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| 1 | Surface Rupture and Co-seismic Displacement Produced by the Ms 8.0 Wenchuan Earthquake of May ^(12)th,2008,Sichuan,China:Eastwards Growth of the Qinghai-Tibet Plateau显示文摘女士 8 的地震给 Wenchuan 以县,西方的四川,中国,在 2008 年 5 月 12 日并且导致了长表面破裂(> 300 km ) 。关于表面破裂的第一手的观察在 Yingxiu, Beichuan 和 Qingchuan 的最糟点击的区域由地震生产了,查明地震的原因的结构在 Longmenshan 构造的带的中央差错地区。沿着 Yingxiu-Beichuan 破裂地区活动范围 2.5-4 m 的单个差错的平均 co 地震的垂直排水量和越过中央、正面的 Longmenshan 差错的累积垂直排水量系上带子是大约 56 m。表面破裂力量从 Beichuan 的北方被归结为 Qingchuan 县和表演 23 m 右罢工滑倒部件。Wenchuan 指责戳的地震是在印度、欧亚的大陆的连续集中的行动下面的西藏的高原的东方生长的表明。 | DONG Shuwen ZHANG Yueqiao WU Zhenhan YANG Non MA Yinsheng SHI Wei CHEN Zhengle LONG Changxin AN Meijian | 2008 | Acta Geologica Sinica(English Edition)2008，82，5： | 59 |
| 2 | Major element,trace element,and Sr,Nd and Pb iso-tope studies of Cenozoic basalts from the South China Sea显示文摘The whole rock K-Ar ages of basalts from the South China Sea basin vary from 3.8 to 7.9 Ma, which suggest that intra-plate volcanism after the cessation of spreading of the South China Sea (SCS) is comparable to that in adjacent regions around the SCS, i.e., Leiqiong Peninsula, northern margin of the SCS, Indochina block, and so on. Based on detailed petrographic studies, we selected many fresh ba-saltic rocks and measured their major element, trace element, and Sr-Nd-Pb isotope compositions. Geochemical characteristics of major element and trace element show that these basaltic rocks belong to alkali basalt magma series, and are similar to OIB-type basalt. The extent of partial melting of mantle rock in source region is very low, and magma may experience crystallization differentiation and cu-mulation during the ascent to or storing in the high-level magma chamber. Sr-Nd-Pb isotopic data of these basaltic rocks imply an inhomogeneous mantle below the South China Sea. The nature of magma origin has a two end-member mixing model, one is EM2 (Enriched Mantle 2) which may be originated from mantle plume, the other is DMM (Depleted MORB Mantle). Pb isotopic characteristics show the Dupal anomaly in the South China Sea, and combined with newly found Dupal anomaly at Gakkel ridge in Arctic Ocean, this implies that Dupal anomaly is not only limited to South Hemisphere. In variation diagrams among Sr, Nd and Pb, the origin nature of mantle below the SCS is similar to those below Leiqiong peninsula, northern margin of the SCS and Indochina peninsula, and is different from those below north and northeast China. This study provides geochemical constraints on Hainan mantle plume. | YAN QuanShu SHI XueFa WANG KunShan BU WenRui XIAO Long | 2008 | Science China Earth Sciences2008，51，4： | 33 |
| 3 | Synthesis of novel nanomaterials and their application in efficient removal of radionuclides显示文摘With the development of nuclear energy, large amounts of radionuclides are inevitably released into the natural environment. It is necessary to eliminate radionuclides from wastewater for the protection of environment. Nanomaterials have been considered as the potential candidates for the effective and selective removal of radionuclides from aqueous solutions under complicated conditions because of their high specific surface area, large amounts of binding sites, abundant functional groups, pore-size controllable and easily surface modification. This review mainly summarized the recent studies for the synthesis, fabrication and surface modification of novel nanomaterials and their applications in the efficient elimination and solidification of radionuclides,and discussed the interaction mechanisms from batch experiments, spectroscopy analysis and theoretical calculations. The sorption capacities with other materials, advantages and disadvantages of different nanomaterials are compared, and at last the perspective of the novel nanomaterials is summarized. | Xiangxue Wang Long Chen Lin Wang Qiaohui Fan Duoqiang Pan Jiaxing Li Fangting Chi Yi Xie Shujun Yu Chengliang Xiao Feng Luo Jun Wang Xiaolin Wang Changlun Chen Wangsuo Wu Weiqun Shi Shuao Wang Xiangke Wang | 2019 | Science China Chemistry2019，62，8： | 20 |
| 4 | Clinical trial with traditional Chinese medicine intervention ''tonifying the kidney to promote liver regeneration and repair by affecting stem cells and their microenvironment'' for chronic hepatitis B-associated liver failure显示文摘AIM:To study the clinical efficacy of traditional Chinese medicine(TCM)intervention'tonifying the kidney to promote liver regeneration and repair by affecting stem cells and their microenvironment'('TTK')for treating liver failure due to chronic hepatitis B.METHODS:We designed the study as a randomized controlled clinical trial.Registration number of Chinese Clinical Trial Registry is Chi CTR-TRC-12002961.A total of 144 patients with liver failure due to infection with chronic hepatitis B virus were enrolled in this randomized controlled clinical study.Participants were randomly assigned to the following three groups:(1)a modern medicine control group(MMC group,36patients);(2)a'tonifying qi and detoxification'('TQD')group(72 patients);and(3)a'tonifying the kidney to promote liver regeneration and repair by affecting stem cells and their microenvironment'('TTK')group(36patients).Patients in the MMC group received general internal medicine treatment;patients in the'TQD'group were given a TCM formula'tonifying qi and detoxification'and general internal medicine treatment;patients in the'TTK'group were given a TCM formula of'TTK'and general internal medicine treatment.All participants were treated for 8 wk and then followed at 48 wk following their final treatment.The primaryefficacy end point was the patient fatality rate in each group.Measurements of various virological and biochemical indicators served as secondary endpoints.The one-way analysis of variance and the t-test were used to compare patient outcomes in the different treatment groups.RESULTS:At the 48-wk post-treatment time point,the patient fatality rates in the MMC,'TQD',and'TTK'groups were 51.61%,35.38%,and 16.67%,respectively,and the differences between groups were statistically significant(P<0.05).However,there were no significant differences in the levels of hepatitis B virus DNA or prothrombin activity among the three groups(P>0.05).Patients in the'TTK'group had significantly higher levels of serum total bilirubin compared to MMC subjects(339.40μmol/L±270.09μmol/L vs 176.13μmol/L±185.70μmol/L,P=0.014).Serum albumin levels were significantly increased in both the'TQD'group and'TTK'group as compared with the MMC group(31.30 g/L±4.77g/L,30.72 g/L±2.89 g/L vs 28.57 g/L±4.56 g/L,P<0.05).There were no significant differences in levels of alanine transaminase among the three groups(P>0.05).Safety data showed that there was one case of stomachache in the'TQD'group and one case of gastrointestinal side effect in the'TTK'group.CONCLUSION:Treatment with'TTK'improved the survival rates of patients with liver failure due to chronic hepatitis B.Additionally,liver tissue was regenerated and liver function was restored. | Han-Min Li Zhi-Hua Ye Jun Zhang Xiang Gao Yan-Ming Chen Xin Yao Jian-Xun Gu Lei Zhan Yang Ji Jian-Liang Xu Ying-He Zeng Fan Yang Lin Xiao Guo-Guang Sheng Wei Xin Qi Long Qing-Jing Zhu Zhao-Hong Shi Lian-Guo Ruan Jia-Yao Yang Chang-Chun Li Hong-Bin Wu Sheng-Duo Chen Xin-La Luo | 2014 | World Journal of Gastroenterology2014，20，48： | 20 |
| 5 | Efects of a bioartificial liver support system on a cetaminophen-induced acute liver failure canines显示文摘Seeinvitedcommentaryonpage286Subjectheadingsliversupportsystem;acuteliverfailure;canines;porcinehepatocytes;bioartificiallive... | XUE Yi Long 1, ZHAO Shi Feng 2, ZHANG Zuo Yun 1, WANG Yue Feng 1, LI Xin Jian 1, HUANG Xiao Qiang 3, LUO Yun 1, HUANG Ying Cai 4 and LIU Cheng Gui 1 | 1999 | World Journal of Gastroenterology1999，5，4： | 19 |
| 6 | ERK kinase phosphorylates and destabilizes the tumor suppressor FBW7 in pancreatic cancer显示文摘 | Shunrong Ji Yi Qin Si Shi Xiangyuan Liu Hongli HU Hu Zhou Jing Gao Bo Zhang Wenyan Xu Jiang Liu Dingkong Liang Liang Liu Chen Liu Jiang Long Haijun Zhou Paul J Chiao Jin Xu Quanxing Ni Daming Gao Xianjun Yu | 2015 | Cell Research2015，25，5： | 19 |
| 7 | Down-regulation of miR-622 in gastric cancer promotes cellular invasion and tumor metastasis by targeting ING1 gene显示文摘AIM:To evaluate the biological and clinical characteristics of miR-622 in gastric cancer. METHODS:We analyzed the expression of miR-622 in 57 pair matched gastric neoplastic and adjacent non-neoplastic tissues by quantitative real-time polymerase chain reaction. Functional analysis of miR-622 expression was assessed in vitro in gastric cancer cell lines with miR-622 precursor and inhibitor. The roles of miR-622 in tumorigenesis and tumor metastasis were analyzed using a stable miR-622 expression plasmid in nude mice. A luciferase reporter assay was used to assess the effect of miR-622 on inhibitor of growth family,member 1 (ING1) expression. RESULTS:Expression of miR-622 was down-regulated in gastric cancer. MiR-622 was found involved in differentia-tion and lymphatic metastasis in human gastric cancer. Ectopic expression of miR-622 promoted invasion,tumorigenesis and metastasis of gastric cancer cells both in vitro and in vivo. ING1 is a direct target of miR-622. CONCLUSION:These findings help clarify the molecular mechanisms involved in gastric cancer metastasis and indicate that miR-622 modulation may be a bona fide treatment of gastric cancer. | Xiao-Bo Guo Chang-Qing Jing Le-Ping Li Li Zhang Yu- Long Shi Jin-Shen Wang Jing-Lei Liu Chen-Sheng Li | 2011 | World Journal of Gastroenterology2011，17，14： | 16 |
| 8 | Xiaotan Sanjie decoction attenuates tumor angiogenesis by manipulating Notch-1-regulated proliferation of gastric cancer stem-like cells显示文摘AIM: To determine the underlying mechanisms of action and influence of Xiaotan Sanjie(XTSJ) decoction on gastric cancer stem-like cells(GCSCs). METHODS: The gastric cancer cell line MKN-45 line was selected and sorted by FACS using the cancer stem cell marker CD44; the stemness of these cells was checked in our previous study. In an in vitro study, the expression of Notch-1, Hes1, Vascular endothelial growth factor(VEGF), and Ki-67 in both CD44-positive gastric cancer stem-like cells(GCSCs) and CD44-negative cells was measured by Western blot. The effect of XTSJ serum on cell viability and on the above markers was measured by MTT assay and Western blot, respectively. In an in vivo study, the ability to induce angiogenesis and maintenance of GCSCs in CD44-positive-MKN-45- and CD44-negative-engrafted mice were detected by immunohistochemical staining using markers for CD34 and CD44, respectively. The role of XTSJ decoction in regulating the expression of Notch-1, Hes1, VEGF and Ki-67 was measured by Western blot and real-time polymerase chain reaction.RESULTS: CD44+ GCSCs showed more cell proliferation and VEGF secretion than CD44-negative cells in vitro, which were accompanied by the high expression of Notch-1 and Hes1 and positively associated with tumor growth(GCSCs vs CD44-negative cells, 2.72 ± 0.25 vs 1.46 ± 0.16, P < 0.05) and microvessel density(MVD)(GCSCs vs CD44-negative cells, 8.15 ± 0.42 vs 3.83 ± 0.49, P < 0.001) in vivo. XTSJ decoction inhibited the viability of both cell types in a dose-dependent manner in vitro. Specifically, a significant difference in the medium-(82.87% ± 6.53%) and high-dose XTSJ groups(77.43% ± 7.34%) was detected at 24 h in the CD44+ GCSCs group compared with the saline group(95.42% ± 5.76%) and the low-dose XTSJ group(90.74% ± 6.57%)(P < 0.05). However, the efficacy of XTSJ decoction was reduced in the CD44- groups; significant differences were only detected in the high-dose XTSJ group at 48 h(78.57% ± 6.94%) and 72 h(72.12% ± 7.68%) when compared with the other CD44- groups(P < 0.05). Notably, these differences were highly consistent with the Notch-1, Hes1, VEGF and Ki-67 expression in these cells. Similarly, in vivo, XTSJ decoction inhibited tumor growth in a dose-dependent manner. A significant difference was observed in the medium(1.76 ± 0.15) and high-dose XTSJ(1.33 ± 0.081) groups compared with the GCSCs control group(2.72 ± 0.25) and the low-dose XTSJ group(2.51 ± 0.25)(P < 0.05). We also detected a remarkable decrease of MVD in the medium-(7.10 ± 0.60) and high-dose XTSJ(5.99 ± 0.47) groups compared with the GCSC control group(8.15 ± 0.42) and the low-dose XTSJ group(8.14 ± 0.46)(P < 0.05). Additionally, CD44 expression was decreased in these groups [medium-(4.43 ± 0.45) and high-dose XTSJ groups(3.56 ± 0.31) vs the GCSC control(5.96 ± 0.46) and low dose XTSJ groups(5.91 ± 0.38)](P < 0.05). The significant differences in Notch-1, Hes1, VEGF and Ki-67 expression highly mirrored the results of XTSJ decoction in inhibiting tumor growth, MVD and CD44 expression.CONCLUSION: Notch-1 may play an important role in regulating the proliferation of GCSCs; XTSJ decoction could attenuate tumor angiogenesis, at least partially, by inhibiting Notch-1. | Bing Yan Long Liu Ying Zhao Li-Juan Xiu Da-Zhi Sun Xuan Liu Ye Lu Jun Shi Yin-Cheng Zhang Yong-Jin Li Xiao-Wei Wang Yu-Qi Zhou Shou-Han Feng Can Lv Pin-Kang Wei Zhi-Feng Qin | 2014 | World Journal of Gastroenterology2014，20，36： | 14 |
| 9 | Modeling and optimal energy management of a power split hybrid electric vehicle显示文摘With the combination modes of engine and two electric machines,the power split device allows higher efficiency of the engine.The operation and of a power split HEV are analyzed,and the system dynamic model HEV is established event-driven for HEV forward system simulation dynamics controller design.Considering the mode,the fact the mode that the operation modes of is the are and the the is continuous theory.time-driven this for each structure selection of the controller built and the described finite with hybrid automaton control In control structure,process is depicted by the state mode machine(FSM).The multi-mode switch controller is designed to realize power distribution.Furthermore,vehicle operations programming are optimized,and finite the prediction nonlinear model horizon.predictive control(NMPC)strategy is applied by that implementing the dynamic(DP)and in the Comparative simulation The results optimal demonstrate strategy hybrid in control structure is effective feasible for HEV energy management design.NMPC is superior improving fuel economy. | SHI DeHua WANG ShaoHua Pierluigi Pisu CHEN Long WANG RuoChen WANG RenGuang | 2017 | Science China(Technological Sciences)2017，60，5： | 14 |
| 10 | Selection of Adaptive Grass and Frutex and Their Planting Benefits in the Arid-Hot Valleys of Yuanmou显示文摘In view of the environment character of the soil and content of the soil organic carbon, 278 species of grass and frutex were introduced from abroad and China, Some were selected by applied production and plantation benefit investigations. The results showed that:In the arid-hot valleys of Yuanmou the selected species showed the characteristics of fast growth and high yield (38 227.00 kg/hm2), high nutrition value (CP% content of legu-minous grass and frutex were 22.47%), as well as the strong adversity resistance to high air temperature and arid climate (soil humidity was 3.4%). The selected species not only effectively meliorated soil and increased fertility, but also improved small environment weather. | LONG Huiying SHA Yucang ZHU Hongye ZHANG Yingcui JIN Jie SHI Liangtao | 2008 | Wuhan University Journal of Natural Sciences2008，13，3： | 13 |
| 11 | Identification of a Newly Isolated Getah Virus in the China-Laos Border,China显示文摘In this study, we isolated a virus strain(YN12031) from specimens of Armigeres subalbatus collected in the China-Laos border. BHK-21 cells infected with YN12031 exhibited an evident cytopathic effect(CPE) 32 h post-infection. The virus particles were spherical, 70 nm in diameter, and enveloped; they also featured surface fibers. Molecular genetic analysis revealed that YN12031 was closely related to alpha viruses such as Chikungunya virus and Sindbis virus, and located in the same clade as MM2021, the prototype of Getahvirus(GETV) isolated in Malaysia in 1955. Phylogenetic analysis of the E2 and capsid genes further revealed that YN12031 was located in the same clade as the Russian isolate LEIV/16275/Mag. Analysis of the homology of nucleotides and amino acids in the coding area and E2 gene demonstrated that the YN12031 isolated from the China-Laos border(tropical region) was related closest to the LEIV/16275/Mag isolate obtained in Russia(North frigid zone area) among other isolates studied. These results suggest that GETV can adapt to different geographical environments to propagate and evolve. Thus, strengthening the detection and monitoring of GETV and its related diseases is very crucial. | LI Yuan Yuan FU Shi Hong GUO Xiao Fang LEI Wen Wen LI Xiao Long SONG Jing Dong CAO Lei GAO Xiao Yan LYU Zhi HE Ying WANG Huan Yu REN Xiao Jie ZHOU Hong Ning WANG Gui Qin LIANG Guo Dong | 2017 | Biomedical and Environmental Sciences2017，30，3： | 12 |
| 12 | Diagnostic accuracy of transient elastography (Fibro Scan) in detection of esophageal varices in patients with cirrhosis: A meta-analysis显示文摘AIM To investigate the diagnostic accuracy of Fibro Scan(FS) in detecting esophageal varices(EV) in cirrhotic patients.METHODS Through a systemic literature search of multiple databases, we reviewed 15 studies using endoscopy as a reference standard, with the data necessary to calculate pooled sensitivity(SEN) and specificity(SPE), positive and negative LR, diagnostic odds ratio(DOR) and area under receiver operating characteristics(AUROC). The quality of the studies was rated by the Quality Assessment of Diagnostic Accuracy studies-2 tool. Clinical utility of FS for EV was evaluated by a Fagan plot. Heterogeneity was explored using meta-regression and subgroup analysis. All statistical analyses were conducted via Stata12.0, MetaD isc1.4 and RevM an5.RESULTS In 15 studies(n = 2697), FS detected the presence of EV with the summary sensitivities of 84%(95%CI: 81.0%-86.0%), specificities of 62%(95%CI: 58.0%-66.0%), a positive LR of 2.3(95%CI: 1.81-2.94), a negative LR of 0.26(95%CI: 0.19-0.35), a DOR of 9.33(95%CI: 5.84-14.92) and an AUROC of 0.8262. FS diagnosed the presence of large EV with the pooled SEN of 0.78(95%CI: 75.0%-81.0%), SPE of 0.76(95%CI: 73.0%-78.0%), a positive and negative LR of 3.03(95%CI: 2.38-3.86) and 0.30(95%CI: 0.23-0.39) respectively, a summary diagnostic OR of 10.69(95%CI: 6.81-16.78), and an AUROC of 0.8321. A meta-regression and subgroup analysis indicated different etiology could serve as a potential source of heterogeneity in the diagnosis of the presence of EV group. A Deek's funnel plot suggested a low probability for publication bias.CONCLUSION Using FS to measure liver stiffness cannot provide high accuracy for the size of EV due to the various cutoff and different etiologies. These limitations preclude widespread use in clinical practice at this time; therefore, the results should be interpreted cautiously given its SEN and SPE. | Ke Pu Jing-Hong Shi Xu Wang Qian Tang Xin-Jie Wang Kai-Lin Tang Zhong-Qi Long Xing-Sheng Hu | 2017 | World Journal of Gastroenterology2017，23，2： | 12 |
| 13 | MicroRNA-191 targets N-deacetylase/N-sulfotransferase 1 and promotes cell growth in human gastric carcinoma cell line MGC803显示文摘作为基因表示的 post-transcriptional 管理者的一个家庭, microRNAs (miRNAs ) 控制包括房间区别,增长和 apoptosis 的生物进程的一个宽数组,和 miRNAs 的 dysregulation 是癌症的一个特点。这里,我们发现 microRNA-191 (miR-191 ) 在在人的胃的腺癌房间线 MGC803 和人的胃的癌症纸巾的高表示的水平。-2,5-diphenyltetrazolium 溴化物和殖民地形成试金显示出的 3-(4,5-dimethylthiazol-2-yl ) 的结果那 miR-191 能支持房间生长并且压制 MGC803 房间的 apoptosis。N-deacetylase/N-sulfotransferase 1 (NDST1 ) 被证实是提高的绿色边的 miR-191 的直接目标基因荧光灯蛋白质记者实验。NDST1 的 mRNA 和蛋白质层次相反地在 MGC803 房间与 miR-191 被相关,建议由 miR-191 的 NDST1 的否定规定。而且, NDST1 起了一个禁止的作用并且能压制 MGC803 房间增长。我们的调查结果建议 miR-191 能在 MGC803 房间充当 oncogene,并且细胞的功能部分由于它 NDST1 的否定规定。 | Xuejun Shi Shicang SU Jian Long Bing Mei Yajun Chen | 2011 | Acta Biochimica et Biophysica Sinica2011，43，11： | 12 |
| 14 | Seasonal and inter-annual variations in carbon fluxes and evapotranspiration over cotton field under drip irrigation with plastic mulch in an arid region of Northwest China显示文摘Xinjiang is the largest semi-arid and arid region in China, and drip irrigation under plastic mulch is widely used in this water-limited area. Quantifying carbon and water fluxes as well as investigating their environmental drivers over cotton fields is critical for understanding regional carbon and water budgets in Xinjiang, the largest cotton production basin of China. In this study, an eddy covariance(EC) technique was used to measure the carbon and water fluxes of cotton field under drip irrigation with plastic mulch in the growing seasons of 2009, 2010, 2012 and 2013 at Wulanwusu Agrometeorological Experiment Station, a representative oasis cropland in northern Xinjiang. The diurnal patterns of gross primary production(GPP), net ecosystem exchange(NEE) and evapotranspiration(ET) showed obviously sinusoidal variations from June to September, while the diurnal ecosystem respiration(Res) was stable between daytime and nighttime. The daytime hourly GPP and ET displayed asymptotic relationships with net solar radiation(Rnet), while showed concave patterns with raising vapor pressure deficit(VPD) and air temperature(Ta). The increases in hourly GPP and ET towards the maximum occurred over half ranges of VPD and Ta. The seasonal variations of GPP, NEE and ET were close to the cotton phenology, which almost reached the peak value in July. The cumulative GPP averaged 816.2±55.0 g C/m2 in the growing season(from April to October), and more than half of GPP was partitioned into NEE(mean value of –478.6±41.4 g C/m2). The mean seasonal ET was 501.3±13.9 mm, and the mean water use efficiency(WUE) was 1.0±0.1(mg C/g H2O)/d. The agro-ecosystem behaved as a carbon sink from squaring to harvest period, while it acted as a carbon source before the squaring time as well as after the harvest time. | Jie BAI Jin WANG Xi CHEN Ge Ping LUO Hao SHI Long Hui LI Jun Li LI | 2015 | Journal of Arid Land2015，7，2： | 12 |
| 15 | Facile synthesis of ultrathin metal-organic framework nanosheets for Lewis acid catalysis显示文摘Ultrathin metalorganic framework (MOF) nanosheets are attracting great interest in catalysis due to their unique and intriguing two-dime nsional (2D) features. Although many progresses have been achieved, it is still highly desirable to develop novel strategies for controllable synthesis of the well-defined ultrathin MOF nanosheets. Herein we report a polyvinylpyrrolidone (PVP)-assisted route to synthesize the ultrathin Ni-MOF nanosheets characteristic of 1.5 nm in thickness, in which PVP is reacted with 2-aminoterephthalic acid (H2BDC-NH2) via formation of C=N bon d, followed by coord inatio n with Ni2+ io ns to form the ultrathi n MOF n anosheets. Impressively, when used in the Kno eve nagel condensation reactions of propane dinitrile with different aldehydes, ultrathin Ni-MOF nanosheets display the significantly enhanced catalytic activity and good stability in respect with the bulk Ni-MOF, mainly owing to the exposed active sites as well as facile mass transfer and diffusion of substrates and products. | Xiaofei Zhang Lin Chang Zhongjie Yang Yanan Shi Chang Long Jianyu Han Binhao Zhang Xueying Qiu Guodong Li Zhiyong Tang | 2019 | Nano Research2019，12，2： | 11 |
| 16 | Bedaquiline-containing regimens in patients with pulmonary multidrug-resistant tuberculosis in China:focus on the safety显示文摘Background:World Health Organization recommends countries introducing new drug and short treatment regimen for drug resistant tuberculosis(DR-TB)should develop and implement a system for active pharmacovigilance that allows for detection,reporting and management of adverse events.The aim of the study is to evaluate the frequency and severity of adverse events(AEs)of bedaquiline-containing regimen in a cohort of Chinese patients with multidrug-resistant(MDR)/extensively drug-resistant(XDR)-TB based on active drug safety monitoring(aDSM)system of New Drug Introduction and Protection Program(NDIP). | Jing-Tao Gao Juan Du Gui-Hui Wu Yi Pei Meng-Qiu Gao Leonardo Martinez Lin Fan Wei Chen Li Xie Yu Chen Hua Wang Long Jin Guo-Bao Li Pei-Lan Zong Yu Xiong Qian-Hong Wu Ming-Wu Li Xiao-Feng Yan Yan-Fang Miao Qing-Shan Cai Xin-Jie Li Da-Peng Bai Shu-Jun Geng Guo-Li Yang Pei-JunTang Yi Zeng Xiao-Hong Chen Tong-Xia Li Cui Cai Yun Zhou Ma Zhuo Jian-Yun Wang Wen-Long Guan Lin Xu Ji-Chan Shi Wei Shu Li-Li Cheng FeiTeng Yu-Jia Ning Shi-Heng Xie Yu-Xian Sun Li-Jie Zhang Yu-Hong Liu | 2021 | Infectious Diseases of Poverty2021，10，2： | 11 |
| 17 | Internal solitons in the northern South China Sea from insitu observations显示文摘In this paper, we demonstrate the characteris- tics of strong internal solitons at the southern edge of Dong- sha Islands in the northern South China Sea (SCS) during May―June 1998, using in situ time series data from the con- ductivity temperature depth (CTD), acoustic Doppler current profiler (ADCP) and thermistor chain. Our measurements indicated that the strongest internal solitons were larger than 90 m in wave amplitude, and propagated approximately westward in traveling direction, with the maximum current speed of about 2 m/s and the period of 10―20 min. The strongest internal solitons occurred noticeably during May 14―16, 1998, which is consistent with the occurrence period of the diurnal-dominated spring internal tides. | FANG Wendong SHI Ping LONG Xiaomin MAO Qingwen | 2005 | Chinese Science Bulletin2005，50，15： | 10 |
| 18 | The Tuerkubantao ophiolite melange in Xinjiang,NW China:New evidence for the Erqis suture zone显示文摘The extension of the suture zone between the Siberian and Kazakhstan continents in China has been a matter of debate because few outcrops of ophiolitic melange have been found so far.The recently found Tuerkubantao ophiolitic melange,which is located east of the Kekesentao Mt.in the Buerjin County of the Chinese Altay,provides an important clue for this problem.This paper presents the results of field investigation,petrology,U-Pb isotope dating of zircons and bulk-rock geochemistry of the Tuerkubantao melange rocks.The melange consists of fault-contacted ultramafic rocks,gabbro, diabase,basalt,flysch and granitoids.The ultramafic-mafic rocks are Mg-rich(Mg~#=4.25—6.35) and w(SiO_2) spans 38.8%—46.8%.Basalt and gabbro are geochemically similar and are characterized by low w(FeO^t)(10.9%),total alkali w(Na_2O+K_2O)=2.58%) and w(TiO_2)(1.17%) and affinity to the Mg-rich tholeiite series.The flat REE and trace-element patterns of the ultramafic-mafic rocks are indicative of their ophiolite origin,i.e.,formation in a mid-oceanic ridge setting.The fragments of low-K gneissic granite formed in suprasubduction or syn-collisional setting.Zircons from gabbro and gneissic granite yielded U-Pb ages of 363 and 355 Ma.respectively,suggesting Late Devonian mid-oceanic spreading and oceanic subduction accompanied by suprasubduction magmatism.The Tiierkubantao ophiolite together with the Qiaoxiahala and Buergen ophiolites of the Kekesentao belt define an ophiolitic melange belt extending along the Erqis fault.This belt probably belongs to the Ural-Zaisan -South Mongolian suture-shear zone formed during the subduction of the Paleo-Asian Ocean and subsequent collision of the Siberian and Kazakhstan continents. | Yuwang Wang Jingbin Wang Lijuan Wang Lingli Long Pingzhi Tang Zhen Liao Huiqiong Zhang Yu Shi | 2012 | Geoscience Frontiers2012，3，5： | 9 |
| 19 | Simulation of Morphological Development of Soil Cracks in Yuanmou Dry-hot Valley Region, Southwest China显示文摘Soil cracking is an important process influencing water and solutes transport in the Yuanmou Dry-hot Valley region of Southwest China. Studying the morphological development of soil cracks helps to further reveal the close relationship between the soil cracking process and water movement in such semi-arid regions. Here we report regular changes on surface morphology of soil cracks with decreasing water in four different soils (Typ-Ustic Ferrisols,Ver-Ustic Ferrisols,Tru-Ustic Vertisols and Typ-Ustic Vertisols) through simulation experiments. Our results indicate the following: 1) Different soils ultimately have different development degrees of soil cracks,according to their various values of crack area density. Soil cracks in Typ-Ustic Ferrisols can only develop to the feeble degree,while those in the other three soils are capable of developing into the intensive degree,and even into the extremely intensive degree. 2) Soil crack complexity,as expressed by the value of the area-weighted mean of crack fractal dimension (AWMFRAC),is found to continuously decrease as a whole through the whole cracking process in all the studied soils. 3) Soil crack connectivity shows a uniform trend in the studied soils,that is to say,connectivity gradually increases with soil crack development. | XIONG Donghong YAN Dongchun LONG Yi LU Xiaoning HAN Jianning HAN Xueqin SHI Liangtao | 2010 | Chinese Geographical Science2010，20，2： | 8 |
| 20 | Cadmium Activates Reactive Oxygen Species-dependent AKT/mT OR and Mitochondrial Apoptotic Pathways in Neuronal Cells显示文摘Objective To examine the role of Cd-induced reactive oxygen species(ROS)generation in the apoptosis of neuronal cells.Methods Neuronal cells(primary rat cerebral cortical neurons and PC12 cells)were incubated with or without Cd post-pretreatment with rapamycin(Rap)or N-acetyl-L-cysteine(NAC).Cell viability was determined by MTT assay,apoptosis was examined using flow cytometry and fluorescence microscopy,and the activation of phosphoinositide 3'-kinase/protein kinase B(Akt)/mammalian target of rapamycin(m TOR)and mitochondrial apoptotic pathways were measured by western blotting or immunofluorescence assays.Results Cd-induced activation of Akt/m TOR signaling,including Akt,m TOR,p70 S6 kinase(p70 S6K),and eukaryotic initiation factor 4E binding protein 1(4E-BP1).Rap,an m TOR inhibitor and NAC,a ROS scavenger,blocked Cd-induced activation of Akt/m TOR signaling and apoptosis of neuronal cells.Furthermore,NAC blocked the decrease of B-cell lymphoma 2/Bcl-2 associated X protein(Bcl-2/Bax)ratio,release of cytochrome c,cleavage of caspase-3 and poly(ADP-ribose)polymerase(PARP),and nuclear translocation of apoptosis-inducing factor(AIF)and endonuclease G(Endo G).Conclusion Cd-induced ROS generation activates Akt/m TOR and mitochondrial pathways,leading to apoptosis of neuronal cells.Our findings suggest that m TOR inhibitors or antioxidants have potential for preventing Cd-induced neurodegenerative diseases. | YUAN Yan WANG Yi HU Fei Fei JIANG Chen Yang ZHANG Ya Jing YANG Jin Long ZHAO Shi Wen GU Jian Hong LIU Xue Zhong BIAN Jian Chun LIU Zong Ping | 2016 | Biomedical and Environmental Sciences2016，29，2： | 8 |
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