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| 1 | Seasonal dynamics of water bloom-forming Microcystis morphospecies and the associated extracellular microcystin concentrations in large,shallow,eutrophic Dianchi Lake显示文摘The increasing occurrence of Microcystis blooms is of great concern to public health and ecosystem due to the potential hepatotoxic microcystins(MCs)produced by these colonial cyanobacteria.In order to interpret the relationships between variations of Microcystis morphospecies and extracellular MC concentrations,the seasonal dynamics of phytoplankton community composition,MC concentrations,and environmental parameters were monitored monthly from August,2009 to July,2010.The results indicated that Microcystis dominated total phytoplankton abundance from May to December(96%–99%of total biovolume),with toxic Microcystis viridis and non-toxic Microcystis wesenbergii dominating after July(constituting 65%–95%of the Microcystis population),followed by M.viridis as the sole dominant species from November to January(49%–93%).Correlation analysis revealed that water temperature and nutrient were the most important variables accounting for the occurrence of M.wesenbergii,while the dominance of M.viridis was related with nitrite and nitrate.The relatively low content of MCs was explained by the association with a large proportion of M.viridis and M.wesenbergii,small colony size of Microcystis populations,and low water temperature,pH and dissolved oxygen.The extracellular MC(mean of 0.5±0.2μg/L)of water samples analyzed by enzyme-linked immunosorbent assay(ELISA)demonstrated the low concentrations of MC in Dianchi Lake which implied the low potential risk for human health in the basin.The survey provides the first whole lake study of the occurrence and seasonal variability of Microcystis population and extracellular MCs that are of particular interest for water quality monitoring and management. | Yanlong Wu Lin Li Nanqin Gan Lingling Zheng Haiyan Ma Kun Shan Jin Liu Bangding Xiao Lirong Song | 2014 | Journal of Environmental Sciences2014，26，9： | 12 |
| 2 | Combination of anti-PD-1 antibody with P-GEMOX as a potentially effective immunochemotherapy for advanced natural killer/T cell lymphoma显示文摘Advanced natural killer/T cell lymphoma(NKTL)has demonstrated poor prognosis with currently available therapies.Here,we report the efficacy of anti-programmed death 1(PD-1)antibody with the P-GEMOX(pegaspargase,gemcitabine,and oxaliplatin)regimen in advanced NKTL.Nine patients underwent six 21-day cycles of anti-PD-1 antibody(day 1),pegaspargase 2000 U/m^(2)(day 1),gemcitabine 1 g/m^(2)(days 1 and 8)and oxaliplatin 130 mg/m^(2)(day 1),followed by anti-PD-1 antibody maintenance every 3 weeks.Programmed death-ligand 1(PD-L1)expression and genetic alterations were determined in paraffin-embedded pretreatment tissue samples using immunohistochemistry and next-generation sequencing(NGS)analysis.Responses were assessed using 18F-fluorodeoxyglucose positron emission tomography(18FDG-PET)and computed tomography or magnetic resonance imaging.Eight patients exhibited significant responses,comprising of seven complete remissions and one partial remission(overall response rate:88.9%).After a median follow-up of 10.6 months,6/9 patients(66.7%)remained in complete remission.The most common grade 3/4 adverse events were anemia(33.3%),neutropenia(33.3%),and thrombocytopenia(33.3%);all of which were manageable and resolved.Immunochemotherapy produced a high response rate in patients with positive PD-L1 expression(5/6,83.3%).NGS analysis suggested that STAT3/JAK3/PD-L1 alterations and ARID1A mutation were associated with immunochemotherapy efficacy.Mutation in DDX3X and alteration in epigenetic modifiers of KMT2D,TET2,and BCORL1 might indicate a poor response to immunochemotherapy.In conclusion,the anti-PD-1 antibody plus P-GEMOX regimen demonstrated promising efficacy in advanced NKTL.PD-L1 expression combined with specific genetic alterations could be used as potential biomarkers to predict therapeutic responses to immunochemotherapy. | Jun Cai Panpan Liu Huiqiang Huang Yajun Li Shuyun Ma Hui Zhou Xiaopeng Tian Yuchen Zhang Yan Gao Yi Xia Xuanye Zhang Hang Yang Lirong Li Qingqing Cai | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 6 |
| 3 | Isolated zinc in mordenite stabilizing carbonylation of dimethyl ether to methyl acetate显示文摘Herein, we prepared a series of H-Zn-mordenite (H-Zn-MOR) catalysts by adding zinc source into the initial sols during the synthesis of mordenite (MOR). The results indicated that isolated Zn ions were highly dispersed in the catalysts. The addition of zinc led to the increase of Si/Al in the framework of MOR,the change of the distribution of acid sites and the change of acid strength. We investigated the catalytic performance of the H-Zn-MOR catalysts and the HMOR catalysts for carbonylation of dimethyl ether to methyl acetate. The addition of zinc improved the catalytic performance and made the drop of the conversion over the Zn-0.003 and Zn-0.005 catalysts to be about the half of that over the HMOR catalyst.We attributed it to the change of the acid properties, which further change the rate of coke deposition. | Zhitao Zhang Na Zhao Kui Ma Qingpeng Cheng Jing Zhang Lirong Zheng Ye Tian Xingang Li | 2019 | Chinese Chemical Letters2019，30，2： | 3 |
| 4 | Ginger-indirect moxibustion plus acupuncture versus acupuncture alone for chronic fatigue syndrome:a randomized controlled trial显示文摘OBJECTIVE:To assess the efficacy and safety of gingerindirect moxibustion for chronic fatigue syndrome(CFS).METHODS:In this central randomized,controlled trial,290 CFS participants were recruited and randomly allocated to group A(ginger-indirect moxibustion plus acupuncture)or group B(acupuncture alone).The study consisted of a treatment period of 8 weeks with a total of 24 treatments(3 sessions per week,every other day),and a follow-up period of 12 weeks.The outcome was measured by Fatigue Severity Scale(FSS),Psychological Health Report(SPHERE),the Self-rating depression scale(SDS)and the Hamilton anxiety scale(HAMA)at baseline,2,4,6,8,12 and 20 weeks.RESULTS:With the treatment undergoing,the changes of FSS,SPHERE,SDS and HAMA scores in both groups increased gradually,and the effect maintained at the 12th week.Between groups,significantly higher score changes were seen in group A in FSS after 4 weeks treatment(11.94 vs 9.12,95%CI:0.94,4.7)and in SPHERE after 2 weeks treatment(3.7 vs 2.27,95%CI:0.56,2.31).But for SDS and HAMA,the improvement did not differ significantly between groups.No severe adverse events were reported.CONCLUSION:Ginger-indirect moxibustion is a safe and effective intervention to relieve fatigue and accompanying physical symptoms of CFS. | MA Tingting WU Jie YANG Lijie FENG Fen YANG Huilin ZHANG Jinhua ZHONG Yanjin NING Qing HUANG Lirong LIN Youbing YAN Jue CHEN Guiquan HOU Tianshu WANG Li REN Yuanfang TAN Jing | 2022 | Journal of Traditional Chinese Medicine2022，42，2： | 2 |
| 5 | Captive Breeding of the Four-eyed Turtle(Sacalia quadriocellata)显示文摘In 1998,a study on forty-five four-eyed turtles(Sacalia quadriocellata) was initiated to gather preliminary biological data of this species and to investigate the feasibility of its captive reproduction.In the following six years,no courtship behavior was found occurring in males and no oviposition in females.From 2004 to 2007,two successful techniques were applied to initiate reproductive behavior:1) injecting exogenous reproductive hormones;and 2) reducing the stress of living in captivity.As a result of the hormone treatments,courtship behavior and copulation were observed during September and October,2005.However,no courtship displays were seen from the CK males,which were not treated with hormones.Ovulation occurred between December and March,and the correlation was not significant between behavior of ovulation and food intake.Females laid only one clutch of eggs each year,with 2.47 eggs(n=34,range=1–4) at average,and 84 eggs were totally obtained,of which 13 were damaged,52 were infertile and 19 fertile.Of the fertile eggs,nine were hatched with mean incubation period of 105.9 days(n=9,range=89–122 days) at temperature ranging from 24 to 27℃. | HE Bin LIU Yuxiang SHI Haitao ZHANG Jie HU Maogui MA Yonggang FU Lirong HONG Meiling WANG Jichao Fong J.Jonathan Parham F.James | 2010 | Asian Herpetological Research2010，1，2： | 2 |
| 6 | Suppression of ETI by PTI priming to balance plant growth and defense through an MPK3/MPK6-WRKYs-PP2Cs module显示文摘Pattern-triggered immunity(PTI)and effector-triggered immunity(ETI)are required for host defense against pathogens.Although PTI and ETI are intimately connected,the underlying molecular mechanisms remain elusive.In this study,we demonstrate that flg22 priming attenuates Pseudomonas syringae pv.tomato DC3000(Pst)AvrRpt2-induced hypersensitive cell death,resistance,and biomass reduction in Arabidopsis.Mitogen-activated protein kinases(MAPKs)are key signaling regulators of PTI and ETI.The absence of MPK3 and MPK6 significantly reduces pre-PTI-mediated ETI suppression(PES).We found that MPK3/MPK6 interact with and phosphorylate the downstream transcription factor WRKY18,which regulates the expression of AP2C1 and PP2C5,two genes encoding protein phosphatases.Furthermore,we observed that the PTI-suppressed ETI-triggered cell death,MAPK activation,and growth retardation are significantly attenuated in wrky18/40/60 and ap2c1 pp2c5 mutants.Taken together,our results suggest that the MPK3/MPK6-WRKYs-PP2Cs module underlies PES and is essential for the maintenance of plant fitness during ETI. | Dacheng Wang Lirong Wei Ting Liu Jinbiao Ma Keyi Huang Huimin Guo Yufen Huang Lei Zhang Jing Zhao Kenichi Tsuda Yiming Wang | 2023 | Molecular Plant2023，16，5： | 1 |
| 7 | Long-term persistence of polychlorinated dibenzo- p -dioxins and dibenzofurans in air, soil and sediment around an abandoned pentachlorophenol factory in China显示文摘 | Cheng Li Minghui Zheng Bing Zhang Lirong Gao Lidan Liu Xin Zhou Xiaodong Ma Ke Xiao | 2011 | Environmental Pollution2011，，： | 1 |
| 8 | Utilization of straw in biomass energy in China 显示文摘 | ZENG Xianyang MA Yitai MA Lirong | 2007 | Renewable and Sustainable Energy Reviews2007，11，5： | 1 |
| 9 | NADPH oxidase AtrbohD and AtrbohF function in ROS-dependent regulation of Na+ /K+ homeostasis in Arabidopsis under salt stress显示文摘 | Ma Liyav Zhang Huan Sun Lirong s ez al | 2012 | Journal of Experimental Botany2012，63，1： | 1 |
| 10 | Utilization of straw in biomass energy in China显示文摘 | Zeng Xianyang Ma Yitai Ma Lirong | 2007 | Renewable & Sustainable Energy Review2007，11，5： | 1 |
| 11 | Utilization of straw in biomass energy in China 显示文摘 | ZENG Xianyang MA Yitai MA Lirong | 2007 | Renewable and Sustainable Energy Reviews2007，，11： | 1 |
| 12 | Genomic and transcriptomic analyses enable the identification of important genes associated with subcutaneous fat deposition in Holstein cows显示文摘Subcutaneous fat deposition has many important roles in dairy cattle,including immunological defense and mechanical protection.The main objectives of this study are to identify key candidate genes regulating subcutaneous fat deposition in high-producing dairy cows by integrating genomic and transcriptomic datasets.A total of 1654 genotyped Holstein cows are used to perform a genome-wide association study(GWAS)aiming to identify genes associated with subcutaneous fat deposition.Subsequently,weighted gene co-expression network analyses(WGCNA)are conducted based on RNA-sequencing data of 34 cows and cow yield deviations of subcutaneous fat deposition.Lastly,differentially expressed(DE)m RNA,lnc RNA,and differentially alternative splicing genes are obtained for 12 Holstein cows with extreme and divergent phenotypes for subcutaneous fat deposition.Forty-six protein-coding genes are identified as candidate genes regulating subcutaneous fat deposition in Holstein cattle based on GWAS.Eleven overlapping genes are identified based on the analyses of DE genes and WGCNA.Furthermore,the candidate genes identified based on GWAS,WGCNA,and analyses of DE genes are significantly enriched for pathways involved in metabolism,oxidative phosphorylation,thermogenesis,fatty acid degradation,and glycolysis/gluconeogenesis pathways.Integrating all findings,the NID2,STARD3,UFC1,DEDD,PPP1R1B,and USP21 genes are considered to be the most important candidate genes influencing subcutaneous fat deposition traits in Holstein cows.This study provides novel insights into the regulation mechanism underlying fat deposition in high-producing dairy cows,which will be useful when designing management and breeding strategies. | Hailiang Zhang Siyuan Mia Luiz F.Brito Lirong Hu Lei Wang Longgang Ma Qing Xu Gang Guo Ying Yu Yachun Wang | 2023 | Journal of Genetics and Genomics2023，50，6： | 1 |
| 13 | Interpolation Fitting Algorithm in Time-Space Domain of Differential Barometric Altimetry显示文摘In order to overcome the limitations of a unitary reference station in mobile communication positioning network differential barometric altimetry(DBA)and broaden the action scope of the reference station and improve positioning accuracy of elevation,an integrated interpolation algorithm model based on generalized extended approximation(GEA)algorithm and Kriging interpolation in time-space domain of reference station is proposed.In the time domain,barometric measured data is considered the maximum value estimated by bilateral extension to avoid wrong direction of estimation,which is approaching true value.In the spatial domain,barometric relevance among multiple reference stations is utilized,the weighted coefficients of multiple reference stations is calculated by the integrated algorithm model based on the GEA algorithm and Kriging interpolation.The impact of each reference station to the measured station is quantified,so that a virtual reference station is constructed,which can overcome the limitation of barometric correction by a unitary reference station.In addition,the measurement error due to irregular change in atmospheric pressure will be eliminated. | Zhengqun Hu Lirong Zhang Guanyi Ma Yuanfa Ji | 2019 | Journal of Beijing Institute of Technology2019，28，1： | 1 |
| 14 | Absolute Frequency Stabilization of a Diode Laser to Cesium Atom-Molecular Hyperfine Transitions via Modulating Molecules显示文摘 | MA JIE WANG LIRONG ZHAO YANTING | 2007 | Applied Physics Letters2007，91，16： | 1 |
| 15 | Utilization of straw in biomass energy in China显示文摘 | Zeng Xianyang Ma Yitai Ma Lirong | 2007 | Renewable and Sustainable Energy Reviews2007，，11： | 1 |
| 16 | Utilization of straw in biomass energy in China 显示文摘 | Zeng Xianyang Ma Yitai Ma Lirong | 2007 | Renewable and Sustainable Energy Reviews2007，11，： | 1 |
| 17 | Utilization of straw in biornass energy in China 显示文摘 | Zeng Xianyang Ma Yitai Ma Lirong | 2007 | Renewable and Sustainable Energy Reviews2007，11，： | 1 |
| 18 | Utilization of straw in biomass energy in China显示文摘 | Zeng Xianyang Ma Yitai Ma Lirong | 2007 | Renewable and Sustainable Energy Reviews2007，，11： | 1 |
| 19 | Utilization of straw in biomass energy in China显示文摘 | Zeng Xianyang Ma Yyitai Ma Lirong | 2007 | Renewable and Sustainable Energy Reviews2007，，11： | 1 |
| 20 | Utilization of straw in biomass energy in China 显示文摘 | Zeng Xian-yang Yitai Ma Lirong Ma | 2007 | Renewable and Sustainable Energy Reviews2007，11，5： | 1 |
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