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| 1 | Outcome of surgical resection in Klatskin tumors显示文摘Cholangiocarcinomas are the second most frequent primary hepatic malignancy,and make up from 5% to 30% of malignant hepatic tumours.Hilar cholangiocarcinoma(HCC) is the most common type,and accounts for approximately 60% to 67% of all cholangiocarcinoma cases.There is not a staging system that permits us to compare all series and extract some conclusions to increase the long-survival rate in this dismal disease.Neither the extension of resection,according to the sort of HCC,is a closed topic.Some authors defend limited resection(mesohepatectomy with S1,S1 plus S4b-S5,local excision for papillary tumours,etc.) while others insist in the compulsoriness of an extended hepatic resection with portal vein bifurcation removed to reach cure.As there is not an ideal adjuvant therapy,R1 resection can be justified to prolong the survival rate.Morbidity and mortality rates changed along the last decade,but variability is the rule,with morbidity and mortality rates ranging from 14% to 76% and from 0% to 19%,respectively.Conclusion:Surgical resection continues to be the main treatment of HCC.Negative resection margins achieved with major hepatic resections are associated with improved outcome.Preresectional management with biliary drainage,portal vein embolization and staging laparoscopy should be considered in selected patients.Additional evidence is needed to fully define the role of orthotopic liver transplant.Portal and lymph node involvement worsen the prognosis and long-term survival,and surgery is the only option that can lengthen it.Improvements in adjuvant therapy are essential for improving long-term outcome.Furthermore,the lack of effective chemotherapy drugs and radiotherapy approaches leads us to can consider R1 resection as an option,because operated patients have a longer survival rate than those who not undergo surgery. | Alejandro Serrablo Luis Tejedor | 2013 | World Journal of Gastrointestinal Oncology2013，5，7： | 18 |
| 2 | Reconstruction after pancreatoduodenectomy:Pancreatojejunostomy vs pancreatogastrostomy显示文摘Pancreatic surgeons try to find the best technique for reconstruction after pancreatoduodenectomy(PD) in order to decrease postoperative complications,mainly pancreatic fistulas(PF).In this work,we compare the two most frequent techniques of reconstruction after PD,pancreatojejunostomy(PJ) and pancreatogastrostomy(PG),in order to determine which of the two is better.A systematic review of the literature was performed,including major meta-analysis articles,clinical randomized trials,systematic reviews,and retrospective studies.A total of 64 articles were finally included.PJ and PG are usually responsible for most of the postoperative morbidity,mainly due to the onset of PF,being considered a major trigger of life-threatening complications such as intra-abdominal abscess and hemorrhagia.The included systematic reviews reported a significant difference only in the incidence of intraabdominal collections favouring PG.PF,delayed gastric emptying and mortality were not different.Although there was heterogeneity between these studies,all were conducted in specialized centers by highly experienced surgeons,and the surgical care was likely to be similar for all the studies.The disadvantages of PG include an increased incidence of delayed gastric emptying and of main pancreatic duct obstruction due to overgrowth by the gastric mucosa.Exocrine function appears to be worse after PG than after PJ,resulting in severe atrophic changes in the remnant pancreas.Depending on the type of PJ or PG used,the PF rate and other complications can also be different.The best method to deal with the pancreatic stump after PD remains questionable.The choice of method of pancreatic anastomosis could be based on individual experience and on the surgeon's preference and adherence to basic principles such as good exposure and visualization.In conclusion,up to now none of the techniques can be considered superior or be recommended as standard for reconstruction after PD. | Tatiana Gómez Ana Palomares Mario Serradilla Luis Tejedor | 2014 | World Journal of Gastrointestinal Oncology2014，6，9： | 3 |
| 3 | Photocatalytic degradation of pesticide pirimiphos-methyl显示文摘 | Jean Marie Herrmann Chantal Guillard M. Arguello Ana Agüera Ana Tejedor Luis Piedra Amadeo Fernández-Alba | 1999 | Catalysis Today1999，，2： | 1 |
| 4 | A 17 bpdeletion in the bone morphogenetic protein 15 (BMP15) gene is associated to increased prolificacy in the Rasa Aragonesa sheep breed显示文摘 | Luis V Monteagudo Ricardo Ponz M Teresa Tejedor | 2009 | Animal Reproduction Science2009，110，12： | 1 |
| 5 | Analysis of the occurrence and distribution of the Omp25/Omp31 family of surface proteins in the six classical Brucella species显示文摘 | Ana I. Martín-Martín Paola Caro-Hernández Pilar Sancho Carmen Tejedor Axel Cloeckaert Luis Fernández-Lago Nieves Vizcaíno | 2008 | Veterinary Microbiology2008，，1： | 1 |
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