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| 1 | Inorganic arsenic: A non-genotoxic carcinogen显示文摘Inorganic arsenic induces a variety of toxicities including cancer. The mode of action for cancer and non-cancer effects involves the metabolic generation of trivalent arsenicals and their reaction with sulfhydryl groups within critical proteins in various cell types which leads to the biological response. In epithelial cells, the response is cell death with consequent regenerative proliferation. If this continues for a long period of time, it can result in an increased risk of cancer. Arsenicals do not react with DNA. There is evidence for indirect genotoxicity in various in vitro and in vivo systems, but these involve exposures at cytotoxic concentrations and are not the basis for cancer development. The resulting markers of genotoxicity could readily be due to the cytotoxicity rather than an effect on the DNA itself. Evidence for genotoxicity in humans has involved detection of chromosomal aberrations, sister chromatid exchanges in lymphocytes and micronucleus formation in lymphocytes, buccal mucosal cells, and exfoliated urothelial cells in the urine. Numerous difficulties have been identified in the interpretation of such results, including inadequate assessment of exposure to arsenic, measurement of micronuclei, and potential confounding factors such as tobacco exposure, folate deficiency, and others. Overall, the data strongly supports a non-linear dose response for the effects of inorganic arsenic. In various in vitro and in vivo models and in human epidemiology studies there appears to be a threshold for biological responses, including cancer. | Samuel M.Cohen Aparajita Chowdhury Lora L.Arnold | 2016 | Journal of Environmental Sciences2016，28，11： | 7 |
| 2 | 3D and 4D ultrasound in fetal cardiac scanning: a new look at the fetal heart显示文摘 | S.Yagel S. M.Cohen I.Shapiro D. V.Valsky | 2007 | Ultrasound Obstet Gynecol2007，，1： | 2 |
| 3 | Review and synthesis of the effects of climate change on amphibians显示文摘Considerable progress has been made in understanding the responses of amphibians to climate change,with successful research carried out on climate change-associated shifts in amphibian phenology,elevational distributions and amphibian-parasite interactions.We review and synthesize the literature on this topic,emphasizing acutely lethal,sublethal,indirect and positive effects of climate change on amphibians,and major research gaps.For instance,evidence is lacking on poleward shifts in amphibian distributions and on changes in body sizes and morphologies of amphibians in response to climate change.We have limited information on amphibian thermal tolerances,thermal preferences,dehydration breaths,opportunity costs of water conserving behaviors and actual temperature and moisture ranges amphibians experience.Even when much of this information is available,there remains little evidence that climate change is acutely lethal to amphibians.This suggests that if climate change is contributing to declines,it might be through effects that are not acutely lethal,indirect,or both,but evidence in support of this suggestion is necessary.In fact,evidence that climate change is directly contributing to amphibian declines is weak,partly because researchers have not often ruled out alternative hypotheses,such as chytrid fungus or climate-fungus interactions.Consequently,we recommend that amphibian-climate research shift from primarily inductive,correlational approach as to studies that evaluate alternative hypotheses for declines.This additional rigor will require interdisciplinary collaborations,estimates of costs and benefits of climate change to amphibian fitness and populations,and the integration of correlative field studies,experiments on‘model’amphibian species,and mathematical and functional,physiological models. | Yiming LI Jeremy M.COHEN Jason R.ROHR | 2013 | Integrative Zoology2013，8，2： | 2 |
| 4 | Fetal cardiac ventricle volumetry in the second half of gestation assessed by 4D ultrasound using STIC combined with inversion mode显示文摘 | B.Messing S. M.Cohen D. V.Valsky D.Rosenak D.Hochner‐Celnikier S.Savchev S.Yagel | 2007 | Ultrasound Obstet Gynecol2007，，2： | 1 |
| 5 | Lessons Learned from Testing the Quality Cost Model of Advanced Practice Nursing (APN) Transitional Care显示文摘 | DorothyBrooten Mary D.Naylor RuthYork Linda P.Brown Barbara HazardMunro Andrea O.Hollingsworth Susan M.Cohen StevenFinkler JanetDeatrick JoAnne M.Youngblut | 2004 | Journal of Nursing Scholarship2004，，4： | 1 |
| 6 | Accessing Postsynthetic Modification in a Series of Met-al-Organic Frameworks and the Influence of Framework Topology on Reactivity显示文摘 | Zhenqiang Wang Kristine K.Tanabe Seth M.Cohen | | 0，，： | 1 |
| 7 | Modular,Active,and Robust Lewis Acid Catalysts Supported on a Metal-Organic Framework显示文摘 | Kristine K.Tanabe Seth M.Cohen | | 0，，： | 1 |
| 8 | Tandem Postsynthetic Modification of Metal-Organic Frame-works Using an Inverse-Electron-Demand Diels-Alder Reaction显示文摘 | Chao Chen Corinne A.Allen Seth M.Cohen | | 0，，： | 1 |
| 9 | The fetal venous system, Part II: ultrasound evaluation of the fetus with congenital venous system malformation or developing circulatory compromise显示文摘 | S.Yagel Z.Kivilevitch S. M.Cohen D. V.Valsky B.Messing O.Shen R.Achiron | 2010 | Ultrasound Obstet Gynecol2010，，1： | 1 |
| 10 | 在家上学谁来买单?显示文摘克里斯蒂娜·摩根(Christine Morgan)是美国佐治亚州皮奇特里市的一位母亲,她称自己是“公立学校的忠实支持者”。但是今年春天,在应对她所在地区的远程学习课程后(她说这些课程缺少教学内容,课外作业繁重),摩根决定考虑让她即将上四年级的孩子在家上学。“如果大家都认真对待新冠疫情并采取预防措施,我会考虑把孩子送回学校上课,”她说,“但是在佐治亚州,他们没有这样做。” | Rachel M.Cohen 孟洁冰(译) | 2020 | 商业周刊(中文版)2020，，12： | 0 |
| 11 | Mode of action for inorganic arsenic toxicity and carcinogenesis显示文摘Inorganic arsenic(iAs) at high doses is a known human carcinogen, inducing tumors of the skin,urinary bladder, and lung. It is also associated with noncancer toxicities. An understanding of the mode of action(MOA) for arsenic-induced effects is needed to develop a scientifically-based risk assessment. To determine an MOA for iAs induced toxicities, it is necessary to understand the metabolism, kinetics, cell transport, and interaction with specific proteins of iAs. Based on in vitro investigations using animal and human cells, studies from animal models,and clinical and epidemiological studies, we have proposed an MOA involving formation of sufficient levels of reactive trivalent metabolites which interact with critical free sulfhydryl groups, leading to cytotoxicity and regenerative cell proliferation. There is a strong correlation between in vitro cytotoxicity([0.1 lmol/L trivalent arsenicals) and the no effect levels in rodents [approximately 1 ppm(1 ppm = 1 mg/L) of water or diet]. In epithelial target tissues, the cytotoxic effects of iAs result in chronic precursor lesions which have the potential for an increased risk of developing cancer. In non-epithelial tissues, noncancer toxicities such as hypertension and atherosclerosis develop. This MOA implies a non-linear, threshold dose–response relationship for both non-cancer and cancer end points of exposure to iAs. | Puttappa R.Dodmane Lora L.Arnold Samuel M.Cohen | 2014 | Chinese Science Bulletin2014，59，11： | 0 |
| 12 | 舌下神经和喉返神经对肺牵张感受器和喉上神经传入冲动的反应显示文摘本实验比较了支配上呼吸道肌的舌下神经和喉返神经放电与支配吸气肌的膈神经放电的异同,并观察了这三种神经对肺牵张感受器传入冲动和喉上神经传入冲动的异同。结果表明:1、舌下神经和喉返神经放电早于膈神经;2、舌下神经和喉返神经均可被肺牵张传入冲动所抑制,尤以舌下神经为最;3、刺激喉上神经在膈神经、舌下神经和喉返神经上引起的反应相似。上述结果提示:1、膈神经、舌下神经和喉返神经在脑干中通过的神经环路不同,通过的神经元数目不同;2、肺牵张感受器和喉上神经传入冲动是通过改变舌下神经和喉返神经的放电类型而影响呼吸道的开闭。 | 张衡 A.Sica D.Donnelly M.Cohen | 1989 | 山东医科大学学报1989，27，1： | 0 |
| 13 | miRNA在儿童持续性脑震荡后综合征唾液中的表达(摘译)显示文摘在美国,每年有高达两百万的儿童受脑震荡影响,约1/3会发展为持续性脑震荡后综合征(persistent post-concussion syndrome,PPCS),影响时长达数月。相较于未发生PPCS的儿童,该群体更有可能缺课、情绪低落、缺乏社交以及拥有低生活质量。目前预测PPCS风险主要依赖于患者报告的症状和临床体征。 | 陈月亮 宋子翊 周家俊(译) 杨静珍 李丽萍(审校) Katherine E.Miller James P.MacDonald Lindsay Sullivan Lakshmi Prakruthi Rao Venkata Junxin Shi Keith Owen Yeates Su Chen Enas Alshaikh H.Gerry Taylor Amanda Hautmann Nicole Asa Daniel M.Cohen Thomas L.Pommering Elaine R.Mardis Jingzhen Yang the NCH Concussion Research Group | 2023 | 伤害医学(电子版)2023，12，2： | 0 |
| 14 | 人口稀少地区的高速互联网显示文摘对宽带接入与日俱增的需求促使电信运营商们配置日渐增多的不对称数字用户线路(ADSL),以提供高速却并不昂贵的互联网接入服务。该项技术日趋成功,并在城市和郊区加速拓展应用。然而,在人口稀少的居民区通常是远离聚居中心数百英里的区域,想要配置该项技术,将会遇到技术上和经济上困难(数字用户线接入复用器:DSLAM). | M.Cohen D.Rouffet L.Brignol M.Coupechoux | 2005 | 网络电信2005，7，6： | 0 |
| 15 | 都灵DVB-SH现场试验——描述和测量结果显示文摘从2008年到2009年,在意大利都灵,阿尔卡特-朗讯、意大利广播电视研究中心(RAI)、和记黄浦(H3G)以及Eutelsal密切协作,对采用卫星手持(DVB—SH)技术的数字视频广播进行了现场试验。该试验的主要目的是:在不同的地面路径(室内、室外、移动……)下评估DVB—SH系统的性能并实现一种新的无线电规划拓扑。本文在概述DVB—SH系统之后,将重点描述试验以及获得的结果。 | M.Cohen Alex(译) | 2012 | 世界广播电视2012，26，2： | 0 |
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