippocampus,thereby improving dysfunction caused by cerebral I/R injury.Every experimental protocol was approved by the Institutional Ethics Review Board at the First Affiliated Hospital of Shihezi University School of Medicine,China(approval No.SHZ A2017-171) on February 27,2017. | Zi-Wei Han Yue-Chen Chang Ying Zhou Hang Zhang Long Chen Yang Zhang Jun-Qiang Si Li Li | 2019 | Neural Regeneration Research2019，14，7： | 16 |
| 3 | Major advances in studies of the physical geography and living environment of China during the past 70 years and future prospects显示文摘The natural environment provides material essentials for human survival and development. The characteristics,processes, regional differentiation and forcing mechanisms of the elements of the natural environment(e.g. geomorphology,climate, hydrology, soil, etc.) are the main objects of research in physical geography. China has a complex natural environment and huge regional differentiation and therefore it provides outstanding reserach opportunities in physical geography. This review summarizes the most important developments and the main contributions of research in the physical geography and human living environment in China during the past 70 years. The major topics addressed are the uplift of the Tibetan Plateau and the evolution of its cryosphere, the development of fluvial systems, the acidification of the vast arid region of the Asian interior, variations in the monsoon and westerly climate systems on multiple timescales, the development of lakes and wetlands, the watershed system model, soil erosion, past human-environment interactions, biogeography, and physical geographic zonality. After briefly introducing international research developments, we review the history of research in physical geography in China, focusing on the major achievements and major academic debates, and finally we summarize the status of current research and the future prospects. We propose that in the context of the national demand for the construction of an ecological civilization, we should make full use of the research findings of physical geography, and determine the patterns and mechanisms of natural environmental processes in order to continue to promote the continued contribution of physical geography to national development strategies, and to further contribute to the theory of physical geography from a global perspective. | Fahu CHEN Bojie FU Jun XIA Duo WU Shaohong WU Yili ZHANG Hang SUN Yu LIU Xiaomin FANG Boqiang QIN Xin LI Tingjun ZHANG Baoyuan LIU Zhibao DONG Shugui HOU Lide TIAN Baiqing XU Guanghui DONG Jingyun ZHENG Wei YANG Xin WANG Zaijun LI Fei Wang Zhenbo HU Jie WANG Jianbao LIU Jianhui CHEN Wei HUANG Juzhi HOU Qiufang CAI Hao LONG Ming JIANG Yaxian HU Xiaoming FENG Xingguo MO Xiaoyan YANG Dongju ZHANG Xiuhong WANG Yunhe YIN Xiaochen LIU | 2019 | Science China Earth Sciences2019，62，11： | 11 |
| 4 | Emerging role of long non-coding RNA in the development of gastric cancer显示文摘Gastric cancer is a common, worldwide malignancy and has a poor prognosis due to late diagnosis. Long non-coding RNAs(lnc RNAs) are a significant subtype of RNA molecules with a length longer than 200 nucleotides(nt) that rarely encode proteins. In recent decades, deregulation of lnc RNAs has been shown to be involved in tumorigenesis and tumor progression in various human carcinomas, including gastric cancer. Accumulating evidence has shown that some lnc RNAs may function as diagnostic biomarkers or therapeutic targets for gastric cancer. Thus, exploring the specific functions of lnc RNAs will help both gain a better understanding of the pathogenesis and develop novel treatments for gastric cancer. In this review, we highlight the expression and functional roles of lncR NAs in gastric cancer, and analyze the potential applications of lncR NAs as diagnostic markers and therapeutic targets. | Hang Yu Long Rong | 2018 | World Journal of Gastrointestinal Oncology2018，10，9： | 8 |
| 5 | Classification of the Gut Microbiota of Patients in Intensive Care Units During Development of Sepsis and Septic Shock显示文摘The gut microbiota of intensive care unit(ICU)patients displays extreme dysbiosis associated with increased susceptibility to organ failure,sepsis,and septic shock.However,such dysbiosis is difficult to characterize owing to the high dimensional complexity of the gut microbiota.We tested whether the concept of enterotype can be applied to the gut microbiota of ICU patients to describe the dysbiosis.We collected 131 fecal samples from 64 ICU patients diagnosed with sepsis or septic shock and performed 16S rRNA gene sequencing to dissect their gut microbiota compositions.During the development of sepsis or septic shock and during various medical treatments,the ICU patients always exhibited two dysbiotic microbiota patterns,or ICU-enterotypes,which could not be explained by host properties such as age,sex,and body mass index,or external stressors such as infection site and antibiotic use.ICU-enterotype I(ICU E1)comprised predominantly Bacteroides and an unclassified genus of Enterobacteriaceae,while ICU-enterotype II(ICU E2)comprised predominantly Enterococcus.Among more critically ill patients with Acute Physiology and Chronic Health Evaluation II(APACHE II)scores>18,septic shock was more likely to occur with ICU E1(P=0.041).Additionally,ICU E1 was correlated with high serum lactate levels(P=0.007).Therefore,different patterns of dysbiosis were correlated with different clinical outcomes,suggesting that ICU-enterotypes should be diagnosed as independent clinical indices.Thus,the microbial-based human index classifier we propose is precise and effective for timely monitoring of ICU-enterotypes of individual patients.This work is a first step toward precision medicine for septic patients based on their gut microbiota profiles. | Wanglin Liu Mingyue Cheng Jinman Li Peng Zhang Hang Fan Qinghe Hu Maozhen Han Longxiang Su Huaiwu He Yigang Tong Kang Ning Yun Long | 2020 | Genomics, Proteomics & Bioinformatics2020，18，6： | 7 |
| 6 | Experimental realization of single-shot nonadiabatic holonomic gates in nuclear spins显示文摘Nonadiabatic holonomic quantum computation has received increasing attention due to its robustness against control errors.However,all the previous schemes have to use at least two sequentially implemented gates to realize a general one-qubit gate.Based on two recent reports,we construct two Hamiltonians and experimentally realized nonadiabatic holonomic gates by a single-shot implementation in a two-qubit nuclear magnetic resonance(NMR)system.Two noncommuting one-qubit holonomic gates,rotating along x?and z?axes respectively,are implemented by evolving a work qubit and an ancillary qubit nonadiabatically following a quantum circuit designed.Using a sequence compiler developed for NMR quantum information processor,we optimize the whole pulse sequence,minimizing the total error of the implementation.Finally,all the nonadiabatic holonomic gates reach high unattenuated experimental fidelities over 98%. | Hang Li Yang Liu GuiLu Long | 2017 | Science China(Physics,Mechanics & Astronomy)2017，60，8： | 5 |
| 7 | Progress of power field effect transistor based on ultra-wide bandgap Ga_2O_3 semiconductor material显示文摘As a promising ultra-wide bandgap semiconductor, gallium oxide(Ga_2O_3) has attracted increasing attention in recent years. The high theoretical breakdown electrical field(8 MV/cm), ultra-wide bandgap(~ 4.8 eV) and large Baliga's figure of merit(BFOM) of Ga_2O_3 make it a potential candidate material for next generation high-power electronics, including diode and field effect transistor(FET). In this paper, we introduce the basic physical properties of Ga_2O_3 single crystal, and review the recent research process of Ga_2O_3 based field effect transistors. Furthermore, various structures of FETs have been summarized and compared, and the potential of Ga_2O_3 is preliminary revealed. Finally, the prospect of the Ga_2O_3 based FET for power electronics application is analyzed. | Hang Dong Huiwen Xue Qiming He Yuan Qin Guangzhong Jian Shibing Long Ming Liu | 2019 | Journal of Semiconductors2019，40，1： | 4 |
| 8 | A Full Quantum Eigensolver for Quantum Chemistry Simulations显示文摘Quantum simulation of quantum chemistry is one of the most compelling applications of quantum computing.It is of particular importance in areas ranging from materials science,biochemistry,and condensed matter physics.Here,we propose a full quantum eigensolver(FQE)algorithm to calculate the molecular ground energies and electronic structures using quantum gradient descent.Compared to existing classical-quantum hybrid methods such as variational quantum eigensolver(VQE),our method removes the classical optimizer and performs all the calculations on a quantum computer with faster convergence.The gradient descent iteration depth has a favorable complexity that is logarithmically dependent on the system size and inverse of the precision.Moreover,the FQE can be further simplified by exploiting a perturbation theory for the calculations of intermediate matrix elements and obtaining results with a precision that satisfies the requirement of chemistry application.The full quantum eigensolver can be implemented on a near-term quantum computer.With the rapid development of quantum computing hardware,the FQE provides an efficient and powerful tool to solve quantum chemistry problems. | Shijie Wei Hang Li GuiLu Long | 2020 | Research2020，，1： | 3 |
| 9 | Whole-Genome Sequences Analysis Displays Relationship of SARS-CoV-2 Delta Variant Between Four Local Cases and Passengers of a Flight from South Africa—Shenzhen City,Guangdong Province,China,June 2021显示文摘On June 14,2021,a customs officer(Case A)went to the infirmary at Baoan International Airport in Shenzhen due to a runny nose and fever.He was admitted to the Central Hospital of Baoan immediately.This patient preliminarily tested positive for coronavirus disease 2019(COVID-19)infection,caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),using a quantitative realtime reverse transcription polymerase chain reaction(qRT-PCR)method in this hospital.Then,a mixed specimen of nasopharyngeal swab. | Yaqing He Renli Zhang Qiuying Lyu Bo Peng Shujiang Mei Ying Sun Dongfeng Kong Chaoqiong Peng Ziquan Lyu Xinyi Wei Can Zhu Xiaoliang Xiao Shimin Li Qingju Lu Jiancheng Chen Hang Zhang Xuan Zou Tiejian Feng Long Chen | 2021 | China CDC weekly2021，3，50： | 3 |
| 10 | Experimental study of Forrelation in nuclear spins显示文摘Correlation functions are often employed to quantify the relationships among interdependent variables or sets of data.Recently,a new class of correlation functions,called FORRELATION,has been introduced by Aaronson and Ambainis for studying the query complexity of quantum devices.It was found that there exists a quantum query algorithm solving 2-fold FORRELATION problems with an exponential quantum speedup over all possible classical means,which represents essentially the largest possible separation between quantum and classical query complexities.Here we report an experimental study probing the2-fold and 3-fold FORRELATIONS encoded in nuclear spins.The major experimental challenge is to control the spin fluctuation to within a threshold value,which is achieved by developing a set of optimized GRAPE pulse sequences.Overall,our small-scale implementation indicates that the quantum query algorithm is capable of determining the values of FORRELATIONS within an acceptable accuracy required for demonstrating quantum supremacy,given the current technology and in the presence of experimental noise. | Hang Li Xun Gao Tao Xin Man-Hong Yung Guilu Long | 2017 | Science Bulletin2017，62，7： | 3 |
| 11 | Origin area and migration route: Chloroplast DNA diversity in the arctic-alpine plant Koenigia islandica显示文摘The Hengduan Mountains(henceforth H-D Mountains) on the Tibet Plateau are a distribution and diversity center for many alpine genera. We examine patterns of genetic variation in an arctic-alpine plant to evaluate the possibility that the H-D Mountains constitute the area of origin of the species as well as to uncover postglacial migration routes. 220 individuals of the arctic-alpine plant Koenigia islandica were sampled from 26 populations distributed in western China and northern Finland. DNA haplotypes were identified using restriction site analysis of two chloroplast DNA intergene spacer regions, atpB-rbcL and trnL-trnF. We examined the geographical distribution of haplotype diversity in relation to latitude, and also compared various indices of diversity in putatively glaciated and unglaciated regions. Patterns of migration were inferred using nested clade analysis. A total of 25 haplotypes were detected. High haplotype diversity was found in the H-D Mountains. H3 and its radiated haplotypes were distributed in the Himalayas. Two haplotypes were fixed concurrently in the H-D Mountains and northern Finland. High genetic diversity of K. islandica and high species diversity of K. islandica are expected in the origin area. Our observations suggest that the H-D Mountains are not only the place of origin of K. islandica, but also the refugia for K. islandica on the Tibet Plateau. What is more, the migration route for the arctic-alpine plant K. islandica must have originated in the region defined by the H-D Mountains in western China extending northward to the Arctic circumpolar, and moved westward along the Himalayas, then northward across the Altay Mountains and the Central Siberian Plateau at different time periods. | LONG Cong MIN YunJiang ZHAO XiuXia YANY ChunLei SUN Hang Lü HouYuan TANG LingYu ZHOU ZhongZe | 2014 | Science China Earth Sciences2014，57，8： | 2 |
| 12 | Regulation of the order-disorder phase transition in a Cs_(2)NaFeCl_(6) double perovskite towards reversible thermochromic application显示文摘Multifunctional lead-free double perovskites demonstrate remarkable potential towards applications in various fields.Herein,an environmentally-friendly,low-cost,high-throughput Cs_(2)NaFeCl_(6) single crystal with exceedingly high thermal stability is designed and grown.It obtains a cubic lattice system in the temperature range of 80-500 K,accompanied by a completely reversible chromatic variation ranging from yellow to black.Importantly,the intriguing thermochromism is proved to own extremely high reproducibility(over 1000 cycles)without a hysteretic effect,originating from its structural flexibility that including(i)the noteworthy distortion/deformation of[NaCl_(6)]5−and[FeCl_(6)]3−octahedra;(ii)order-disorder arrangement transition of[NaCl_(6)]5−and[FeCl6]3−octahedra as the function of temperature.This study paves the way towards a new class of smart windows and camouflage coatings with an unprecedented colour range based on a Cs_(2)NaFeCl_(6) perovskite. | Wenzhe Li Naveed Ur Rahman Yeming Xian Hang Yin Yunkai Bao Yi Long Songyang Yuan Yangyi Zhang Yaxuan Yuan Jiandong Fan | 2021 | Journal of Semiconductors2021，42，7： | 2 |
| 13 | Bioinformatic analysis and functional characterization of CFEM proteins in Setosphaeria turcica显示文摘Common in Fungal Extracellular Membrane(CFEM)domains are uniquely found in fungal extracellular membrane proteins which are important for pathogens.This study identified 13 StCFEM proteins in the genome of Setosphaeria turcica,the hemibiotrophic fungus that causes northern corn leaf blight.Sequence alignment and WebLogo analysis of their CFEM domains indicated that the amino acids were highly conserved and that,with the exception of StCFEM1,2,3,and 6,they contained eight cysteines.Phylogenic analysis suggested that these 13 proteins(StCFEM1–13)could be divided into 2 clades based on the presence of the trans-membrane domain.Six StCFEM proteins with a signal peptide and without a trans-membrane domain were considered as candidate effector proteins.The CFEM domain in the candidate effector proteins could form a helical-basket structure homologous to Csa2 in Candida albicans.Transcriptome analysis suggested that the 13 genes were expressed during fungal infection and a yeast secretion assay revealed that these candidate effectors were secreted proteins.It was also found that StCFEM3,4,and 5 couldn't affect BAX/INF1-induced programmed cell death(PCD)in Nicotiana benthamiana and while StCFEM12 could suppress INF1-induced PCD,it showed no effect on BAXinduced PCD.This study found that there were 13 members of the S.turcica CFEM protein family and that StCFEM12 was a candidate effector.This study laid the foundation for illustrating the roles of CFEM proteins during the pathogenic processes of phytopathogens. | WANG Jian-xia LONG Feng ZHU Hang ZHANG Yan WU Jian-ying SHEN Shen DONG Jin-gao HAO Zhi-min | 2021 | Journal of Integrative Agriculture2021，20，9： | 2 |
| 14 | A policy gradient algorithm integrating long and short-term rewards for soft continuum arm control显示文摘The soft continuum arm has extensive application in industrial production and human life due to its superior safety and flexibility. Reinforcement learning is a powerful technique for solving soft arm continuous control problems, which can learn an effective control policy with an unknown system model. However, it is often affected by the high sample complexity and requires huge amounts of data to train, which limits its effectiveness in soft arm control. An improved policy gradient method, policy gradient integrating long and short-term rewards denoted as PGLS, is proposed in this paper to overcome this issue. The shortterm rewards provide more dynamic-aware exploration directions for policy learning and improve the exploration efficiency of the algorithm. PGLS can be integrated into current policy gradient algorithms, such as deep deterministic policy gradient(DDPG). The overall control framework is realized and demonstrated in a dynamics simulation environment. Simulation results show that this approach can effectively control the soft arm to reach and track the targets. Compared with DDPG and other model-free reinforcement learning algorithms, the proposed PGLS algorithm has a great improvement in convergence speed and performance. In addition, a fluid-driven soft manipulator is designed and fabricated in this paper, which can verify the proposed PGLS algorithm in real experiments in the future. | DONG Xiang ZHANG Jing CHENG Long XU WenJun SU Hang MEI Tao | 2022 | Science China(Technological Sciences)2022，65，10： | 2 |
| 15 | Adaptive spatial channel mapping in MIMO relay sys- tems: a unified framework 显示文摘 | Long Hang Kuang Jinghua Shen Shanshan | 2010 | IEEE Signal Processing Letters2010，17，3： | 1 |
| 16 | The Empirical Mode Decomposition and the Hilbert Spectrum for Nonlinear and Non - Stationary Time Series Analysis 显示文摘 | Hang N E Shen Z Long S R | 1998 | Proceed- ings of the Royal Society A Mathematical Physical & Engineering Sciences1998，，： | 1 |
| 17 | Isolation and characterization of a high H2-producing strain Klebsiella oxytoca HP1 from a hot spring显示文摘 | LONG Minnan HANG Jinli WU Xiaobin | 2005 | Research in Microbiology2005，156，1： | 1 |
| 18 | A naturally occurring rat model of X-linked cone dysfunction显示文摘 | Gu YH hang ZM Long T | 2003 | Invest Ophthalmol Vision Sci2003，44，12： | 1 |
| 19 | Operation methods of resistive random access memory显示文摘In this paper, different electrical measurement and operation methods of resistive random access memory(RRAM) have been summarized, including voltage sweeping mode(VSM), current sweeping mode(CSM), constant current stress(CCS), constant voltage stress(CVS), rectangular pulse mode(RPM), and triangle pulse mode(TPM). Meanwhile, the effects of these measurement methods on the forming, set, reset and read operation as well as endurance performance have been compared. Finally, their respective controllability of various resistive switching parameters have been summarized and analyzed. | WANG Guo Ming LONG Shi Bing ZHANG Mei Yun LI Yang XU Xiao Xin LIU Hong Tao WANG Ming SUN Peng Xiao SUN Hai Tao LIU Qi Lü Hang Bing YANG Bao He LIU Ming | 2014 | Science China(Technological Sciences)2014，57，12： | 1 |
| 20 | The outcomes of glucose abnormalities in pre‐diabetic chronic hepatitis C patients receiving peginterferon plus ribavirin therapy显示文摘 | Jee‐Fu Huang Ming‐Lung Yu Chung‐Feng Huang Suh‐Hang Hank Juo Chia‐Yen Dai Ming‐Yen Hsieh Nei‐Jen Hou Ming‐Lun Yeh Meng‐Hsuan Hsieh Jeng‐Fu Yang Zu‐Yau Lin Shinn‐Chern Chen Shyi‐Jang Shin Wan‐Long Chuang | 2012 | Liver Int2012，，6： | 1 |
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