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| 1 | Rapid remission of refractory synovitis, acne, pustulosis, hyperostosis, and osteitis syndrome in response to the Janus kinase inhibitor tofacitinib: A case report显示文摘BACKGROUND Synovitis,acne,pustulosis,hyperostosis,and osteitis(SAPHO)syndrome is a rare autoinflammatory disease for which clinical treatment has not been standardized.Janus kinase(JAK)inhibitors represent a novel therapeutic option for rheumatoid arthritis,psoriatic arthritis,and some other autoinflammatory diseases.However,the clinical utility of JAK inhibitors in treating SAPHO syndrome has not been thoroughly investigated.In this study,we describe a patient with SAPHO syndrome who failed to respond to conventional treatment but demonstrated a remarkable and rapid response to the JAK inhibitor tofacitinib.CASE SUMMARY A 62-year-old female patient presented with swelling and pain at the sternoclavicular joints,back pain that limited her activities,arthralgia in the right knee,and cutaneous lesions.Her symptoms were unresponsive to nonsteroidal anti-inflammatory drugs,disease-modifying antirheumatic drugs,Tripterygium wilfordii hook f,and bisphosphonates.SAPHO syndrome was diagnosed in accordance with dermatological and osteoarticular manifestations and abnormal inflammatory factors.Multiple image studies have illustrated bone lesions and pathological fractures of vertebral bodies.Oral treatment with tofacitinib at 5 mg twice daily with methotrexate and bisphosphonates was initiated.The patient reported that her pain symptoms were relieved after 3 d and her cutaneous lesions were reduced after 4 wk of treatment.Vertebral lesions were improved after 6 mo on tofacitinib.No serious adverse effects were noted.CONCLUSION JAK inhibitor therapy may be a promising strategy to treat SAPHO syndrome. | Ben Li Guan-Wu Li Luan Xue Yue-Ying Chen | 2020 | World Journal of Clinical Cases2020，8，19： | 4 |
| 2 | The effects of stabilizers on the bath stability of electroless Ni deposition and the deposit 显示文摘 | Luan Ben L Shoesmith David W | 2004 | Applied Surface Science2004，229，： | 1 |
| 3 | The Effects of Stabilizers on the Bath Stability of Electroless Ni Deposition and the Deposit显示文摘 | W J Cheong Ben L Luan David W Shoesmith | 2004 | Applied Surface Science2004，，229： | 1 |
| 4 | Residual stress analysis-an important consideration for coating of stereolithography polymers显示文摘 | Luan Ben Liu X Y Nagata John | 2005 | Surface and Coatings Technology2005，192，23： | 1 |
| 5 | Novel copper immersion coating on magnesium alloy AZ91D in an alkaline bath显示文摘 | Lianxi Yang Ben Luan John Nagata | 2006 | Journal of Coatings Technology and Research2006，，3： | 1 |
| 6 | Optimization and performance analysis of copper immersion coating on AZ91 magnesium alloy显示文摘 | Lianxi Yang Ben Luan Woo-Jae Cheong Jiaren Jiang | 2005 | Journal of Coatings Technology and Research2005，，6： | 1 |
| 7 | Nano SiO 2 particle formation and deposition on polypropylene separators for lithium-ion batteries显示文摘 | Dong Fu Ben Luan Steve Argue Martin N. Bureau Isobel J. Davidson | 2011 | Journal of Power Sources2011，，： | 1 |
| 8 | An investigation of new barium phosphate chemical conversion coating on AZ31 magnesium alloy显示文摘 | Yougui Chen Ben Li Luan Guang-Ling Song Qi Yang David M. Kingston Farid Bensebaa | 2012 | Surface & Coatings Technology2012，，： | 1 |
| 9 | Protective Coating on Mg AZ91D Alloy The Effect of Electroless Nickel (EN) Bath Stabilizers on Corrosion Behavior of Ni-P Deposit显示文摘 | CHEONG Woo-jae LUAN Ben L SHOESMITH David W | 2007 | Corrosion Sci- ence2007，49，4： | 1 |
| 10 | Protective coating on Mg AZ91 D alloy -The effect of electroless nickel (EN) bath stabilizers on corrosion behaviour of Ni- P deposit 显示文摘 | Woo-Jae Cheong Ben L Luan David W Shoesmith | 2007 | Corrosion Science2007，49，： | 1 |
| 11 | The effects of stabilizers on the bath stability of electroless Ni deposition and the deposit显示文摘 | CHEONG W J LUAN Ben L SHOESMITH David W | 2004 | Applied Surface Science2004，229，： | 1 |
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