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| 1 | Use of siRNA molecular beacons to detect and attenuate mycobacterial infection in macrophages显示文摘Tuberculosis is one of the leading infectious diseases plaguing mankind and is mediated by the facultative pathogen, Mycobacterium tuberculosis(MTB). Once the pathogen enters the body, it subverts the host immune defenses and thrives for extended periods of time within the host macrophages in the lung granulomas, a condition called latent tuberculosis(LTB). Persons with LTB are prone to reactivation of the disease when the body's immunity is compromised. Currently there are no reliable and effective diagnosis and treatment options for LTB, which necessitates new research in this area. The mycobacterial proteins and genes mediating the adaptive responses inside the macrophage is largely yet to be determined. Recently, it has been shown that the mce operon genes are critical for host cell invasion by the mycobacterium and for establishing a persistent infection in both in vitro and in mouse models of tuberculosis. The Yrb E and Mce proteins which are encoded by the MTB mce operons display high degrees of homology to the permeases and the surface binding protein of the ABC transports, respectively. Similarities in structure and cell surface location impute a role in cell invasion at cholesterol rich regions and immunomodulation. The mce4 operon is also thought to encode a cholesterol transport system that enables the mycobacterium to derive both energy and carbon from the host membrane lipids and possibly generating virulence mediating metabolites, thus enabling the bacteria in its long term survival within the granuloma. Various deletion mutation studies involving individual or whole mce operon genes have shown to be conferring varying degrees of attenuation of infectivity or at times hypervirulence to the host MTB, with the deletion of mce4 A operon gene conferring the greatest degree of attenuation of virulence. Antisense technology using synthetic si RNAs has been used in knocking down genes in bacteria and over the years this has evolvedinto a powerful tool for elucidating the roles of various genes mediating infectivity and survival in mycobacteria. Molecular beacons are a newer class of antisense RNA tagged with a fluorophore/quencher pair and their use for in vivo detection and knockdown of mR NA is rapidly gaining popularity. | Remo George Renata Cavalcante Celso Carvalho Jr Elyana Marques Jonathan B Waugh M Tino Unlap | 2015 | World Journal of Experimental Medicine2015，5，3： | 2 |
| 2 | Platelets induce neutrophil extracellular traps in transfusion-related acute lung injury显示文摘 | Caudrillier Axelle Kessenbrock Kai Gilliss Brian M Nguyen John X Marques Marisa B Monestier Marc Toy Pearl Werb Zena Looney Mark R | 2012 | EN2012，，7： | 2 |
| 3 | Antimicrobial resistance profiles of dairy and clinical isolates and type strains of Enterococci 显示文摘 | Figueiredo Marques J J Tenreiro R Crespo M T B | 2005 | Inter J Food Microbiol2005，103，2： | 1 |
| 4 | Synthesis and antiviral evaluation of benzimidazoles,quinoxalines and indoles from dehydroabietic acid显示文摘 | Fonseca T Gigante B Marques M M | 2004 | Bioorganic Med Chem2004，12，1： | 1 |
| 5 | Modelling of anethanol-water distillation column assisted by an external heat pump显示文摘 | Oliveira S B M Parise J A R Pitanga Marques R | 2002 | International Journal of Energy Research2002，26，12： | 1 |
| 6 | Synthesis and antiviral evaluation of benzimidazoles, quinoxalines and indoles from dehydroabietic acid 显示文摘 | FONSECA T GIGANTE B MARQUES M M | 2004 | Bioorganic & Medicinal Chemistry2004，12，1： | 1 |
| 7 | Oxygen and electronic transport in apatite-type La10-x(Si,Al)6)26显示文摘 | SHAULA A L KHARTON V V MARQUES F M B | 2005 | Journal of Solid State Chemistry2005，178，： | 1 |
| 8 | Is agricultural policy promo- ting a new role for farmers? a case study显示文摘 | MARTINS M B MARQUES C | 2006 | Journal of Policy Modeling2006，，28： | 1 |
| 9 | U- niversity-industry collaboration and innovation in emergent and mature industries in new industrialized countries显示文摘 | FREITAS I M B MARQUES R A SILVA E M D P | 2013 | General Information2013，42，2： | 1 |
| 10 | Synthesis and antiviral evaluation of benzimidazoles, quinoxalines and indoles from de- hydroabietic acid显示文摘 | Fonseea T Gigante B Marques M M | 2004 | Bioorganic & Medicinal Chemistry2004，12，1： | 1 |
| 11 | Synthe- sis and antiviral evaluation of benzimidazoles,quinox- alines and indoles from dehydroabietie acid 显示文摘 | Fonseca T Gigante B Marques M M | 2004 | Bioorg Med Chem2004，12，1： | 1 |
| 12 | Carbon solubility in nanostructured copper显示文摘 | Marques M T Correia J B Conde O | 2004 | Scripta Materialia2004，50，： | 1 |
| 13 | The major genetic determinants of HIV-1control affect HLA class I peptide presentation显示文摘 | International HIV Controllers Study Pereyra F Jia X McLaren P J Telenti A de Bakker P I Walker B D Ripke S Brumme C J Pulit S L Carrington M Kadie C M Carlson J M Heckerman D Graham R R Plenge R M Deeks S G Gianniny L Crawford G Sullivan J Gonzalez E Davies L Camargo A Moore JM Beattie N Gupta S Crenshaw A Burtt N P Guiducci C Gupta N Gao X Qi Y Yuki Y Piechocka-Trocha A Cutrell E Rosenberg R Moss K L Lemay P O'Leary J Schaefer T Verma P Toth I Block B Baker B Rothchild A Lian J Proudfoot J Alvino D M Vine S Addo M M Allen T M Altfeld M Henn M R Le Gall S Streeck H Haas D W Kuritzkes D R Robbins G K Shafer R W Gulick R M Shikuma C M Haubrich R Riddler S Sax P E Daar E S Ribaudo H J Agan B Agarwal S Ahern R L Allen B L Altidor S Altschuler E L Ambardar S Anastos K Anderson B Anderson V Andrady U Antoniskis D Bangsberg D Barbaro D Barrie W Bartczak J Barton S Basden P Basgoz N Bazner S Bellos N C Benson A M Berger J Bernard N F Bernard A M Birch C Bodner S J Bolan R K Boudreaux E T Bradley M Braun J F Brndjar J E Brown S J Brown K Brown S T Burack J Bush LM Cafaro V Campbell O Campbell J Carlson R H Carmichael J K Casey K K Cavacuiti C Celestin G Chambers S T Chez N Chirch L M Cimoch P J Cohen D Cohn LE Conway B Cooper D A Cornelson B Cox D T Cristofano M V Cuchural G Jr Czartoski J L Dahman J M Daly J S Davis B T Davis K Davod S M DeJesus E Dietz C A Dunham E Dunn M E Ellerin T B Eron J J Fangman J J Farel C E Ferlazzo H Fidler S Fleenor-Ford A Frankel R Freedberg K A French N K Fuchs JD Fuller J D Gaberman J Gallant J E Gandhi R T Garcia E Garmon D Gathe J C Jr Gaultier C R Gebre W Gilman F D Gilson I Goepfert P A Gottlieb M S Goulston C Groger R K Gurley T D Haber S Hardwicke R Hardy W D Harrigan P R Hawkins T N Heath S Hecht F M Henry W K Hladek M Hoffman R P Horton J M Hsu R K Huhn G D Hunt P Hupert M J Illeman M L Jaeger H Jellinger R M John M Johnson J A Johnson K L Johnson H Johnson K Joly J Jordan W C Kauffman C A Khanlou H Killian R K Kim A Y Kim D D Kinder C A Kirchner J T Kogelman L Kojic E M Korthuis P T Kurisu W Kwon D S LaMar M Lampiris H Lanzafame M Lederman M M Lee D M Lee J M Lee M J Lee E T Lemoine J Levy J A Llibre J M Liguori M A Little S J Liu A Y Lopez A J Loutfy M R Loy D Mohammed D Y Man A Mansour M K Marconi V C Markowitz M Marques R Martin J N Martin H L Jr Mayer K H McElrath M J McGhee T A McGovern B H McGowan K McIntyre D Mcleod GX Menezes P Mesa G Metroka CE Meyer-Olson D Miller A O Montgomery K Mounzer K C Nagami E H Nagin I Nahass R G Nelson M O Nielsen C Norene D L O'Connor D H Ojikutu B O Okulicz J Oladehin O O Oldfield E C Olender S A Ostrowski M Owen WF Jr Pae E Parsonnet J Pavlatos A M Perlmutter A M Pierce M N Pincus J M Pisani L Price L J Proia L Prokesch R C Pujet H C Ramgopal M Rathod A Rausch M Ravishankar J Rhame F S Richards C S Richman D D Rodes B Rodriguez M Rose R C 3rd Rosenberg E S Rosenthal D Ross P E Rubin D S Rumbaugh E Saenz L Salvaggio M R Sanchez WC Sanjana V M Santiago S Schmidt W Schuitemaker H Sestak P M Shalit P Shay W Shirvani V N Silebi V I Sizemore J M Jr Skolnik P R Sokol-Anderson M Sosman J M Stabile P Stapleton J T Starrett S Stein F Stellbrink H J Sterman FL Stone V E Stone D R Tambussi G Taplitz R A Tedaldi E M Telenti A Theisen W Torres R Tosiello L Tremblay C Tribble M A Trinh P D Tsao A Ueda P Vaccaro A Valadas E Vanig T J Vecino I Vega V M Veikley W Wade B H Walworth C Wanidworanun C Ward D J Warner D A Weber R D Webster D Weis S Wheeler D A White D J Wilkins E Winston A Wlodaver C G van't Wout A Wright D P Yang O O Yurdin D L Zabukovic B W Zachary K C Zeeman B Zhao M | 2010 | Science2010，330，6010： | 1 |
| 14 | La2Zr2O7 formed at ceramic electrode/YSZ contacts 显示文摘 | Labrincha J A Frade J R Marques F M B | 1993 | Journal of Materials Science1993，28，： | 1 |
| 15 | Synthesis and antiviral evaluation of benzimidazoles, quinoxalines and indoles from dehydroabietic acid显示文摘 | Fonseca T Gigante B Marques M M | 2004 | Bioorganic & Medicinal Chemistry2004，12，1： | 1 |
| 16 | Novel SiO2/cellulose nanocomposite obtained by instu synthesis and via polyelectrolyte assembly显示文摘 | Pinto R J B Marques P A A P Barros-Timmons A M | 2008 | Composite Science and Technology2008，68，： | 1 |
| 17 | Cathode materials for intermediate temperature SOFCs 显示文摘 | Maguire E Gharbage B Marques F M B | 2000 | Solid State Ionics2000，127，： | 1 |
| 18 | Inter-turn stator winding fault diagnosis in three-phase induction motors by park's vector approach显示文摘 | Marques Cardoso A J Cmz S M A Fonseca D S B | 1999 | IEEE Transactions on Energy Conversion1999，14，3： | 1 |
| 19 | Estimating blood needs for very- low-birth-weight infants显示文摘 | Fabres J Wehrli G Marques M B | 2006 | Transfusion2006，44，1： | 1 |
| 20 | Cardiotrophin-1 is an essential factor in the natural defense of the liver against apoptosis显示文摘 | MARQUES J M BELZE I HOLTMANN B | 2007 | Hepatology2007，45，3： | 1 |
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