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| 1 | Polymorphisms of MTHFD,plasma homocysteine levels, and risk of gastric cancer in ahigh-risk Chinese population显示文摘Purpose:Accumulative evidence suggests that folate has a protective effect on gastric cancer. The methylenetetrahyd-rofolate dlehydrogenase(MTHFD) plays an important role in folate and homocysteine metabolisms, and polymorphisms of MTHFD may result in disturbance of the folate-mediated homocysteine pathway. The aim of this study is to test the hypothesis that genetic variants of MTHFD and plasma homocysteine levels are associated with risk of gastric cancer and modulated by genotypes of methylenetetrahydrofolate reductase(MTHFR). Experimental Design: We genotyped G1958A and T401C in MTHFD and C677T in MTHFR and detected total plasma homocysteine(tHcy) levels in a case-control study of 589 gastric cancer cases and 635 cancer-free controls in a high-risk Chinese population. Results:The variant genotypes of MTHFD 1958AA and 401CC were associated with a significantly increased risk of gastric canceradjusted odds ratio(OR), 2.05; 95% confidence interval(95% CI),1.34-3.13 for 1958AA; adjusted OR,1.43; 95% CI,1.14-1.80 for 401CC compared with 1958GG/GA and 401TT/TC genotypes, respectively. Both of the effects were more evident in the subjects carrying MTHFR 677CT/TT genotypes. The average tHcy level was significantly higher in gastric cancer cases than in controls(P < 0.01), and the upper quartile of tHcy (> 13.6 mu mol/L) was associated with an 82% significantly increased risk of gastric cancer, compared with the lowest quartile of tHcy(<= 8.0 pmol/L;adjusted OR,1.82; 95% CI,1.20-2.75). Conclusions:The strong associations between MTHFD variants and the plasma tHcy levels and gastric cancer risk suggest, for the first time, a possible gene-environment interaction between genetic variants of folate-metabolizing genes and high tHcy levels in gastric carcinogenesis. | Wang, L. N Ke, Q Chen, W. S Wang, J. M Tan, Y. F Zhou, Y Hua, Z. L Ding, W. L Niu, J. Y Shen, J Zhang, Z. F Wang, X. R Xu, Y. H Shen, H. B Yi Xing | 2007 | 南京医科大学学报(自然科学版)2007，27，7： | 10 |
| 2 | 铅对肾上腺皮质细胞线粒体的氧化损伤显示文摘【目的】研究铅对肾上腺皮质细胞氧化应激和线粒体功能的影响 ,为了解其肾上腺皮质毒作用机制提供依据。【方法】原代分离培养豚鼠肾上腺皮质细胞 ,以 0、6 2 5、12 5、2 5、5 0、10 0 μmol/L醋酸铅 (PbAc)处理细胞 ,观察PbAc诱导肾上腺皮质细胞活性氧 (ROS)产生和线粒体损伤作用。ROS检测采用荧光分光光度法 ,线粒体膜电位 (MMP)和细胞存活状态采用Rh12 3和PI双标记、流式细胞术检测 ,细胞ATP水平采用化学发光法测定。【结果】PbAc染毒后肾上腺皮质细胞ROS形成水平随剂量增加而增加 ,具有剂量效应关系 [^y=4 16 +10 2 1× 1g(x+1) ,P <0 0 1,R2 =0 6 41];线粒体膜电位呈剂量依赖性降低 ,Rh12 3的平均荧光强度 (MFI)在 6 2 5~ 10 0 μmol/L各剂量组依次为 1 0 1,0 94,0 96 ,0 95和 0 91,与对照组(1 35 )比较具有显著性差异 (P <0 0 1) ;染毒后细胞死亡率轻度增加 ,与对照组 (1 0 2 % )比较 ,5 0 μmol/L和 10 0 μmol/L的PbAc组分别为 3 16 %和 3 40 % ,差异具有显著性 (P <0 0 5 ) ;ATP水平降低与PbAc剂量之间存在剂量效应关系 [^y =2 12 96 5 7- 5 15 92 5× 1g(x +1) ,P <0 0 1,R2 =0 5 6 8],剂量和时间对ATP水平的影响呈协同抑制作用 (P <0 0 1)。【结论】线粒体氧化应激介导肾? | 杨杏芬 庄志雄 魏青 凌莉 范瑞泉 Shen H M Ong C N | 2001 | 中山医科大学学报2001，22，1： | 8 |
| 3 | 金刚石中的冰-Ⅶ相包裹体:来自地球深部地幔的含水流体证据显示文摘水在地球内部不同圈层的存在形态、分布、含量以及全球水循环一直以来都是固体地球科学研究的前沿热点问题之一。冰-Ⅶ相作为水的一种高压相,目前已经被国际矿物学会认定为一种新矿物。 | Tschauner O Huang S Greenberg E Prakapenka V B Rossman G R Shen A H Zhang D Newville M Lanzirotti A Tait K 张宝华 | 2018 | 矿物岩石地球化学通报2018，37，6： | 4 |
| 4 | Medial temporal lobe atrophy on MRI scans and the diagnosis of Alzheimer disease显示文摘 | R Duara D A. Loewenstein E Potter J Appel M T. Greig R Urs Q Shen A Raj B Small W Barker E Schofield Y Wu H Potter | 2008 | Neurology2008，，24： | 2 |
| 5 | Neutral Pd(II) and Ni (II) aeetylide catalysts for the polymerization of methyl methaerylate 显示文摘 | SUN H M SHEN Q PENG X G | 2002 | Catalysis Letters2002，80，12： | 1 |
| 6 | Formation of regular arrays of silicon microspikes by femtosecond laser irradiation through a mask显示文摘 | Shen M Crouch C H Carey J E | 2003 | Appl Phys Lett2003，82，： | 1 |
| 7 | Nonconservative amino acid substitution variants exist at polymorphic frequency in DNA repair genes in healthy humans 显示文摘 | Shen MR Jones M Mohrenweiser H | 1998 | Cancer Res1998，58，4： | 1 |
| 8 | Fabrication of Mo-Ti Functionally Graded Materials显示文摘 | Xiong H P Zhang L M Shen Q | | Transaction of Nonferrous Metals Society of China0，9，3： | 1 |
| 9 | Structural damage detection and identifi-cation using neural network显示文摘 | Tsou P Shen M H H | 1994 | American Institute of Areonautics and Astronautics Journal1994，32，1： | 1 |
| 10 | A new modeling technique for piezoelectrically actuated beams 显示文摘 | Shen M H H | 1994 | Comput Struct1994，，3： | 1 |
| 11 | Plant proteomics in the post-genomic era显示文摘 | Guo Y M Shen S H Jing Y X | 2002 | Acta Bot Sin2002，44，6： | 1 |
| 12 | A new method in locating and segmenting palmprint into region-of-interest显示文摘 | Poon C Wong D C M Shen H C | 2004 | ICPR2004，，： | 1 |
| 13 | Inhibitory activity of kinetin on free radical formation of activatedplatelets in vitro and on thrombus formation in vivo显示文摘 | GEORGE H SHEN M LIN K | 2003 | Eur J Pharmacol2003，465，3： | 1 |
| 14 | The Influence of retained austenite in high chromium cast iron on impact-abrasive wear显示文摘 | TONG J M ZHOU Y Z SHEN T Y and DENG H J | 1990 | Wear1990，135，2： | 1 |
| 15 | Chinese SF - 36 Health Survey: translation, cultural adaptation, validation, and normalization 显示文摘 | L Li H M Wang Y Shen | 2003 | Journal of Epidemlology and Community Health2003，57，： | 1 |
| 16 | Role of intracellular thiol depletion, mitochondrial dysfunction and reactive oxygen species in Salvia Miltiorrhiza-induced apoptosis in human hepatoma HepG2 cells 显示文摘 | Liu J Shen H M Ong C N | 2001 | Life Sciences2001，69，16： | 1 |
| 17 | Carbohydrates from Cynanchum otophyllum 显示文摘 | Zhao Y B Shen Y M He H P | 2004 | Carbohydrate Research2004，339，11： | 1 |
| 18 | Structure based drug design of crizotinib (PF-02341066), a potent and selective dual inhibitor of mesenchymal-epithelial transition factor (c- MET) kinase and anaplastic lymphoma kinase (ALK) 显示文摘 | Cui JJ Tran-Dube M Shen H | 2011 | d Med Chem2011，54，18： | 1 |
| 19 | Penicidones A-C,three cytotoxic alkaloidal metabolites of an endophytic Penicillium sp显示文摘 | GE H M SHEN Y ZHU C H | 2008 | Phytochemistry2008，69，2： | 1 |
| 20 | Nitrogen transfer of fuel-N in chemical looping combustion 显示文摘 | Song T Shen L H Xiao J Chen D Q Gu H M Zhang S W | 2012 | Combustion and Flame2012，159，3： | 1 |
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