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| 1 | Dysfunctional stem and progenitor cells impair fracture healing with age显示文摘Successful fracture healing requires the simultaneous regeneration of both the bone and vasculature;mesenchymal stem cells (MSCs) are directed to replace the bone tissue, while endothelial progenitor cells (EPCs) form the new vasculature that supplies blood to the fracture site. In the elderly, the healing process is slowed, partly due to decreased regenerative function of these stem and progenitor cells. MSCs from older individuals are impaired with regard to cell number, proliferative capacity, ability to migrate, and osteochondrogenic differentiation potential. The proliferation, migration and function of EPCs are also compromised with advanced age. Although the reasons for cellular dysfunction with age are complex and multidimensional, reduced expression of growth factors, accumulation of oxidative damage from reactive oxygen species, and altered signaling of the Sirtuin-1 pathway are contributing factors to aging at the cellular level of both MSCs and EPCs. Because of these geriatric-specific issues, effective treatment for fracture repair may require new therapeutic techniques to restore cellular function. Some suggested directions for potential treatments include cellular therapies, pharmacological agents, treatments targeting age-related molecular mechanisms, and physical therapeutics. Advanced age is the primary risk factor for a fracture, due to the low bone mass and inferior bone quality associated with aging;a better understanding of the dysfunctional behavior of the aging cell will provide a foundation for new treatments to decrease healing time and reduce the development of complications during the extended recovery from fracture healing in the elderly. | Diane R Wagner Sonali Karnik Zachary J Gunderson Jeffery J Nielsen Alanna Fennimore Hunter J Promer Jonathan W Lowery M Terry Loghmani Philip S Low Todd O McKinley Melissa A Kacena Matthias Clauss Jiliang Li | 2019 | World Journal of Stem Cells2019，11，6： | 3 |
| 2 | Inhibition of aphid (Homoptera: Aphididae) reproduction by neem seed oil and azadirachtin 显示文摘 | LOWERY D T ISMAN M B | 1996 | J Econ Entomol1996，89，3： | 1 |
| 3 | circulating microRNAs as novel minimal y invasive biomarkers for breast cancer显示文摘 | Heneghan H M Mil er N Lowery A J | | 0，，03： | 1 |
| 4 | Electromyogram Median Frequency, Spectral Compression and Muscle Fiber Conduction Velocity during Sustained submaximal Contraction of the Brachioradialis Muscle显示文摘 | M LOWERY P NOLAN M O'Malley | 2002 | J Electromyography Kinesiol2002，12，： | 1 |
| 5 | Fluorescence in situ hybridization(FISH)for detection of HER-2/neu amplification in breast cancer: a multicenter portability study显示文摘 | Persons D L Bui M M Lowery M C | 2000 | Ann Clin Lab Sci2000，30，1： | 1 |
| 6 | Structure and function of Polo-like kinases 显示文摘 | Lowery D M Lin D Yaffe M B | 2005 | Oncogene2005，24，2： | 1 |
| 7 | Electric field distribution in a finite-volume head model of deep brain stimulation显示文摘 | Grant P F Lowery M M | | 0，，09： | 1 |
| 8 | Conduction calorimetric investigation of the effect of retarders on the hydration of portland- cement显示文摘 | RANACHANDRAN V S LOWERY M S | 1992 | Thermochimica Acta1992，195，： | 1 |
| 9 | Electrospun poly(styrene- block-dimethylsiloxane) block copolymer fibers exhibiting superhydrophobicity显示文摘 | Ma M L Hill R M Lowery J L | 2005 | Langmuir2005，21，： | 1 |
| 10 | Physical properties of estolides and their ester derivatives 显示文摘 | Isbella T A Edgcomb M R Lowery B A | 2001 | Industrial Crops and Products2001，13，1： | 1 |
| 11 | Identification of Pasteu- rella multocida virulence genes in septicemic mouse model using signature-tagged mutagenesis显示文摘 | Fuller T E Kennedy M J Lowery D E | 2000 | Microb Pathog2000，29，1： | 1 |
| 12 | Calculation of power limit due to fiber nonlinearity in optical OFDM system 显示文摘 | LOWERY A J WANG S J PREMRATE M | 2007 | Optics Express2007，15，13： | 1 |
| 13 | Sequential dual chamber extrastimulation: a novel pacing maneuver to identify the presence of a slowly conducting concealed accessory pathway 显示文摘 | Sauer W H Lowery C M Cooper J M | 2008 | Heart Rhythm2008，5，2： | 1 |
| 14 | Relationships BetweenOrganizational Culture and Organizational Performance 显示文摘 | PERRY M BEADLES N LOWERY C | 1995 | Psychological Reports1995，76，2： | 1 |
| 15 | Interleukin-2 treatment for persistent cryptococcal meningi-tis in a child with idiopathic CD4+ T lymphocytopenia显示文摘 | YilmazDemirdag Y Wilson B Lowery Nordberg M | 2008 | Allergy Asthma Proc2008，29，： | 1 |
| 16 | Physical tests for monitoring soil quality显示文摘 | ARSHAD M A LOWERY B GROSSMAN B | 1996 | Soil Science Society of America Journal1996，49，： | 1 |
| 17 | Assessing the risks of manufactured nanomaterials 显示文摘 | Wiesner M R Lowery G V Alvarez P | 2006 | Environ Sci Techno12006，40，14： | 1 |
| 18 | US extended-field-of-view imaging technology显示文摘 | WENG L TIRUMALAI A P LOWERY C M | 1997 | Radiology1997，203，3： | 1 |
| 19 | Fluorescence in situ hybridization (FISH) for detection of HER-2/neu amplification in breast cancer: a multicenter portability study显示文摘 | Persons D L Bui M M Lowery M C | 2000 | Ann Clin Lab Sci2000，30，1： | 1 |
| 20 | Conduction calorimetric investigation of the effects of retarders on the hydration of Portland cement显示文摘 | RAMACHANDRAN V S LOWERY M S | 1992 | Thermochim Acta1992，195，2： | 1 |
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