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| 1 | Noninvasive optical imaging method to evaluatepostantibiotic effects on biofilm infection in vivo显示文摘 | Kadurugamuwa JL Sin LV Yu J | | 0，，6： | 1 |
| 2 | Study on ultra-precise machining of CLBO crystal显示文摘 | LV X Yuan JL | 2006 | Key Engineering Materials2006，，： | 1 |
| 3 | Noninvasive optical imaging method to evaluate postantibiotic effects on biofilm infection in vivo显示文摘 | Kadurugamuwa JL Sin LV Yu J | 2004 | Antimicrob Agents Chemother2004，6，： | 1 |
| 4 | Acute hemiplegia associated with cat scratch disease 显示文摘 | Rocha JL Pellegrino LN Riella LV | 2004 | Braz J Infect Dis2004，8，3： | 1 |
| 5 | Dietary intervention in pa- tients with gestational diabetes mellitus: A systematic review and meta - analysis of randomized clinical trials on maternal and newborn outcomes显示文摘 | Viana LV Gross JL Azevedo MJ | 2014 | Diabetes Care2014，37，12： | 1 |
| 6 | Candidate colorectal cancer predisposing gene variants in Chinese early-onset and familial cases显示文摘AIM: To investigate whether whole-exome sequencing may serve as an efficient method to identify known or novel colorectal cancer(CRC) predisposing genes in early-onset or familial CRC cases.METHODS: We performed whole-exome sequencing in 23 Chinese patients from 21 families with nonpolyposis CRC diagnosed at ≤ 40 years of age, or from multiple affected CRC families with at least 1 firstdegree relative diagnosed with CRC at ≤ 55 years of age.Genomic DNA from blood was enriched for exome sequences using the Sure Select Human All Exon Kit, version 2(Agilent Technologies) and sequencing was performed on an Illumina Hi Seq 2000 platform.Data were processed through an analytical pipeline to search for rare germline variants in known or novel CRC predisposing genes.RESULTS: In total, 32 germline variants in 23 genes were identified and confirmed by Sanger sequencing.In 6 of the 21 families(29%), we identified 7 mutations in 3 known CRC predisposing genes including MLH1(5 patients), MSH2(1 patient), and MUTYH(biallelic, 1 patient), five of which were reported as pathogenic.Inthe remaining 15 families, we identified 20 rare and novel potentially deleterious variants in 19 genes, six of which were truncating mutations.One previously unreported variant identified in a conserved region of EIF2AK4(p.Glu738_Asp739insA rgA rg) was found to represent a local Chinese variant, which was significantly enriched in our early-onset CRC patient cohort compared to a control cohort of 100 healthy Chinese individuals scored negative by colonoscopy(33.3% vs 7%, P < 0.001).CONCLUSION: Whole-exome sequencing of early-onset or familial CRC cases serves as an efficient method to identify known and potential pathogenic variants in established and novel candidate CRC predisposing genes. | Jun-Xiao Zhang Lei Fu Richarda M de Voer Marc-Manuel Hahn Peng Jin Chen-Xi Lv Eugène TP Verwiel Marjolijn JL Ligtenberg Nicoline Hoogerbrugge Roland P Kuiper Jian-Qiu Sheng Ad Geurts van Kessel | 2015 | World Journal of Gastroenterology2015，21，14： | 1 |
| 7 | Ginseng saponin metabolite 20(S)-protopanaxadiol inhibits tumor growth by targeting multiple cancer signaling pathways 显示文摘 | Gao JL Lv GY He BC | 2013 | Oncol Rep2013，，： | 1 |
| 8 | Seasonal distribution of total and pathogenic Vibrio parahaemolyticus in Chesapeake Bay oysters and waters 显示文摘 | Parveen S Hettiarachchi KA Bowers JC Jones JL Tamplin ML McKay R Beatty W Brohawn K Dasilva LV Depaola A | 2008 | Int J Food Microbiol2008，128，2： | 1 |
| 9 | Differential expression and parent of origin effect of the 5-HT2A receptor gene C102T poly- morphism:Analysis of suicidality in schizophrenia and bipolar disorder 显示文摘 | De LV Likhodi O Kennedy JL | 2007 | American Journal of Medical Genetics Part B:Neuropsychiatric Ge- netics2007，144，3： | 1 |
| 10 | Acute hemiplegia associated with cat scratch disease显示文摘 | Rocha JL Pellegrino LN Riella LV | 2004 | Braz J Infect Dis2004，8，3： | 1 |
| 11 | Japonicasins A and B, two new isoprenylated flavanones from Sophora japonica 显示文摘 | Zhang LB Lv JL Chen HL | 2013 | Fitoterapia2013，87，： | 1 |
| 12 | How hastrnicrobial interactionsshape the nutrient environment of the mammalian intestine显示文摘 | Hooper LV Midtvedt T Gordon Jl | 2002 | AnnRev Nutr2002，22，： | 1 |
| 13 | Commensal host-bacterial relation ships in the gut显示文摘 | Hooper LV Gordon Jl | 2001 | Science2001，292，： | 1 |
| 14 | Intesti- nal epithelial autophagy is essential for host defense against invasive bacteria 显示文摘 | Benjamin JL Sumpter R Jr Levine B Hooper LV | 2013 | Cell Host Microbe2013，13，6： | 1 |
| 15 | Prediction of cardiovascular events,diabetic nephropathy,and mortality by albumin concentration in a spot urine sample in patients with type 2 diabetes显示文摘 | Viana LV Gross JL Camargo JL | 2012 | J Diabetes Complications2012，26，5： | 1 |
| 16 | Commensal host - bacterial relationshipsin the gut显示文摘 | Hooper LV Gordon JL | 2001 | Science2001，292，： | 1 |
| 17 | Association of IRF5 gene polymotphisms and lupus nephritis in a Chinese population 显示文摘 | Qin L X Lv J C Zhou X Jl | 2010 | Nephrology2010，15，： | 1 |
| 18 | Efficacy of tolterodine for medical treatment of intramural ureteral stone with vesical irritability显示文摘 | LV JL | 2011 | Urol res2011，39，3： | 1 |
| 19 | Noninvasive opticalimaging method to evaluate postantibiotic effects on biofilminfection in vivo显示文摘 | Kadurugamuwa JL Sin LV Yu J | 2004 | Antimicrob Agents Chemother2004，48，6： | 1 |
| 20 | Dietary intervention in patients with gestational diabetes mellitus:a systematic review and meta-analysis of randomized clinical trials on maternal and newborn outcomes显示文摘 | Viana LV Gross JL Azevedo MJ | 2014 | Diabetes Care2014，37，12： | 1 |
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