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| 1 | Wnt/b-catenin signaling plays an ever-expanding role in stem cell self-renewal,tumorigenesis and cancer chemoresistance显示文摘Wnt signaling transduces evolutionarily conserved pathways which play important roles in initiating and regulating a diverse range of cellular activities,including cell proliferation,calcium homeostasis,and cell polarity.The role of Wnt signaling in controlling cell proliferation and stem cell self-renewal is primarily carried out through the canonical pathway,which is the best-characterized the multiple Wnt signaling branches.The past 10 years has seen a rapid expansion in our understanding of the complexity of this pathway,as many new components of Wnt signaling have been identified and linked to signaling regulation,stem cell functions,and adult tissue homeostasis.Additionally,a substantial body of evidence links Wnt signaling to tumorigenesis of cancer types and implicates it in the development of cancer drug resistance.Thus,a better understanding of the mechanisms by which dysregulation of Wnt signaling precedes the development and progression of human cancer may hasten the development of pathway inhibitors to augment current therapy.This review summarizes and synthesizes our current knowledge of the canonical Wnt pathway in development and disease.We begin with an overview of the components of the canonical Wnt signaling pathway and delve into the role this pathway has been shown to play in stemness,tumorigenesis,and cancer drug resistance.Ultimately,we hope to present an organized collection of evidence implicating Wnt signaling in tumorigenesis and chemoresistance to facilitate the pursuit of Wnt pathway modulators that may improve outcomes of cancers in which Wnt signaling contributes to aggressive disease and/or treatment resistance. | Maryam K.Mohammed Connie Shao Jing Wang Qiang Wei Xin Wang Zachary Collier Shengli Tang Hao Liu Fugui Zhang Jiayi Huang Dan Guo Minpeng Lu Feng Liu Jianxiang Liu Chao Ma Lewis L.Shi Aravind Athiviraham Tong-Chuan He Michael J.Lee | 2016 | Genes & Diseases2016，3，1： | 70 |
| 2 | Wnt and BMP signaling crosstalk in regulating dental stem cells:Implications in dental tissue engineering显示文摘Tooth is a complex hard tissue organ and consists of multiple cell types that are regulated by important signaling pathways such as Wnt and BMP signaling.Serious injuries and/or loss of tooth or periodontal tissues may significantly impact aesthetic appearance,essential oral functions and the quality of life.Regenerative dentistry holds great promise in treating oral/dental disorders.The past decade has witnessed a rapid expansion of our understanding of the biological features of dental stem cells,along with the signaling mechanisms governing stem cell self-renewal and differentiation.In this review,we first summarize the biological characteristics of seven types of dental stem cells,including dental pulp stem cells,stem cells from apical papilla,stem cells from human exfoliated deciduous teeth,dental follicle precursor cells,periodontal ligament stem cells,alveolar bone-derived mesenchymal stem cells(MSCs),and MSCs from gingiva.We then focus on how these stem cells are regulated by bone morphogenetic protein(BMP)and/or Wnt signaling by examining the interplays between these pathways.Lastly,we analyze the current status of dental tissue engineering strategies that utilize oral/dental stem cells by harnessing the interplays between BMP and Wnt pathways.We also highlight the challenges that must be addressed before the dental stem cells may reach any clinical applications.Thus,we can expect to witness significant progresses to be made in regenerative dentistry in the coming decade. | Fugui Zhang Jinlin Song Hongmei Zhang Enyi Huang Dongzhe Song Viktor Tollemar Jing Wang Jinhua Wang Maryam Mohammed Qiang Wei Jiaming Fan Junyi Liao Yulong Zou Feng Liu Xue Hu Xiangyang Qu Liqun Chen Xinyi Yu Hue H.Luu Michael J.Lee Tong-Chuan He Ping Ji | 2016 | Genes & Diseases2016，3，4： | 16 |
| 3 | Design and experimental study of the SPKM165, a five-axis serial-parallel kinematic milling machine显示文摘A five-axis serial-parallel kinematic milling machine, the SPKM 165, is introduced. This machine consists of a three-degree of-freedom parallel module and a two-degree-of-freedom serial table. The SPKM 165 is capable of five-face machining. A discussion of the inverse kinematics of the five-axis control is provided. A dimensional synthesis procedure is presented in terms of motion/force transmissibility. Finite-element analysis was used to evaluate the stiffness of a CAD model before the machine was manufactured. Kinematic calibration was implemented to improve the accuracy of the end effector. The results of a calibration experiment are presented. The stiffness of the developed machine was then measured. Milling experiments were conducted, and the test piece showed that the developed machine has satisfactory performance. | XIE FuGui LIU XinJun ZHANG Hui WANG JinSong | 2011 | Science China(Technological Sciences)2011，54，5： | 6 |
| 4 | Proteomic analysis of heterosis in the leaves of sorghum-sudangrass hybrids显示文摘 | Pingan Han Xiaoping Lu Fugui Mi Jing Dong Chunlei Xue Jianke Li Bin Han Xiaoyu Zhang | 2016 | Acta Biochimica et Biophysica Sinica2016，48，2： | 5 |
| 5 | Transition to resistance:An unexpected role of the EMT in cancer chemoresistance显示文摘Two recent studies provide intriguing evidence that challenges the role of the epithelialemesenchymal transition(EMT)as a critical mediator of cancer metastasis,while revealing an unexpected role in cancer drug resistance.1,2 While these findings may not settle the EMT’s role in metastasis,these studies suggest that targeting the EMT may inhibit both cancer metastasis and chemoresistance. | Jing Wang Qiang Wei Xin Wang Shengli Tang Hao Liu Fugui Zhang Maryam K.Mohammed Jiayi Huang Dan Guo Minpeng Lu Feng Liu Jianxiang Liu Chao Ma Xue Hu Rex C.Haydon Tong-Chuan He Hue H.Luu | 2016 | Genes & Diseases2016，3，1： | 4 |
| 6 | Beclin-1/LC3-II dependent macroautophagy was uninfluenced in ischemia-challenged vascular endothelial cells显示文摘Autophagy has been extensively studied and occurs in many biological settings.However,a question remains as to whether ischemia enhances Beclin-1/LC3-II-dependent macroautophagy in vascular endothelial cells,as has been previously thought.Furthermore,the effect of the level of autophagy on cell or skin flap survival still requires elucidation.We created a lethal ischemia model in human umbilical vascular endothelial cells(HUVECs),performed quantitative proteomics and bioinformatics analyses,and verified the autophagic status and effect both in vitro and in vivo.The significantly upregulated proteins encoded by autophagy-related genes(ATGs)included ATG2A,ATG3,ATG4B,ATG5,ATG7,ATG9A,ATG12,ATG16,and ATG101.The significantly enhanced lysosomal proteins were cathepsin B,cathepsin D,lysosome-associated membrane protein 1(LAMP1),and LAMP2.However,the differentially expressed proteins excluded Beclin-1,microtubule-associated protein light chain 3(LC3)-I,and LC3-II.Western blot analyses verified that the protein expression levels of Beclin-1,LC3-I,and LC3-II were neither upregulated nor downregulated in ischemia-challenged HUVECs.The autophagic status was not enhanced by rapamycin in ischemic HUVECs but appeared to be inhibited by chloroquine.Our in vivo study on rats showed that a downregulation in autophagic status jeopardized skin flap survival.In conclusion,Ischemia neither enhanced nor inhibited Beclin-1/LC3-II-dependent canonical macroautophagy both in vitro and in vivo,in contradiction to previous studies.An appropriate autophagic homeostasis can minimize cell or skin flap damage. | Yaping Ma Chaofan Li Yan He Tiwei Fu Li Song Qingsong Ye Fugui Zhang | 2022 | Genes & Diseases2022，9，2： | 3 |
| 7 | A Study on Some Causes of Rubble Mound Breakwater Failure显示文摘- Rubble mound breakwater, one of the protection structures, has been widely used in coastal and port engineering. Block stones were first used as its armor layer, and its use was limited to shallow sea areas where there is no large waves. Since the specially-shaped armor unit was developed, the rubble mound breakwater has become the main sort of the protection structures, which can be used in deep water zones where storm sometimes occurs. Owing to severe and complex surrounding conditions, the rubble mound breakwater failure sometimes occurs, thus the study on the causes of failure is of great importance. In the present study some breakwater failures at home and abroad are illustrated and the causes of failure are investigated from the point of view of design, test, construction and maintenance. | Zhang Fugui Ge Zhijin Senior Engineer, River and Harbour Department, Nanjing Hydraulic Research Institute, Nanjing 210024 | 1996 | China Ocean Engineering1996，11，4： | 3 |
| 8 | Transcriptome analysis reveals genes expression pattern of seed response to heat stress in Brassica napus L.显示文摘Seeds might deteriorate,and lose the ability to germinate when stored under high temperature and high humidity.Brassica napus is one of the most important oil crops in China.However,B.napus seeds were generally stored through summer season with high ambient temperature,which lead to seed viability loss.In order to understand the mechanism of seed response to heat stress and improve seed heat tolerance,B.napus seeds were treated with high temperature(40℃)and ultra-high temperature(60℃)for 4 h.The germination of heatstressed seeds were obviously slower,the germination index and vigor index decreased with temperature increase from 40 to 60℃,and the 40℃ pretreatment could improve the seed tolerance to 60℃ heat stress.Transcriptomics results showed that 442 differentially expressed genes(DEGs)were identified in seeds after heat stress.Gene ontology and KEGG pathway enrichment analysis revealed that some of the genes were involved in posttranslational modification,protein turnover,chaperones and carbohydrate transport,metabolic pathways and secondary metabolites biosynthesis pathway.Among these DEGs,sHSP and transcription factors genes were involved in heat stress tolerance.Thirty-two overlapping genes under different high temperature stress(40℃ and 60℃)were enriched in biological processes of response to oxidative stress and abiotic stimulus.The expression trends of 12 genes randomly selected from the RNA-seq data were almost consistent with the results of qRT-PCR.Our results revealed several potential candidate genes and pathways related to heat responsive by high temperature,which is beneficial for further improving the heat tolerance in B.napus seeds. | Guizhen Gao Jihong Hu Xiaojun Zhang Fugui Zhang Mei Li Xiaoming Wu | 2021 | Oil Crop Science2021，6，2： | 1 |
| 9 | Influence of anisotropy of the magnesium alloy AZ31 sheets on warm negative incremental forming 显示文摘 | Zhang Qinglai Guo Hailing Xiao Fugui | 2009 | Journal of Material Proeessing Technology2009，209，1516： | 1 |
| 10 | Growth of Czochralski silicon under magnetic field显示文摘Growth of Czochralski (CZ) silicon crystals under the magnetic field induced by a cusp-shaped permanent magnet of NdFeB has been investigated. It is found that the mass transport in silicon melt was controlled by its diffusion while the magnetic intensity at the edge of a crucible was over 0.15 T. In comparison with the growth of conventional CZ silicon without magnetic field, the resistivity homogeneity of the CZ silicon under the magnetic field was improved. Furthermore, the Marangoni convection which has a significant influence on the control of oxygen concentration was observed on the surface of silicon melt. It is suggested that the crystal growth mechanism in magnetic field was similar to that in micro-gravity if a critical value was reached, named the growth of equivalent micro-gravity. The relationship of the equivalent micro-gravity and the magnetic intensity was derived as g=(v0/veff)g0. Finally, the orders of the equivalent micro-gravity corresponding to two crucibles with characteristic sizes were calculated. | XU Yuesheng LIU Caichi WANG Haiyun ZHANG Weilian YANG Qingxin LI Yangxian REN Binyan LIU Fugui | 2004 | Science China(Technological Sciences)2004，47，3： | 1 |
| 11 | Warm Negative Incremental Forming of Magnesium Alloy AZ31 Sheet: New Lubrication Method显示文摘 | Zhang Qinglai Xiao Fugui Guo Hailing | 2010 | Journal of Material Processing Technology2010，210，2： | 1 |
| 12 | 显示文摘 | Liu Jingsong Zhang Shuren Chen Fugui | 2004 | Physics Letters A2004，321，： | 1 |
| 13 | On L-fuzzy topological spaces显示文摘 | Zhang Jie Shi Fugui Zheng Chongyou | 2005 | Fuzzy Set and Systems2005，，149： | 1 |
| 14 | Warm negative incremental forming of magnesium alloy AZ31 sheet:New lubricating method显示文摘 | Zhang Qinglai Xiao Fugui Guo Hailing | | 0，，02： | 1 |
| 15 | SATB2:A versatile transcriptional regulator of craniofacial and skeleton development,neurogenesis and tumorigenesis,and its applications in regenerative medicine显示文摘SATB2(special AT-rich sequence-binding protein 2)is a member of the special AT-rich binding protein family.As a transcription regulator,SATB2 mainly integrates higher-order chromatin organization.SATB2 expression appears to be tissue-and stage-specific,and is governed by several cellular signaling molecules and mediators.Expressed in branchial arches and osteoblast-lineage cells,SATB2 plays a significant role in craniofacial pattern and skeleton development.In addition to regulating osteogenic differentiation,SATB2 also displays versatile functions in neural development and cancer progression.As an osteoinductive factor,SATB2 holds great promise in improving bone regeneration toward bone defect repair.In this review,we have summarized our current understanding of the physiological and pathological functions of SATB2 in craniofacial and skeleton development,neurogenesis,tumorigenesis and regenerative medicine. | Xia Huang Qiuman Chen Wenping Luo Mikhail Pakvasa Yuxin Zhang Liwen Zheng Shuang Li Zhuohui Yang Huan Zeng Fang Liang Fugui Zhang Daniel A.Hu Kevin H.Qin Eric J.Wang David S.Qin Russell R.Reid Tong-Chuan He Aravind Athiviraham Mostafa El Dafrawy Hongmei Zhang | 2022 | Genes & Diseases2022，9，1： | 0 |
| 16 | The Spread of Cosmopolitanism in China and Lu Xun's Understanding of the "World Citizen"显示文摘 | Fugui Zhang Chuangong Ren | 2012 | Frontiers of Literary Studies in China-Selected Publications from Chinese Universities2012，6，4： | 0 |
| 17 | Global Warming:Increases in the Instability of Climate in Minqin Desert Area显示文摘The instability of climate in Minqin desert area during the process of global warming was analyzed based on meteorological data during 1961-2013. The results show that the instability of monthly average temperature in January and April increased. Isothermal date in February was 10.36 d earlier from 1961 to 2013. The instability of extreme maximum temperature in December and January enhanced. The instability of extreme minimum temperature in July increased. The coefficient of variation of extreme minimum temperature in May was up to 287.3%. The instability of average precipitation in January enhanced. At the same time,the stability of annual average precipitation increased. The stability of climate is more worthy of attention. | Zhang Dabiao Chang Zhaofeng Wang Dawei Han Fugui Duan Xiaofeng Wang Qiangqiang Zhang Jianhui | 2016 | Meteorological and Environmental Research2016，7，6： | 0 |
| 18 | Stability and Ecological Effects of Main Plant Communities in Minqin Desert Area显示文摘[Objective] To elucidate the change trend in stability and ecological effects of plant communities in desert along with global warming. [Method]The data of site-specific observation on five main plant communities at ten plots in Minqin desert area were used to analyze the stability and ecological effects of desert plant communities by using two indicators vegetation coverage and projective cover degree. [Results] The vegetation coverage of Artemisia arenaria and Ephedra przewalskii,and the projective cover degree of A. arenaria and man-made Haloxylon ammodendron forest decreased remarkably; and the vegetation coverage of Nitraria tangutorum was also decreased to some extent. [Conclusion]( 1) The plant communities with poor vegetation coverage gives a relatively strong stability,while that with high vegetation coverage has a relatively poor stability;( 2) the yearly precipitation is the determinant of vegetation coverage and projective cover degree;( 3) the ecological function is found to be most remarkable in per unit area N. tangutorum,followed by E. przewalskii and N. tangutorum + H. ammodendron,and least in per unit area A. Arenaria. The vegetation is sparse in desert and plant branches does not distribute regularly,thus the crown-based vegetation coverage can not reflect the actual surface coverage. | Chang Zhaofeng Duan Xiaofeng Han Fugui Zhong Shengnian Wang Qiangqiang Zhang Jianhui | 2015 | Animal Husbandry and Feed Science2015，7，3： | 0 |
| 19 | Evaluation of China Healthy Lifestyle for All Interventions Based on RE-AIM Framework — China, 2007–2020显示文摘Summary What is already known about this topic?Since the launch of China Healthy Lifestyle for All(CHLA),each action area has been evaluated at the local level and effective results have been achieved in most areas.What is added by this report?Based on the Reach,Effectiveness,Adoption,Implementation,and Maintenance(RE-AIM)model,the study found that there is an imbalance in the development of CHLA,and some of the action goals and indicators are not satisfactory.What are the implications for public health practices?A national action evaluation index system should be built to ensure the sustainability and scientific nature of this strategy.In addition,the government needs to attach great importance to CHLA to effectively help residents take health actions. | Fugui Wu Lu Zhang Wenbo Guo Mingyang Wang Yang Gao Dan Liu Yamin Bai Yanfang Zhao Shengquan Mi Wenhua Zhao Zhuoqun Wang Man Li | 2022 | China CDC weekly2022，4，19： | 0 |
| 20 | Investigation on the Extraction of Chloroplast Proteome显示文摘As an important subcellular organelle for plant photosynthesis,chloroplast proteome research has become an important branch and hot issue of plant proteomics. However,no efficient method has been established for extracting chloroplast proteome from plant leaves. In this paper,recent advances in extraction methods of plant chloroplast proteome were summarized,which laid solid foundation for establishing efficient and practicable extraction methods of chloroplast proteome. | Chengcheng SHAO Qianqian QIN Xu ZHANG Yun WANG Xiaodan YAN Fugui CHEN | 2014 | Agricultural Biotechnology2014，3，2： | 0 |
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