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| 1 | Dysfunctional stem and progenitor cells impair fracture healing with age显示文摘Successful fracture healing requires the simultaneous regeneration of both the bone and vasculature;mesenchymal stem cells (MSCs) are directed to replace the bone tissue, while endothelial progenitor cells (EPCs) form the new vasculature that supplies blood to the fracture site. In the elderly, the healing process is slowed, partly due to decreased regenerative function of these stem and progenitor cells. MSCs from older individuals are impaired with regard to cell number, proliferative capacity, ability to migrate, and osteochondrogenic differentiation potential. The proliferation, migration and function of EPCs are also compromised with advanced age. Although the reasons for cellular dysfunction with age are complex and multidimensional, reduced expression of growth factors, accumulation of oxidative damage from reactive oxygen species, and altered signaling of the Sirtuin-1 pathway are contributing factors to aging at the cellular level of both MSCs and EPCs. Because of these geriatric-specific issues, effective treatment for fracture repair may require new therapeutic techniques to restore cellular function. Some suggested directions for potential treatments include cellular therapies, pharmacological agents, treatments targeting age-related molecular mechanisms, and physical therapeutics. Advanced age is the primary risk factor for a fracture, due to the low bone mass and inferior bone quality associated with aging;a better understanding of the dysfunctional behavior of the aging cell will provide a foundation for new treatments to decrease healing time and reduce the development of complications during the extended recovery from fracture healing in the elderly. | Diane R Wagner Sonali Karnik Zachary J Gunderson Jeffery J Nielsen Alanna Fennimore Hunter J Promer Jonathan W Lowery M Terry Loghmani Philip S Low Todd O McKinley Melissa A Kacena Matthias Clauss Jiliang Li | 2019 | World Journal of Stem Cells2019，11，6： | 3 |
| 2 | A simple method to retrieve 3 hourly estimates of global tropical and subtropical precipitation from International Satellite Cloud Climatology Program (ISCCP) D1 data显示文摘 | Todd M R Washington | 1999 | J Atmos Ocean Technol1999，16，： | 2 |
| 3 | Stability of fruit quality traits in diverse watermelon cultivars tested in multiple environments显示文摘Lycopene is a naturally occurring red carotenoid compound that is found in watermelon.Lycopene has antioxidant properties.Lycopene content,sugar content and hollowheart resistance are subject to significant genotype×environment interaction(G×E),which makes breeding for these fruit quality traits difficult.The objectives of this study were to(i)evaluate the influence of years and locations on lycopene content,sugar content and hollowheart resistance for a set of watermelon genotypes,and(ii)identify genotypes with high stability for lycopene,sugar,and hollowheart resistance.A diverse set of 40 genotypes was tested over 3 years and 8 locations across the southern United States in replicated,multi-harvest trials.Lycopene was tested in a subset of 10 genotypes.Data were analyzed using univariate and multivariate stability statistics(BLUP-GGE biplot)using SASGxE and RGxE programs.There were strong effects of environment as well as G×E interaction on watermelon quality traits.On the basis of stability measures,genotypes were classified as stable or unstable for each quality trait.'Crimson Sweet'is an inbred line with high quality trait performance as well as trait stability.'Stone Mountain','Tom Watson','Crimson Sweet'and'Minilee'were among the best genotypes for lycopene content,sugar content and hollowheart resistance.We developed a stability chart based on marketable yield and average ranking generated from different stability measures for yield attributes and quality traits.The chart will assist in choosing parents for improvement of watermelon cultivars.See http://gffzz783b6e01a04243c3hoo6qckp595uq69f5.ffgz.tsg.suse.edu.cn/cucurbit/wmelon/wmelonmain.html. | Mahendra Dia Todd C Wehner Penelope Perkins-Veazie Richard Hassell Daniel S Price George E Boyhan Stephen M Olson Stephen R King Angela R Davis Gregory E Tolla Jerome Bernier Benito Juarez | 2016 | Horticulture Research2016，3，1： | 2 |
| 4 | Dust-storm source areas determined by the total ozone monitoring spectrometer and surface observations显示文摘 | Washington R Todd M Middleton N J | 2003 | Annals of the Association of American Geographers2003，93，2： | 1 |
| 5 | A study of chemical aging effects on HDD Fe-zeolite SCR catalyst显示文摘 | Silver R G Stefanick M O Todd B I | 2008 | Catalysis Today2008，72，： | 1 |
| 6 | Selective electrodeposition of metal from simulated waste solutions 显示文摘 | Armstrong R D Todd M Atkinson J W | 1996 | Applied Electrochem1996，26，： | 1 |
| 7 | Transgenic soybeans expressing siRNAs specific to a major sperm protein gene suppress Heterodera glycines reproduction 显示文摘 | Steeves R M Todd T C Essig J S | 2006 | Functional Plant Biology2006，33，： | 1 |
| 8 | The use of conjoint analysis to assess the impact of the cross - cultural exchange between hosts and guests 显示文摘 | Thyne M Lawson R Todd S | 2006 | Tourism Management2006，27，2： | 1 |
| 9 | The development, testing, and application of a numerical simulator for predicting miscible flood performance显示文摘 | Todd M R Longstaff W J | 1972 | Journal of Petroleum Technology1972，24，7： | 1 |
| 10 | Nutritional status of hae- modialysis patients:comparison of Australian cohorts of Aborigi- nal and European descent显示文摘 | Todd A Carroll R Gallagher M | 2013 | Nephrology (Carlton)2013，18，12： | 1 |
| 11 | Responses of spectral indices to variations in vegetation cover and soil background 显示文摘 | Todd S W Hoffer R M | 1998 | Photogrammetric engineering and remote sensing1998，64，9： | 1 |
| 12 | Induced pyroelectricity in sputtered lead scandium tantalate films and their merit for IR detector arrays显示文摘 | WATTON R TODD M A | 1991 | Ferroelectrics1991，118，： | 1 |
| 13 | Evaluation of candidate vaccine approaches for mers-cov显示文摘 | Wang L Shi W Joyce M G Modjarrad K Zhang Y Leung K Lees C R Zhou T Yassine H M KanekiyoM Yang Z Y Chen X Becker M M Freeman M Vogel L Johnson J C Olinger G Todd J P Bagci U Solomon J Mollura D J Hensley L Jahrling P Deni- son M R Rao S S Subbarao K Kwong P D Mascola J R Kong W P Graham B S | 2015 | Nat Commun2015，6，： | 1 |
| 14 | A study of chemical aging effects on HDD Fe–zeolite SCR catalyst显示文摘 | Silver R G Stefanick M O Todd B I | 2008 | Catalysis Today2008，72，： | 1 |
| 15 | Methods for increased accuracy in numerical reservoir simulators显示文摘 | M R Todd P M O'dell G J Hirasaki | 1972 | Soc Petrol Engry J1972，，12： | 1 |
| 16 | On the nesterov-todd direction in semidefinite programming显示文摘 | Todd M J Toh K C Tutuncu R H | 1998 | SIAM J Optim1998，8，： | 1 |
| 17 | The use of conjoint analysis to assess the impact of the cross-cultural ex-change between hosts and guests显示文摘 | Thyne M Lawson R Todd S | 2006 | Tourism Manage-ment2006，27，： | 1 |
| 18 | Microfluidics: fluid physics at the nanoliter scale 显示文摘 | Todd M Squires Stephen R Quake | 2005 | Reviews of Modern Physics2005，77，3： | 1 |
| 19 | Increased Sensi- tivity of the Rapid Hydrophobic Grid Membrane Filter Enzyme- Labeled Antibody Procedure for Eschcrichia coli O157 Detection in Foods and Bovine Feces显示文摘 | Szabo R A Todd E C D Mackenzie J M | 1990 | Applied and Environmental Mi- crobiology1990，56，11： | 1 |
| 20 | Influence of wetland networks on bat activity in mixed-use landscapes显示文摘 | Todd R L Andrew J E Katharina A M E | 2010 | Biological Conservation2010，14，4： | 1 |
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