|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Prognostic significance of combined preoperative fibrinogen and CA199 in gallbladder cancer patients显示文摘AIM To investigate the prognostic value of the combination of preoperative plasma fibrinogen and CA199 in patients with gallbladder carcinoma(GBC).METHODS The clinicopathological data of 154 GBC patients were retrospectively reviewed after surgery. A receiver operating characteristic(ROC) curve was plotted to verify the optimum cut-off values for plasma fibrinogen and CA199. Univariate and multivariate survival analyses were performed to identify the factors associated with GBC prognosis. based on the HRs calculated via multivariate survival analyses, patients with elevated plasma fibrinogen and CA199 levels were allocated a score of 2.1; those with an elevated plasma fibrinogen level only were allocated a score of 1, those with an elevated CA199 level only were allocated a score of 1.1, and those with neither of these abnormalities were allocated a score of 0.RESULTS ROC curve analysis showed that the optimum cut-off values for preoperative plasma fibrinogen and CA199 were 3.47 g/L and 25.45 U/mL, respectively. Multivariate analysis indicated that elevated preoperative plasma fibrinogen and CA199 levels were significantly correlated with worse overall survival(OS)(HR = 1.711, 95%CI: 1.114-2.627, P = 0.014, and HR = 1.842, 95%CI: 1.111-3.056, P = 0.018). When we combined these two parameters, the area under the ROC curve increased from 0.735(for preoperative plasma fibrinogen only) and 0.729(for preoperative CA199 only) to 0.765. When this combined variable was added to the multivariate analysis, the combination of plasma fibrinogen and CA199(P < 0.001), resection margin(P < 0.001) and TNM stage(P = 0.010) were independent prognostic factors for GBC.CONCLUSION The combination of plasma fibrinogen and CA199 may serve as a more efficient independent prognostic biomarker for postoperative GBC patients than either parameter alone. | Wei-Yu Xu Hao-Hai Zhang Xiao-Bo Yang Yi Bai Jian-Zhen Lin Jun-Yu Long Jian-Ping Xiong Jun-Wei Zhang Xin-Ting Sang Hai-Tao Zhao | 2018 | World Journal of Gastroenterology2018，24，13： | 24 |
| 2 | Prognostic significance of the fibrinogen-to-albumin ratio in gallbladder cancer patients显示文摘AIM To investigate the prognostic role of fibrinogen-toalbumin ratio(FAR) on patients with gallbladder cancer(Gbc) in this study.METHODS One hundred and fifty-four Gbc patients were retro-spectively analyzed, who received potentially curative cholecystectomy in our institute from March 2005 to December 2017. Receiver operating characteristic curve(ROc curve) was used to determine the optimal cut-offs for these biomarkers. In addition, Kaplan-Meier survival analysis as well as multivariate analysis were applied for prognostic analyses.RESULTS ROc curve revealed that the optimal cut-off value for FAR was 0.08. FAR was significantly correlated with age(P = 0.045), jaundice(P < 0.001), differentiation(P = 0.002), resection margin status(P < 0.001), T stage(P < 0.001), TNM stage(P < 0.001), and c A199(P < 0.001) as well as albumin levels(P < 0.001). Multivariate analysis indicated that the resection margin status [hazard ratio(HR): 2.343, 95% confidence interval(c I): 1.532-3.581, P < 0.001], TNM stage(P = 0.035), albumin level(HR = 0.595, 95%c I: 0.385-0.921, P = 0.020) and FAR(HR: 2.813, 95%c I: 1.765-4.484, P < 0.001) were independent prognostic factors in Gbc patients.CONCLUSION An elevated preoperative FAR was significantly correlated with unfavorable overall survival in Gbc patients, while an elevated preoperative albumin level was a protective prognostic factor for patients with Gbc. The preoperative FAR could be used to predict the prognosis of Gbc patients, which was easily accessible, costeffective and noninvasive. | Wei-Yu Xu Hao-Hai Zhang Jian-Ping Xiong Xiao-bo Yang Yi bai Jian-Zhen Lin Jun-Yu Long Yong-chang Zheng Hai-Tao Zhao Xin-Ting Sang | 2018 | World Journal of Gastroenterology2018，24，29： | 23 |
| 3 | Downstaging and resection of hepatocellular carcinoma in patients with extrahepatic metastases after stereotactic therapy显示文摘Background:A combination of tyrosine kinase inhibitors(TKIs)and anti-PD-1 antibodies with local regional therapy has elicited yield substantial clinical benefits in patients who have hepatocellular carcinoma(HCC)with extrahepatic metastases.Using this treatment strategy to convert HCC patients with extrahepatic metastases from unresectable to resectable has not yet been reported.Methods:Consecutive hepatocellular carcinoma patients with extrahepatic metastases who received first-line therapy with a combination of TKIs and anti-PD-1 antibodies and at least one local regional therapy were analysed.Results:Nine patients with localized disease who received first-line systemic therapy were enrolled.At baseline,all of them had oligometastatic disease,namely,Barcelona Clinic Liver Cancer stage C(or Chinese Liver Cancer stage IIIB).The most common treatment administered was lenvatinib plus anti-PD-1 antibody and transarterial chemoembolization,and the median time span from systemic therapy to surgery was 3.2(IQR,2.8-6.2)months.Three patients achieved a pathological complete response.Six patients underwent laparoscopic surgery,and the other 3 patients underwent open surgery.After a median follow-up of 10.2(IQR,8.6-20.0)months,7 patients survived without disease recurrence,and 2 experienced tumour recurrence.All patients had any-grade AEs,and 55.6%of the patients experienced grade 3 AEs.Fatigue was the most common AE,followed by elevated aminotransferase levels and hypertension.Conclusions:Stereotactic therapy is a feasible conversion therapy for HCC patients with extrahepatic metastases to become resectable.This is the first study to analyse therapeutic outcomes of patients receiving these therapies for HCC with extrahepatic metastases. | Xiaobo Yang Haifeng Xu Bangyou Zuo Xu Yang Jin Bian Junyu Long Dongxu Wang Junwei Zhang Cong Ning Yanyu Wang Ziyu Xun Yunchao Wang Xin Lu Yilei Mao Xinting Sang Haitao Zhao | 2021 | Hepatobiliary Surgery and Nutrition2021，10，4： | 17 |
| 4 | Selenium Supplementation Alleviates Autoimmune Thyroiditis by Regulating Expression of Th1/Th2 Cytokines显示文摘Selenium (Se) is an essential trace element.Autoimmune thyroid diseases (AITD) are destructive inflammatory or anti-receptor autoimmune diseases characterized by reactivity to self-thyroid antigens.However,the effects of Se on the cytokines in AITD are still unclear.So we researched the role of Selenium (Se) and Th1/Th2 cytokine productions in the pathogenesis of autoimmune thyroid diseases (AITD).The data shown that high Se intake reduced the autoantibody titers and alleviated the | TAN Long SANG Zhong Na SHEN Jun WU Yun Tang YAO Zhai Xiao ZHANG Jin Xiang ZHAO Na ZHANG Wan Qi | 2013 | Biomedical and Environmental Sciences2013，26，11： | 10 |
| 5 | Mechanisms of organized atrial tachycardia during catheter ablation of chronic atrial fibrillation by stepwise approach显示文摘背景广泛的 atrial 纤维性颤动(AF ) 脱离在长期的 AF 病人和 atrial 心悸亢进的增加的率与导管脱离的增加的成功率被联系(在) 在过程期间。这些 Ats 的机制在以前的研究变化。我们的学习试图报导机制在发生在逐步的脱离期间组织了长期的 AF.Methods 的过程为长期的 atrial 纤维性颤动(CAF ) 经历了一个脱离过程的 86 个连续病人的一个未来的队被调查。逐步的过程在下列顺序被执行:环绕的肺的静脉脱离,复杂 fractionated atrial 电记录图脱离,印射并且脱离在。在湾穴节奏(SR ) 被恢复或过程时间在 6 hours.Results 以外以后,端点是 AF/AT 的 noninducibility (80%) 69 病人变换成 SR 经由在。179 持续 ATs 的一个总数在过程期间在 69 个病人被观察。有 81%(n=145 ) 包括了 65 个 perimitral 电路, 48 peritricuspid 心悸亢进和 32 个房顶依赖者电路的 macroreentrant ATs, 12%(n=21 ) 局部性重入并且 7%(n=13 ) 焦点的 ATs。三十(15%) 病人们在过程经历了重要左中庭(LA ) 和 LA 附器(LAA ) 传导延期或分离或在后续 period.Conclusions 期间,大多数 CAF 病人经由脱离变换成 SR 在发生在逐步的过程期间组织了。大多数这些 ATs 的机制是宏再废。 | NING Man DONG Jian-zeng LIU Xing-peng YU Rong-hui LONG De-yong TANG Ri-bo SANG Cai-hua MA Chang-sheng | 2010 | Chinese Medical Journal2010，，7： | 10 |
| 6 | Prognostic impact of the red cell distribution width in esophageal cancer patients: A systematic review and meta-analysis显示文摘AIM To clarify the previous discrepant conclusions, we performed a meta-analysis to evaluate the prognostic value of red cell distribution width(RDW) in esophageal cancer(EC). METHODS We searched the PubM ed, EMBASE, Web of Science and Cochrane Library databases to identify clinical studies, followed by using STATA version 12.0 for statistical analysis. Studies that met the following criteria were considered eligible:(1) Studies including EC patients who underwent radical esophagectomy;(2) studies including patients with localized disease without distant metastasis;(3) studies including patients without preoperative neoadjuvant therapy;(4) studies including patients without previous antiinflammatory therapies and with available preoperative laboratory outcomes;(5) studies reporting association between the preoperative RDW and overall survival(OS)/disease-free survival(DFS)/cancer-specific survival(CSS); and(6) studies published in English.RESULTS A total of six articles, published between 2015 and 2017, fulfilled the selection criteria in the end. Statistical analysis showed that RDW was not associated with the prognosis of EC patients, irrespective of OS/CSS [hazard ratio(HR) = 1.27, 95% confidence interval(CI): 0.97-1.57, P = 0.000] or DFS(HR = 1.42, 95%CI: 0.96-1.88, P = 0.000). Subgroup analysis indicated that elevated RDW was significantly associated with worse OS/CSS of EC patients when RDW > 13%(HR = 1.45, 95%CI: 1.13-1.76, P = 0.000), when the patient number ≤ 400(HR = 1.45, 95%CI: 1.13-1.76, P = 0.000) and when the study type was retrospective(HR = 1.42, 95%CI : 1.16-1.69, P = 0.000).CONCLUSION Contrary to our general understanding, this meta-analysis revealed that RDW cannot serve as an indicator of poor prognosis in patients with EC. However, it may still be a useful predictor of unfavorable prognosis using an appropriate cut-off value. | Wei-Yu Xu Xiao-Bo Yang Wen-Qin Wang Yi Bai Jun-Yu Long Jian-Zhen Lin Jian-Ping Xiong Yong-Chang Zheng Xiao-Dong He Hai-Tao Zhao Xin-Ting Sang | 2018 | World Journal of Gastroenterology2018，24，19： | 9 |
| 7 | Impact of different termination modes on atrial fibrillation termination in catheter ablation of persistent atrial fibrillation显示文摘 | WANG Ping DONG Jian-zeng LONG De-yong NING Man TANG Ri-bo YU Rong-hui XUE Zeng-ming SANG Cai-hua JIANG Chen-xi MA Chang-sheng | 2012 | Chinese Medical Journal2012，，11： | 7 |
| 8 | Efficacy of catheter ablation of atrial fibrillation beyond HATCH score显示文摘 | TANG Ri-bo DONG Jian-zeng LONG De-yong YU Rong-hui NING Man JIANG Chen-xi SANG Cai-hua LIU Xiao-hui MA Chang-sheng | 2012 | Chinese Medical Journal2012，，19： | 7 |
| 9 | Autotransfusion in the management of cardiac tamponade occurring during catheter ablation of atrial fibrillation显示文摘 | GAO Ling-yun TANG Ri-bo DONG Jian-zeng LIU Xing-peng LONG De-yong YU Rong-hui JIANG Chen-xi CHEN Gang SANG Cai-hua ZHANG Xin-yong NING Man MA Chang-sheng | 2010 | Chinese Medical Journal2010，，7： | 6 |
| 10 | Catheter ablation of persistent atrial fibrillation with and without a history of paroxysmal atrial fibrillation显示文摘 | MIAO Cheng-long YIN Xian-dong DONG Jian-zeng LIU Xing-peng YU Rong-hui LONG De-yong TANG Ri-bo SANG Cai-hua MA Chang-sheng | 2012 | Chinese Medical Journal2012，，6： | 6 |
| 11 | Impact of the origin of sinus node artery on recurrence after pulmonary vein isolation in patients with paroxysmal atrial fibrillation显示文摘 | ZHANG Zhi-jun CHEN Ke TANG Ri-bo SANG Cai-hua Edmundo Patricio Lopes Lao YAN Qian HE Xiao-nan DU Xin LONG De-yong YU Rong-hui DONG Jian-zeng MA Chang-sheng | 2013 | Chinese Medical Journal2013，，9： | 5 |
| 12 | Long-term results of single-procedure catheter ablation for atrial fibrillationin pre-and post-menopausal women显示文摘ObjectivesTo 地址经绝期是否由比较安全和长期的结果为 atrial 纤维性颤动(AF ) 影响导管脱离(CA ) 的结果一在经历了药倔强的 AF 的一个单个 CA 过程的 743 个女病人全部的绝经前、绝经后的 women.MethodsA 单个过程回顾地被分析。在为在绝经前的女人之间的 AF 的 CA 的临床的表示和结果的差别(PreM 组, 94 个病人, 12.7%) 并且绝经后的女人(PostM 组, 649 个病人, 87.3%) 在 PreM 组的 assessed.ResultsThe 病人更年轻(P <0.001 ) 并且不太可能有高血压(P <0.001 ) 并且糖尿病(P = 0.005 ) 比那些在 PostM 组。二个组关于伴随物的比例是类似的僧帽形的阀门流回冠的动脉疾病,左中庭尺寸,和左室的喷射部分。与 AF 脱离有关的复杂并发症的全面的率在两个组是类似的(P = 0.385 ) 。在 43 以后(16-108 ) 后续的月,脱离的成功率在 PreM 组是 54.3% , 54.2% 在 PostM 组织(P = 0.842 ) 。从 atrial tachyarrhythmia 复发的全面自由在两个组是类似的。经绝期没被发现是为 AF 的单个过程的 CA 的长期的结果是的 atrial tachyarrhythmia.ConclusionsThe 的复发的一个独立预兆的因素在绝经前、绝经后的女人类似。结果显示 AF 的 CA 看起来在绝经前的女人同样象在绝经后的女人安全、有效。 | Tao LIN Xing DU Rong BAI Ying-Wei CHEN Rong-Hui YU De-Yong LONG Ri-Bo TANG Cai-Hua SANG Song-Nan LI Chang-Sheng MA Jian-Zeng DONG | 2014 | Journal of Geriatric Cardiology2014，11，2： | 5 |
| 13 | Outcome of catheter ablation of atrial fibrillation in patients with prior ischemic stroke显示文摘 | LI Song-nan KANG Jun-ping DU Xin HE Xiao-nan LONG De-yong YU Rong-hui TANG Ri-bo SANG Cai-hua JIANG Chen-xi NING Man DONG Jian-zeng MA Chang-sheng | 2013 | Chinese Medical Journal2013，，6： | 4 |
| 14 | A simple and easily implemented risk model to predict 1-year ischemic stroke and systemic embolism in Chinese patients with atrial fibrillation显示文摘Background:Accurate prediction of ischemic stroke is required for deciding anticoagulation use in patients with atrial fibrillation(AF).Even though only 6%to 8%of AF patients die from stroke,about 90%are indicated for anticoagulants according to the current AF management guidelines.Therefore,we aimed to develop an accurate and easy-to-use new risk model for 1-year thromboembolic events(TEs)in Chinese AF patients.Methods:From the prospective China Atrial Fibrillation Registry cohort study,we identified 6601 AF patients who were not treated with anticoagulation or ablation at baseline.We selected the most important variables by the extreme gradient boosting(XGBoost)algorithm and developed a simplified risk model for predicting 1-year TEs.The novel risk score was internally validated using bootstrapping with 1000 replicates and compared with the CHA2DS2-VA score(excluding female sex from the CHA2DS2-VASc score).Results:Up to the follow-up of 1 year,163 TEs(ischemic stroke or systemic embolism)occurred.Using the XGBoost algorithm,we selected the three most important variables(congestive heart failure or left ventricular dysfunction,age,and prior stroke,abbreviated as CAS model)to predict 1-year TE risk.We trained a multivariate Cox regression model and assigned point scores proportional to model coefficients.The CAS scheme classified 30.8%(2033/6601)of the patients as low risk for TE(CAS score=0),with a corresponding 1-year TE risk of 0.81%(95%confidence interval[CI]:0.41%–1.19%).In our cohort,the C-statistic of CAS model was 0.69(95%CI:0.65–0.73),higher than that of CHA2DS2-VA score(0.66,95%CI:0.62–0.70,Z=2.01,P=0.045).The overall net reclassification improvement from CHA2DS2-VA categories(low=0/high≥1)to CAS categories(low=0/high≥1)was 12.2%(95%CI:8.7%–15.7%).Conclusion:In Chinese AF patients,a novel and simple CAS risk model better predicted 1-year TEs than the widely-used CHA2DS2-VA risk score and identified a large proportion of patients with low risk of TEs,which could potentially improve anticoagulation decision-making.Trial Registration:www.chictr.org.cn(Unique identifier No.ChiCTR-OCH-13003729). | Chao Jiang Tian-Ge Chen Xin Du Xiang Li Liu He Yi-Wei Lai Shi-Jun Xia Rong Liu Yi-Ying Hu Ying-Xue Li Chen-Xi Jiang Nian Liu Ri-Bo Tang Rong Bai Cai-Hua Sang De-Yong Long Guo-Tong Xie Jian-Zeng Dong Chang-Sheng Ma | 2021 | Chinese Medical Journal2021，，19： | 4 |
| 15 | Stomach cancer screening and preventive behaviors in relatives of gastric cancer patients显示文摘AIM:To investigate gastric cancer screening and preventive behaviors among the relatives of patients with gastric cancer[i.e.,gastric cancer relatives(GCRs)].METHODS:We examined the Korean National Health and Nutrition Examination Survey 2005(KNHANESⅢ) database and compared the gastric cancer screening and preventive behaviors of GCRs(n=261)with those of non-GCRs(n=454)and controls without a family history of cancer(n=2842).RESULTS:The GCRs were more likely to undergo gastric cancer screening compared with the control group(39.2%vs 32.3%,adjusted odds ratio:1.43,CI:1.05-1.95),although the absolute screening rate was low.Dietary patterns and smoking rates did not differ significantly between the groups,and a high proportion of GCRs reported inappropriate dietary habits(i.e.,approximately 95%consumed excessive sodium,30% were deficient in vitamin C,and 85%were deficient in dietary fiber).CONCLUSION:The gastric cancer screening and preventive behaviors of GCRs have yet to be improved.To increase awareness among GCRs,systematic family education programs should be implemented. | Jung Min Kang Dong Wook Shin Young Min Kwon Sang Min Park Min Sun Park Jin Ho Park Ki Young Son Be Long Cho | 2011 | World Journal of Gastroenterology2011，17，30： | 4 |
| 16 | Differential mRNA expression profiling of oral squamous cell carcinoma by high-throughput RNA sequencing显示文摘Differentially expressed genes are thought to regulate the development and progression of oral squamous cell carcinomas(OSCC).The purpose of this study was to screen differentially expressed mRNAs in OSCC and matched paraneoplastic normal tissues,and to explore the intrinsic mechanism of OSCC development and progression.We obtained the differentially expressed mRNA expression profiles in 10 pairs of fresh-frozen OSCC tissue specimens and matched paraneoplastic normal tissue specimens by high-throughput RNA sequencing.By using Gene Ontology enrichment analysis and Kyoto Encyclopedia of Genes and Genomes(KEGG) pathway enrichment analyses,the functional significance of the differentially expressed genes were analyzed.We identified 1,120 significantly up-regulated mRNAs and 178 significantly down-regulated mRNAs in OSCC,compared to normal tissue.The differentially expressed mRNAs were involved in 20 biological processes and 68 signal pathways.Compared to adjacent normal tissue,the expression of MAGEA11 was up-regulated;TCHH was down-regulated.These findings were verified by real-time PCR.These differentially expressed mRNAs may function as oncogenes or tumor suppressors in the development and progression of OSCC.This study provides novel insights into OSCC.However,further work is needed to determine if these differentially expressed mRNAs have potential roles as diagnostic biomarkers and candidate therapeutic targets for OSCC. | Liangyu Ge Siyu Liu Long Xie Lei Sang Changyan Ma Hongwei Li | 2015 | The Journal of Biomedical Research2015，29，5： | 4 |
| 17 | Interobserver agreement for contrast-enhanced ultrasound of liver imaging reporting and data system:A systematic review and metaanalysis显示文摘BACKGROUND Hepatocellular carcinoma is the most common primary liver malignancy.From the results of previous studies,Liver Imaging Reporting and Data System(LIRADS)on contrast-enhanced ultrasound(CEUS)has shown satisfactory diagnostic value.However,a unified conclusion on the interobserver stability of this innovative ultrasound imaging has not been determined.The present metaanalysis examined the interobserver agreement of CEUS LI-RADS to provide some reference for subsequent related research.AIM To evaluate the interobserver agreement of LI-RADS on CEUS and analyze the sources of heterogeneity between studies.METHODS Relevant papers on the subject of interobserver agreement on CEUS LI-RADS published before March 1,2020 in China and other countries were analyzed.The studies were filtered,and the diagnostic criteria were evaluated.The selected references were analyzed using the“meta”and“metafor”packages of R software version 3.6.2.RESULTS Eight studies were ultimately included in the present analysis.Meta-analysis results revealed that the summary Kappa value of included studies was 0.76[95%confidence interval,0.67-0.83],which shows substantial agreement.Higgins I2 statistics also confirmed the substantial heterogeneity(I2=91.30%,95%confidence interval,85.3%-94.9%,P<0.01).Meta-regression identified the variables,including the method of patient enrollment,method of consistency testing,and patient race,which explained the substantial study heterogeneity.CONCLUSION CEUS LI-RADS demonstrated overall substantial interobserver agreement,but heterogeneous results between studies were also obvious.Further clinical investigations should consider a modified recommendation about the experimental design. | Jun Li Ming Chen Zi-Jing Wang Shu-Gang Li Meng Jiang Long Shi Chun-Li Cao Tian Sang Xin-Wu Cui Christoph F Dietrich | 2020 | World Journal of Clinical Cases2020，8，22： | 2 |
| 18 | Catheter ablation for atrial fibrillation is associated with reduced risk of mortality in the elderly:a prospective cohort study and propensity score analysis显示文摘Background It is unclear whether catheter ablation(CA)for atrial fibrillation(AF)affects the long-term prognosis in the elderly.This study aims to evaluate the relationship between CA and long-term outcomes in elderly patients with AF.Methods Patients more than 75 years old with non-valvular AF were prospectively enrolled between August 2011 and December 2017 in the Chinese Atrial Fibrillation Registry Study.Participants who underwent CA at baseline were propensity score matched(1:1)with those who did not receive CA.The outcome events included all-cause mortality,cardiovascular mortality,stroke/transient ischemic attack(TIA),and cardiovascular hospitalization.Results Overall,this cohort included 571 ablated patients and 571 non-ablated patients with similar characteristics on 18 dimensions.During a mean follow-up of 39.75±19.98 months(minimum six months),24 patients died in the ablation group,compared with 60 deaths in the non-ablation group[hazard ratio(HR)=0.49,95%confidence interval(CI):0.30-0.79,P=0.0024].Besides,6 ablated and 29 non-ablated subjects died of cardiovascular disease(HR=0.25,95%CI:0.11-0.61,P=0.0022).A total of 27 ablated and 40 non-ablated patients suffered stroke/TIA(HR=0.79,95%CI:0.48-1.28,P=0.3431).In addition,140 ablated and 194 non-ablated participants suffered cardiovascular hospitalization(HR=0.84,95%CI:0.67-1.04,P=0.1084).Subgroup analyses according to gender,type of AF,time since onset of AF,and anticoagulants exposure in initiation did not show significant heterogeneity.Conclusions In elderly patients with AF,CA may be associated with a lower incidence of all-cause and cardiovascular mortality. | Xin SU Xin DU Shang-Xin LU Chao JIANG Jing DU Shi-Jun XIA Zhao-Jie DONG Zhao-Xu JIA De-Yong LONG Cai-Hua SANG Ri-Bo TANG Nian LIU Song-Nan LI Rong BAI Jian-Zeng DONG Chang-Sheng MA | 2020 | Journal of Geriatric Cardiology2020，17，12： | 2 |
| 19 | Factors associated with use of gastric cancer screening services in Korea显示文摘AIM: To identify the factors associated with participation in gastric cancer screening programs. METHODS: Using data from the Korea National Health and Nutrition Examination Survey 2005 (KNHANES Ⅲ), a nationwide health-related surveyin Korea, a cross-sectional study was performed to investigate the multiple factors associated with gastric cancer screening attendance among persons aged at least 40 years. The study population included 4593 individuals who completed a gastric cancer screening questionnaire and had no previous cancer history. Four groups ofindividual-level or environmental level covariates were considered as potential associated factors.RESULTS: Using KNHANES Ⅲdata, an estimated31.71% of Korean individuals aged at least 40 years adhered to gastric cancer screening recommendations. Subjects who graduated from elementary school[adjusted odds ratio (aOR), 1.66; 95% CI: 1.21-2.26], middle/high school (aOR, 1.38; 95% CI: 1.01-1.89), and university or higher (aOR, 1.64; 95% CI: 1.13-2.37) were more likely to undergo gastric cancer screening than those who received no formal education at all. The population with the highest income tertile had more attendance at gastric screening compared to those with the lowest income tertile (aOR, 1.36; 95% CI: 1.06-1.73). Gastric screening was also negatively associated with excessive alcohol consumption (aOR, 0.71; 95% CI: 0.53-0.96). A positive attitude to preventive medical evaluation was significantly associated with better participation in gastric cancer screening programs (aOR, 5.26; 95% CI: 4.35-6.35). CONCLUSION: Targeted interventions for vulnerable populations and public campaigns about preventive medical evaluation are needed to increase gastric cancer screening participation and reduce gastric cancer mortality. | Young Min Kwon Hyung Taek Lim Kiheon Lee Be Long Cho Min Sun Park Ki Young Son Sang Min Park | 2009 | World Journal of Gastroenterology2009，15，29： | 2 |
| 20 | Effects of PP4 suppression on the proliferation of MCF7 cells显示文摘PP4, one of the few protein phosphata- ses associated with centrosome in cells of many species such as Drosophila, C. elegans and mam- mals, plays an essential role in the regulation of cen- trosome functions in Drosophila and C. elegans. In order to explore the role of PP4 in mammalian cells, full-length PP4 gene was obtained by RT-PCR from MCF7 cell total RNA and inserted into eukaryotic expression vector pEGFP-C1. The resultant con- struct pEGFP-C1-PP4 was transfected into MCF7 cells and immunostaining was carried out to confirm the centrosome localization of PP4. Then we re- versely subcloned a non-conserved domain of PP4 into pXJ41 to construct an anti-sense vector pXJ41- as-PP4. By transfecting pXJ41-as-PP4 into MCF7 cells and screening with G418, we obtained a stable cell line in which PP4 expression was stably sup- pressed. The cell line was analyzed on cell mor- phology, cytoskeleton structure, growth characteris- tics and the mitosis process. It was found that the proliferation rate decreased and serum-dependence increased in PP4-suppressed cells. Furthermore, flow cytometry and mitotic index analysis showed that G2/M transition was prolonged. PP4 suppression resulted in abnormal interphase microtubule, forma- tion of multipolar spindles and an increase in per- centage of multinuclear cells. These results sug- gested that PP4 is required for centrosome function in mammalian cells. | NING Lifeng LONG Zhitao HUANG Xiuqing SUN Lingling SANG Jianli | 2006 | Chinese Science Bulletin2006，51，19： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员