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| 1 | Interfacial adsorption-insertion mechanism induced by phase boundary toward better aqueous Zn-ion battery显示文摘Biphasic and multiphasic compounds have been well clarified to achieve extraordinary electrochemical properties as advanced energy storage materials.Yet the role of phase boundaries in improving the performance is remained to be illustrated.Herein,we reported the biphasic vanadate,that is,Na_(1.2)V_(3)O_(8)/K_(2)V_(6)O_(16)·1.5H_(2)O(designated as Na0.5K0.5VO),and detected the novel interfacial adsorption-insertion mechanism induced by phase boundaries.Firstprinciples calculations indicated that large amount of Zn^(2+)and H^(+)ions would be absorbed by the phase boundaries and most of them would insert into the host structure,which not only promote the specific capacity,but also effectively reduce diffusion energy barrier toward faster reaction kinetics.Driven by this advanced interfacial adsorption-insertion mechanism,the aqueous Zn/Na_(0.5)K_(0.5)VO is able to perform excellent rate capability as well as long-term cycling performance.A stable capacity of 267 mA h g^(-1)after 800 cycles at 5 A g^(-1)can be achieved.The discovery of this mechanism is beneficial to understand the performance enhancement mechanism of biphasic and multiphasic compounds as well as pave pathway for the strategic design of highperformance energy storage materials. | Lutong Shan Yiren Wang Shuquan Liang Boya Tang Yongqiang Yang Ziqing Wang Bingan Lu Jiang Zhou | 2021 | InfoMat2021，3，9： | 8 |
| 2 | Physicochemical Control of the Early Permian Xiangshan Fe-Ti Oxide Deposit in Eastern Tianshan(Xinjiang),NW China显示文摘The Xiangshan mafic-ultramafic complex is one of the major Early Permian mafic-ultramafic intrusions in eastern Tianshan(Xinjiang, NW China), and consists of two major intrusive phases. The first intrusive phase is mainly gabbroic rocks hosting ilmenite mineralization, while the second intrusive phase is mainly lherzoilite associated with Ni-Cu sulfide mineralization. The Xiangshan ilmenite orebodies hosted in the Fe-Ti oxide-bearing gabbro occur along the contact between hornblende gabbros and leucogabbros. The hornblende gabbros and Fe-Ti oxide rich gabbros at Xiangshan are newly dated to be Early Permian(280.1 and 279.2 Ma, respectively). Major and trace element compositions of zircons and whole rocks from Xiangshan hornblende gabbro and Fe-Ti oxide gabbro have been measured by in situ excimer laser ablation ICP-MS. Zircon Ce^(4+)/Ce^(3+) ratios based on lattice-strain model and Ti-in-zircon temperatures of hornblende gabbro and Fe-Ti oxide gabbro of the Xiangshan complex are calculated to evaluate the physicochemical variations during the ilmenite mineralization. Whole-rock geochemistry and zircon trace element geochemistry suggest that Fe-Ti oxide gabbros were formed from a basaltic parent magma which had undergone a transfromation from being H_2O-rich to H_2O-poor. During the magmatic evolution, primitive, H_2O-poor basaltic melts may have been replenished into the system, increasing its solidus temperature and decreasing its oxygen fugacity and H_2O contents. This may have supperessed the Ti-rich poikilitic hornblende fractionation and promoted the plagioclase fractionation, which consequently concentrated the ore-forming components in the residual melts and generated the ilmenite mineralization. | Yu Shi Yuwang Wang Jingbin Wang Lutong Zhao Hongjing Xie Lingli Long Tao Zou Dedong Li Guochao Zhou | 2018 | Journal of Earth Science2018，29，3： | 6 |
| 3 | Petrogenesis and Metallogenesis of the Niumaoquan Gabbroic Intrusion Associated with Fe-Ti Oxide Ores in the Eastern Tianshan, NW China显示文摘The Niumaoquan layered gabbroic intrusion is in the southern margin of the Central Asian Orogenic Belt in North Xinjiang, China, and hosts a Fe-Ti oxide deposit in its evolved gabbroic phases. In this paper, we report zircon U-Pb age, Sr-Nd-Hf isotopes, plagioclase chemistry, and whole-rock geochemistry of the Niumaoquan layered gabbroic intrusion. Zircon grains separated from an anorthosite sample analyzed by laser ablation inductively coupled plasma mass spectrometry yielded a concordia age of 314.7±0.74 Ma, indicating that the Niumaoquan ore-bearing gabbroic intrusion was emplaced during the Late Carboniferous. The olivine gabbro texture and plagioclase chemistry suggest that plagioclase was an early crystallized silicate phase that crystallized prior to olivine. Fractional crystallization and accumulation of plagioclase significantly controlled the evolution of the Niumaoquan gabbroic intrusion and contributed to the formation of anorthosite layers, causing metallogenic elements to become enriched in the residual melt. The Niumaoquan gabbroic intrusion is characterized by the enrichment of large ion lithophile elements and depletion of high field strength elements, positive zircon εHf(t) values(+2.1 to +12.2), positive εNd(t) values(+3.3 to +5.2), and low initial ^(87)Sr/^(86)Sr ratios(0.7039 to 0.7047), suggesting that the parental magma was produced by interactions between metasomatized lithospheric mantle and depleted asthenospheric melts at an early post-collision stage. The Fe-Ti oxide mineralization of the Niumaoquan intrusion benefited from interactions between depleted asthenospheric melts and lithospheric mantle, and fractional crystallization of abundant plagioclase and magnesian minerals. | SHI Yu WANG Yuwang WANG Jingbin XIE Hongjing MAO Qigui ZHAO Lutong LONG Lingli LI Dedong ZHOU Guochao | 2018 | Acta Geologica Sinica(English Edition)2018，92，5： | 3 |
| 4 | Octave-spanning microcomb generation in 4H-silicon-carbide-on-insulator photonics platform显示文摘Silicon carbide has recently emerged as a promising photonics material due to its unique properties, including possessing strong second-and third-order nonlinear coefficients and hosting various color centers that can be utilized for a wealth of quantum applications. Here, we report the design and demonstration of octave-spanning microcombs in a 4H-silicon-carbide-on-insulator platform for the first time, to our knowledge. Such broadband operation is enabled by optimized nanofabrication achieving >1 million intrinsic quality factors in a 36-μm-radius microring resonator, and careful dispersion engineering by investigating the dispersion properties of different mode families. For example, for the fundamental transverse-electric mode whose dispersion can be tailored by simply varying the microring waveguide width, we realized a microcomb spectrum covering the wavelength range from 1100 nm to 2400 nm with an on-chip power near 120 mW. While the observed comb state is verified to be chaotic and not soliton, attaining such a large bandwidth is a crucial step towards realizing f-2f self-referencing.In addition, we also observed a coherent soliton-crystal state for the fundamental transverse-magnetic mode,which exhibits stronger dispersion than the fundamental transverse-electric mode and hence a narrower bandwidth. | Lutong Cai Jingwei Li Ruixuan Wang Qing Li | 2022 | Photonics Research2022，10，4： | 2 |
| 5 | An Improved Whale Algorithm and Its Application in Truss Optimization显示文摘The current Whale Optimization Algorithm(WOA)has several drawbacks,such as slow convergence,low solution accuracy and easy to fall into the local optimal solution.To overcome these drawbacks,an improved Whale Optimization Algorithm(IWOA)is proposed in this study.IWOA can enhance the global search capability by two measures.First,the crossover and mutation operations in Differential Evolutionary algorithm(DE)are combined with the whale optimization algorithm.Second,the cloud adaptive inertia weight is introduced in the position update phase of WOA to divide the population into two subgroups,so as to balance the global search ability and local development ability.ANSYS and Matlab are used to establish the structure model.To demonstrate the application of the IWOA,truss structural optimizations on 52-bar plane truss and 25-bar space truss were performed,and the results were are compared with that obtained by other optimization algorithm.It is verified that,compared with WOA,the IWOA has higher efficiency,fast convergence speed,better solution accuracy and stability.So IWOA can be used in the optimization design of large truss structures. | Fengguo Jiang Lutong Wang Lili Bai | 2021 | Journal of Bionic Engineering2021，18，3： | 2 |
| 6 | E3 ligase FBXW7 aggravates TMPD-induced systemic lupus erythematosus by promoting cell apoptosis显示文摘Systemic lupus erythematosus(SLE)is a systemic autoimmune disease,and the pathogenesis of SLE has not been fully elucidated.The E3 ubiquitin ligase FBXW7 has been well characterized in cancer as a tumor suppressor that can promote the ubiquitination and subsequent degradation of various oncoproteins;however,the potential role of FBXW7 in autoimmune diseases is unclear.In the present study,we identified that FBXW7 is a crucial exacerbating factor for SLE development and progression in a mouse model induced by 2,6,10,14-tetramethylpentadecane(TMPD).Myeloid cell-specific FBXW7-deficient(Lysm+FBXW7f/f)C57BL/6 mice showed decreased immune complex accumulation,glomerulonephritis,glomerular mesangial cell proliferation,and basemembrane thickness in the kidney.Lysm+FBXW7f/f mice produced fewer anti-Sm/RNP and anti-ANA autoantibodies and showed a decreased MHC II expression in B cells.In Lysm+FBXW7f/f mice,we observed that cell apoptosis was reduced and that fewer CD11b+Ly6Chi inflammatory monocytes were recruited to the peritoneal cavity.Consistently,diffuse pulmonary hemorrhage(DPH)was also decreased in Lysm+FBXW7f/f mice.Mechanistically,we clarified that FBXW7 promoted TMPD-induced cell apoptosis by catalyzing MCL1 degradation through K48-linked ubiquitination.Our work revealed that FBXW7 expression in myeloid cells played a crucial role in TMPD-induced SLE progression in mice,which may provide novel ideas and theoretical support for understanding the pathogenesis of SLE. | Zhenlu Chong Chunjing Bao Jia He Tianxiao Chen Lijia Zhong Gaopeng Li Huanle Li Lutong Fang Yinjing Song Guoxiang Fu Xuyan Yang Lihua Lai Yang Liu Qingqing Wang | 2018 | Cellular & Molecular Immunology2018，15，12： | 2 |
| 7 | Macrophage membrane-coated nanovesicles for dual-targeted drug delivery to inhibit tumor and induce macrophage polarization显示文摘Background:Immunosuppressive M2 macrophages in the tumor microenvironment(TME)can mediate the therapeutic resistance of tumors,and seriously affect the clinical efficacy and prognosis of tumor patients.This study aims to develop a novel drug delivery system for dual-targeting tumor and macrophages to inhibit tumor and induce macrophage polarization.Methods:The anti-tumor effects of methyltransferase like 14(METTL14)were investigated both in vitro and in vivo.The underlying mechanisms of METTL14 regulating macrophages were also explored in this study.We further constructed the cyclic(Arg-Gly-Asp)(cRGD)peptide modified macrophage membrane-coated nanovesicles to co-deliver METTL14 and the TLR4 agonist.Results:We found that METTL14 significantly inhibits the growth of tumor in vitro.METTL14 might downregulate TICAM2 and inhibit the Toll-like receptor 4(TLR4)pathway of macrophages,meanwhile,the combination of METTL14 and the TLR4 agonist could induce M1 polarization of macrophages.Macrophage membrane-coated nanovesicles are characterized by easy modification,drug loading,and dual-targeting tumor and macrophages,and cRGD modification can further enhance its targeting ability.It showed that the nanovesicles could improve the in vivo stability of METTL14,and dual-target tumor and macrophages to inhibit tumor and induce M1 polarization of macrophages.Conclusions:This study anticipates achieving the dual purposes of tumor inhibition and macrophage polarization,and providing a new therapeutic strategy for tumors. | Xin Huang Lutong Wang Haoyu Guo Weiyue Zhang | 2023 | Bioactive Materials2023，，5： | 1 |
| 8 | Oleic acid reduces steroidogenesis by changing the lipid type stored in lipid droplets of ovarian granulosa cells显示文摘Background:Oleic acid is an abundant free fatty acid present in livestock that are in a negative energy-balance state,and it may have detrimental effects on female reproduction and fertility.Oleic acid induces lipid accumulation in bovine granulosa cells,which leads to a foam cell-like morphology and reduced steroidogenesis.However,why oleic acid increases lipid accumulation but decreases steroidogenesis remains unclear.This study focused on oleic acid’s effects on lipid type and steroidogenesis.Results:Oleic acid increased the lipid accumulation in a concentration-dependent manner and mainly increased the triglyceride level and decreased the cholesterol ester level.Oleic acid also led to a decline in estradiol and progesterone production in porcine granulosa cells in vitro.In addition,oleic acid up-regulated the expression of CD36 and diacylglycerol acyltransferase 2,but down-regulated the expression of 3-hydroxy-3-methylglutarylcoenzyme A reductase,scavenger receptor class B member 1 and acetyl-Coenzyme A acetyltransferase 2,as well as steroidogenesis-related genes,including cytochrome P450 family 11 subfamily A member 1,cytochrome P450family 19 subfamily A member 1 and 3 as well as steroidogenic acute regulatory protein at the mRNA and protein levels.An oleic acid-rich diet also enhanced the triglyceride levels and reduced the cholesterol levels in ovarian tissues of female mice,which resulted in lower estradiol levels than in control-fed mice.Compared with the control,decreases in estrus days and the numbers of antral follicles and corpora lutea,as well as an increase in the numbers of the atretic follicles,were found in the oleic acid-fed female mice.Conclusions:Oleic acid changed the lipid type stored in lipid droplets of ovarian granulosa cells,and led to a decrease in steroidogenesis.These results improve our understanding of fertility decline in livestock that are in a negative energy-balance state. | Xiaoge Zhou Zhaoyi Mo Yankun Li Liang Huang Sihai Yu Lan Ge Yamei Hu Shengjie Shi Lutong Zhang Liguang Wang Lei Gao Gongshe Yang Guiyan Chu | 2022 | Journal of Animal Science and Biotechnology2022，13，3： | 1 |
| 9 | A general method for growth of perovskite single-crystal arrays for high performance photodetectors显示文摘Perovskite single-crystal arrays have attracted intensive attention because of their great potentials for integrated optoelectronic devices.However,the traditional top-down lithography strategy requires complex processing and is detrimental to perovskite crystal structures,which is incompatible to directly pattern perovskite single crystals.Herein,we report a lithography-free method to realize the controllable growth of perovskite single-crystal arrays.Through introducing a printed hydrophilic-hydrophobic substrate into the crystallization system,the MAPbCl_(3) single-crystal arrays with precise location and uniform size are effectively fabricated.This method can be applied to prepare diverse perovskite single-crystal arrays,including MAPbBr_(3),CsPbCl_(3),CsPbBr_(3),Cs_(3)Cu_(2)I_(5),Cs_(3)Bi_(2)I_(9),and(BA)_(2)(MA)_(3)Pb_(4)I_(11).The perovskite single crystals can be selectively grown on the electrodes to fabricate ultraviolet photodetectors.The strategy demonstrates a facile approach to fabricate large-scale perovskite single-crystal arrays and opens a pathway to produce diverse perovskite optoelectronic devices. | Shiheng Wang Zhenkun Gu Rudai Zhao Ting Zhang Yunjie Lou Lutong Guo Meng Su Lihong Li Yiqiang Zhang Yanlin Song | 2022 | Nano Research2022，15，7： | 0 |
| 10 | Engineered microorganisms-based delivery systems for targeted cancer therapy:a narrative review显示文摘Microorganisms with innate and artificial advantages have been regarded as intelligent drug delivery systems for cancer therapy with the help of engineering technology.Although numerous studies have confirmed the promising prospects of microorganisms in cancer,several problems such as immunogenicity and toxicity should be addressed before further clinical applications.This review aims to investigate the developments of engineered microorganisms-based delivery systems for targeted cancer therapy.The main types and characteristics of microorganisms such as bacteria,viruses,fungi,microalgae,and their components are introduced in detail.Moreover,the engineering strategies and biomaterials design of microorganisms are further discussed.Most importantly,we discussed the innovative attempts and therapeutic effects of engineered microorganisms in cancer.Taken together,engineered microorganisms-based delivery systems hold tremendous prospects for biomedical applications in targeted cancer therapy. | Xin Huang Haoyu Guo Lutong Wang Zengwu Shao | 2022 | Biomaterials Translational2022，3，3： | 0 |
| 11 | CO_(2)fractional laser-assisted transdermal delivery of silk nanofiber carriers in a rabbit ear hypertrophic scar model显示文摘Background:Hypertrophic scars are skin fibrotic diseases,characterized by fibroblast hyperprolif-eration and excessive accumulation of extracellular matrix.However,topical drug application for hypertrophic scars are unsatisfactory.The purpose of this study was to explore the permeability of silk nanofiber hydrogels(SNFs)loaded with rhodamine 6G(R6G)and rhodamine 110(R110)mediated by CO_(2)fractional laser irradiation into hypertrophic scar tissues.Methods:In this work,R6G and R110 were chosen as hydrophilic and hydrophobic model molecules.They were loaded inside SNFs.In vivo rabbit ear hypertrophic scars were treated with CO_(2)fractional laser irradiation and then R6G/R110-laden SNFs were applied to the scars to evaluate their synergetic effect on drug penetration efficiency.Their permeability was quantified by fluorescence intensity and measured by confocal laser scanning microscopy on days 1,3,5 and 7.More specifically,the thermal coagulation zone(CZ)and its surrounding area(peri-CZ)caused by the thermal coagulation of the laser were discussed separately.Results:Our data indicated that the SNFs promoted the penetration of R6G but not that of R110 in the peri-CZ on day 1 when combined with laser irradiation.Interestingly,both R6G and R110 were abundant in the CZ and remained stable on days 1,3 and 5.Moreover,rapid re-epithelialization hindered the long-term permeability of both drugs.Conclusion:Combining CO_(2)fractional laser irradiation with SNF drug delivery could improve the efficiency of hydrophilic drug delivery within 24 h before total re-epithelialization. | Yan Yang Lutong Liu Xiaojin Wu Xue Wang Qiang Lu Zhen Zhang | 2022 | Burns & Trauma2022，10，1： | 0 |
| 12 | Synthesis of(HfZrTiNbTa)N powders via nitride thermal reduction with soft mechano-chemical assistance显示文摘High-entropy nitride powders are one of prerequisite materials for the preparation of high-performance high-entropy nitride ceramics.In this paper,high-entropy(HfZrTiNbTa)N powders were synthesized via nitride(i.e.,silicon nitride(Si_(3)N_(4)))thermal reduction with soft mechanochemical assistance.The results show that metal oxides like hafnium dioxide(HfO_(2)),zirconium dioxide(ZrO_(2)),titanium dioxide(TiO_(2)),niobium pentoxide(Nb_(2)O_(5)),and tantalum pentoxide(Ta_(2)O_(5))can all be transformed into the corresponding metal nitrides in the presence of Si_(3)N_(4)at 1700℃,and solid solution of the metal nitrides can be formed as the temperature increases to 2100℃.The high-entropy(HfZrTiNbTa)N powders with submicron-sized particles,a narrower size distribution,and a single face-centered cubic(fcc)structure are obtained from raw material mixtures ground for 10 h and subsequently sintered at 1800℃.In addition,the high-entropy bulk nitride ceramics with relative density(Rw)of 94.31%±0.76%,Vickers hardness of 21.00±0.94 GPa,and fracture toughness(KIC)of 3.18±0.16 MPa·m1/2 are obtained with submicron-sized powders,which are superior to those obtained with micron-sized powders. | Xiang Liu Youjun Lu Qian Xu Lutong Yang Hongfang Shen Wenzhou Sun Xiao Zhang Yanmin Wang | 2023 | Journal of Advanced Ceramics2023，12，3： | 0 |
| 13 | miR-24-3p promotes proliferation and inhibits apoptosis of porcine granulosa cells by targeting P27显示文摘Ovarian follicle development is associated with the physiological functions of granulosa cells(GCs),including proliferation and apoptosis.The level of miR-24-3p in ovarian tissue of high-yielding Yorkshire×Landrace sows was significantly higher than that of low-yielding sows.However,the functions of miR-24-3p on GCs are unclear.In this study,using flow cytometry,5-ethynyl-2′-de-oxyuridine(EdU)staining,and cell count,we showed that miR-24-3p promoted the proliferation of GCs increasing the proportion of cells in the S phase and upregulating the expression of cell cycle genes,moreover,miR-24-3p inhibited GC apoptosis.Mechanistically,on-line prediction,bioinformatics analysis,a luciferase reporter assay,RT-qPCR,and Western blot results showed that the target gene of miR-24-3p in proliferation and apoptosis is cyclin-dependent kinase inhibitor 1B(P27/CDKN1B).Furthermore,the effect of miR-24-3p on GC proliferation and apoptosis was attenuated by P27 overexpression.These findings suggest that miR-24-3p regulates the physiological functions of GCs. | Shengjie Shi Lutong Zhang Liguang Wang Huan Yuan Haowei Sun Mielie Madaniyati Chuanjiang Cai Weijun Pang Lei Gao Guiyan Chu | 2024 | Journal of Integrative Agriculture2024，23，4： | 0 |
| 14 | Measurement of CO_(2) adsorption capacity with respect to different pressure and temperature in sub-bituminous: implication for CO_(2) geological sequestration显示文摘CCUS (carbon capture, utilization, and storage) technology is regarded as a bottom method to achieve carbon neutrality globally. CO_(2) storage in deep coal reservoirs serves as a feasible selection for CCUS, and its storage potential can be attributed to the CO_(2) adsorption capacity of the coal. In this paper, a series of CO_(2) adsorption isotherm experiments were performed at different pressures and temperatures in sub-bituminous coal from the southern Junggar Basin (reservoir temperature ∼25.9°C and pressure ∼3.91 MPa). In addition, the high-pressure CO_(2) adsorption characteristics of the southern Junggar Basin coal were characterized using a supercritical D-R adsorption model. Finally, the CO_(2) storage capacities in sub-bituminous coal under the in situ reservoir temperature and pressure were analyzed. Results indicated that the excess adsorption capacities increase gradually with increasing injection pressure before reaching an asymptotic maximum magnitude of ∼34.55 cm3/g. The supercritical D-R adsorption model is suitable for characterizing the excess/absolute CO_(2) adsorption capacity, as shown by the high correlation coefficients > 0.99. The CO_(2) adsorption capacity increases with declining temperature, indicating a negative effect of temperature on CO_(2) geological sequestration. By analyzing the statistical relationships of the D-R adsorption fitting parameters with the reservoir temperature, a CO_(2) adsorption capacity evolution model was established, which can be further used for predicting CO_(2) sequestration potential at in situ reservoir conditions. CO_(2) adsorption capacity slowly increases before reaching the critical CO_(2) density, following a rapid decrease at depths greater than ∼800 m in the southern Junngar Basin. The research results presented in this paper can provide guidance for evaluating CO_(2) storage potential in deep coal seams. | Sijian ZHENG Shuxun SANG Shiqi LIU Meng WANG Lutong CAO Xin JIN Guangjun FENG Yi YANG | 2023 | Frontiers of Earth Science2023，17，3： | 0 |
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