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| 1 | Antidiabetic Effects of Gegen Qinlian Decoction via the Gut Microbiota Are Attributable to Its Key Ingredient Berberine显示文摘Gegen Qinlian Decoction(GQD),a traditional Chinese medicine(TCM)formula,has long been used for the treatment of common metabolic diseases,including type 2 diabetes mellitus.However,the main limitation of its wider application is ingredient complexity of this formula.Thus,it is critically important to identify the major active ingredients of GQD and to illustrate mechanisms underlying its action.Here,we compared the effects of GQD and berberine,a hypothetical key active pharmaceutical ingredient of GQD,on a diabetic rat model by comprehensive analyses of gut microbiota,short-chain fatty acids,proinflammatory cytokines,and ileum transcriptomics.Our results show that berberine and GQD had similar effects on lowering blood glucose levels,modulating gut microbiota,inducing ileal gene expression,as well as relieving systemic and local inflammation.As expected,both berberine and GQD treatment significantly altered the overall gut microbiota structure and enriched many butyrate-producing bacteria,including Faecalibacterium and Roseburia,thereby attenuating intestinal inflammation and lowering glucose.Levels of short-chain fatty acids in rat feces were also significantly elevated after treatment with berberine or GQD.Moreover,concentration of serum proinflammatory cytokines and expression of immune-related genes,including Nfkb1,Stat1,and Ifnrg1,in pancreatic islets were significantly reduced after treatment.Our study demonstrates that the main effects of GQD can be attributed to berberine via modulating gut microbiota.The strategy employed would facilitate further standardization and widespread application of TCM in many diseases. | Xizhan Xu Zezheng Gao Fuquan Yang Yingying Yang Liang Chen Lin Han Na Zhao Jiayue Xu Xinmiao Wang Yue Ma Lian Shu Xiaoxi Hu Na Lyu Yuanlong Pan Baoli Zhu Linhua Zhao Xiaolin Tong Jun Wang | 2020 | Genomics, Proteomics & Bioinformatics2020，18，6： | 29 |
| 2 | Geochemical characteristics and geological significance of the Neoproterozoic carbonates from northern Anhui Province, China显示文摘Petrographical and geochemical studies were carried out of the Neoproterozoic carbonates from northern Anhui Province, China. These carbonates can be subdivided into two types, including purified limestone (PL) and mixed limestone and siliclastic rocks (MLS). PLs are low in Si, Al, Zr and total REE but high in CaO compared with MLSs. Correlations between Zr, Fe2O3, P2O5 and total REE are also less remarkable, indicating that they were not obviously contaminated by continental materials but directly precipitated from seawater. So they can be used for the inversion of paleo-seawater REE patterns. The inversed results indicated that the REE pattern of Neoproterozoic seawater was similar to that of the modern seawater except for the lack of Ce depletion, which was probably affected by the reduced hydrothermal solution. In combination with previous studies, the geochemical trending of these carbonatic samples towards the continental arc in the La- Th-Sc and Th-Sc-Zr/10 diagrams is interpreted as the contamination of arc volcanism. The tectonic background of the southern margin of the North China Craton in the Neoproterozoic was probably related to the Grenville orogeny during the convergence of the Rodinia supercontinent, rather than an intra-plate environment. | SUN Linhua GUI Herong CHEN Song MA Yanping HE Zhenyu | 2011 | Chinese Journal Of Geochemistry2011，30，1： | 9 |
| 3 | Effect of soil management on soil erosion on sloping farmland during crop growth stages under a large-scale rainfall simulation experiment显示文摘Soil erosion on farmland is a critical environmental issue and the main source of sediment in the Yellow River, China. Thus, great efforts have been made to reduce runoff and soil loss by restoring vegetation on abandoned farmland. However, few studies have investigated runoff and soil loss from sloping farmland during crop growth season. The objective of this study was to investigate the effects of soil management on runoff and soil loss on sloping farmland during crop growth season. We tested different soybean growth stages (i.e., seedling stage (R1), initial blossoming stage (R2), full flowering stage (R3), pod bearing stage (R4), and initial filling stage (R5)) and soil management practice (one plot applied hoeing tillage (HT) before each rainfall event, whereas the other received no treatment (NH)) by applying simulated rainfall at an intensity of 80 mm/h. Results showed that runoff and soil loss both decreased and infiltration amount increased in successive soybean growth stages under both treatments. Compared with NH plot, there was less runoff and higher infiltration amount from HT plot. However, soil loss from HT plot was larger than that from NH plot in R1–R3, but lower in R4 and R5. In the early growth stages, hoeing tillage was effective for reducing runoff and enhancing rainfall infiltration. By contrast, hoeing tillage enhanced soil and water conservation during the late growth stages. The total soil loss from HT plot (509.0 g/m^2) was 11.1% higher than that from NH plot (457.9 g/m^2) in R1–R5. However, the infiltration amount from HT plot (313.9 mm) was 18.4% higher than that from NH plot (265.0 mm) and the total runoff volume from HT plot was 49.7% less than that from NH plot. These results indicated that crop vegetation can also act as a type of vegetation cover and play an important role on sloping farmland. Thus, adopting rational soil management in crop planting on sloping farmland can effectively reduce runoff and soil loss, as well as maximize rainwater infiltration during crop growth period. | WANG Linhua WANG Yafeng Keesstra SASKIA Cerdà ARTEMI MA Bo WU Faqi | 2018 | Journal of Arid Land2018，10，6： | 5 |
| 4 | Phylogenomic Insights into Deep Phylogeny of Angiosperms Based on Broad Nuclear Gene Sampling显示文摘Angiosperms(flowering plants)are the most diverse and species-rich group of plants.The vast majority(99.95%)of angiosperms form a clade called Mesangiospermae,which is subdivided into five major groups:eudicots,monocots,magnoliids,Chloranthales,and Ceratophyllales.The relationships among these Mesangiospermae groups have been the subject of long debate.In this study,we assembled a phylogenomic dataset of 1594 genes from 151 angiosperm taxa,including representatives of all five lineages,to investigate the phylogeny of major angiosperm lineages under both coalescent-and concatenationbased methods.We dissected the phylogenetic signal and found that more than half of the genes lack phylogenetic information for the backbone of angiosperm phylogeny.We further removed the genes with weak phylogenetic signal and showed that eudicots,Ceratophyllales,and Chloranthales form a clade,with magnoliids and monocots being the next successive sister lineages.Similar frequencies of gene tree conflict are suggestive of incomplete lineage sorting along the backbone of the angiosperm phylogeny.Our analyses suggest that a fully bifurcating species tree may not be the best way to represent the early radiation of angiosperms.Meanwhile,we inferred that the crown-group angiosperms originated approximately between 255.1 and 222.2 million years ago,and Mesangiospermae diversified into the five extant groups in a short time span(27 million years)at the Early to Late Jurassic. | Lingxiao Yang Danyan Su Xin Chang Charles SPFoster Linhua Sun Chien-Hsun Huang Xiaofan Zhou Liping Zeng Hong Ma Bojian Zhong | 2020 | Plant Communications2020，1，2： | 2 |
| 5 | Study on the distribution law of random code structure of irregular LDPC codes and its application in eliminating short cycles显示文摘The distribution law of the random code structure of randomly constructed irregu- lar low-density parity-check (LDPC) codes is studied. Based on the Progressive Edge-Growth (PEG) algorithm, a new algorithm which can both eliminate short cy- cles and keep the distribution of the random code structure is presented. The ex- perimental results show that the performance of the irregular LDPC codes con- structed by the new algorithm is superior to that of the PEG algorithm. | MA LinHua CHANG YiLin Wang ShengDa | 2007 | Science in China(Series F)2007，50，1： | 2 |
| 6 | 2021 Chinese consensus on the diagnosis and management of primary immune thrombocytopenia in pregnancy显示文摘Immune thrombocytopenia(ITP)is an acquired disease characterized by isolated thrombocytopenia,which is one of the most common causes of thrombocytopenia during pregnancy.Women with ITP who have severe thrombocytopenia are at an increased risk for life-threatening obstetric complications.Therefore,we established this consensus statement on the diagnosis and management of ITP during pregnancy(detailed information is available in the Supplementary File,http://gffzz16e312a87a7141a5h55w9fknkoop96wux.ffgz.tsg.suse.edu.cn/A978). | Zhang Xiaohui Chen Fangping Chen Xiequn Cheng Yunfeng Fang Meiyun Feng Jianming Fu Haixia Gao Hong Han Yue He Aili Hou Ming Hu Yu Huang Ruibin Huang Wenrong Jing Zhicheng Kong Peiyan Liang Aibin Liang Meiying Liu Daihong Liu Junling Liu Lin Liu Xiaowei Ma Liangming Mei Heng Ni Heyu Niu Ting Peng Jun Qiao Jianlin Ren Jinhai Song Yongping Tang Liang V Tong Tong Wang Shaoyuan Wang Xin Wang Zhao Wei Hui Wu Depei Wu Guangsheng Xu Caigang Xu Xue Xu Yajing Yang Linhua Yang Renchi Yang Tonghua Yin Chenghong Yu Li Zhang Guangsen Zhang Lei Zhang Liansheng Zhang Xi Zhao Weili Zhao Yongqiang Zhou Daobin Zhou Hu Zhou Zeping Zhu Tienan Wang Jianliu Huang Xiaojun | 2022 | Chinese Medical Journal2022，，8： | 2 |
| 7 | Genomic insights on the contribution of introgressions from Xian/Indica to the genetic improvement of Geng/Japonica rice cultivars显示文摘Hybridization between Xian/indica(XI)and Geng/japonica(GJ)rice combined with utilization of plant ideotypes has greatly contributed to yield improvements in modern GJ rice in China over the past 50 years.To explore the genomic basis of improved yield and disease resistance in GJ rice,we conducted a large-scale genomic landscape analysis of 816 elite GJ cultivars representing multiple eras of germplasm from China.We detected consistently increasing introgressions from three XI subpopulations into GJ cultivars since the 1980s and found that the XI genome introgressions significantly increased the grain number per panicle(GN)and decreased the panicle number per plant.This contributed to the improvement of plant type during modern breeding,changing multi-tiller plants tomoderate tiller plants with a large panicle size and increasing the blast resistance.Notably,we found that key gene haplotypes controlling plant architecture,yield components,and pest and disease resistance,including IPA1,SMG1,DEP3,Pib,Pi-d2,and Bph3,were introduced from XI rice by introgression.By GWAS analysis,we detected a GN-related gene Gnd5,which had been consistently introgressed from XI into GJ cultivars since the 1980s.Gnd5 is a GRAS transcription factor gene,and Gnd5 knockout mutants showed a significant reduction in GN.The estimated genetic effects of genes varied among different breeding locations,which explained the distinct introgression levels of XI gene haplotypes,including Gnd5,DEP3,etc.,to these GJ breeding pedigrees.These findings reveal the genomic contributions of introgressions from XI to the trait improvements of GJ rice cultivars and provide new insights for future rice genomic breeding. | Di Cui Han Zhou Xiaoding Ma Zechuan Lin Linhua Sun Bing Han Maomao Li Jianchang Sun Jin Liu Guixiu Jin Xianju Wang Guilan Cao Xing Wang Deng Hang He Longzhi Han | 2022 | Plant Communications2022，3，3： | 0 |
| 8 | Practice and principle of traditional Chinese medicine for the prevention and treatment of COVID-19显示文摘Traditional Chinese medicine(TCM)has played an important role in the prevention and treatment of Coronavirus disease 2019(COVID-19)epidemic in China.The integration of Chinese and Western medicine is an important feature of Chinese COVID-19 prevention and treatment.According to a series of evidence-based studies,TCM can reduce the infection rate of severe acute respiratory syndrome coronavirus 2 in high-risk groups.For patients with mild and moderate forms of COVID-19,TCM can relieve the related signs and symptoms,shorten the period of nucleic-acid negative conversion,and reduce conversion rate to the severe form of the disease.For COVID-19 patients with severe and critical illnesses,TCM can improve inflammatory indicators and blood oxygen saturation,shorten the hospital stay,and reduce the mortality rate.During recovery,TCM can improve patients’symptoms,promote organ function recovery,boost the quality of patients’life,and reduce the nucleic-acid repositive conversion rate.A series of mechanism research studies revealed that capability of TCM to treat COVID-19 through antiviral and anti-inflammatory effects,immune regulation,and protection of organ function via a multicomponent,multitarget,and multipathway approach. | Linhua Zhao Chuanxi Tian Yingying Yang Huifang Guan Yu Wei Yuxin Zhang Xiaomin Kang Ling Zhou Qingwei Li Jing Ma Li Wan Yujiao Zheng Xiaolin Tong | 2023 | Frontiers of Medicine2023，17，6： | 0 |
| 9 | Synergistic promotion of particulate matter reduction and production performance via adjusting electrochemical reactions in the zinc electrolysis industry显示文摘Heavy particulate matter (PM) pollution and high energy consumption are the bottlenecks of hydrometallurgy, especially in the electrolysis process. Therefore, an urgent need is to explore PM reduction methods with production performance co-benefits. This study presents three PM reduction methods based on controlling operating parameters, i.e., lowering electrolyte temperature, H2SO4 concentration, and current density of the cathode. The optimized conditions were also investigated using the response surface methodology to balance the PM reduction effect and Zn production. The results showed that lowering electrolyte temperature is the most efficient, with an 89.0% reduction in the PM generation flux (GFPM). Reducing H2SO4 concentration led to the minimum side effects on the current efficiency of Zn deposition (CEZn) or power consumption (PC). With the premise of non-deteriorating CEZn and PC, GFPM can be reduced by 86.3% at the optimal condition (electrolyte temperature = 295 K, H2SO4 = 110 g/L, current density = 373 A/m^(2)). In addition, the reduction mechanism was elucidated by comprehensively analyzing bubble characteristics, electrochemical reactions, and surface tension. Results showed that lower electrolyte temperature inhibited the oxygen evolution reaction (OER) and compressed gas volume. Lower H2SO4 concentration inhibited the hydrogen evolution reaction (HER) and reduced electrolyte surface tension. Lower current density inhibited both OER and HER by decreasing the reaction current. The inhibited gas evolutions reduced the microbubbles’ number and size, thereby reducing GFPM. These results may provide energy-efficient PM reduction methods and theoretical hints of exploring cleaner PM reduction approaches for industrial electrolysis. | Zizhen Ma Jingkun Jiang Lei Duan Jianguo Deng Fuyuan Xu Zehui Li Linhua Jiang Ning Duan | 2024 | Frontiers of Environmental Science & Engineering2024，18，1： | 0 |
| 10 | A NOVEL VARIABLE-LENGTH CODE FOR ROBUST VIDEO CODING显示文摘A novel Variable-Length Code (VLC), called Alternate VLC (AVLC), is proposed in this letter, which employs two types of VLC to encode source symbols alternately. Its advantage is that it can not only stop the symbol error propagation effect, but also correct symbol insertion errors and avoid symbol deletion er-rors, so the original sequence number of symbols can be kept correctly, which is very important in video com-munication. | Ma Linhua Chang Yilin | 2006 | Journal of Electronics(China)2006，23，4： | 0 |
| 11 | Hydrogen storage performance of LaNi_(3.95)Al_(0.75)Co_(0.3) alloy with different preparation methods显示文摘Rare-earth AB5-type La–Ni–Al hydrogen storage alloys are widely studied due to their extensive application potentials in hydrogen isotope storage,hydrogen isotope isolation and hydrogen compressors,etc.Good hydriding/dehydriding kinetics,easily activation,high reversibility are important factors for their practical application.However,their overall hydrogen storage performance,especially plateau pressure and hydrogen absorption/desorption durability need to be further optimized.In this study,the microstructures and the hydrogen storage properties of as-cast,annealed,and melt-spun LaNi_(3.95)Al_(0.75)Co_(0.3) alloys were investigated.The experimental results of XRD and SEM showed that all alloys contained a pure CaCu5 type hexagonal structure LaNi_(4)Al phase.The cell volume increased in an order of annealed>melt-spun>as-cast,resulting in a lower hydrogen absorption/desorption plateau pressure and a more stable hydride phase.The hydrogen storage capacity of three alloys was almost the same.The slope factor of the annealed and melt-spun alloys is smaller than the as-cast alloy,indicating that heat-treatment process can make the alloys more uniform.For the cycle stability of the alloys,the hydrogen absorption rate of the annealed alloy and melt-spun alloy was much faster than that of the as-cast alloy after 500 cycles.The melt-spun alloy showed high pulverization resistance during hydrogen absorption/desorption,and exhibited an excellent cycling retention of 99%after 500 cycles,suggesting that melt-spinning process can enhance the cycle stability and improve the cycle life of the alloy. | Lijun Lv Jian Lin Guo Yang Zhaowei Ma Linhua Xu Xiujie He Xingbo Han Wei Liu | 2022 | Progress in Natural Science:Materials International2022，32，2： | 0 |
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