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| 1 | A New Four-Ary Run-Length-Limited (2,12) Code for Multilevel Optical Recording Channels显示文摘 | Hua HU Duanyi XU Longfa PAN | 2005 | Japanese Journal of Applied Physics2005，44，12： | 1 |
| 2 | Trophic Mode-Dependent Proteomic Analysis Reveals Functional Significance of Light- Independent Chlorophyll Synthesis in Synechocystis sp. PCC 6803显示文摘光合的模型有机体 Synechocystis sp。PCC 6803 能在不同营养的模式成长,取决于光和外长的器官的碳来源的可获得性。然而,便于房间差别的蛋白质侧面变化怎么在不同模式宣传,包括地没被调查。用等压的基于标签的量的 proteomics,我们同时识别了并且确定越过四个不同营养的模式的 45% Synechocystis proteome,即,自造营养物质,不是自养, photoheterotrophic,和 mixotrophic 模式。在是越过四个营养的模式表示的差别的 155 蛋白质之中,涉及氮吸收和光无关的叶绿素合成的蛋白质是戏剧性地在 mixotrophic 模式的 upregulated,有 P 察觉到的 II phosphorylation 碳和氮吸收地位。而且,用在光无关的叶绿素合成的一个变异的有缺陷者的功能的学习表明这条小径为在骑车的光 / 黑暗的照明政体下面的叶绿素累积是重要的,一条件 mimicking 天 / 夜里在某些自然产地骑车。一起,这些结果在 cyanobacterium 在营养的模式依赖者蛋白质表示上提供最全面的信息,并且在营养的生长揭示光无关的叶绿素合成的功能的意义。 | Longfa Fang Haitao Ge Xiahe Huana Ye Liu Min Lu Jinlong Wang Weiyang Chen Wu Xu Yingchun Wang | 2017 | Molecular Plant2017，10，1： | 0 |
| 3 | Development of A Neonatal Mouse Model for Coxsackievirus B1 Antiviral Evaluation显示文摘Coxsackievirus B1(CVB1) is a leading causative agent of severe infectious diseases in humans and has been reported to be associated with outbreaks of aseptic meningitis, myocarditis, and the development of chronic diseases such as type 1 diabetes mellitus(T1DM). There is no approved vaccine or effective antiviral therapy to treat CBV1 infection. And animal models to assess the effects of antiviral agents and vaccine remain limited. In this study, we established a neonatal mouse model of CVB1 using a clinically isolated strain to characterize the pathological manifestations of virus infection and to promote the development of vaccines and antiviral drugs against CVB1. One-day-old BALB/c mice were susceptible to CVB1 infection by intraperitoneal injection. Mice challenged with CVB1 at a low dose [10 median tissue culture infective dose(TCID_(50))] exhibited a series of clinical symptoms, such as inactivity, emaciation, limb weakness, hair thinning,hunching and even death. Pathological examination and tissue viral load analysis showed that positive signals of CVB1 were detected in the heart, spinal cord, limb muscle and kidney without pathological damage. Particularly, CVB1 had a strong tropism towards the pancreas, causing severe cellular necrosis with inflammatory infiltration, and was spread by viraemia. Notably, the monoclonal antibody(mAb) 6H5 and antisera elicited from CVB1-vaccinated mice effectively protected the mice from CVB1 infection in the mouse model. In summary, the established neonatal mouse model is an effective tool for evaluating the efficacy of CVB1 antiviral reagents and vaccines. | Zhichao Yin Yuanyuan Wu Rui Zhu Longfa Xu Yu Lin Hongwei Yang Wenkun Fu Qiongzi Huang Dongqing Zhang Jue Wang Wei Wang Yingbin Wang Tong Cheng Ningshao Xia | 2021 | Virologica Sinica2021，36，6： | 0 |
| 4 | The quantitative proteome atlas of a model cyanobacterium显示文摘Cyanobacteria are a group of oxygenic photosynthetic bacteria with great potentials in biotechnological applications and advantages as models for photosynthesis research. The subcellular localizations of the majority of proteins in any cyanobacteria remain undetermined, representing a major challenge in using cyanobacteria for both basic and industrial researches. Here, using label-free quantitative proteomics, we map 2027 proteins of Synechocystis sp. PCC6803, a model cyanobacterium, to different subcellular compartments and generate a proteome atlas with such information. The atlas leads to numerous unexpected but important findings, including the predominant localization of the histidine kinases Hik33 and Hik27 on the thylakoid but not the plasma membrane. Such information completely changes the concept regarding how the two kinases are activated. Together, the atlas provides subcellular localization information for nearly 60% proteome of a model cyanobacterium, and will serve as an important resource for the cyanobacterial research community. | Jinlong Wang Xiahe Huang Haitao Ge Yan Wang Weiyang Chen Limin Zheng Chengcheng Huang Haomeng Yang Lingyu Li Na Sui Yu Wang Yuanya Zhang Dandan Lu Longfa Fang Wu Xu Yuqiang Jiang Fang Huang Yingchun Wang | 2022 | Journal of Genetics and Genomics2022，49，2： | 0 |
| 5 | Determination of total flavonoids and its antioxidant activity in the exocarp of Aronia melanocarpa显示文摘As a kind of berry food rich in flavonoids,the determination method of total flavonoids content of Aronia melanocarpa is of great significance.This paper compares the applicability of NaNO_(2)-Al(NO_(3))_(3)-NaOH colorimetry and AlCl_(3)colorimetry to total flavonoids content of the exocarp of Aronia melanocarpa by Ultraviolet-visible Spectrophotometry.At the same time,we determined hydroxyl radical(OH·-)inhibition rate,superoxide anion radical(O_(2)·-)inhibition rate and 1,1-diphenyl-2-picrylhydrazyl radical free radical(DPPH·)scavenging rate of total flavonoids extracted from Aronia melanocarpa.It is found that AlCl_(3)colorimetry has good repeatability,precision,and accuracy.The method is suitable for the determination of total flavonoids in the exocarp of Aronia melanocarpa.Thus,by the established method the content of total flavonoids in the exocarp of Aronia melanocarpa was determined as high as(36.711±0.034)mg/g.The results of antioxidant activity showed superoxide anion radical scavenging ability,hydroxyl radical scavenging ability and DPPH radical scavenging ability of the total flavonoids extract reached 45.33%,87.87%and 98.05%,respectively,indicating that it had good antioxidant activity. | Longfa Li Weizhuo Xu Wei Xu Ming Song | 2022 | Journal of Polyphenols2022，4，2： | 0 |
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