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| 1 | 用模型和模拟方法设计氨氯地平的群体药动学研究方案显示文摘合理的采样设计是建立可靠群体药动学模型的重要基础。应用非线性混合效应模型的群体药动学研究,是一种有效利用稀疏血样数据估算群体药动学参数的方法。本研究根据D最优化设计和贝叶斯法设计采样方案。以已报道的氨氯地平群体药动学模型为基础,根据临床研究的目的、给药方案和随访时间等设计几套采样方案,采用WinPOPT软件计算优化采样方案,用蒙特卡罗法(Monte Carlo)对各优化的采样方案分别建立一套含400个患者的NONMEM数据文件,用NONMEM7.2软件模拟氨氯地平的浓度数据,然后估算其重要药动学参数(CL/F,V/F和Ka),并计算其平均预测误差(MPE)和平均绝对预测误差(MAPE)。在6个采样方案中,以方案6和3对CL/F估算的准确度和精密度较优,MPE分别为0.1%和0.6%,MAPE均为0.7%。对V的估算,各采样方案间无明显差异。因此,选用氨氯地平拟合药动学参数的准确度和精密度较优,且采样点个数较少的方案3为最佳临床研究方案。本研究旨在为开展氨氯地平在肾功能损害合并高血压患者的群体药动学研究提供科学、有效的采样方法,为群体PK/PD研究提供一种优化设计临床研究方案的科学方法。 | 左笑丛 袁洪 张毕奎 Chee M.NG Jeff S.BARRETT 阳国平 黄志军 裴奇 郭韧 周亚男 荆宁宁 DI Wu | 2012 | 药学学报2012，47，7： | 2 |
| 2 | Acute cholangitis—predictive factors for emergency ERCP显示文摘 | C.‐K.Hui K.‐C.Lai M.‐F.Yuen M.Ng C.‐L.Lai S.‐K.Lam | 2008 | Alimentary Pharmacology & Therapeutics2008，，10： | 1 |
| 3 | Cost‐effectiveness analysis on screening for colorectal neoplasm and management of colorectal cancer in Asia显示文摘 | K. K. F.TSOI S. S. M.NG M. C. M.LEUNG J. J. Y.SUNG | 2008 | Alimentary Pharmacology & Therapeutics2008，，3： | 1 |
| 4 | Philippine retinoblastoma initiative multi-eye center study 2010-2020显示文摘AIM:To provide a comprehensive and more representative national data on the disease,especially on treatment options and outcomes,and to determine access of retinoblastoma patients from Luzon,Visayas and Mindanao to eye care,and determine if access is associated with delay in consultation,staging and outcomes.METHODS:Cohort study of retinoblastoma patients seen in eleven institutions located in the three major areas of the Philippines namely Luzon,Vizayas and Mindanao from 2010-2020.RESULTS:Totally 636 patients,involving 821 eyes,were included.Majority(57%)were from Luzon and were seen in institutions in Luzon(72%).Annually,58±10 new cases were seen with 71%having unilateral disease.Median delay of consultation remained long at 9(3,17)mo,longest in patients with unilateral disease(P<0.02)and those from the Visayas(P<0.003).Based on the International Retinoblastoma Staging System,only 35%of patients had Stage 1 while 47%already had extraocular disease.Enucleation was the most common treatment received by 484 patients while intravenous chemotherapy was received by 469.There were 250(39%)patients alive,195(31%)dead,85(13%)abandoned,17(3%)refused and 89(14%)with no data.CONCLUSION:This study presents the largest cohort of retinoblastoma patients in the Philippines in terms of patients’and participating institutions’number and geographical location and type of institution(private and public).It also presents more comprehensive data on the treatments used and outcomes(survival,globe salvage,and vision retention rates).Delay in consultation was still long among patients leading to advanced disease stage and lower survival rate.Despite increasing capacity to diagnose and manage retinoblastoma in the country,the delay of consultation remains long primarily due to accessibility issues to eye care institutions especially in the Visayas and financial concerns.The delay was still significant that overall survival rate remain low. | Roland Joseph D.Tan Gary John V.Mercado Patricia E.Cabrera Paulita Pamela P.Astudillo Rolando Enrique D.Domingo Josept Mari S.Poblete Charmaine Grace M.Cabebe Adriel Vincent R.Te Melissa Anne S.Gonzales Jocelyn G.Sy Beltran Alexis A.Aclan Jayson T.So Fatima G.Regala Kimberley Amanda K.Comia Josemaria M.Castro Mara Augustine S.Galang Aldous Dominic C.Cabanlas Benedicto Juan E.Aguilar Gabrielle S.Evangelista Jo Michael Maniwan Andrei P.Martin Calvin Y.Martinez John Alfred H.Lim Rena Ivy Bascuna Rachel M.Ng Kevin B.Agsaoay Kris Zanna A.Acluba-Arao Ellaine Rose V.Apostol Beatriz M.Prieto | 2024 | International Journal of Ophthalmology(English edition)2024，17，1： | 0 |
| 5 | Computational design of structured chemical products显示文摘In chemical product design,the aim is to formulate a product with desired performance.Ingredients and internal product structure are two key drivers of product performance with direct impact on the mechanical,electrical,and thermal properties.Thus,there is a keen interest in elucidating the dependence of product performance on ingredients,structure,and the manufacturing process to form the structure.Design of product structure,particularly microstructure,is an intrinsically complex problem that involves different phases of different physicochemical properties,mass fraction,morphology,size distribution,and interconnectivity.Recently,computational methods have emerged that assist systematic microstructure quantification and prediction.The objective of this paper is to review these computational methods and to show how these methods as well as other developments in product design can work seamlessly in a proposed performance,ingredients,structure,and manufacturing process framework for the design of structured chemical products.It begins with the desired target properties and key ingredients.This is followed by computation for microstructure and then selection of processing steps to realize this microstructure.The framework is illustrated with the design of nanodielectric and die attach adhesive products. | Faheem Mushtaq Xiang Zhang Ka Y.Fung Ka M.Ng | 2021 | Frontiers of Chemical Science and Engineering2021，15，5： | 0 |
| 6 | 数据挖掘与建模进展显示文摘数据挖掘与数据模型化是两个热门的课题,它们都在快速地发展。由于其广泛的应用和丰富的研究内容,引起许多专业人员和学术界人士的极大兴趣。2002年6月27~28日在香港举行了“数据挖掘与数据建模研究讨论会”。这个讨论会得到了香港大学数学研究所和香港数学学会的支持。本书是这次讨论会的论文集,会议的主题有两个:数据挖掘与数据建模,数据挖掘涉及了模式的发现、群集算法、 | W.ching(编) M.Ng(编) 胡海伦 | 2005 | 国外科技新书评介2005，，7： | 0 |
| 7 | 晶圆边缘缺陷的控制策略显示文摘在晶圆边缘芯片上的系统性工艺缺陷进入到晶圆内部芯片之前,如果发现并解决这些缺陷问题,可以防止产品成品率损失并加快成品率的提升速度。 | M.F.Hsu J.H.Yang E.Yang H.Chen M.Ng M.Li C.Perry-Sullivan | 2009 | 集成电路应用2009，26，9： | 0 |
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