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| 1 | Stripe Rust Effector PstGSRE1 Disrupts Nuclear Localization of ROS-Promoting Transcription Factor TaLOL2 to Defeat ROS-Induced Defense in Wheat显示文摘Puccinia striiformis f.sp.tritici(Pst),a biotrophic plant pathogen,secretes numerous effectors to modulate host defense systems.Understanding the molecular mechanisms by which Pst effectors regulate wheat immunity is of great importance for the development of novel strategies for durable control of stripe rust.In this study,we identified a glycine-serine-rich effector gene,PstGSRE1,which is highly induced dur-ing early infection.Transgenic expression of PstGSRE1 RNAi constructs in wheat significantly reduced virulence of Pst and increased H2O2 accumulation in wheat.PstGSRE1 was shown to target the reactive ox-ygen species(ROS)-associated transcription factor TaLOL2,a positive regulator of wheat immunity.PstGSRE1 disrupted nuclear localization of TaLOL2 and suppressed ROS-mediated cell death induced by TaLOL2,thus compromising host immunity.This work reveals a previously unrecognized strategy whereby rust fungi exploit the PstGSRE1 effector to defeat ROS-associated plant defense by modulating the subcellular compartment of a host immune regulator and facilitate pathogen infection. | Tuo Qi Jia Guo Peng Liu Fuxin He Cuiping Wan Md Ashraful Islam Brett M.Tyler Zhensheng Kang Jun Guo | 2019 | Molecular Plant2019，12，12： | 11 |
| 2 | Targeting of anti-microbial proteins to the hyphal surface amplifies protection of crop plants against Phytophthora pathogens显示文摘Phytophthora pathogens are a persistent threat to the world's commercially important agricultural crops,including potato and soybean.Current strategies aim at reducing crop losses rely mostly on disease-resistance breeding and chemical pesticides,which can be frequently overcome by the rapid adaptive evolution of pathogens.Transgenic crops with intrinsic disease resista nee offer a promising alternative and con tinue to be developed.Here,we explored Phytophthora-derived PI3P(phosphatidylinositol 3-phosphate)as a novel control target,using proteins that bind this lipid to direct secreted anti-microbial peptides and proteins(AMPs)to the surface of Phytophthora pathogens.In transgenic Nicotiana benthamiana,soybean,and potato plants,significantly enhanced resistance to different pathogen isolates was achieved by expression of two AMPs(GAFP1 or GAFP3 from the Chinese medicinal herb Gastrodia elata)fused with a PI3P-specific binding domain(FYVE).Using the soybean pathogen P.sojae as an example,we demonstrated that the FYVE domain could boost the activities of GAFPs in multiple independent assays,including those performed in vitro,in vivo,and in planta.Mutational analysis of P.sojae PI3K1 and PI3K2 genes of this pathogen confirmed that the enhanced activities of the targeted GAFPs were correlated with PI3P levels in the pathogen.Collectively,our study provides a new strategy that could be used to confer resistance not only to Phytophthora pathogens in many plants but also potentially to many other kinds of plant pathogens with unique targets. | Yang Zhou Kun Yang Qiang Yan Xiaodan Wang Ming Cheng Jierui Si Xue Xue Danyu Shen Maofeng Jing Brett M.Tyler Daolong Dou | 2021 | Molecular Plant2021，14，8： | 2 |
| 3 | Phytophthora sojae: root rot pathogen of soybean and model oomycete显示文摘 | BRETT M.TYLER | 2006 | Molecular Plant Pathology2006，，1： | 1 |
| 4 | 积极的师生互动有助于增强学生对学校的归属感显示文摘初中阶段是青少年开始清晰地认识自我并与他人建立联系的关键时期,这个时期的学生开始对学校产生归属感,而师生问的互动是促进学生产生归属感的关键因素,同时也影响着学生的各种适应性行为,例如学业表现。美国一项调查以776存仞中阶段学生为样本.研究师生间的互动和家校间的差异在学生对学校的归属感中的影响,其中,家校间的差异主要指学饺文化和家庭文化在教育方式、价值观等方面所表现出的差异。研究表明,师生之间愉悦和正而的互动体验有助于学生对学校产生更强的归属感, | Kenneth M.Tyler Ruby Stevens-Morgan Lynda Brown-Wright | 2017 | 中国德育2017，12，7： | 0 |
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