|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Down-expression of tumor protein p53-induced nuclear protein 1 in human gastric cancer显示文摘瞄准:肿瘤蛋白质的 Overexpression 导致 p53 的原子蛋白质(TP53INP1 ) 1 导致 G1 房间周期拘捕并且增加调停 p53 的 apoptosis。澄清 TP53INP1 的临床的重要性,我们在胃的癌症分析了 TP53INP1 和 p53 表示。方法:TP53INP1 和 p53 表示在胃的癌症的 142 种情况中用免疫组织化学被检验。胃的癌症房间的 apoptosis 用 TUNEL 方法被分析。在 TP53INP1 和 clinicopathological 因素的表示之间的关系统计上被分析。结果:TP53INP1 在 98% 被表示(139/142 盒子) 非癌的胃的纸巾并且在 64% 是下面表示的(91/142 盒子) 从一样的病人的胃的癌症损害。TP53INP1 表示显著地被减少(43.9%) 与井相比或中等在糟糕区分的腺癌区分了腺癌(81.6%) 。入侵粘膜下层的癌症或更深出现了断然降低(59.1%) 与粘膜癌症(85.2%) 相比。TP53INP1 表示的减少或损失显著地与淋巴的侵略被相关(54.3% 对 82.0% 没有淋巴的侵略) 并且节点积极的病人(31.3% 对 68.3% 在节点否定的病人) 。P53 在 68 被表示(47.9%) 胃的癌症的病人,而它在正常胃的纸巾是不在的。一个重要协会也在肿瘤房间在 TP53INP1 地位和 apoptosis 的水平之间被观察:在 TP53INP1 积极的纸巾的 apoptotic 索引在 TP53INP1 否定的部分比那显著地高。最后,当幸存数据被分析时, TP53INP1 表示的损失在预言差的预后(P=0.0006 ) 有重要效果。结论:有胃的癌症的前进的 TP53INP1 积极的率减少。TP53INP1 蛋白质否定性显著地与胃的癌症的好攻击的病理学的显型被联系。TP53INP1 与胃的癌症房间的 apoptosis 有关。TP53INP1 蛋白质的减少的表示可以反映胃的癌症的恶意的等级并且被认为是一个不利预示的因素。 | Pei-Hong Jiang Yoshiharu Motoo Stéphane Garcia Juan Lucio Iovanna Marie-Josèphe Pébusque Norio Sawabu | 2006 | World Journal of Gastroenterology2006，12，5： | 3 |
| 2 | Determination of phenolic compounds in wines by novel matrix solid-phase dispersion extraction and gas chromatography-mass spectrometry 显示文摘 | LUCIO M ROBERTO P | 2008 | Journal of Chromatography A2008，1185，： | 1 |
| 3 | Kinetics of non en- zymatic oxidation reactions:Browning in white wines显示文摘 | Francisco J P Z Francisco B A Lucio G C | 2000 | Eu rope Food Research Technology2000，211，4： | 1 |
| 4 | On CK2 regulation of chronic lymphocytic leukemia cell viability显示文摘 | Martins LR Lucio P Silva MC | | 0，，1： | 1 |
| 5 | Bioactivity of TiN-coated titanium implants显示文摘 | Stefano P Lucio C C Erik V | 2004 | Acta Mater2004，52，5： | 1 |
| 6 | Apoptosis induced in neuronal cells by oxidative stress:role played by caspases and intracellular calcium ions显示文摘 | Lucio A Salvatore A Anna P | 2003 | Toxicol Lett2003，139，： | 1 |
| 7 | Long-term results of induction chemo therapy followed by concurrent chemotherapy and thoracic irradiation in limited small cell lung cancer显示文摘 | Ernesto M Lucio C Fabrizio P | 2002 | Lung Cancer2002，37，1： | 1 |
| 8 | Circulatory dynamics during dental extractions in normal,cardiac and transplant patients显示文摘 | Carlo P | 2002 | J Am Dent Assoc2002，133，4： | 1 |
| 9 | Saving, Growth, and Investment : Microeconomic Analysis Using a Panel of Countries 显示文摘 | Orazio P Atanasic Lucio Pici Autonello E Scorcu | 2001 | The Review of Economics and Statistics2001，，2： | 1 |
| 10 | Stigmasterols from Typha latifolia显示文摘 | MARINA D G PIETRO M LUCIO P | 1990 | Journal of Natural Products1990，33，6： | 1 |
| 11 | Microwave assisted crystallization of zeolite A from dense gels 显示文摘 | Lucio B Edoardo P | 2003 | Journal of crystal growth2003，247，： | 1 |
| 12 | Official Intervention in the Foreign Exchange Market: Is It Effective and , If so, How does It Work? 显示文摘 | Sarno Lucio and Taylor Mark P | 2001 | Journal of Economic Literature2001，39，3： | 1 |
| 13 | A quantitative polymerase chain reaction assay completely discriminates between Duchenc and Becker muscular dystrophy deletion carriers and normal females显示文摘 | Maria GC Giulia F | 1996 | Mol Cell Probes1996，10，： | 1 |
| 14 | Microwave assisted crystallization of zeolite a from dense gels 显示文摘 | Lucio B Edoardo P | 2003 | J Crystal Growth2003，247，： | 1 |
| 15 | Stigmasterols from Typhalatifolia显示文摘 | Marina D G Pietro M Lucio P | 1990 | J Nat Prod1990，53，6： | 1 |
| 16 | BIOMED-1 concerted action report : flow cytometriccharacterization of CD7 + cell subsets in normal bonemarrow as a basis for the diagnosis and follow-up of Tcell acute lymphoblastic leukemia ( T-ALL ) 显示文摘 | Porwit-MacDonald A Bjorklund E Lucio P | 2000 | Leukemia2000，14，5： | 1 |
| 17 | Fast and selective ox-idation of primary alcohols to aldehydes or to carboxylicacids and of secondary alcohols to ketones mediated byoxoammonium salts under two-phase conditions显示文摘 | Lucio Anelli P Biffi C Montanari F | 1987 | J OrgChem1987，52，： | 1 |
| 18 | Allelochemical activity of phenylpropanes from Acorus gramineus 显示文摘 | Marina D G Pietro M Lucio P | 1989 | Phytochemistry1989，28，9： | 1 |
| 19 | Glutamate-independent Calcium Toxicity Introduction显示文摘 | LUCIO A MAURO C GIUSEPPE P | 2007 | Stroke(S0039-2499)2007，38，： | 1 |
| 20 | Effects of a multimodal exercise protocol on functional outcomes,epigenetic modulation and brain-derived neurotrophic factor levels in institutionalized older adults:a quasi-experimental pilot study显示文摘Epigenetic changes have been shown to be associated with both aging process and aging-related diseases.There is evidence regarding the benefits of physical activity on the functionality,cognition,and quality of life of institutionalized older adults,however,the molecular mechanisms involved are not elucidated.The purpose of this pilot study was to investigate the effects of a multimodal exercise intervention on functional outcomes,cognitive performance,quality of life(QOL),epigenetic markers and brain-derived neurotrophic factor(BDNF)levels among institutionalized older adult individuals.Participants(n=8)without dementia who were aged 73.38±11.28 years and predominantly female(87.5%)were included in this quasi-experimental pilot study.A multimodal exercise protocol(cardiovascular capacity,strength,balance/agility andflexibility,perception and cognition)consisted of twice weekly sessions(60 minutes each)over 8 weeks.Balance(Berg Scale),mobility(Timed Up and Go test),functional capacity(Six-Minute Walk test),cognitive function(Mini-Mental State Examination)and QOL(the World Health Organization Quality of Life-BREF Scale questionnaire)were evaluated before and after the intervention.Blood sample(15 mL)was also collected before and after intervention for analysis of biomarkers global histone H3 acetylation and brain-derived neurotrophic factor levels.Significant improvements were observed in cognitive function,balance,mobility,functional capacity and QOL after the intervention.In addition,a tendency toward an increase in global histone H3 acetylation levels was observed,while brain-derived neurotrophic factor level remained unchanged.This study provided evidence that an 8-week multimodal exercise protocol has a significant effect on ameliorating functional outcomes and QOL in institutionalized older adult individuals.In addition,it was also able to promote cognitive improvement,which seems to be partially related to histone hyperacetylation status.The Ethics Research Committee of Centro Universitário Metodista-IPA,Brazil approved the current study on June 6,2019(approval No.3.376.078). | Iasmin Fraga Camila Weber Wériton Baldo Galiano Lucio Iraci Mariana Wohlgemuth Gabriela Morales Camila Cercato Juliana Rodriguez Daniela Pochmann Caroline Dani Pérsia Menz Adriane Dal Bosco Viviane Rostirola Elsner | 2021 | Neural Regeneration Research2021，16，12： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员