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| 1 | Unsedated ultrathin upper endoscopy is better than conventional endoscopy in routine outpatient gastroenterology practice:A randomized trial显示文摘AIM: to compare the feasibility and patients' tolerance of esophagogastroduodenoscopy (EGD) using a thin endoscope with those of conventional oral EGD and to determine the optimal route of introduction of small-caliber endoscopes. METHODS: One hundred and sixty outpatients referred for diagnostic EGD were randomly allocated to 3 groups: conventional (C)-EGD (9.8 mm in diameter), transnasal (TN)-EGD and transoral (TO)-EGD (5.9 mm in diameter). Pre-EGD anxiety was measured using a 100-mm visual analogue scale (VAS). After EGD, patients and endoscopists completed a questionnaire on the pain, nausea, choking, overall discomfort, and quality of the examination either using VAS or answering some questions. The duration of EGD was timed. Blood oxygen saturation (SaO2) and heart rate (HR) were monitored during EGD. RESULTS: Twenty-one patients refused to participate in the study. The 3 groups were well-matched for age, gender, experience with EGD, and anxiety. EGD was completed in 91.1% (41/45), 97.5% (40/41), and 96.2% (51/53) of cases in TN-EGD, TO-EGD, and C-EGD groups, respectively. TN-EGD lasted longer (3.11 ± 1.60 min) than TO-EGD (2.25 ± 1.45 min) and C-EGD (2.49 ± 1.64 min) (P < 0.05). The overall tolerance was higher (P < 0.05) and the overall discomfort was lower (P < 0.05) in TN-EGD group than in C-EGD group. EGD was tolerated 'better than expected' in 73.2% of patients in TN-EGD group and 55% and 39.2% of patients in TO-EGD and C-EGD groups, respectively (P < 0.05). Endoscopy was tolerated 'worst than expected' in 4.9% of patients in TN-EGD group and 17.5% and 23.5% of patients in TO-EGD and C-EGD groups, respectively (P < 0.05). TN-EGDcaused mild epistaxis in one case. The ability to insufflate air, wash the lens, and suction of the thin endoscope were lower than those of conventional instrument (P < 0.001). All biopsies performed were adequate for histological assessment. CONCLUSION: Diagnostic TN-EGD is better tolerated than C-EGD. Narrow-diameter endoscope has a level of diagnostic accuracy comparable to that of conventional gastroscope, even though some technical characteristics of these instruments should be improved. Transnasal EGD with narrow-diameter endoscope should be proposed to all patients undergoing diagnostic EGD. | Lucio Trevisani Viviana Cifalà Sergio Sartori Giuseppe Gilli Giancarlo Matarese Vincenzo Abbasciano | 2007 | World Journal of Gastroenterology2007，13，6： | 24 |
| 2 | 丙烯酰胺和环氧丙酰胺的神经毒性研究显示文摘环氧丙酰胺(GA)是丙烯酰胺(AA)的环氧化代谢物。为了探讨AA的神经毒性与其代谢过程的关系,通过对大鼠的行为学和神经生化试验以及神经病理检查,对比了AA和GA的神经毒性。分别给大鼠腹腔注射AA(25和50mg/kg)和GA(50和100mg/kg),每天1次,连续8天。结果表明:在转轮试验、后肢撑力试验和外周神经组织甘油醛-3-磷酸脱氢酶活性的测定中,均表现为AA的毒害作用大于GA。神经病理检查也提供了AA引起外周神经损伤的证据,而GA染毒的大鼠却未见病理改变,可见神经组织更易受到AA的损害。提示:AA的神经毒性作用系由其本身引起,而受其代谢物影响较小。 | 邓海 焦小云 何凤生 Lucio G.Costa | 1997 | 中华预防医学杂志1997，31，4： | 14 |
| 3 | Reliability in endoscopic diagnosis of portal hypertensive gastropathy显示文摘AIM: To analyze reliability among endoscopists in diagnosing portal hypertensive gastropathy (PHG) and to determine which criteria from the most utilized classifications are the most suitable. METHODS: From January to July 2009, in an academic quaternary referral center at Santa Casa of S o Paulo Endoscopy Service, Brazil, we performed this singlecenter prospective study. In this period, we included 100 patients, including 50 sequential patients who had portal hypertension of various etiologies; who were previously diagnosed based on clinical, laboratory and imaging exams; and who presented with esophageal varices. In addition, our study included 50 sequentialpatients who had dyspeptic symptoms and were referred for upper digestive endoscopy without portal hypertension. All subjects underwent upper digestive endoscopy, and the images of the exam were digitally recorded. Five endoscopists with more than 15 years of experience answered an electronic questionnaire, which included endoscopic criteria from the 3 most commonly used Portal Hypertensive Gastropathy classifications (McCormack, NIEC and Baveno) and the presence of elevated or flat antral erosive gastritis. All five endosco- pists were blinded to the patients' clinical information, and all images of varices were deliberately excluded for the analysis. RESULTS: The three most common etiologies of portal hypertension were schistosomiasis (36%), alcoholic cirrhosis (20%) and viral cirrhosis (14%). Of the 50 patients with portal hypertension, 84% were Child A, 12% were Child B, 4% were Child C, 64% exhibited previous variceal bleeding and 66% were previously endoscopic treated. The endoscopic parameters, presence or absence of mosaic-like pattern, red point lesions and cherry-red spots were associated with high inter-observer reliability and high specificity for diagnosing Portal Hypertensive Gastropathy. Sensitivity, specificity and reliability for the diagnosis of PHG (%) were as follows: mosaic-like pattern (100; 92.21; High); fine pink speckling (56; 76.62; Unsatisfactory); superficial reddening (69.57; 66.23; Unsatisfactory); red-point lesions (47.83; 90.91; High); cherry-red spots (39.13; 96.10; High); isolated red marks (43.48; 88.31; High); and confluent red marks (21.74; 100; Unsatisfactory). Antral elevated erosive gastritis exhibited high reliability and high specificity with respect to the presence of portal hypertension (92%) and the diagnosis of portal hypertensive gastropathy (88.31%). CONCLUSION: The most suitable endoscopic criteria for the diagnosis of PHG were mosaic-like pattern, redpoint lesions and cherry-red spots with no subdivisions,which were associated with a high rate of inter-observer reliability. | George Fred Soares de Macedo Fabio Gon alves Ferreira Maurício Alves Ribeiro Luiz Arnaldo Szutan Mauricio Saab Assef Lucio Giovanni Battista Rossini | 2013 | World Journal of Gastrointestinal Endoscopy2013，5，7： | 9 |
| 4 | Intestinal obstruction caused by torsed gangrenous Meckel's diverticulum encircling terminal ileum显示文摘Meckel's diverticulum(MD)is considered the most prevalent congenital anomaly of the gastrointestinal tract. It may result in a number of complications including hemorrhage,obstruction,and inflammation.Obstruction of various types is the most common presenting symptom in the adult population.Loop formations with the end of an MD and adjacent mesentery constricting the distal ileum is an uncommon cause of obstruction. Axial torsion and gangrene of MD is the rarest of the complications.The correct diagnosis of complicated MD before surgery is often difficult because this condition may mimic other acute abdominal pathologies.Delay in the diagnosis of a complicated MD can lead to signifi- cant morbidity and mortality.Here we describe the case of a patient with a very rare form of acute small bowel obstruction secondary to giant torsed gangrenous MD encircling the terminal ileum.To our knowledge, this co-occurrence of axial torsion and a loop-forming mechanism of obstruction has been reported only once in English medical literature. | Carmine Cartanese Tommaso Petitti Ernesto Marinelli Antonio Pignatelli Davide Martignetti Matteo Zuccarino Lucio Ferrozzi | 2011 | World Journal of Gastrointestinal Surgery2011，3，7： | 7 |
| 5 | Gastric cancer:The times they are a-changin'显示文摘Gastric cancer is the third leading cause of cancer death worldwide.Even though during these last decades gastric cancer incidence decreased in Western countries,it remains endemic and with a high incidence in Eastern countries.The survival in advanced and metastatic stage of gastric cancer is still very poor.Recently the Cancer Genoma Atlas Research Network identified four subtypes with different molecular profiles to classify gastric cancer in order to offer the optimal targeted therapies for pre-selected patients.Indeed,the key point is still the selection of patients for the right treatment,on basis of molecular tumor characterization.Since chemotherapy reached a plateau of efficacy for gastric cancer,the combination between cytotoxic therapy and biological agents gets a better prognosis and decreases chemotherapeutic toxicity.Currently,Trastuzumab in combination with platinum and fluorouracil is the only approved targeted therapy in the first line for c-erb B2 positive patients,whereas Ramucirumab is the only approved targeted agent for patients with metastatic gastric cancer.New perspectives for an effective treatment derived from the immunotherapeutic strategies.Here,we report an overview on gastric cancer treatments,with particular attention to recent advances in targeted therapies and in immunotherapeutic approach. | Maria Antonietta Satolli Lucio Buffoni Rosella Spadi Ilaria Roato | 2015 | World Journal of Gastrointestinal Oncology2015，7，11： | 6 |
| 6 | Efficient fully laser-patterned flexible perovskite modules and solar cells based on low-temperature solution-processed SnO2/mesoporous-TiO2 electron transport layers显示文摘 | Janardan Dagar Sergio Castro-Hermosa Matteo Gasbarri Alessandro L. Palma Lucio Cina Fabio Matteocci Emanuele Calabro Aldo Di Carlo Thomas M. Brown | 2018 | Nano Research2018，11，5： | 6 |
| 7 | Post-Anaesthetic Discharge Scoring System to assess patient recovery and discharge after colonoscopy显示文摘AIM: To investigate whether discharge scoring criteria are as safe as clinical criteria for discharge decision and allow for earlier discharge.METHODS: About 220 consecutive outpatients undergoing colonoscopy under sedation with Meperidine plus Midazolam were enrolled and assigned to 2 groups: in Control-group(110 subjects) discharge decision was based on the clinical assessment; in PADSS-group(110subjects) discharge decision was based on the modified Post-Anaesthetic Discharge Scoring System(PADSS).Measurements of the PADDS score were taken every20 min after colonoscopy, and patients were discharged after two consecutive PADSS scores ≥ 9. The investigator called each patient 24-48 h after discharge to administer a standardized questionnaire, to detect any delayed complications. Patients in which cecal intubation was not performed and those who were not found at follow-up phone call were excluded from the study.RESULTS: Thirteen patients(7 in Control-group and6 in PADSS-group) were excluded from the study. Recovery from sedation was faster in PADSS-group than in Control-group(58.75 ± 18.67 min vs 95.14 ± 10.85min, respectively; P < 0.001). Recovery time resulted shorter than 60 min in 39 patients of PADSS-group(37.5%), and in no patient of Control-group(P < 0.001).At follow-up phone call, no patient declared any hospital re-admission because of problems related to colonoscopy and/or sedation. Mild delayed post-discharge symptoms occurred in 57 patients in Control-group(55.3%)and in 32 in PADSS-group(30.7%). The most common symptoms were drowsiness, weakness, abdominal distension, and headache. Only 3 subjects needed to take some drugs because of post-discharge symptoms.CONCLUSION: The Post-Anaesthetic Discharge Scoring System is as safe as the clinical assessment and allows for an earlier patient discharge after colonoscopy performed under sedation. | Lucio Trevisani Viviana Cifalà Giuseppe Gilli Vincenzo Matarese Angelo Zelante Sergio Sartori | 2013 | World Journal of Gastrointestinal Endoscopy2013，5，10： | 5 |
| 8 | 意大利水文地质调查编图指南解读及其借鉴意义显示文摘对《意大利水文地质调查编图指南(1∶50 000)》(Quaderni,serie III,N.5英文版)的产生背景、结构特点和主要内容进行解读,并与中国现行《水文地质调查规范(1∶50 000)》(DZ/T 0282—2015)进行对比,得出如下认识:(1)《意大利水文地质调查编图指南(1∶50 000)》融调查规范与编图规范于一体。在编排结构上,编图内容在前,调查内容在后,调查内容紧扣编图内容,体现了围绕编图搞调查的技术路线。(2)中国现行《水文地质调查规范(1∶50 000)》未涵盖编图内容,亟需出台《水文地质编图规范(1∶50 000)》与之配套。《意大利水文地质调查编图指南(1∶50 000)》在图例组织、编图规则、工作量定额等方面值得中国借鉴。(3)意大利水文地质工作程度与中国接近,两国地质调查局都在推进1∶50 000水文地质调查工作,'一带一路'上的两个文明古国开展水文地质调查与编图合作,对于促进两国乃至世界水文地质调查编图技术水平提高具有重要意义。 | 吴爱民 Giovanni Conte Lucio Martarelli 马荣 | 2016 | 水文地质工程地质2016，43，5： | 5 |
| 9 | The role of the serum testosterone levels as a predictor of prostate cancer in patients with atypical small acinar proliferation at the first prostate biopsy显示文摘当前的文学不在预言哪个上支持临床的标记的实用性有不正常的小 acinar 增长的病人(尽快) 是更可能的进行到前列腺癌症(PCa ) 。雄激素长被认为是为 PCa 的潜在的风险因素。然而,睾丸激素的角色是争论的。到在浆液睾丸激素(TS ) 之间的关系铺平的分析和在在病人的第一前列腺活体检视以后的 PCa 的诊断的现在的学习目的影响了由尽快。这回顾的研究包括了诊断与的 143 个病人尽快在起始的 transrectal 为可疑 PCa 的指导超声的前列腺活体检视根据泌尿学指南的欧洲协会。他们的 TS 层次,年龄, PSA,前列腺体积,数字直肠的考试,和前列腺活体检视格利森分数(GS ) 为统计分析回顾地被收集。在学习包括的所有病人有两手准备活体检视并且对进一步的分析合适。重新活体检视被执行在第一诊断以后的 3-6 月尽快。低、正常的 TS 组由 29 组成(20.3%) 并且 114 (79.7%) 病人分别地。第二活体检视的诊断是尽快在 25.2% 并且在 36.4% 病人的 PCa。在有 PCa 和那些与的病人之间的比较否定或一尽快,在第二活体检视的结果报导有癌症的人显著地有 TS 的高水平(P < 0.001 ) 。然而,在 GS postbiopsy 和 TS 之间没有统计上重要的协会(P = 0.324 ) 。我们的经验证明 eugonadal 病人可以是为重新活体检视在以后上的 PCa 的诊断的一个临床的风险因素尽快诊断比 hypogonadal。 | Lucio DelrAtti Andrea B Galosi | 2018 | Asian Journal of Andrology2018，20，1： | 4 |
| 10 | Cardiovascular risk after orthotopic liver transplantation, a review of the literature and preliminary results of a prospective study显示文摘Improved surgical techniques and greater efficacy of new anti-rejection drugs have significantly improved the survival of patients undergoing orthotopic liver transplantation(OLT). This has led to an increased incidence of metabolic disorders as well as cardiovascular and cerebrovascular diseases as causes of morbidity and mortality in OLT patients. In the last decade, several studies have examined which predisposing factors lead to increased cardiovascular risk(i.e., age, ethnicity, diabetes, NASH, atrial fibrillation, and some echocardiographic parameters) as well as which factors after OLT(i.e., weight gain, metabolic syndrome, immunosuppressive therapy, and renal failure) are linked to increased cardiovascular mortality. However, currently, there are no available data that evaluate the development of atherosclerotic damage after OLT. The awareness of high cardiovascular risk after OLT has not only lead to the definition of new but generally not accepted screening of high risk patients before transplantation, but also to the need for careful patient follow up and treatment to control metabolic and cardiovascular pathologies after transplant. Prospective studies are needed to better define the predisposing factors for recurrence and de novo occurrence of metabolic alterations responsible for cardiovascular damage after OLT. Moreover, such studies will help to identify the timing of disease progression and damage,which in turn may help to prevent morbidity and mortality for cardiovascular diseases. Our preliminary results show early occurrence of atherosclerotic damage, which is already present a few weeks following OLT, suggesting that specific, patient-tailored therapies should be started immediately post OLT. | Giuseppina Pisano Anna L Fracanzani Lucio Caccamo Maria F Donato Silvia Fargion | 2016 | World Journal of Gastroenterology2016，22，40： | 4 |
| 11 | Colonoscopy,pain and fears:Is it an indissoluble trinomial?显示文摘Colonoscopy is the reference method in the secondary prevention,diagnosis and,in some cases,treatment of colorectal cancer.It can often cause pain associated with embarrassment,anxiety,and physical and emotional discomfort.Pain intensity is influenced by a lot of factors,and there is a strict relationship among pain,pain perception,and mind.Several methods can be used to break the trinomial colonoscopy,pain and fear.Sedoanalgesia is recommended by several guidelines.If no sedation is offered,the patient must accept a higher chance of unacceptable discomfort and the endoscopist a lower chance of completing the procedure because of patient discomfort.Other non-pharmacologic methods such as acupuncture,music,and hydrocolonoscopy can be used as alternatives to pharmacologic sedoanalgesia.Furthermore,new endoscopic technologies such as variable-stiffness colonoscopes and ultrathin colonoscopes,or the use of carbon dioxide instead of air for colon insufflation,can reduce the pain caused by colonoscopy.In the future,technical improvements such as wireless capsules or robotic probes,will probably enable to overcome the present concept of colonoscopy,avoiding the use of traditional endoscopes.However,at present the poor attention paid by endoscopists to the pain and discomfort caused by colonoscopy can not be justified.There are several methods to reduce pain and anxiety and to break the trinomial colonoscopy,pain and fear.We must use them. | Lucio Trevisani Angelo Zelante Sergio Sartori | 2014 | World Journal of Gastrointestinal Endoscopy2014，6，6： | 4 |
| 12 | LED照明应该变得更加智能显示文摘能量效率更高、功能更强的新型LED固态发光(SSL)产品的发展很快,被认为是照明市场上的主要革命性进步。在许多垂直应用中,如信号灯、汽车、LCDTV背光,LED已经毫无争议地成为传统光源的替代产品。但对于范围更广的通用照明,LED还没有被广泛接受,其应用也将落后这些垂直应用数年。固态发光产品的成本和效率无疑将继续快速改进,并将很快到达被广泛接受的门槛,有可能是2007年或2008年,也有人认为将推迟到2010年前后。 | Lucio Di Jasio | 2007 | 今日电子2007，，5： | 3 |
| 13 | MicroRNA Signature in Metastatic Colorectal Cancer Patients Treated With Anti-EGFR Monoclonal Antibodies显示文摘 | Federico Cappuzzo Andrea Sacconi Lorenza Landi Vienna Ludovini Francesca Biagioni Armida D’Incecco Alessandra Capodanno Jessica Salvini Enrichetta Corgna Samanta Cupini Cecilia Barbara Gabriella Fontanini Lucio Crinò Giovanni Blandino | 2013 | Clinical Colorectal Cancer2013，，： | 3 |
| 14 | Down-expression of tumor protein p53-induced nuclear protein 1 in human gastric cancer显示文摘瞄准:肿瘤蛋白质的 Overexpression 导致 p53 的原子蛋白质(TP53INP1 ) 1 导致 G1 房间周期拘捕并且增加调停 p53 的 apoptosis。澄清 TP53INP1 的临床的重要性,我们在胃的癌症分析了 TP53INP1 和 p53 表示。方法:TP53INP1 和 p53 表示在胃的癌症的 142 种情况中用免疫组织化学被检验。胃的癌症房间的 apoptosis 用 TUNEL 方法被分析。在 TP53INP1 和 clinicopathological 因素的表示之间的关系统计上被分析。结果:TP53INP1 在 98% 被表示(139/142 盒子) 非癌的胃的纸巾并且在 64% 是下面表示的(91/142 盒子) 从一样的病人的胃的癌症损害。TP53INP1 表示显著地被减少(43.9%) 与井相比或中等在糟糕区分的腺癌区分了腺癌(81.6%) 。入侵粘膜下层的癌症或更深出现了断然降低(59.1%) 与粘膜癌症(85.2%) 相比。TP53INP1 表示的减少或损失显著地与淋巴的侵略被相关(54.3% 对 82.0% 没有淋巴的侵略) 并且节点积极的病人(31.3% 对 68.3% 在节点否定的病人) 。P53 在 68 被表示(47.9%) 胃的癌症的病人,而它在正常胃的纸巾是不在的。一个重要协会也在肿瘤房间在 TP53INP1 地位和 apoptosis 的水平之间被观察:在 TP53INP1 积极的纸巾的 apoptotic 索引在 TP53INP1 否定的部分比那显著地高。最后,当幸存数据被分析时, TP53INP1 表示的损失在预言差的预后(P=0.0006 ) 有重要效果。结论:有胃的癌症的前进的 TP53INP1 积极的率减少。TP53INP1 蛋白质否定性显著地与胃的癌症的好攻击的病理学的显型被联系。TP53INP1 与胃的癌症房间的 apoptosis 有关。TP53INP1 蛋白质的减少的表示可以反映胃的癌症的恶意的等级并且被认为是一个不利预示的因素。 | Pei-Hong Jiang Yoshiharu Motoo Stéphane Garcia Juan Lucio Iovanna Marie-Josèphe Pébusque Norio Sawabu | 2006 | World Journal of Gastroenterology2006，12，5： | 3 |
| 15 | Long-term effect of aspirin on cancer risk in carriers of hereditary colorectal cancer: an analysis from the CAPP2 randomised controlled trial显示文摘 | John Burn Anne-Marie Gerdes Finlay Macrae Jukka-Pekka Mecklin Gabriela Moeslein Sylviane Olschwang Diane Eccles D Gareth Evans Eamonn R Maher Lucio Bertario Marie-Luise Bisgaard Malcolm G Dunlop Judy WC Ho Shirley V Hodgson Annika Lindblom Jan Lubinski Pa | 2011 | The Lancet2011，，9809： | 3 |
| 16 | Efficient fully blade-coated perovskite solar cells in air with nanometer-thick bathocuproine buffer layer显示文摘Fully printed perovskite solar cells(PSCs)were fabricated in air with all constituent layers,except for electrodes,deposited by the blade coating technique.The PSCs incorporated,for the first time,a nanometer-thick printed bathocuproine(BCP)hole blocking buffer using blade coating and deposited at relative humidity up to 50%.The PSCs with a p-i-n structure(glass/indium tin oxide(ITO)/poly(3,4-ethylenedioxythiophene)polystyrene sulfonate(PEDOT:PSS)/CH_(3)NH_(3)Pbl_(3)/[6,6]-phenyl-C_(61)-butyric acid methyl ester(PCBM)/BCP/Ag)delivered a maximum power conversion efficiency(PCE)of 14.9%on an active area of 0.5 cm^(2)when measured under standard test conditions.The PSCs with a blade coated BCP delivered performance of 10%and 63%higher(in relative terms)than those incorporating a spin coated BCP or without any BCP film,respectively.The atomic force microscopy(AFM)showed that blade coated films were more homogeneous and acted also as a surface planarizer leading to a reduction of roughness which improved BCP/Ag interface lowering charge recombination.The demonstration of 15%efficient devices with all constituent layers,including nanometer-thick BCP(〜10 nm),deposited by blade coating in air,demonstrates a route for industrialization of this technology. | Sergio Castro-Hermosa Luana Wouk Izabela Silva Bicalho Luiza de Queiroz Correa Bas de Jong Lucio Cina Thomas M.Brown Diego Bagnis | 2021 | Nano Research2021，14，4： | 2 |
| 17 | Genistein Down-Regulates miR-223 Expression in Pancreatic Cancer Cells显示文摘 | Jia Ma Long Cheng Hao Liu Jing Zhang Ying Shi Fanpeng Zeng Lucio Miele Fazlul H Sarkar Jun Xia Zhiwei Wang | 2013 | Current Drug Targets2013，，10： | 2 |
| 18 | The westward lithospheric drift,its role on the subduction and transform zones surrounding Americas:Andean to cordilleran orogenic types cyclicity显示文摘We investigate the effect of the westerly rotation of the lithosphere on the active margins that surround the Americas and find good correlations between the inferred easterly-directed mantle counterflow and the main structural grain and kinematics of the Andes and Sandwich arc slabs.In the Andes,the subduction zone is shallow and with low dip,because the mantle flow sustains the slab;the subduction hinge converges relative to the upper plate and generates an uplifting doubly verging orogen.The Sandwich Arc is generated by a westerly-directed SAM(South American) plate subduction where the eastward mantle flow is steepening and retreating the subduction zone.In this context,the slab hinge is retreating relative to the upper plate,generating the backarc basin and a low bathymetry single-verging accretionary prism.In Central America,the Caribbean plate presents a more complex scenario:(a) To the East,the Antilles Arc is generated by westerly directed subduction of the SAM plate,where the eastward mantle flow is steepening and retreating the subduction zone.(b) To the West,the Middle America Trench and Arc are generated by the easterly-directed subduction of the Cocos plate,where the shallow subduction caused by eastward mantle flow in its northern segment gradually steepens to the southern segment as it is infered by the preexisting westerly-directed subduction of the Caribbean Plateau.In the frame of the westerly lithospheric flow,the subduction of a divergent active ridge plays the role of introducing a change in the oceanic/continental plate’s convergence angle,such as in NAM(North American)plate with the collision with the Pacific/Farallon active ridge in the Neogene(Cordilleran orogenic type scenario).The easterly mantle drift sustains strong plate coupling along NAM,showing at Juan de Fuca easterly subducting microplate that the subduction hinge advances relative to the upper plate.This lower/upper plate convergence coupling also applies along strike to the neighbor continental strike slip fault systems where subduction was terminated(San Andreas and Queen Charlotte).The lower/upper plate convergence coupling enables the capture of the continental plate ribbons of Baja California and Yakutat terrane by the Pacific oceanic plate,transporting them along the strike slip fault systems as para-autochthonous terranes.This Cordilleran orogenic type scenario,is also recorded in SAM following the collision with the Aluk/Farallon active ridge in the Paleogene,segmenting SAM margin into the eastwardly subducting Tupac Amaru microplate intercalated between the proto-LiquineOfqui and Atacama strike slip fault systems,where subduction was terminated and para-autochthonous terranes transported.In the Neogene,the convergence of Nazca plate with respect to SAM reinstalls subduction and the present Andean orogenic type scenario. | Eugenio Aragon Fernando D'Eramo Marco Cuffaro Carlo Doglioni Eleonora Ficini Lucio Pinotti Silvina Nacif Manuel Demartis Irene Hernando Tomas Fuentes | 2020 | Geoscience Frontiers2020，11，4： | 2 |
| 19 | Training Load Monitoring Algorithms on Highly Sub-Metered Home Electricity Consumption Data显示文摘The growing interest in energy-efficient buildings is driving changes in investment, design, and occupant behavior. To better focus cost and resource conservation efforts, electricity consumption feedback can be used to provide motivation, guidance, and verification. Disaggregating by end-use helps both consumers and producers to identify targets for conservation. While hardware-based sub-metering is costly and labor-intensive, non-intrusive load monitoring (NILM) is capable of gathering detailed energy-use data with minimal equipment cost and installation time. However, variations in measurements between metering devices complicate the process of compiling the necessary appliance profiles. Future work involves the devel-opment of NILM algorithms using sensor fusion and detailed appliance-level data gathered from a highly-sensed house currently being constructed near Pittsburgh, Pennsylvania. | Mario Berges Ethan Goldman H. Scott Matthews Lucio Soibelman | 2008 | Tsinghua Science and Technology2008，13，S1： | 2 |
| 20 | Evaluation of antibody-dependent cell-mediatedcy totoxicity activity and cetuximab response in KRAS wildtype metastatic colorectal cancer patients显示文摘AIM:To investigate the prognostic role of invariant natural killer T(iNKT) cells and antibody-dependent cell-mediated cytotoxicity(ADCC) in wild type KRAS metastatic colorectal cancer(mC RC) patients treated with cetuximab.METHODS: Forty-one KRAS wt mC RC patients,treated with cetuximab and irinotecan-based chemotherapy in Ⅱ and Ⅲ lines were analyzed. Genotyping of single nucleotide polymorphism(SNP)s in the FCGR2A,FCGR3A and in the 3' untranslated regions of KRAS and mutational analysis for KRAS,BRAF and NRAS genes was determined either by sequencing or allelic discrimination assays. Enriched NK cells were obtained from lymphoprepperipheral blood mononuclear cell and iN KT cells were defined by co-expression of CD3,TCRVα24,TCRVβ11. ADCC was evaluated as ex vivo NK-dependent activity,measuring lactate dehydrogenase release.RESULTS: At basal,mCRC patients performing ADCC activity above the median level(71%) showed an improved overall survival(OS) compared to patients with ADCC below(median 16 vs 8 mo;P=0.026). We did not find any significant correlation of iN KT cells with OS(P=0.19),albeit we observed a trend to a longer survival after 10 mo in patients with iN KT above median basal level(0.382 cells/microliter). Correlation of OS and progression-free survival(PFS) with interesting SNPs involved in ADCC ability revealed not to be significant. Patients carrying alleles both with A in FCGR2 A and TT in FCGR3A presented a trend of longer PFS(median 9 vs 5 mo;P=0.064). Chemotherapy impacted both iN KT cells and ADCC activity. Their prognostic values get lost when we analysed them after 2 and 4 mo of treatment.CONCLUSION: Our results suggest a link between iN KT cells,basal ADCC activity,genotypes in FCGR2A and FCGR3A,and efficacy of cetuximab in KRAS wt mC RC patients. | cristiana lo nigro vincenzo ricci daniela vivenza martino monteverde giuliana strola francesco lucio federica tonissi emanuela miraglio cristina granetto mirella fortunato marco carlo merlano | 2016 | World Journal of Gastrointestinal Oncology2016，8，2： | 2 |
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