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| 1 | Wnt/b-catenin signaling plays an ever-expanding role in stem cell self-renewal,tumorigenesis and cancer chemoresistance显示文摘Wnt signaling transduces evolutionarily conserved pathways which play important roles in initiating and regulating a diverse range of cellular activities,including cell proliferation,calcium homeostasis,and cell polarity.The role of Wnt signaling in controlling cell proliferation and stem cell self-renewal is primarily carried out through the canonical pathway,which is the best-characterized the multiple Wnt signaling branches.The past 10 years has seen a rapid expansion in our understanding of the complexity of this pathway,as many new components of Wnt signaling have been identified and linked to signaling regulation,stem cell functions,and adult tissue homeostasis.Additionally,a substantial body of evidence links Wnt signaling to tumorigenesis of cancer types and implicates it in the development of cancer drug resistance.Thus,a better understanding of the mechanisms by which dysregulation of Wnt signaling precedes the development and progression of human cancer may hasten the development of pathway inhibitors to augment current therapy.This review summarizes and synthesizes our current knowledge of the canonical Wnt pathway in development and disease.We begin with an overview of the components of the canonical Wnt signaling pathway and delve into the role this pathway has been shown to play in stemness,tumorigenesis,and cancer drug resistance.Ultimately,we hope to present an organized collection of evidence implicating Wnt signaling in tumorigenesis and chemoresistance to facilitate the pursuit of Wnt pathway modulators that may improve outcomes of cancers in which Wnt signaling contributes to aggressive disease and/or treatment resistance. | Maryam K.Mohammed Connie Shao Jing Wang Qiang Wei Xin Wang Zachary Collier Shengli Tang Hao Liu Fugui Zhang Jiayi Huang Dan Guo Minpeng Lu Feng Liu Jianxiang Liu Chao Ma Lewis L.Shi Aravind Athiviraham Tong-Chuan He Michael J.Lee | 2016 | Genes & Diseases2016，3，1： | 70 |
| 2 | Millennial-scale climate change since the last glaciation recorded by grain sizes of loess deposits on the northeastern Tibetan Plateau显示文摘Whether climatic changes in high latitudes of the Northern Hemisphere since the last glaciation have effects on the Tibetan Plateau monsoon, and the variation characteristics of the Plateau monsoon itself are still not solved but of great significance. The 22-m high-resolution Ioess-paleosol sequence in the Hezuo Basin on the northeastern Tibetan Plateau demonstrates that the Plateau winter monsoon experienced a millennial variation similar to high latitude Northern Hemisphere, with cold events clearly correlated with Heinrich events but less for the warm events (Dansgarrd-Oeschger events). It may indicate that the climate system at high latitudes in the Northern Hemisphere had played an important role in both the Plateau monsoon and the high-level westerlies. On 10^4 year scale, there are two distinct anomalous changes, which are not found in the records from high latitude northern hemisphere, revealed by the loess grain size in the Hezuo Basin. One is that there was a considerable grain size increase at -36 kaBP, suggesting an abrupt enhancement of the Plateau winter monsoon at that time; the other is that, during 43--36 kaBP, the grain size decreased distinctly, indicating a notable weakening of the Plateau winter monsoon around that period. Both of the two anomalies suggest that the Tibetan climate may have been controlled by some other factors, besides the high latitude climatic changes in the Northern Hemisphere. | Lü Lianqing FANG Xiaomin LU Huayu HAN Yongxiang YANG Shengli LI Jijun AN Zhisheng | 2004 | Chinese Science Bulletin2004，49，11： | 13 |
| 3 | Synthesis and fluorescent properties in complexes of Eu( Ⅲ), Tb( Ⅲ), and Sm( Ⅲ) with β-diketone and 2,2′-bipyridine显示文摘Three new rare earth ternary complexes, RE(PB)_3bpy (RE=Sm^(3+) , Eu^(3+) , and Tb^(3+) ), were synthesized by the reaction of 1-(p-phenylethynyl- phenyl)-1,3-butanedione (HPB) and 2,2′-bipyridine (bpy) with rare earth chloride RECl_3 , respectively, in alcohol solution. The compositions were characterized by means of infrared (IR) spectra, chemical analysis, elemental analysis, and thermodynamic analysis. Luminescent properties of the three complexes were studied. At room temperature, under UV light excitation, the Sm^(3+) , Eu^(3+) , and Tb^(3+) complexes exhibit characteristic emission of the central ions. The fluorescence spectra show that the fluorescence emission intensity of Eu^(3+) complex is the strongest. The narrow strongest emission band of Eu^(3+) complex is considered to be a valuable material with bright red fluorescence. | LIU Xingwang JIANG Jiadong GUO Yuwei YONG Shengli YANG Kun NIE Lu | 2012 | Rare Metals2012，31，5： | 9 |
| 4 | Improved Hybrid Robust Control Method for the Electromechanical Actuator in Aircrafts显示文摘In the flight process of aircrafts, their electromechanical actuators(EMA) must have the ability of enduring uncertainties caused by factors such as load disturbance, the variation of work temperature and the EMA’s nonlinearity. At present, in order to increase the EMA’s robustness on the uncertainties, the H∞ control method has been applied in aircrafts. The major problems with standard H∞ control lie in the large overshoot of step response and the high orders of the controller. For the purpose of addressing the two problems, this paper investigates several kinds of robust control strategies of the EMA. A mathematical model of the EMA is first built, and then with MATLAB software a H∞ controller and an improved hybrid robust controller composed of a reduced order H∞ controller and a lead compensator are designed. In order to make a scientific comparison of the control effects of H∞ controller, hybrid controller and classic proportion-integral-differential(PID) controller, a simulation research is made in respect of the open loop frequency response and the closed loop step response of the three controllers. For comparing the robustness of the three controllers, the load torque is entered as a disturbance and the disturbance response of error and control input are thus obtained. The experiments with the three controllers are also conducted. Through giving the EMA a command and a disturbance torque successively, the transient response and disturbing process of EMA are recorded. The simulation and experiment results show that with the help of the hybrid controller, the EMA not only guarantees good dynamic characteristics, but also has strong robustness of disturbance rejection. Therefore, the excogitated H∞ hybrid control method effectively solves the problem of large overshoot in dynamic response, and moderately meets the requirement of overcoming the uncertainties in the EMA of aircrafts. | LU Hao LI Yunhu TIAN Shengli NIE Zhenjin | 2010 | Chinese Journal of Mechanical Engineering2010，23，4： | 8 |
| 5 | A more consistent intraluminal rhesus monkey model of ischemic stroke显示文摘Endovascular surgery is advantageous in experimentally induced ischemic stroke because it causes fewer cranial traumatic lesions than invasive surgery and can closely mimic the pathophysiology in stroke patients. However, the outcomes are highly variable, which limits the accuracy of evaluations of ischemic stroke studies. In this study, eight healthy adult rhesus monkeys were randomized into two groups with four monkeys in each group: middle cerebral artery occlusion at origin segment(M1) and middle cerebral artery occlusion at M2 segment. The blood flow in the middle cerebral artery was blocked completely for 2 hours using the endovascular microcoil placement technique(1 mm × 10 cm)(undetachable), to establish a model of cerebral ischemia. The microcoil was withdrawn and the middle cerebral artery blood flow was restored. A reversible middle cerebral artery occlusion model was identified by hematoxylin-eosin staining, digital subtraction angiography, magnetic resonance angiography, magnetic resonance imaging, and neurological evaluation. The results showed that the middle cerebral artery occlusion model was successfully established in eight adult healthy rhesus monkeys, and ischemic lesions were apparent in the brain tissue of rhesus monkeys at 24 hours after occlusion. The rhesus monkeys had symptoms of neurological deficits. Compared with the M1 occlusion group, the M2 occlusion group had lower infarction volume and higher neurological scores. These experimental findings indicate that reversible middle cerebral artery occlusion can be produced with the endovascular microcoil technique in rhesus monkeys. The M2 occluded model had less infarction and less neurological impairment, which offers the potential for application in the field of brain injury research. | Bo Zhao Guowei Shang Jian Chen Xiaokun Geng Xin Ye Guoxun Xu Ju Wang Jiasheng Zheng Hongjun Li Fauzia Akbary Shengli Li Jing Lu Feng Ling Xunming Ji | 2014 | Neural Regeneration Research2014，9，23： | 6 |
| 6 | A rotary-shear low to high-velocity friction apparatus in Beijing to study rock friction at plate to seismic slip rates显示文摘This paper reviews 19 apparatuses having highvelocity capabilities,describes a rotary-shear low to highvelocity friction apparatus installed at Institute of Geology,China Earthquake Administration,and reports results from velocity-jump tests on Pingxi fault gouge to illustrate technical problems in conducting velocity-stepping tests at high velocities.The apparatus is capable of producing plate to seismic velocities(44 mm/a to 2.1 m/s for specimens of 40 mm in diameter),using a 22 kW servomotor with a gear/belt system having three velocity ranges.A speed range can be changed by 103 or 106by using five electromagnetic clutches without stopping the motor.Two cam clutches allow fivefold velocity steps,and the motor speed can be increased from zero to 1,500 rpm in 0.1–0.2 s by changing the controlling voltage.A unique feature of the apparatus is a large specimen chamber where different specimen assemblies can be installed easily.In addition to a standard specimen assembly for friction experiments,two pressure vessels were made for pore pressures to 70 MPa;one at room temperature and the other at temperatures to 500 °C.Velocity step tests are needed to see if the framework of rate-and-state friction is applicable or not at high velocities.We report results from velocity jump tests from 1.4 mm/s to 1.4 m/s on yellowish gouge from a Pingxi fault zone,located at the northeastern part of the Longmenshan fault system that caused the 2008 Wenchuan earthquake.An instantaneous increase in friction followed by dramatic slip weakening was observed for the yellowish gouge with smooth sliding surfaces of host rock,but no instantaneous response was recognized for the same gouge with roughened sliding surfaces.Instantaneous and transient frictional properties upon velocity steps cannot be separated easily at high velocities,and technical improvements for velocity step tests are suggested. | Shengli Ma Toshihiko Shimamoto Lu Yao Tetsuhiro Togo Hiroko Kitajima | 2014 | Earthquake Science2014，27，5： | 6 |
| 7 | Transition to resistance:An unexpected role of the EMT in cancer chemoresistance显示文摘Two recent studies provide intriguing evidence that challenges the role of the epithelialemesenchymal transition(EMT)as a critical mediator of cancer metastasis,while revealing an unexpected role in cancer drug resistance.1,2 While these findings may not settle the EMT’s role in metastasis,these studies suggest that targeting the EMT may inhibit both cancer metastasis and chemoresistance. | Jing Wang Qiang Wei Xin Wang Shengli Tang Hao Liu Fugui Zhang Maryam K.Mohammed Jiayi Huang Dan Guo Minpeng Lu Feng Liu Jianxiang Liu Chao Ma Xue Hu Rex C.Haydon Tong-Chuan He Hue H.Luu | 2016 | Genes & Diseases2016，3，1： | 4 |
| 8 | Genome-wide Identification of microRNAs that Respond to Drought Stress in Seedlings of Tertiary Relict Ammopiptanthus mongolicus显示文摘microRNAs(miR NAs) are important post-transcriptional regulators of gene expression in plant abiotic stress responses. Ammopiptanthus mongolicus is a typical evergreen woody xerophyte, which makes it an ideal model system for studying drought tolerance in woody plants. The response of mi RNAs to drought stress is still unknown in this plant. In this research, we obtained 34 695 665 raw reads from two small RNA libraries constructed from control and drought-treated A. mongolicus seedlings by the Illumina deep sequencing technology. Length analysis revealed that reads of 20, 21, and 24 nucleotides accounted for the majority of the small RNAs in the two libraries. Sequence analyses identified 65 conserved mi RNA sequences from 190 members of 31 mi RNA families and 20 potential novel mi RNAs from 17 families that were differentially expressed between the two libraries. The expression patterns of 25 of these mi RNAs were significantly different in the two libraries, but only am-mi R4 a-c was downregulated during drought stress, the other 24 were upregulated. The expression trends determined by the Hi Seq sequencing and by q RT-PCR were similar. Furthermore, 35 target genes for the conserved mi RNA were markedly changed and 52 target genes for the potential novel mi RNAs were predicted and their functions were annotated by computational analysis. Our results provide new molecular evidence for understanding the molecular mechanisms of drought response and tolerance in A. mongolicus. | LIU Shengli NI Yanjie HE Qian WANG Jinyu CHEN Yuzhen LU Cunfu | 2017 | Horticultural Plant Journal2017，3，5： | 3 |
| 9 | Internal structures and high-velocity frictional properties of Longmenshan fault zone at Shenxigou activated during the 2008 Wenchuan earthquake显示文摘This paper reports internal structures of a wide fault zone at Shenxigou,Dujiangyan,Sichuan province,China,and high-velocity frictional properties of the fault gouge collected near the coseismic slip zone during the 2008 Wenchuan earthquake.Vertical offset and horizontal displacement at the trench site were 2.8 m(NW side up)and 4.8 m(right-lateral),respectively.The fault zone formed in Triassic sandstone,siltstone,and shale about 500 m away from the Yingxiu-Beichuan fault,a major fault in the Longmenshan fault system.A trench survey across the coseismic fault,and observations of outcrops and drill cores down to a depth of 57 m revealed that the fault zone consists of fault gouge and fault breccia of about0.5 and 250–300 m in widths,respectively,and that the fault strikes N62°E and dips 68° to NW.Quaternary conglomerates were recovered beneath the fault in the drilling,so that the fault moved at least 55 m along the coseismic slip zone,experiencing about 18 events of similar sizes.The fault core is composed of grayish gouge(GG) and blackish gouge(BG) with very complex slip-zone structures.BG contains low-crystalline graphite of about 30 %.High-velocity friction experiments were conducted at normal stresses of 0.6–2.1 MPa and slip rates of 0.1–2.1 m/s.Both GG and BG exhibit dramatic slip weakening at constant high slip rates that can be described as an exponential decay from peak friction coefficient lpto steadystate friction coefficient lssover a slip-weakening distance Dc.Deformation of GG and BG is characterized by overlapped slip-zone structures and development of sharp slickenside surfaces,respectively.Comparison of our data with those reported for other outcrops indicates that the high-velocity frictional properties of the Longmenshan fault zones are quite uniform and the high-velocity weakening must have promoted dynamic rupture propagation during the Wenchuan earthquake. | Yu Wang Shengli Ma Toshihiko Shimamoto Lu Yao Jianye Chen Xiaosong Yang Honglin He Jiaxiang Dang Linfeng Hou Tetsuhiro Togo | 2014 | Earthquake Science2014，27，5： | 3 |
| 10 | Kinetic calculations for the thermal decomposition of calcium propionate under non-isothermal conditions显示文摘Calcium propionate (CP) is shown to be useful for simultaneous SO2/NO reduction in coal-fired power plants and its thermal decomposition characteristics are measured by thermogravimetric analysis in a feasibility study into more complete reduction of these hazardous gases. Calcium carbonate (CC), which has been used primarily for in-furnace desulfuration, was used for comparison. The thermal decomposition of this organic calcium-based sorbent began at low temperature, i.e. the carboxylic radical was evaporated from 565 K to 759 K for CP and the corresponding mass loss percentage was 47.79%. The residual was subsequently decomposed to release carbon dioxide between 843 K and 1012 K. The latter phase of the process occurred more readily than with CC because of the loose structure of CP resulting from evaporation of the carboxylic radical in the low temperature zone, which could be seen directly by scanning electron microscope. The maximum mass loss rates of this phase occurred at temperatures of 972 K and 1012 K for CP and CC, respectively. The Ozawa-Flynn-Wall method was used to calculate the activation energy during the thermal decomposition process at heating rates of 5, 7.5, 10 and 15 K/min. The result further confirmed the multistage characteristic of CP thermal decomposition, which could be seen in differential thermogravimetry curves. The reaction orders of CP in the conversion range 20%-80%, calculated using the Avrami theory were from 0.061 to 0.608, smaller than those of CC, which were 1.647 to 2.084. | NIU ShengLi HAN KuiHua LU ChunMei | 2011 | Chinese Science Bulletin2011，56，12： | 3 |
| 11 | Non-Invasive Measurement of Brain Neurotransmitter: One Novel Model显示文摘 | LI Wenshi LU Shengli SHI Longxing | 2008 | Chinese Journal of Electronics2008，17，2： | 3 |
| 12 | Open reduction and internal fixation with conventional plate via L-shaped lateral approach versus internal fixation with percutaneous plate via a sinus tarsi approach for calcaneal fractures – A randomized controlled trial显示文摘 | Shengli Xia Xiuhui Wang Yaogang Lu Huizhong Wang Zuming Wu Ziping Wang | 2014 | International Journal of Surgery2014，，： | 2 |
| 13 | Experimental study on the effect of urea and additive injection for controlling nitrogen oxide emissions显示文摘 | Niu Shengli Han Kuihua Lu Chunmei | 2010 | Environmental Engineering Science2010，27，1： | 1 |
| 14 | Thennogravimentric analysis of the relationship among calcium magnesium acetate, calcium acetate and magnesium acetate 显示文摘 | Niu Shengli Han Kuihua Lu Chunmei | 2010 | Applied Energy2010，87，7： | 1 |
| 15 | Growth of the Huoerguosi anticline (north Tianshan Mountains) by limb rotation since the late Miocene显示文摘Huoerguosi 背斜,在北方 Tianshan 山山麓 fold-and-thrust 带定位了,是 trending 东方西方差错相关的褶层。在沿着 Jingou 河的生气的节,它的南方手足由 Anjihaihe 的生长前阶层组成( E ( 2-3 )一), Shawan (( E-3-N-1 ) s ), Taxihe ( N ( 1 ) t )和 Dushanzi ( N ( 2 ) d )的更低的部分形成, trending 东方西方并且蘸到南方 55 学位,并且 Dushanzi ( N ( 2 ) d )和 Xiyu 的上面的部分的生长阶层(( N-2-Q ( 1 )) x )形成,哪个在 Xiyu 的底部在生长阶层的底从 55 个学位减少到 47 个学位的剧降(( N-2-Q ( 1 )) x )形成到类似于在 Xiyu 的顶的 0 个学位(( N-2-Q ( 1 )) x )形成。在背斜的北方手足的阶层垂直或打翻,并且被突破戳切导致 drag 褶层。深入地,背斜是对称的,并且它的核心包括白垩纪和侏罗记忍受煤的床。在地震侧面,在背斜的南方手足的生长前阶层的地震反射镜常常蘸到南方,并且生长阶层之一扇向南方,谁的向上蘸减少。沿着 Jingou 河山谷和在地震侧面显示出的背斜的深结构的南方手足生长阶层 outcropped 的几何学显示 Huoerguosi 背斜是由手足旋转成长的分开褶层背斜。基于生长模型和 magnetostratigraphic 年龄,在 Huoerguosi 背斜的成长过程期间,南方手足吸收的平均弄短率类似于 0.46 mm/a ,和背斜的平均高举率类似于超过平均免职率的 0.86 mm/a ,它根据背斜的顶强烈地被侵蚀的事实。考虑 Huoerguosi 背斜的对称的几何学并且忽略突破推进,整个背斜弄短应该非常类似于 0.92 mm/a,加倍在南方手足从生长决定的弄短的率。 | WANG ShengLi CHEN Yan LU HuaFu | 2008 | Chinese Science Bulletin2008，53，19： | 1 |
| 16 | An experimental study on the effect of operating parameters and sodium additive on the NO x OUT Process显示文摘 | Shengli Niu Kuihua Han Chunmei Lu | 2011 | Process Safety and Environmental Protection2011，，2： | 1 |
| 17 | Asynchronous physical-layer network coding显示文摘 | Lu Lu Zhang Shengli | 2012 | Wireless Communications IEEE Transactions2012，11，2： | 1 |
| 18 | Transesterifica- tion catalyzed by industrial waste-lime mud doped with potassium fluoride and the kinetic calculation显示文摘 | Li Hui Niu Shengli Lu Chunmei | 2014 | Energy Conversion and Management2014，86，： | 1 |
| 19 | Thermogravimetric analysis of the relationship among calcium magnesium acetate, cal- cium acetate and magnesium acetate显示文摘 | Niu Shengli Han Kuihua Lu Chunmei | 2010 | Appl Energy2010，87，7： | 1 |
| 20 | Loess in Kunlun Mountains and its implication on desert development and Tibetan Plateau uplift in west China 显示文摘 | Fang Xiaomin Lu Lianqing Yang Shengli | 2002 | Science in China (series D)2002，45，4： | 1 |
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