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| 1 | Drp1-dependent remodeling of mitochondrial morphology triggered by EBV-LMP1 increases cisplatin resistance显示文摘Latent membrane protein 1(LMP1)is a major Epstein–Barr virus(EBV)-encoded oncoprotein involved in latency infection that regulates mitochondrial functions to facilitate cell survival.Recently,mitochondrial fission has been demonstrated as a crucial mechanism in oncovirus-mediated carcinogenesis.Mitochondrial dynamin-related protein 1(Drp1)-mediated mitochondrial fission has an impact on the chemoresistance of cancers.However,the mechanism by which oncogenic stress promotes mitochondrial fission,potentially contributing to tumorigenesis,is not entirely understood.The role of Drp1 in the oncogenesis and prognosis of EBV-LMP1-positive nasopharyngeal carcinoma(NPC)was determined in our study.We show that EBV-LMP1 exhibits a new function in remodeling mitochondrial morphology by activating Drp1.A high level of p-Drp1(Ser616)or a low level of p-Drp1(Ser637)correlates with poor overall survival and disease-free survival.Furthermore,the protein level of p-Drp1(Ser616)is related to the clinical stage(TNM stage)of NPC.Targeting Drp1 impairs mitochondrial function and induces cell death in LMP1-positive NPC cells.In addition,EBV-LMP1 regulates Drp1 through two oncogenic signaling axes,AMPK and cyclin B1/Cdk1,which promote cell survival and cisplatin resistance in NPC.Our findings provide novel insight into the role of EBV-LMP1-driven mitochondrial fission in regulating Drp1 phosphorylation at serine 616 and serine 637.Disruption of Drp1 could be a promising therapeutic strategy for LMP1-positive NPC. | Longlong Xie Feng Shi Yueshuo Li We Li Xinfang Yu Lin Zhao Min Zhou Jianmin Hu Xiangjian Luo Min Tang Jia Fan Jian Zhou Qiang Gao Weizhong Wu Xin Zhang Weihua Liao Ann MBode Ya Cao | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 1 |
| 2 | Unusual Transforma-tion from Strong Negative to Positive Thermal Expansion in PbTi03-BiFe03 Perovskite 显示文摘 | Chen Jun Fan Longlong Ren Yang | 2013 | Physical Review Letters2013，110，11： | 1 |
| 3 | Non-target plant testing of the flea beetle Agasicles hygrophila, a biological control agent for Alternanthera philoxeroides (alligatorweed) in China显示文摘 | Junjiao Lu Longlong Zhao Ruiyan Ma Renjun Fan Jintong Zhang Ren Wang | 2012 | Biocontrol Science and Technology2012，，9： | 1 |
| 4 | Unusual Transforma-tion from Strong Negative to Positive Thermal Expansion in PbTi03-BiFe03 Perovskite 显示文摘 | Chen Jun Fan Longlong Ren Yang | 2013 | Phys Rev Lett2013，110，11： | 1 |
| 5 | Semi-empirical estimation for enhancing negative thermal expansion in PbTiO_(3)-based perovskites显示文摘Generally,most materials expand when heated and contract when cooled,whereas negative thermal expansion(NTE)materials are very rare.As a typical NTE material,PbTiO_(3) and related compounds have drawn particular interest in recent years.The discovery of an enhanced NTE system in PbTiO_(3) is beneficial to deepen our understanding of its mechanism and regulate its properties.At present,the method of discriminating an enhanced NTE material based on PbTiO_(3) is not universal.Here,we propose a semi-empirical method through evaluating the average lattice distortion in related systems to estimate the relative coefficient of thermal expansion conveniently.The rationality of the method was verified by the analysis of the 0.6PbTiO_(3)-0.4Bi(Ga_(x)Fe_(1-x))O_(3) system.So far,all PbTiO_(3)-based compounds with enhanced NTE conform well to this method.This method provides the possibility to find more enhanced NTE PbTiO_(3)-based materials. | Tao Yang Longlong Fan Yilin Wang Kun Lin Jun Chen Xianran Xing | 2022 | International Journal of Minerals,Metallurgy and Materials2022，29，4： | 1 |
| 6 | Unusual Transformationfrom Strong Negative to Positive Thermal Expansion in PbTi03 -BiFe03 Perovskite 显示文摘 | Chen Jun Fan Longlong Ren Yang | 2013 | Physical Review Letters2013，，11： | 1 |
| 7 | Gas-phase Chemistry of Carbonyl Complexes Formed in Hot-atom Reactions with Short-lived Isotopes of Mo显示文摘 | Wang Yang Qin Zhi Fan Fangli Cao Shiwei Wu Xiaolei Fan Fuyou Tian Longlong Zhao Liang Guo Junsheng H. W. Gaeggeler | 2011 | IMP & HIRFL Annual Report2011，，1： | 0 |
| 8 | Chemical Properties of Volatile Mo, Tc and Ru Carbonyl Complexes显示文摘 | Wang Yang Qin Zhi Fan Fangli Cao Shiwei Wu Xiaolei Fan Fuyou Tian Longlong Zhao Liang Guo Junsheng H. W. Gaeggeler | 2011 | IMP & HIRFL Annual Report2011，，1： | 0 |
| 9 | Correction:Drp1-dependent remodeling of mitochondrial morphology triggered by EBV-LMP1 increases cisplatin resistance显示文摘Correction to:Signal Transduction and Targeted Therapy(2020)5:56,http://gffzzd3cc09b8251d45dfs9qxonn9fbfo960wk.ffgz.tsg.suse.edu.cn/10.1038/s41392-020-0151-9,published online 20 May 2020 In this article1 an error was noticed in Fig.3d left(p-Drp1 Ser637).The images were misassigned.And one writing error was found in Fig.S1c.The correct figures are given.The authors confirm that these corrections do not change the result interpretation or conclusions of the article. | Longlong Xie Feng Shi Yueshuo Li We Li Xinfang Yu Lin Zhao Min Zhou Jianmin Hu Xiangjian Luo Min Tang Jia Fan Jian Zhou Qiang Gao Weizhong Wu Xin Zhang Weihua Liao Ann M.Bode Ya Cao | 2023 | Signal Transduction and Targeted Therapy2023，8，1： | 0 |
| 10 | 2 - 41 Gas Phase Chemistry of Short-lived W and Os Carbonyls显示文摘 | Wang Yang Qin Zhi Fan Fangli Cao Shiwei Wu Xiaolei Fan Fuyou Tian Longlong Zhao Liang Guo Junsheng H. W. Gaeggeler | 2012 | IMP & HIRFL Annual Report2012，，1： | 0 |
| 11 | Phase engineering oriented defect-rich amorphous/crystalline RuO_(2) nanoporous particles for boosting oxygen evolution reaction in acid media显示文摘Imposing phase engineering to porous materials is promising to realize outperforming electrocatalytic performances by taking advantages of the merits of porous nanoarchitecture and heterophase structure.In this work,amorphous/crystalline ruthenium oxide(RuO_(2))porous particles with rationally regulated heterophases are successfully prepared by integrating the phase engineering into the porous material synthesis.The resultant defect-rich amorphous/crystalline RuO_(2)porous particles exhibit excellent electrocatalytic performance toward the oxygen evolution reaction,achieving a low overpotential of 165 mV at a current density of 10 mA·cm^(−2)and a high mass activity up to 133.8 mA·cm^(-2)at a low overpotential of 200 mV.This work indicates that the synergistic effect of amorphous/crystalline heterophase and porous structural characteristics enables RuO_(2)to trigger a superior electrocatalytic activity. | Chengming Wang Qinghong Geng Longlong Fan Jun-Xuan Li Lian Ma Cuiling Li | 2023 | Nano Research Energy2023，2，3： | 0 |
| 12 | Enhanced electroreduction of CO_(2)to C_(2+)fuels by the synergetic effect of polyaniline/CuO nanosheets hybrids显示文摘Electrochemically converting CO_(2)to value-added multi-carbon(C_(2+))fuels and chemicals is a favorable way to achieve carbon neutrality.Herein,polyaniline/CuO nanosheets(PANI/CuO NSs)hybrid electrocatalysts are developed in order to achieve superior C_(2+)selectivity by imparting PANI functional component to the CuO NSs.The decorated PANI nanoparticles(NPs)can effectively stabilize the*CO intermediates and increase their coverage on the active Cu sites,which facilitates the C-C coupling to form multi-carbon products.Benefiting from the synergetic effect of PANI and CuO NSs,best Faradaic efficiency(FE)for C_(2+)product up to 66.4%at-1.6 V vs.reversible hydrogen electrode(RHE)in a H-cell measurement and 60.0%at 400 mA·cm^(-2) in a flow cell measurement are demonstrated by PANI/CuO NSs-25 sample.More importantly,the C_(2+)selectivity keeps stable even in a continuous measurement time period of 92 h in H-cell measurement.The present study may provide more insights for designing efficient hybrid materials toward superior C_(2+)production from electrocatalytic CO_(2)reduction. | Lian Ma Qinghong Geng Longlong Fan Jun-Xuan Li Dawei Du Junli Bai Cuiling Li | 2023 | Nano Research2023，16，7： | 0 |
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