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| 1 | Lanreotide in Metastatic Enteropancreatic Neuroendocrine Tumors显示文摘 | Martyn E. Caplin Marianne Pavel Jaros?aw B. ?wik?a Alexandria T. Phan Markus Raderer Eva Sedlá?ková Guillaume Cadiot Edward M. Wolin Jaume Capdevila Lucy Wall Guido Rindi Alison Langley Séverine Martinez Jo?lle Blumberg Philippe Ruszniewski | 2014 | The New England Journal of Medicine2014，，： | 3 |
| 2 | Significance of postoperative follow-up of patients with metastatic colorectal cancer using circulating tumor DNA显示文摘BACKGROUND One of the most notable applications for circulating tumor DNA(ctDNA)detection in peripheral blood of patients with metastatic colorectal cancer(mCRC)is a long-term postoperative follow-up.Sometimes referred to as a“liquid(re)biopsy”it is a minimally invasive procedure and can be performed repeatedly at relatively short intervals(months or even weeks).The presence of the disease and the actual extent of the tumor burden(tumor mass)within the patient’s body can be monitored.This is of particular importance,especially when evaluating radicality of surgical treatment as well as for early detection of disease progression or recurrence.AIM To confirm the radicality of surgery using ctDNA and compare available methods for detection of recurrence in metastatic colorectal cancer.METHODSA total of 47 patients with detected ctDNA and indications for resection of mCRC were enrolled in the multicenter study involving three surgical centers.Standard postoperative follow-ups using imaging techniques and the determination of tumor markers were supplemented by ctDNA sampling.In addition to the baseline ctDNA testing prior to surgery,a postoperative observation was conducted by evaluating ctDNA presence up to a week after surgery and subsequently at approximately three-month intervals.The presence of ctDNA was correlated with radicality of surgical treatment and the actual clinical status of the patient.RESULTS Among the monitored patients,the R0(curative)resection correlated with postoperative ctDNA negativity in 26 out of 28 cases of surgical procedures(26/28,93%).In the remaining cases of R0 surgeries that displayed ctDNA,both patients were diagnosed with a recurrence of the disease after 6 months.In 7 patients who underwent an R1 resection,4 ctDNA positivities(4/7,57%)were detected after surgery and associated with the confirmation of early disease recurrence(after 3 to 7 months).All 15 patients(15/15,100%)undergoing R2 resection remained constantly ctDNA positive during the entire follow-up period.In 22 cases of recurrence,ctDNA positivity was detected 22 times(22/22,100%)compared to 16 positives(16/22,73%)by imaging methods and 15 cases(15/22,68%)of elevated tumor markers.CONCLUSION ctDNA detection in patients with mCRC is a viable tool for early detection of disease recurrence as well as for confirmation of the radicality of surgical treatment. | Lucie Benešová Tereza Hálková Renata Ptáčková Anastasiya Semyakina Kateřina Menclová JiříPudil Miroslav Ryska Miroslav Levý JaromírŠimša Filip Pazdírek JiříHoch Milan Blaha Marek Minárik | 2019 | World Journal of Gastroenterology2019，25，48： | 3 |
| 3 | Alternative treatments to inhibit VEGF in age-related choroidal neovascularisation: 2-year findings of the IVAN randomised controlled trial显示文摘 | Usha Chakravarthy Simon P Harding Chris A Rogers Susan M Downes Andrew J Lotery Lucy A Culliford Barnaby C Reeves | 2013 | The Lancet2013，，： | 2 |
| 4 | Ultra-rapid analysis of nitrate and nitrite by capillary electrophoresis 显示文摘 | MELANSON J E LUCY C A | 2000 | J Chromatogr A2000，88，4： | 1 |
| 5 | RN-BSN edueation: 21 st century barriers and in- actives显示文摘 | Lucy A Megginson | 2008 | Journal of Nursing Management2008，16，1： | 1 |
| 6 | Characterization of a novel endopolygalacturonase from Aspergillus niger with unique kinetic properties显示文摘 | Lucie Parenicova Harry C M Kester Jacques A E Benen | 2000 | FEBS Letters2000，467，： | 1 |
| 7 | Oxidative desulphurisation of oils via hydrogen peroxide and heteropolyanion catalysis 显示文摘 | COLLINS E M LUCY A H SHARP C | 1997 | J Mol Catal A1997，117，13： | 1 |
| 8 | Is DD3 a new prostate-specific gene显示文摘 | GANDINI O LUCI L STIGLIANO A | 2003 | Anticancer res2003，23，1： | 1 |
| 9 | Characterization of the rheological, textural and sensory properties of samples of commercial us cream cheese with different fat contents显示文摘 | Brighenti M Lucy S G Lucey J A | 2008 | Journal of Dairy Science2008，91，12： | 1 |
| 10 | Influence of the transcription factor RORgammat on the development of NKp46 + cell populations in gut and skin 显示文摘 | Luci C Reynders A Ivanov II | 2009 | Nat Immunol2009，10，1： | 1 |
| 11 | DNA forms of the geminivirus African cassava mosaic virus consistent with a rolling circle mechanism of replication显示文摘 | Saundems K Lucy A Stanley J | 1991 | Nucleic Acids Research1991，19，： | 1 |
| 12 | Isotopic separation of- and aniline by capillary electrophoresis using surfactant-controlled reversed electroosmotic flow显示文摘 | Lucy C A | 1998 | Anal Chem1998，70，15： | 1 |
| 13 | People's Collection Wales:online access to the heritage of Wales from museums,archives and libraries显示文摘 | Lucy A T | 2011 | Program2011，45，3： | 1 |
| 14 | Non-covalent capillary coatings for protein separations in capillary electrophoresis显示文摘 | Lucy C A MacDonald A M Gulcev M D | 2008 | J Chromatogr A2008，，1184： | 1 |
| 15 | Genetic algorithms and traveling salesman problems显示文摘 | Chatterjee Sangitl Carrera Cecilial Lynch Lucy A | 1996 | European Journal of Operational Research1996，93，3： | 1 |
| 16 | Healthy Hearts-A community-based primary prevention to reduce coronary heart disease 显示文摘 | Gill R Hugo C W Lucy M et a l | 2008 | BMC Cardio- vascular Disorders2008，26，8： | 1 |
| 17 | Polymorphisms of the 5-HT2C receptor and leptin genes are associated with antipsychotic drug-induced weight gain in Caucasian subjects with a first-episode psychosis显示文摘 | Templeman Lucy A Reynolds Arranz | 2005 | Pharmacogenetics & Genomics2005，15，4： | 1 |
| 18 | Delineation of the domains required for physical and functional interaction of p14ARF with human topoisomerase I 显示文摘 | Olivier A Lucie K Jean-Francois R | 2003 | Oncogene2003，22，： | 1 |
| 19 | Influence of the transcription factor RORgammat on the development o{ NKp46+ cell populations in gut and skin显示文摘 | Luci C Reynders A Ivanov II etal | 2009 | Nat Immunol2009，10，： | 1 |
| 20 | Oxidative desulphurisation of oils via hydrogen peroxide and heteropolyanion catalysis 显示文摘 | COLLINS E M LUCY A H SHARP C | 1997 | J Mol Catal A1997，117，13： | 1 |
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