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| 1 | Novel genetic markers in inflammatory bowel disease显示文摘Genetic factors play a significant role in determining inflammatory bowel disease(IBD)susceptibility.Epidemiologic data support genetic contribution to the pathogenesis of IBD,which include familial aggregation,twin studies,racial and ethnic differences in disease prevalence.Linkage studies have identified several susceptibility genes contained in different genomic regions named IBD1 to IBD9.Nucleotide oligomerization domain(NOD2)and human leukocyte antigen(HLA)genes are the most extensively studied genetic regions(IBD1 and IBD3 respectively)in IBD.Mutations of the NOD2 gene are associated with Crohn's disease(CD)and several HLA genes are associated with ulcerative colitis(UC)and CD.Toll like receptors(TLRs)have an important role in the innate immune response against infections by mediating recognition of pathogen-associated microbial patterns.Studying single-nucleotide polymorphisms(SNPs)in molecules involved in bacterial recognition seems to be essential to define genetic backgrounds at risk of IBD.Recently,numerous new genes have been identified to be involved in the genetic susceptibility to IBD:NOD1/Caspase-activation recruitment domains 4(CARD4),Chemokine ligand 20(CCL20),IL-11,and IL-18 among others.The characterization of these novel genes potentially will lead to the identification of therapeutic agents and clinical assessment of phenotype and prognosis in patients with IBD. | Lorena Rodríguez-Bores Gabriela C Fonseca Marco A Villeda Jesús K Yamamoto-Furusho | 2007 | World Journal of Gastroenterology2007，13，42： | 8 |
| 2 | Relationship between Th17 immune response and cancer显示文摘Cancer is the second leading cause of death worldwide and epidemiological projections predict growing cancer mortality rates in the next decades.Cancer has a close relationship with the immune system and,although Th17 cells are known to play roles in the immune response against microorganisms and in autoimmunity,studies have emphasized their roles in cancer pathogenesis.The Th17 immune response profile is involved in several types of cancer including urogenital,respiratory,gastrointestinal,and skin cancers.This type of immune response exerts pro and antitumor functions through several mechanisms,depending on the context of each tumor,including the protumor angiogenesis and exhaustion of T cells and the antitumor recruitment of T cells and neutrophils to the tumor microenvironment.Among other factors,the paradoxical behavior of Th17 cells in this setting has been attributed to its plasticity potential,which makes possible their conversion into other types of T cells such as Th17/Treg and Th17/Th1 cells.Interleukin(IL)-17 stands out among Th17-related cytokines since it modulates pathways and interacts with other cell profiles in the tumor microenvironment,which allow Th17 cells to prevail in tumors.Moreover,the IL-17 is able to mediate pro and antitumor processes that influence the development and progression of various cancers,being associated with variable clinical outcomes.The understanding of the relationship between the Th17 immune response and cancer as well as the singularities of carcinogenic processes in each type of tumor is crucial for the identification of new therapeutic targets. | Hanna Santos Marques Breno Bittencourt de Brito Filipe Antônio França da Silva Maria Luísa Cordeiro Santos Júlio César Braga de Souza Thiago Macêdo Lopes Correia Luana Weber Lopes Nayara Silva de Macêdo Neres Rafael Santos Dantas Miranda Dórea Anna Carolina Saúde Dantas Lorena Lôbo Brito Morbeck Iasmin Souza Lima Amanda Alves de Almeida Maiara Raulina de Jesus Dias Fabrício Freire de Melo | 2021 | World Journal of Clinical Oncology2021，12，10： | 5 |
| 3 | Study of canine parvovirus evolution: comparative analysis of full-length VP2 gene sequences from Argentina and international field strains 显示文摘 | Marina G C Maximiliano W Lorena B | 2012 | Virus Genes2012，44，： | 1 |
| 4 | Sensitive determination of free benzophenone-3 in human urine samples based on an ionic liquid as ertractant phase in single-drop microertraction prior to liquid chromatography analysis显示文摘 | Lorena V Alberto C Antonio C Amparo S | | 0，，1： | 1 |
| 5 | TLR4 mutations are associated with endotoxin hyporesponsiveness in humans 显示文摘 | Arbour N C Lorena E Schutte B C | 2000 | Nat Genet2000，25，2： | 1 |
| 6 | Diagnosis and treatment of sick sinus syndrome 显示文摘 | Victor A Lorena C | 2003 | American Family Physician2003，67，8： | 1 |
| 7 | Kinetic characterization of the substrate specificity and mechanism of mushroom tyrosinase 显示文摘 | JUAN C E RAMON V LORENA G F | 2000 | European Journal of Biochemistry2000，267，5： | 1 |
| 8 | Kinetic models for nitrification inhibition by ammonium and nitrite in a suspended and an immobilized biomass systems显示文摘 | Irene J Lorena C | 2004 | (39):1159-11652004，，39： | 1 |
| 9 | Eotaxin ex-pression in oral squamous cell carcinomas with and without tumour associated tissue eosinophilia显示文摘 | Lorena S C Oliveira D T Dorta R G | 2003 | Oral Dis2003，9，6： | 1 |
| 10 | A review on the combination of binary classifiers in multiclass problems 显示文摘 | LORENA A C DE CARVALHO C P L F GAMA J M P | 2008 | Artificial Intelligence Review2008，30，1234： | 1 |
| 11 | Adult hippocampal neurogenesis in aging and Alzheimer's disease显示文摘 | Lorena Varela-Nallar Florencia C Aranguiz Ana C Abbott | 2010 | Birth Defects Research Part C:Embryo Today:Reviews2010，90，4： | 1 |
| 12 | Protein cellular localization prediction with support vector machines and decision trees显示文摘 | Lorena A C Andre C P | 2007 | Computers in Biology and Medicine2007，37，2： | 1 |
| 13 | Adult hippocampal neurogenesis in aging and Alzheimer's disease显示文摘 | Lorena Varela-Nallar Florencia C Aranguiz Ana C Abbott | 2010 | Birth Defects Res C Embryo Today2010，90，4： | 1 |
| 14 | Increasing the bind ingstrength of proteins to PEI coated supports by immobilizing at high ionic strength 显示文摘 | Benevides C C Lorena B Fernando L G | 2005 | Enzyme and Microbial Technology2005，37，8： | 1 |
| 15 | Kinetic characterization of the substrate specificity and mechanism of mushroom tyrosinase显示文摘 | JUAN C E RAMON V LORENA G F | 2000 | European Journal of Biochemistry2000，267，5： | 1 |
| 16 | An autonomous multi-agent ap- proach to supply chain event management显示文摘 | Lorena A B Enrique S Omar J C | 2012 | International Journal of Production Economics2012，135，： | 1 |
| 17 | Endothelial nitric synthase polymorphisms are associated with type 2 diabetes and the insulin resistance syndrome 显示文摘 | Lucilla DM Cristina B Lorena C | 2003 | Diabetes2003，52，5： | 1 |
| 18 | Yeast influence on volatile composition of wines显示文摘 | ANTONELLI A LORENA C CARLO Z | 1999 | J Agric Food Chem1999，47，3： | 1 |
| 19 | Primary Aldosteronism and Hypertensive Disease显示文摘 | Lorena M Cristian C Alexis G | 2003 | Hypertension2003，42，： | 1 |
| 20 | Eotaxin expression in oral squamous cell carcinomas with and without tumour associated tissue eosinophilia显示文摘 | OLIVEIRA D T DORTA R G | 2003 | Oral Dis2003，9，6： | 1 |
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