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| 1 | Mechanisms of hepatocellular carcinoma progression显示文摘Hepatocellular carcinoma(HCC) is the most common primary malignancy of the liver. It is the second leading cause of cancer-related deaths worldwide, with a very poor prognosis. In the United States, there has been only minimal improvement in the prognosis for HCC patients over the past 15 years. Details of the molecular mechanisms and other mechanisms of HCC progression remain unclear. Consequently, there is an urgent need for better understanding of these mechanisms. HCC is often diagnosed at advanced stages, and most patients will therefore need systemic therapy, with sorafenib being the most common at the present time. However, sorafenib therapy only minimally enhances patient survival. This review provides a summary of some of the known mechanisms that either cause HCC or contribute to its progression. Included in this review are the roles of viral hepatitis, non-viral hepatitis, chronic alcohol intake, genetic predisposition and congenital abnormalities, toxic exposures, and autoimmune diseases of the liver. Well-established molecular mechanisms of HCC progression such as epithelial-mesenchymal transition, tumor-stromal interactions and the tumor microenvironment, cancer stem cells, and senescence bypass are also discussed. Additionally, we discuss the roles of circulating tumor cells,immunomodulation, and neural regulation as potential new mechanisms of HCC progression. A better understanding of these mechanisms could have implications for the development of novel and more effective therapeutic and prognostic strategies, which are critically needed. | Olorunseun O Ogunwobi Trisheena Harricharran Jeannette Huaman Anna Galuza Oluwatoyin Odumuwagun Yin Tan Grace X Ma Minhhuyen T Nguyen | 2019 | World Journal of Gastroenterology2019，25，19： | 21 |
| 2 | Virulence factors of Enterococcus strains isolated from patients with inflammatory bowel disease显示文摘AIM: To determine the features of Enterococcus that contribute to the development and maintenance of the inflammatory process in patients with inflammatory bowel disease (IBD). METHODS: Multiplex polymerase chain reaction (PCR) was applied to assess the presence of genes that encode virulence factors [surface aggregating protein (asa1), gelatinase (gelE), cytolysin (cylA), extracellular surface protein (esp) and hyaluronidase (hyl)] in the genomic DNA of 28 strains of Enterococcus isolated from the intestinal tissues of children with IBD (n =16) and of children without IBD (controls; n = 12). Additionally, strains with confirmed presence of the gelE gene were tested by PCR for the presence of quorum sensing genes (fsrA, fsrB, fsrC) that control the gelatinase production. Gelatinase activity was tested on agar plates containing 1.6% gelatin. We also analysed the ability of Enterococcus strains to release and decompose hydrogen peroxide (using Analytical Merckoquant peroxide test strips) and tested their ability to adhere to Caco-2 human gut epithelium cells and form biofilms in vitro. RESULTS: A comparison of the genomes of Enterococcus strains isolated from the inflamed mucosa of patients with IBD with those of the control group showed statistically significant differences in the frequency of theasa1 gene and thegelE gene. Furthermore, the cumulative occurrence of different virulence genes in the genome of a single strain ofEnterococcus isolated from the IBD patient group is greater than in a strain from the control group, although no significant difference was found. Statistically significant differences in the decomposition of hydrogen peroxide and adherence to the Caco-2 epithelial cell line between the strains from the patient group and control group were demonstrated. The results also showed that profuse biofilm production was more frequent amongEnterococcus strains isolated from children with IBD than in control strains. CONCLUSION: Enterococcus strains that adhere strongly to the intestinal epithelium, form biofilms and possess antioxidant defence mechanisms seem to have the greatest influence on the inflammatory process. | Edyta Golińska Anna Tomusiak Tomasz Gosiewski Gra yna Wiecek Agnieszka Machul Diana Mikoajczyk Magorzata Bulanda Piotr B Heczko Magdalena Strus | 2013 | World Journal of Gastroenterology2013，19，23： | 8 |
| 3 | Spatial pattern of grassland aboveground biomass and its environmental controls in the Eurasian steppe显示文摘Vegetation biomass is an important component of terrestrial ecosystem carbon stocks. Grasslands are one of the most widespread biomes worldwideplaying an important role in global carbon cycling. Thereforestudying spatial patterns of biomass and their correlations to environment in grasslands is fundamental to quantifying terrestrial carbon budgets. The Eurasian steppean important part of global grasslandsis the largest and relatively well preserved grassland in the world. In this studywe analyzed the spatial pattern of aboveground biomass(AGB)and correlations of AGB to its environment in the Eurasian steppe by meta-analysis. AGB data used in this study were derived from the harvesting method and were obtained from three data sources(literatureglobal NPP database at the Oak Ridge National Laboratory Distributed Active Archive Center(ORNL)some data provided by other researchers). Our results demonstrated that:(1) as for the Eurasian steppe overallthe spatial variation in AGB exhibited significant horizontal and vertical zonality. In detailAGB showed an inverted parabola curve with the latitude and with the elevationwhile a parabola curve with the longitude. In additionthe spatial pattern of AGB had marked horizontal zonality in the Black Sea-Kazakhstan steppe subregion and the Mongolian Plateau steppe subregionwhile horizontal and vertical zonality in the Tibetan Plateau alpine steppe subregion.(2) Of the examined environmental variablesthe spatial variation of AGB was related to mean annual precipitation(MAP)mean annual temperature(MAT)mean annual solar radiation(MAR)soil Gravel contentsoil p H and soil organic content(SOC) at the depth of 0–30 cm. NeverthelessMAP dominated spatial patterns of AGB in the Eurasian steppe and its three subregions.(3) A Gaussian function was found between AGB and MAP in the Eurasian steppe overallwhich was primarily determined by unique patterns of grasslands and environment in the Tibetan Plateau. AGB was significantly positively related to MAP in the Black Sea-Kazakhstan steppe subregion(elevation < 3000 m)the Mongolian Plateau steppe subregion(elevation < 3000 m) and the surface(elevation ≥ 4800 m) of the Tibetan Plateau. Neverthelessthe spatial variation in AGB exhibited a Gaussian function curve with the increasing MAP in the east and southeast margins(elevation < 4800 m) of the Tibetan Plateau. This study provided more knowledge of spatial patterns of AGB and their environmental controls in grasslands than previous studies only conducted in local regions like the Inner Mongolian temperate grasslandthe Tibetan Plateau alpine grasslandetc. | JIAO Cuicui YU Guirui HE Nianpeng MA Anna GE Jianping HU Zhongmin | 2017 | Journal of Geographical Sciences2017，27，1： | 7 |
| 4 | DICER-LIKE3 Activity in Physcomitrella patens DICER-LIKE4 Mutants Causes Severe Developmental Dysfunction and Sterility显示文摘交易的小介入 RNA (ta-siRNAs ) 是在 microRNA 依赖的劈开,进双 stranded RNA 的变换,和骰子依赖者分阶段执行处理以后,免除 TAS 先锋抄本的植物特定的 siRNAs。象 microRNAs (miRNAs ) 一样, ta-siRNAs 在广泛的补充的地点的目标 RNA 的直接地点特定的劈开。这里,我们证明像骰子 Physcomitrella 圣餐盘(PpDCL4 ) 的 4 蛋白质为 21 核苷酸(nt ) 的生物的续生说是必要的 ta-siRNAs。在 PpDCL4 异种,离开缩放 23 并且 24-nt ta-siRNAs 作为 PpDCL3 的结果积累了活动。PpDCL4 异种在整个 Physcomitrella 开发显示严重畸形,包括绝育,那充分在 PpDCL3/PpDCL4 双异种植物被颠倒。因此, PpDCL3 活动,不是 PpDCL4 功能本身的损失,是 PpDCL4 显型的原因。另外,我们描述几新 Physcomitrella 交易 siRNA loci,其三属于一个新家庭, TAS6。TAS6 loci 被切的 miR156 和 miR529 目标地点代表并且在到 PpTAS3 loci 的靠近的最近。 | M. Asif Arif Isam Fattash Zhaorong Ma Sung Hyun Cho Anna K. Beike Ralf Reski Michael J. Axtell Wolfgang Frank | 2012 | Molecular Plant2012，5，6： | 4 |
| 5 | Fatty acid changes help to better understand regression of nonalcoholic fatty liver disease显示文摘AIM: To investigate whether liver steatosis reduction due to a six-month dietary intervention results in significant changes in the concentrations of fatty acids.METHODS: A group of 35 Caucasian individuals diagnosed with different levels of steatosis were prospectively enrolled in the present study.Analysis of the fatty acid profiles was performed according to changes in liver steatosis(liver steatosis reduction by one or two degrees) after a six-month dietary intervention.The diet helped reduce body mass in obese and overweight patients,and stabilize both glycemia and dyslipidemia.Fatty acids were extracted according to the Folch method and analyzed by gas chromatography.RESULTS: This study showed significant changes in fatty acid profiles in patients who had reduced liver steatosis by one as well as two degrees.A reduction in liver steatosis by one degree caused a significant increase in the level of the n-3 family: eicosapentaenoic acid(P < 0.055),docosapentaenoic acid-C 22:5(P < 0.05) and docosahexaenoic acid(P < 0.05).A reduction in liver steatosis by two degrees caused a significant decrease in serum palmitoleic acid-C 16:1(P < 0.05).CONCLUSION: Liver steatosis reduction is associated with changes in fatty acid profiles,and these changes may reflect an alteration in fatty acid synthesis and metabolism.These findings may help better understand regression of nonalcoholic fatty liver disease. | Dominika Maciejewska Arleta Drozd Piotr Ossowski Karina Ryterska Dominika Jamio-Milc Marcin Banaszczak Joanna Raszeja-Wyszomirska Magorzata Kaczorowska Anna Sabinicz Ewa Stachowska | 2015 | World Journal of Gastroenterology2015，21，1： | 4 |
| 6 | 中国企业在欧盟市场的知识产权保护显示文摘欧盟是中国第一大国际贸易伙伴,随着欧盟对知识产权保护更为严格,在对欧商贸中知识产权保护的重要性更为凸现。通过介绍在欧盟当地调研收集的诸多案例,分析和总结出中资公司在生产、出口以及在欧盟当地经营中关于知识产权保护的经验和教训,提出涉及到商标、专利、著作权、外观设计等方面的具体建议和警示,供企业和法务部门在商贸活动中参考。 | 马琳 Anna Ma | 2013 | 电子知识产权2013，，5： | 2 |
| 7 | Glucagon-like peptide-1 receptor imaging with [Lys 40 (Ahx-HYNIC- 99m Tc/EDDA)NH 2 ]-exendin-4 for the detection of insulinoma显示文摘 | Anna Sowa-Staszczak Dorota Pach Renata Miko?ajczak Helmut M?cke Agata Jabrocka-Hybel Agnieszka Stefańska Monika Tomaszuk Barbara Janota Aleksandra Gilis-Januszewska Maciej Ma?ecki Grzegorz Kamiński Aldona Kowalska Jan Kulig Andrzej Matyja Czes?aw Osuch Al | 2013 | European Journal of Nuclear Medicine and Molecular Imaging2013，，4： | 2 |
| 8 | Comparison of the prognostic value of frailty assessment tools in patients aged≥65 years hospitalized in a cardiac care unit with acute coronary syndrome显示文摘BACKGROUND Frailty is associated with adverse events in elderly patients with acute coronary syndrome(ACS).Our aim was to compare the prognostic value of four frailty scales in patients aged≥65 years hospitalized with ACS in a cardiac care unit(CCU).METHODS Patients aged≥65 years with ACS were included.Frailty was assessed using the Fried frailty scale(reference standard),the Edmonton Frail Scale(EFS),the FRAIL scale,and the Clinical frailty scale(CFS).The primary end point was all-cause mortality and the secondary end point was unscheduled rehospitalization.RESULTS One hundred and seventy four patients aged≥65 years with ACS were recruited.The median follow-up was 637.5 days.Frailty was identified in 41.4%,40.2%,39.1%and 36.3%patients by the Fried frailty scale,EFS,FRAIL scale and CFS,re-spectively.The agreement coefficients were 0.88,0.86,and 0.79 for the FRAIL scale,EFS and CFS,respectively.In the Cox regres-sion model,frailty was associated with all-cause mortality regardless of the scale used(univariate:hazard ratio[HR]95%CI=10.5,2.4-46.8 Fried frailty scale;12.0,2.7-53.4 FRAIL scale;7.1,2.0-25.2 EFS;8.3,2.4-29.6 CFS.Multivariate:HR=5.1,1.1-23.8 Fried frailty scale;5.7,1.2-26.8 FRAIL scale;3.7,1.0-14.0 EFS;4.2,1.1-15.9 CFS).The FRAIL scale had the highest HR.In the uni-variate analysis,frailty was associated with unscheduled rehospitalization(HR=3.2,1.7-6.0 Fried frailty scale;3.4,1.8-6.3 FRAIL scale;3.5,1.8-6.6 EFS;3.1,1.7-5.8 CFS).In the multivariate analysis,only the EFS independently predicted unscheduled rehospit-alization(HR=2.2,1.1-4.63).CONCLUSIONS Frailty assessed by the Fried frailty scale,FRAIL scale,EFS and CFS is associated with all-cause mortality and unscheduled rehospitalization in elderly patients hospitalized in a CCU with ACS.The adjusted HR of the FRAIL scale for all-cause mortality was the highest among the scales compared,whereas the EFS was an independent predictor of unscheduled re-hospitalization.These data should be taken into consideration when choosing a frailty assessment tool. | Wojciech Nowak Ilona Kowalik Małgorzata Kuzin Agnieszka Krauze Anna Mierzyńska Ewa Sadowy Kamil Marcinkiewicz Janina Stępińska | 2022 | Journal of Geriatric Cardiology2022，19，5： | 2 |
| 9 | Ceramic precursor in flame retardant systems显示文摘 | Marosi G Ma' rton A Anna P | 2002 | Polym Degrad Stab2002，77，2： | 1 |
| 10 | The correlation between zinc and insulin-like growth factor 1 (IGF-1), its binding protein (IGFBP-3) and prostate-specific antigen (PSA) in prostate cancer显示文摘 | Adam Daragó Andrzej Sapota Józef Matych Marzenna Nasiadek Ma?gorzata Skrzypińska-Gawrysiak Anna Kilanowicz | 2011 | Clinical Chemistry and Laboratory Medicine2011，，10： | 1 |
| 11 | The evaluation of IL-12 concentration, PAF-AH, and PLA 2 activity in patients with type 1 diabetes treated with intensive insulin therapy显示文摘 | Ma?gorzata Wegner Aleksandra Araszkiewicz Anna Pioruńska-Miko?ajczak Dorota Zozulińska-Zió?kiewicz Bogna Wierusz-Wysocka Maria Pioruńska-Stolzmann | 2009 | Clinical Biochemistry2009，，16： | 1 |
| 12 | Overexpression of SHORT VEGETATIVE PHASE-LIKE (SVL) in Populus delays onset and reduces abundance of flowering in field-grown trees显示文摘The spread of transgenes and exotic germplasm from planted crops into wild or feral species is a difficult problem for public and regulatory acceptance of genetically engineered plants,particularly for wind-pollinated trees such as poplar.We report that overexpression of a poplar homolog of the floral repressor SHORT VEGETATIVE PHASE-LIKE(SVL),a homolog of the Arabidopsis MADS-box repressor SHORT VEGETATIVE PHASE(SVP),delayed the onset of flowering several years in three genotypes of field-grown transgenic poplars.Higher expression of SVL correlated with a delay in flowering onset and lower floral abundance,and did not cause morphologically obvious or statistically significant effects on leaf characteristics,tree form,or stem volume.Overexpression effects on reproductive and vegetative phenology in spring was modest and genotype-specific.Our results suggest that use of SVL and related floral repressors can be useful tools to enable a high level of containment for vegetatively propagated short-rotation woody energy or pulp crops. | Greg S.Goralogia Glenn T.Howe Amy M.Brunner Emily Helliwell Michael F.Nagle Cathleen Ma Haiwei Lu Amanda L.Goddard Anna C.Magnuson Amy L.Klocko Steven H.Strauss | 2021 | Horticulture Research2021，8，1： | 1 |
| 13 | Exercise capacity, arrhythmic risk profile, and pulmonary function is not influenced by intracoronary injection of Bone Marrow Stem Cells in patients with acute myocardial infarction显示文摘 | Ewa Straburzyńska-Migaj Ma?gorzata Popiel Stefan Grajek Agnieszka Katarzyńska-Szymańska Maciej Lesiak Piotr Br?borowicz Krzysztof Sawiński Anna Czy? Lidia Gil Maria Koz?owska-Skrzypczak Mieczys?aw Komarnicki | 2011 | International Journal of Cardiology2011，，2： | 1 |
| 14 | Trends and dynamics of changes in calcification score over the 1-year observation period in patients on peritoneal dialysis显示文摘 | Tomasz P. Stompór Mieczys?aw Pasowicz W?adys?aw Su?owicz Aldona Dembińska-Kie? Katarzyna Janda Katarzyna Wójcik Wies?awa Tracz Anna Zdzienicka Ma?gorzata Konieczyńska Piotr Klimeczek Eve Janusz-Grzybowska | 2004 | American Journal of Kidney Diseases2004，，3： | 1 |
| 15 | The role of vascular endothelial growth factor, tumor necrosis factor alpha and interleukin-6 in pathogenesis of diabetic retinopathy显示文摘 | Ma?gorzata My?liwiec Anna Balcerska Katarzyna Zorena Jolanta My?liwska Pawe? Lipowski Krystyna Raczyńska | 2007 | Diabetes Research and Clinical Practice2007，，1： | 1 |
| 16 | GABA B receptors as a therapeutic strategy in substance use disorders: Focus on positive allosteric modulators显示文摘 | Ma?gorzata Filip Ma?gorzata Frankowska Anna Sadakierska-Chudy Agata Suder ?ukasz Szumiec Pawe? Mierzejewski Przemyslaw Bienkowski Edmund Przegaliński John F. Cryan | 2015 | Neuropharmacology2015，，： | 1 |
| 17 | Influence of Cu2+ ions on structural and magnetic properties of NiZn ferrites显示文摘 | Mariana U?áková Jozef Luká? Rastislav Dosoudil Vladimír Jan?árik Anna Grusková Elemír U?ák Jozef Sláma Jan ?ubrt | 2007 | Journal of Materials Science: Materials in Electronics2007，，12： | 1 |
| 18 | The 8k event: cause and sequence of a major Holocene abrupt climate change显示文摘 | Richard B A Anna Ma | 2005 | Quaternary Science Review2005，24，： | 1 |
| 19 | Effect of BCG revaccination on incidence of tuberculosis in school-aged children in Brazil:the BCGREVAC cluster-randomised trial显示文摘 | Rodrigues LC Pereira SM Cunha SS Genser B Ichihara MY de Brito SC Hijar MA Dourado I Cruz AA Sant'Anna C Bierrenbach AL Barreto ML | 2005 | Lancet2005，366，9493： | 1 |
| 20 | The VEGF receptor, neuropilin‐1, represents a promising novel target for chronic lymphocytic leukemia patients显示文摘 | Agnieszka Piechnik Anna Dmoszynska Marcin Omiotek Rados?aw Mlak Ma?gorzata Kowal Stephan Stilgenbauer Lars Bullinger Krzysztof Giannopoulos | 2013 | Int J Cancer2013，，6： | 1 |
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