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42篇 您的检索式：作者名="Louis D W"

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	题名	作者	年代	出处	被引量
1	Ron receptor-dependent gene regulation in a mouse model of endotoxin-induced acute liver failure显示文摘BACKGROUND:Prior experimentation has shown that loss of the tyrosine kinase(TK) signaling domain of the Ron receptor leads to marked hepatocyte protection in a model of lipopolysaccharideinduced acute liver failure(ALF) in D-galactosamine(GalN)sensitized mice.The aim of this study was to identify the role of Ron in the regulation of hepatic gene expression.METHODS:Microarray analyses were performed on liver RNA isolated sequentially from wild-type(WT) and TK-/mice during the progression of ALF.Gene array data were validated using Western and immunohistochemistry analyses as well as with ex vivo culture systems.RESULTS:At baseline,101 genes were differentially expressed between WT and TK-/-livers,which regulate processes involved in hypoxia,proliferation,apoptosis and metabolism.One hour after ALF induction,WT livers exhibited increased cytokine expression compared to TK-/-livers,and after 4 hours,an induction of suppressor of cytokine signaling(SOCS) genes as well as JAK-STAT pathway activation were prominent in TK-/livers compared to controls.CONCLUSION:Our studies suggest a novel hepato-protective mechanism in Ron TK-/-mice wherein increased and sustained SOCS production and JAK-STAT activation in the hepatocyte may inhibit the destructive proinflammatory milieu and promote survival factors which blunt hepatic death and the ensuing development of ALF.	Rishikesh M Kulkarni Louis W Kutcher William D Stuart Daniel J Carson Mike A Leonis Susan E Waltz	2012	Hepatobiliary & Pancreatic Diseases International2012，11，4：	3
2	Recent trends in the development of health management显示文摘	EDINGTON D W LOUIS Y KUKU L I	2001	Health management research2001，76，103：	1
3	Perceptions of the intergroup struc- ture and anti -Asian Prejudice among white australians 显示文摘	Johnson D Terry D Louis W	2005	Group Processes & Intergroup Relation2005，8，1：	1
4	Recent trends in the development of health management显示文摘	EDINGTON D W LOUIS Y KUKU L I	2001	Health management research2001，76，103：	1
5	Disease outbreak detection system using syndromic data in the greater Washington DC area 1 1 Information for the full text of this article is available via AJPM Online at www.ajpm-online.net.显示文摘	Michael D Lewis Julie A Pavlin Jay L Mansfield Sheilah O’Brien Louis G Boomsma Yevgeniy Elbert Patrick W Kelley	2002	American Journal of Preventive Medicine2002，，3：	1
6	Correlation of high-resolution magic angle spinning proton magnetic resonance spectroscopy with histopathology of intact human brain tumour specimens显示文摘	Cheng L L Chang I W Louis D A	1998	Cancer Res1998，58，9：	1
7	Sleep estima- tion from wrist movement quantified by different actigraphic moda- lities显示文摘	JEAN LOUIS G KRIPKE D F MASON W J	2001	J Neurosci Methods2001，105，2：	1
8	Evaluation of 24-Second Cyanide-Containing and cyanide-free methods for whole blood hemoglobin on the technicon H * 1TM analyzer with normal and abnormal blood samples显示文摘	Michael J M Louis D S James L W	1989	Am J Clin Pathol1989，9，：	1
9	The 2007 WHO classification of tumours of the central nervous system显示文摘	Louis D N Ohgaki H Wiestler O D Cavenee W K Burger P C Jouvet A	2007	Aeta Neuropathol2007，，：	1
10	How common is the most common adult movement disorder? Estimates of the prevalence of essential tremor throughout the world显示文摘	Louis E D Ottman R Hauser W A	1998	Mov Disord1998，13，：	1
11	Cus-tomer-driven Distribution System 显示文摘	Louis W S Sturdivant F D	1987	Harvard Business Review1987，65，4：	1
12	Recent trends in the devel-opment if health manage ment显示文摘	EDINGTON D W LOUIS Y KUKU LI	2001	Health manage ment research2001，76，103：	1
13	Marsh vegetation patterns and soil phosphorus gradients in the Everglades ecosystem显示文摘	Robert F D Thomas V A Louis D W	1997	Aquatic Botany1997，56，2：	1
14	The WHO classification of tumors of the nervous systeem 显示文摘	Kleihues P Louis D N Scheithauer B W	2002	J Neuropathol Exp Neurol2002，61，3：	1
15	Interaction Effects in the Theory of Planned Behavior: The Interplay of Self - Identity and Past Behavior 显示文摘	mith J R Terry D J Martstead A S R Louis W R Kot- terman D Wolfs J	2007	Journal of Applied Social Psyehology2007，37，11：	1
16	Rencent trends in the development of the health management显示文摘	Edington D W Louis Y Kuku L	2001	Health Management Reaeaeh2001，76，103：	1
17	Use of MIB-1(Ki-67)immunoreactivity in breast cancer显示文摘	Hsu D W Louis D N Efird J T	1997	J Pathol1997，56，8：	1
18	Effects of dexamethasoneon the profile of cytokine secretion in human whole blood cellcultures显示文摘	Franchimont D Louis E Dewe W	1998	Regul Pept1998，73，1：	1
19	Comparative Effectiveness Research and Medical Informatics 显示文摘	D'Avolio Leonard W Farwell Wildon R Fiore Louis D	2009	American Journal of Medicine2009，123，12：	1
20	The WHO classification of tumors of the nervous system 显示文摘	Kleihues P Louis D N Scheitauer B W	2002	J Neuropthol Exp Neurol2002，61，3：	1

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