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| 1 | Preoperative immunonutrition in patients undergoing liver resection:A prospective randomized trial显示文摘BACKGROUND Preoperative supplementation with immunonutrients, including arginine and n-3 fatty acids, has been shown in a number of systematic reviews to reduce infectious complications in patients who have undergone gastrointestinal surgery. Limited information, however, is available on the benefits of nutritional supplementation enriched with arginine and n-3 fatty acids in patients undergoing liver resection.AIM To evaluate the effects of preoperative nutritional supplementation enriched with arginine and n-3 fatty acids on inflammatory and immunologic markers and clinical outcome in patients undergoing liver resection.METHODS Thirty-four patients undergoing liver resection were randomized to either five days of preoperative Impact? [1020 kcal/d, immunonutrition(IMN) group], or standard care [no supplementation, standard care(STD) group]. Nutritional status was measured at study entry by subjective global assessment(SGA).Functional assessments(grip strength, fatigue and performance status) were carried out at study entry, on the day prior to surgery, and on postoperative day(POD) 7 and 30. Inflammatory and immune markers were measured at study entry, on the day prior to surgery, and POD 1, 3, 5, 7, 10 and 30. Postoperative complications were recorded prospectively until POD30.RESULTS A total of 32 patients(17 IMN and 15 STD) were analysed. All except four patients were SGA class A. The plasma ratio of(eicosapentaenoic acid plus docosahexaenoic acid) to arachidonic acid was higher in IMN patients on the day prior to surgery and POD 1, 3, 5 and 7(P < 0.05). Plasma interleukin(IL)-6 concentrations were elevated in the IMN group(P = 0.017 for POD7). No treatment effect was detected for functional measures, immune response(white cell count and total lymphocytes) or markers of inflammation(C-reactive protein,tumour necrosis factor-α, IL-8, IL-10). There were 10 patients with infectious complications in the IMN group and 4 in the STD group(P = 0.087). Median hospital stay was 9(range 4–49) d in the IMN group and 8(3-34) d in the STD group(P = 0.476).CONCLUSION In well-nourished patients undergoing elective liver resection, this study failed to show any benefit of preoperative immunonutrition. | Kylie Russell Han-Guang Zhang Lyn K GillANDers Adam SJR Bartlett Helena L Fisk Philip C Calder Peter J Swan Lindsay D Plank | 2019 | World Journal of Hepatology2019，11，3： | 3 |
| 2 | Experimental study of bimolecular reaction in Poiseuille flow显示文摘 | Kapoor V Jafvert C T Lyn D A | | 0，，08： | 1 |
| 3 | Intervention strategies for the retro-fitment of Rollover Protective Structures (ROPS) and fleet characteristic farm tractors 显示文摘 | Richard C F Kerri-Lynn S Lyn F | 2006 | Safety Science2006，44，9： | 1 |
| 4 | Identification of dehydration-responsive cysteine proteases during post-harvest senescence of broccoli florets显示文摘 | SIMON A C BEN K S LYN M | 2003 | Exp Bot2003，53，384： | 1 |
| 5 | Efficient power coupling from 980nm broad area laser to a single mode fiber using a wedging shaped fiber endface 显示文摘 | VIRENDRA S S LYN C RICHARD S V | 1990 | J Lightwave Technol1990，18，9： | 1 |
| 6 | A survey of credit and behavioral scoring: Forecasting financial risk of lending to consumers 显示文摘 | Lyn C T | 2000 | International Journal of Forecasting2000，，16： | 1 |
| 7 | Thevascular endothelial growth factor (VEGF)-E enco-ded by orf virus regulates keratinocyte proliferationand migration and promotes epidermal regeneration显示文摘 | Lyn M Wise Marie K Inder Nicola C Real | 2012 | Cellular microbiol2012，14，9： | 1 |
| 8 | The Influence of Extraversion on Leisure Constraints Negotiation Process: A Case of Korean People with Disabilities 显示文摘 | LYN S O OH C O LEE H | 2013 | Journal of Leisure Research2013，45，2： | 1 |
| 9 | The Septin9 (MSF)gene 23 amplified and overexpressed in mouse mammarygland adenocarcinomas and human breast cancer cell Lines显示文摘 | Montagna C Lyn M S Hunter K | 2003 | Cancer Res2003，63，9： | 1 |
| 10 | Endoscopic Third Ventriculostomy:An Outcome Analysis显示文摘 | Douglas B Kevvan A Lyn C | 1998 | Pediar Neurosurg1998，28，： | 1 |
| 11 | Preparation of Accurate, Low-Concentration Gas Cylinder Standards by Cryogenic Trapping of a Permeation Tube Gas Stream 显示文摘 | Lyn Gameson Rhoderick G C Guenther F R | 2012 | Anal Chem2012，84，： | 1 |
| 12 | Hearing screening in Jamaica:prevalence of otitis media with effusion显示文摘 | Lyn C Jadusingh WA Ashman H | | 0，，02： | 1 |
| 13 | Identification of Structural and Spatial Features that Influence Storm-Related Dune Erosion along a Barrier-Island Ecosystem in the Gulf of Mexico显示文摘 | Pries Alexander J Miller Deborah L Branch Lyn C | 2008 | Journal of Coastal Research (C)2008，，4： | 1 |
| 14 | Biogas Digesters to Recycle Green Waste Waste显示文摘 | Lyn C | 2004 | BilCycle2004，45，5： | 1 |
| 15 | Directimaging of the disruption of hepatitis C virus replicationcomplexes by inhibitors of lipid metabolism 显示文摘 | Lyn R K Kennedy D C Sagan S M | 2009 | Virology2009，394，1： | 1 |
| 16 | A hidden Markov chain model for the term structure of bond credit risk spreads显示文摘 | Lyn C T David E A Nigel M K | 2001 | International Review of Financial Analysis2001，，： | 1 |
| 17 | Non-invasive Diagnosis of Fetal Sex: Utilisation of Free Fetal DNA in Maternal Plasma and Ultrasound 显示文摘 | Neil D A Lyn S C | 2006 | Prenatal Diagnosis2006，26，7： | 1 |
| 18 | Hearing screening in Jamaica:prevalence of otitis media with effusion显示文摘 | Lyn C Jadusingh WA Ashman H | 1998 | Laryngoscope1998，108，： | 1 |
| 19 | Gene expression analysis reveals new possible mechanisms of vancomycin-induced nephrotoxicity and identifies gene markers candidates显示文摘 | Dieterich C Puey A Lyn S | 2009 | Toxicol Sci2009，107，1： | 1 |
| 20 | Gene expression analysis reveals new possible mechanisms of vancomycin-induced nephrotoxicity and identifies gene markers candidates 显示文摘 | Dieterich C Puey A Lyn S | 2009 | Toxicol Sci2009，107，： | 1 |
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