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| 1 | Chronic myeloid leukemia-from the Philadelphia chromosome to specific target drugs:A literature review显示文摘Chronic myeloid leukemia(CML)is a myeloproliferative neoplasm and was the first neoplastic disease associated with a well-defined genotypic anomaly―the presence of the Philadelphia chromosome.The advances in cytogenetic and molecular assays are of great importance to the diagnosis,prognosis,treatment,and monitoring of CML.The discovery of the breakpoint cluster region(BCR)-Abelson murine leukemia(ABL)1 fusion oncogene has revolutionized the treatment of CML patients by allowing the development of targeted drugs that inhibit the tyrosine kinase activity of the BCR-ABL oncoprotein.Tyrosine kinase inhibitors(known as TKIs)are the standard therapy for CML and greatly increase the survival rates,despite adverse effects and the odds of residual disease after discontinuation of treatment.As therapeutic alternatives,the subsequent TKIs lead to faster and deeper molecular remissions;however,with the emergence of resistance to these drugs,immunotherapy appears as an alternative,which may have a cure potential in these patients.Against this background,this article aims at providing an overview on CML clinical management and a summary on the main targeted drugs available in that context. | Mariana Miranda Sampaio Maria Luísa Cordeiro Santos Hanna Santos Marques Vinícius Lima de Souza Gonçalves Glauber Rocha Lima Araújo Luana Weber Lopes Jonathan Santos Apolonio Camilo Santana Silva Luana Kauany de SáSantos Beatriz Rocha Cuzzuol Quézia Estéfani Silva Guimarães Mariana Novaes Santos Breno Bittencourt de Brito Filipe Antônio França da Silva Márcio Vasconcelos Oliveira Cláudio Lima Souza Fabrício Freire de Melo | 2021 | World Journal of Clinical Oncology2021，12，2： | 3 |
| 2 | A rice high-afinity potassium transporter (HTK) conceals a calcium-permeable cation 显示文摘 | Lan W Z Wang W Wang S M Li L G Buchanan B B Lin H X Gao J P Luana S | 2010 | Proceedings of the National Academy of Sciences of the United States of America2010，107，15： | 1 |
| 3 | Multi-element determination of Cu, Fe, Ni and Zn content in vegetable oils samples by high-resolution continuum source atomic absorption spectrometry and microemulsion sample preparation 显示文摘 | LUANA S N JOSE T P B ANDREA P F | 2011 | Food Chemistry2011，127，2： | 1 |
| 4 | Multi-element de- termination of Cu, Fe, Ni and Zn content in vegetable oils sam- pies by high-resolution continuum source atomic absorption spec- trometry and microemulsion sample preparation显示文摘 | Luana S N Jose T P B Andrea P F | 2011 | Food Chem- istry2011，127，2： | 1 |
| 5 | Optimizationof J3-glucosidase, |3-xylosidase and xylanase produc-tion by colletotrichum graminicoLa under solid-statefermentation and application in raw sugarcane trashsaccharification 显示文摘 | Ana L R L Z Cesar S?Luana P M | 2013 | Int J Mol Sci2013，14，2： | 1 |
| 6 | Multi-element determination of Cu, Fe, Ni and Zn content in vegetable oils samples by high-resolution continuum source atomic absorption spectrometry and microemulsion sample preparation 显示文摘 | Luana S Nunes L S Barbosa J T P | 2011 | Food Chemistry2011，127，2： | 1 |
| 7 | Multi-element determination of Cu, Fe, Ni and Zn content in vegetable oils samples by high-resolution continuum source atomic absorption spectrometry and microemulsion sample preparation显示文摘 | LUANA S N JOSE T P B ANDREA P F | 2011 | Food Chemistry2011，127，2： | 1 |
| 8 | Multi-element determina-tion of Cu,Fe,Ni and Zn content in vegetable oils samples by high-resolution continuum source atomic absorption spectrometry and mi-croemulsion sample preparation显示文摘 | Luana S N Jose TPB Andrea P F | 2011 | Food Chemistry2011，127，2： | 1 |
| 9 | Multi-element determination of Cu, Fe, Ni and Zn content in vegetable oils samples by high-resolution continuum source atomic absorp- tion spectrometry and microemulsion sample preparation 显示文摘 | Luana S N Jose T P B Andrea P F | 2011 | Food Chemistry2011，127，2： | 1 |
| 10 | Multi-element determination of Cu, Fe, Ni and Zn content in vegetable oils samples by high-resolution continuum source atomic absorption spectrometry and microemulsion sample preparation 显示文摘 | LUANA S N JOSE T P B ANDREA P F | 2011 | Food Chemistry2011，127，2： | 1 |
| 11 | Multi-element determination of Cu, Fe, Ni and Zn content in vegetable oils samples by high-resolution continuum source atomic absorption spectrometry and microemulsion sample preparation 显示文摘 | Luana S N Jose T P B Andrea P F | 2011 | Food Chemistry2011，127，2： | 1 |
| 12 | Multi-element determination of Cu, Fe, Ni and Zn content in veg- etable oils samples by high-resolution continuum source atomic ab- sorption spectrometry and microemulsion sample preparation 显示文摘 | Luana S Nunesa Jose T P Barbosaa AndrEa P Fernandesa | 2011 | Food chemistry2011，127，2： | 1 |
| 13 | Syndemic aspects between COVID-19 pandemic and social inequalities显示文摘Although the coronavirus disease 2019(COVID-19)pandemic has reached all over the world population,it has demonstrated a heterogeneous impact on different populations.The most vulnerable communities which coexist daily with the social inequalities like low access to hygiene and personal protection products,crowded residences,and higher levels of chronic diseases have a higher risk of contact and the spread of infection,beyond unfavorable clinical outcomes.The elevation of the risk of infection exposure can be related to gender due to the presence of a larger contingent of women in essential services,as well as frontline and cleaning professionals who regardless of gender have the greatest exposure to the virus.Such exposures can contribute to the development of fear of contaminating themselves or their family members associated also with the work stress,both of which are related to the emergence of mental disturbances in these populations.Furthermore,conditions of unsanitary living and low socioeconomic status,populations at war,pre-existing social barriers,and ethnicity have contributed to more impact of the pandemic both in the exposure to the virus and access to health services,COVID-19 management,and management of other pathologies.At the same time,factors such as the closing of non-essential services,the loss of jobs,and the increase in household spending aggravated the social vulnerabilities and impacted the family economy.Lastly,the COVID-19 pandemic contributed still more to the impact on women's health since it propitiated a favorable environment for increasing domestic violence rates,through the segregation of women from social life,and increasing the time of the victims with their aggressors. | Jonathan Santos Apolonio Ronaldo Teixeira da Silva Júnior Beatriz Rocha Cuzzuol Glauber Rocha Lima Araújo Hanna Santos Marques Isadora de Souza Barcelos Luana Kauany de SáSantos Luciano Hasimoto Malheiro Vinícius Lima de Souza Gonçalves Fabrício Freire de Melo | 2022 | World Journal of Methodology2022，12，5： | 0 |
| 14 | COVID-19 neuropsychiatric repercussions:Current evidence on the subject显示文摘Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection has affected the entire world,causing the coronavirus disease 2019(COVID-19)pandemic since it was first discovered in Wuhan,China in December 2019.Among the clinical presentation of the disease,in addition to fever,fatigue,cough,dyspnea,diarrhea,nausea,vomiting,and abdominal pain,infected patients may also experience neurological and psychiatric repercussions during the course of the disease and as a post-COVID-19 sequelae.Thus,headache,dizziness,olfactory and gustatory dysfunction,cerebrovascular disorders,neuromuscular abnormalities,anxiety,depression,and post-traumatic stress disorder can occur both from the infection itself and from social distancing and quarantine.According to current evidence about this infection,the virus has the ability to infect the central nervous system(CNS)via angiotensin-converting enzyme 2(ACE2)receptors on host cells.Several studies have shown the presence of ACE2 in nerve cells and nasal mucosa,as well as transmembrane serine protease 2,key points for interaction with the viral Spike glycoprotein and entry into the CNS,being olfactory tract and blood-brain barrier,through hematogenous dissemination,potential pathways.Thus,the presence of SARS-CoV-2 in the CNS supports the development of neuropsychiatric symptoms.The management of these manifestations seems more complex,given that the dense parenchyma and impermeability of brain tissue,despite protecting the brain from the infectious process,may hinder virus elimination.Still,some alternatives used in non-COVID-19 situations may lead to worse prognosis of acute respiratory syndrome,requiring caution.Therefore,the aim of this review is to bring more current points related to this infection in the CNS,as well as the repercussions of the isolation involved by the pandemic and to present perspectives on interventions in this scenario. | Ronaldo Teixeira da Silva Júnior Jonathan Santos Apolonio Beatriz Rocha Cuzzuol Bruna Teixeira da Costa Camilo Santana Silva Glauber Rocha Lima Araújo Marcel Silva Luz Hanna Santos Marques Luana Kauany de SáSantos Samuel Luca Rocha Pinheiro Vinícius Lima de Souza Gonçalves Mariana Santos Calmon Fabrício Freire de Melo | 2022 | World Journal of Methodology2022，12，5： | 0 |
| 15 | Assessing the prognosis of cirrhotic patients in the intensive care unit:What we know and what we need to know better显示文摘Critically ill cirrhotic patients have high in-hospital mortality and utilize significant health care resources as a consequence of the need for multiorgan support.Despite this fact,their mortality has decreased in recent decades due to improved care of critically ill patients.Acute-on-chronic liver failure(ACLF),sepsis and elevated hepatic scores are associated with increased mortality in this population,especially among those not eligible for liver transplantation.No score is superior to another in the prognostic assessment of these patients,and both liver-specific and intensive care unit-specific scores have satisfactory predictive accuracy.The sequential assessment of the scores,especially the Sequential Organ Failure Assessment(SOFA)and Chronic Liver Failure Consortium(CLIF)-SOFA scores,may be useful as an auxiliary tool in the decision-making process regarding the benefits of maintaining supportive therapies in this population.A CLIF-ACLF>70 at admission or at day 3 was associated with a poor prognosis,as well as SOFA score>19 at baseline or increasing SOFA score>72.Additional studies addressing the prognostic assessment of these patients are necessary. | Fernando da Silveira Pedro H R Soares Luana Q Marchesan Roberto S A da Fonseca Wagner L Nedel | 2021 | World Journal of Hepatology2021，13，10： | 0 |
| 16 | Effects of nutrients on immunomodulation in patients with severe COVID-19:Current knowledge显示文摘Recent research has demonstrated that critically ill patients with coronavirus disease 2019(COVID-19)show significant immune system dysregulation.Due to that,some nutrients that influence immunomodulation have been suggested as a form of treatment against the infection.This review collected the information on the impact of vitamins on the prognosis of COVID-19,with the intention of facilitating treatment and prevention of the disease risk status in patients.The collected information was obtained using the PubMed electronic database by searching for articles that relate COVID-19 and the mechanisms/effects of the nutrients:Proteins,glucose,lipids,vitamin B12,vitamin D,calcium,iron,copper,zinc,and magnesium,including prospective,retrospective,and support articles.The findings reveal an optimal response related mainly to omega-3,eicosapentaenoic acid,docosahexaenoic acid,calcium,and iron that might represent benefits in the treatment of critically ill patients.However,nutrient supplementation should be done with caution due to the limited availability of randomized controlled studies. | Bruna Teixeira da Costa Glauber Rocha Lima Araújo Ronaldo Teixeira da Silva Júnior Luana Kauany de SáSantos Vinícius Lima de Souza Gonçalves Daniel Bastos Alves Lima Beatriz Rocha Cuzzuol Jonathan Santos Apolonio Lorena Sousa de Carvalho Hanna Santos Marques Camilo Santana Silva Isadora de Souza Barcelos Márcio Vasconcelos Oliveira Fabrício Freire de Melo | 2022 | World Journal of Critical Care Medicine2022，11，4： | 0 |
| 17 | Usher syndrome:Genetic diagnosis and current therapeutic approaches显示文摘Usher Syndrome(USH)is the most common deaf-blind syndrome,affecting approximately 1 in 6000 people in the deaf population.This genetic condition is characterized by a combination of hearing loss(HL),retinitis pigmentosa,and,in some cases,vestibular areflexia.Among the subtypes of USH,USH type 1 is considered the most severe form,presenting profound bilateral congenital deafness,vestibular areflexia,and early onset RP.USH type 2 is the most common form,exhibiting congenital moderate to severe HL for low frequencies and severe to profound HL for high frequencies.Conversely,type 3 is the rarest,initially manifesting mild symptoms during childhood that become more prominent in the first decades of life.The dual impact of USH on both visual and auditory senses significantly impairs patients'quality of life,restricting their daily activities and interactions with society.To date,9 genes have been confirmed so far for USH:MYO7A,USH1C,CDH23,PCDH15,USH1G,USH2A,ADGRV1,WHRN and CLRN1.These genes are inherited in an autosomal recessive manner and encode proteins expressed in the inner ear and retina,leading to functional loss.Although non-genetic methods can assist in patient triage and disease extension evaluation,genetic and molecular tests play a pivotal role in providing genetic counseling,enabling appropriate gene therapy,and facilitating timely cochlear implantation(CI).The CRISPR/Cas9 system and viral-based gene replacement therapy have recently emerged as highly promising techniques for treating USH.Regarding drug therapy,PTC-124 and Nb54 have been identified as promising drug interventions for genetic HL in USH.Simultaneously,CI has proven to be critical in the restoration of hearing.This review aims to summarize the genetic and molecular diagnosis of USH and highlight the importance of early diagnosis in Cuzzuol BR et al.Diagnosis and current treatments of USH WJO http://gffzz01c13a3805cf4476sbpc6ofnp6ppn69uu.ffgz.tsg.suse.edu.cn 2 January 19,2024 Volume 11 Issue 1 guiding appropriate treatment strategies and improving patient prognosis. | Beatriz Rocha Cuzzuol Jonathan Santos Apolonio Ronaldo Teixeira da Silva Júnior Lorena Sousa de Carvalho Luana Kauany de SáSantos Luciano Hasimoto Malheiro Marcel Silva Luz Mariana Santos Calmon Henrique de Lima Crivellaro Fabian Fellipe Bueno Lemos Fabrício Freire de Melo | 2024 | World Journal of Otorhinolaryngology2024，11，1： | 0 |
| 18 | Treatment of Helicobacter pylori infection in children:A systematic review显示文摘BACKGROUND Helicobacter pylori(H.pylori)infection is predominantly acquired in childhood.When indicated,the most accepted treatment for H.pylori eradication in this age group is first-line triple therapy.However,the increasing resistance to clarithromycin and nitroimidazoles has been associated with treatment failure,and thus,alternative treatment regimens have been proposed.AIM To perform a systematic review of randomized controlled trials on treatment regimens for H.pylori infection in children.METHODS We surveyed relevant articles published in English from 2010 to April 2020 in the PubMed and MEDLINE databases.Keywords included“Helicobacter pylori“/”children or childhood“/”treatment or eradication.”The risk of bias was evaluated according to the Cochrane Handbook of Systematic Reviews for Interventions.RESULTS Among the 1144 records identified through the database,20 articles were selected.Four studies compared the eradication rates of H.pylori infection between standard triple therapies,changing only the main antibiotic used.Seven studies evaluated the effectiveness of standard triple therapy with the addition of probiotics.One study investigated the relationship between the effectiveness in the eradication rates of standard triple therapy and vitamin E levels.Six studies analyzed the eradication rates of sequential therapy.CONCLUSION The findings suggest that although standard triple therapy is the most recommended regimen for children by the current guidelines,other therapeutic schemes have shown promising results and may also be recommended for clinical practice in the future. | Filipe Antônio França da Silva Breno Bittencourt de Brito Maria Luísa Cordeiro Santos Hanna Santos Marques Mariana Miranda Sampaio Ronaldo Teixeira da Silva Júnior Jonathan Santos Apolonio Lorena Sousa de Carvalho Camilo Santana Silva Luana Kauany de SáSantos Márcio Vasconcelos Oliveira Gifone Aguiar Rocha Dulciene Maria de Magalhães Queiroz Fabrício Freire de Melo | 2020 | World Journal of Meta-Analysis2020，8，4： | 0 |
| 19 | Helicobacter pylori infection in pregnant women:Gastrointestinal symptoms and pregnancy-related disorders显示文摘Helicobacter pylori(H.Pylori)is a gram-negative,flagellated and spiral-shaped bacterial pathogen that impacts approximately 46%among pregnant women globally and has been associated with various maternal-fetal complications.Iron deficiency anemia,fetal growth restriction,cardiovascular diseases,and insufficient nutrient absorption can be observed in pregnant women,as well as miscarriages and pregnancy-specific hypertensive disease,such as pre-eclampsia.Thus,the evidence supports the influence of H.pylori infection on fetal implantation/placentation failure,and positive strains of the cytotoxin-associated gene A of H.Pylori were reported as the most prevalent in these conditions.However,current knowledge indicates a relationship between this infection and the occurrence of hyperemesis gravidarum,characterized by frequent nausea and vomiting.Regarding the diagnosis of this bacterial infection,non-invasive approaches such as stool antigen test,urea breath test,and serological tests are more accepted during pregnancy,as they are easy to carry out and cost-effective.Finally,the bacteria eradication therapy should consider the risks and benefits for the pregnant woman and her child,with pharmacological intervention depending on the clinical presentation. | Luana Kauany de SáSantos Jonathan Santos Apolonio Beatriz Rocha Cuzzuol Bruna Teixeira da Costa Vinícius Lima de Souza Gonçalves Ronaldo Teixeira da Silva Júnior Marcel Silva Luz Fabian Fellipe Bueno Lemos Samuel Luca Rocha Pinheiro Fabrício Freire de Melo | 2023 | World Journal of Clinical Infectious Diseases2023，13，5： | 0 |
| 20 | Rupture of a hepatic adenoma in a young woman after an abdominal trauma: A case report显示文摘Unlike hepatic haemorrhage following blunt abdominal trauma, spontaneous abdomen bleeding is rare, even in the presence of a hepatocellular adenoma (HA) or carcinoma. However, the diagnosis of a tumour underlying a haematoma after liver trauma is unusual, especially when it occurs more after two years after the accident. Here, we report a case of a ruptured HA due to blunt abdominal trauma. A 36-year-old woman was admitted to our hospital with sudden onset of upper abdominal pain. Her medical history revealed a blunt abdominal trauma two years prior. Initial abdominal computed tomography scan revealed a large haematoma measuring more than 16 cm in diameter in the right lobe of the liver. Magnetic resonance imaging showed haemorrhagic areas and some regions with hepatocyte hyperplasia, suggesting HA. The patient underwent right hepatic lobectomy, and a histopathological examination confirmed a diagnosis of HA. In conclusion, it is important to consider that abdominal trauma may hide old, asymptomatic and not previously detected injuries, as in the case reported. | Ricardo Lemos Cotta-Pereira Luana Ferreira Valente Daniela Goncalves De Paula Antnio Luís Eiras-Araújo Antnio Carlos Iglesias | 2013 | World Journal of Gastroenterology2013，19，27： | 0 |
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