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| 1 | Chemical Compositions and Distribution Characteristics of Cements in Longmaxi Formation Shales, Southwest China显示文摘Shale gas resources have been regarded as a viable energy source, and it is of great significance to characterize the shale composition of different cements, such as quartz and dolomite. In this research, chemical analysis and the multifractal method have been used to study the mineral compositions and petrophysical structures of cements in shale samples from the Longmaxi Formation, China. X-ray diffraction, electron microprobe, field emission scanning electron microscopy, cathodoluminescence microscopy and C-O isotope analyses confirmed that cements in the Longmaxi Formation shales are mainly composed of Fe-bearing dolomite and quartz. Fe-bearing dolomite cements concentrate around dolomite as annuli, filling micron-sized inorganic primary pores. Quartz cements in the form of nanoparicles fill primary inter-crystalline pores among clay minerals. Theoretical calculation shows that the Fe-bearing dolomite cements formed slightly earlier than the quartz cements, but both were related to diagenetic illitization of smectite. Moreover, multifractal analysis reveals that the quartz cements are more irregularly distributed in pores than the Fe-bearing dolomite cements. These results suggest that the plugging effect of the quartz cements on the primary inoraganic pore structures is the dominant factor resulting in low interconnected porosity of shales, which are unfavorable for the enrichment of shale gas. | Wenda Zhou Shuyun Xie Zhengyu Bao Emmanuel John M. Carranza Lei Lei Zhenzhen Ma | 2019 | Journal of Earth Science2019，30，5： | 12 |
| 2 | Geochemical Characteristics of Selenium and Its Correlation to Other Elements and Minerals in Selenium-Enriched Rocks in Ziyang County,Shaanxi Province,China显示文摘Ziyang County, Shaanxi Province, China is a world known selenium(Se)-enriched area, and a severe selenosis incident was reported in Naore Village during the 1990 s. This study investigated the geochemical characteristics of Se and its fractions in Se-enriched rocks from Ziyang. Se distribution is uneven, ranging from 0.23 to 57.00 μg/g(17.29±15.52 μg/g). Se content is higher in slate than chert, and even lower in carbonate rocks. Cd, As and V are enriched but Pb is depleted in Se-enriched strata. Se has different correlations both with TS(total sulfur)(R^2=0.59 for chert) and TC(total carbon)(R^2=0.77 for slate, R^2=0.87 for carbonate). Se has significant positive correlations with V(r=0.65), As(r=0.485), Cd(r=0.459) and Pb(r=0.405). The Se level correlates with mineral content, positively with pyrite, chlorite and illite, negatively with albite. Se associated with sulfide/selenide and elemental Se are the predominant fractions of total recovered Se, suggesting that a reducing environment and the formation of sulfides were significant to Se deposition during its geochemical cycle. Although low concentration of bio-available Se(average 5.62%±3.69%) may reduce the risk of Se poisoning in the target area, utilization of Se-rich rock as natural fertilizer should be restricted. | Huan Tian Zhenzhen Ma Xiaolei Chen Hongyu Zhang Zhengyu Bao Changhua Wei Shuyun Xie Shitou Wu | 2016 | Journal of Earth Science2016，27，5： | 7 |
| 3 | Combination of anti-PD-1 antibody with P-GEMOX as a potentially effective immunochemotherapy for advanced natural killer/T cell lymphoma显示文摘Advanced natural killer/T cell lymphoma(NKTL)has demonstrated poor prognosis with currently available therapies.Here,we report the efficacy of anti-programmed death 1(PD-1)antibody with the P-GEMOX(pegaspargase,gemcitabine,and oxaliplatin)regimen in advanced NKTL.Nine patients underwent six 21-day cycles of anti-PD-1 antibody(day 1),pegaspargase 2000 U/m^(2)(day 1),gemcitabine 1 g/m^(2)(days 1 and 8)and oxaliplatin 130 mg/m^(2)(day 1),followed by anti-PD-1 antibody maintenance every 3 weeks.Programmed death-ligand 1(PD-L1)expression and genetic alterations were determined in paraffin-embedded pretreatment tissue samples using immunohistochemistry and next-generation sequencing(NGS)analysis.Responses were assessed using 18F-fluorodeoxyglucose positron emission tomography(18FDG-PET)and computed tomography or magnetic resonance imaging.Eight patients exhibited significant responses,comprising of seven complete remissions and one partial remission(overall response rate:88.9%).After a median follow-up of 10.6 months,6/9 patients(66.7%)remained in complete remission.The most common grade 3/4 adverse events were anemia(33.3%),neutropenia(33.3%),and thrombocytopenia(33.3%);all of which were manageable and resolved.Immunochemotherapy produced a high response rate in patients with positive PD-L1 expression(5/6,83.3%).NGS analysis suggested that STAT3/JAK3/PD-L1 alterations and ARID1A mutation were associated with immunochemotherapy efficacy.Mutation in DDX3X and alteration in epigenetic modifiers of KMT2D,TET2,and BCORL1 might indicate a poor response to immunochemotherapy.In conclusion,the anti-PD-1 antibody plus P-GEMOX regimen demonstrated promising efficacy in advanced NKTL.PD-L1 expression combined with specific genetic alterations could be used as potential biomarkers to predict therapeutic responses to immunochemotherapy. | Jun Cai Panpan Liu Huiqiang Huang Yajun Li Shuyun Ma Hui Zhou Xiaopeng Tian Yuchen Zhang Yan Gao Yi Xia Xuanye Zhang Hang Yang Lirong Li Qingqing Cai | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 6 |
| 4 | Effects of Driving Mode on the Performance of Multiple-Chamber Piezoelectric Pumps with Multiple Actuators显示文摘Due to the limited output capability of piezoelectric diaphragm pumps, the driving voltage is frequently increased to obtain the desired output. However, the excessive voltage application may lead to a large deformation in the piezoelectric ceramics, which could cause it to breakdown or become damaged. Therefore, increasing the number of chambers to obtain the desired output is proposed. Using a check-valve quintuple-chamber pump with quintuple piezoelectric actuators, the characteristics of the pump under different driving modes are investigated through experiments. By changing the number and connection mode of working actuators, pump performances in terms of flow rate and backpressure are tested at a voltage of 150 V with a frequency range of 60 Hz ?400 Hz. Experiment results indicate that the properties of the multiple-chamber pump change significantly with distinct working chambers even though the number of pumping chambers is the same. Pump performance declines as the distance between the working actuators increases. Moreover, pump performance declines dramatically when the working piezoelectric actuator closest to the outlet is involved. The maximum backpressures of the pump with triple, quadruple, and quintuple actuators are increased by 39%, 83%, and 128%, respectively, compared with the pump with double working actuators; the corresponding maximum flow rates of the pumps are simply increased by 25.9%, 49.2%, and 67.8%, respectively. The proposed research offers practical guidance for the effective utilization of the multiple-chamber pumps under different driving modes. | ZHANG Zhonghua KAN Junwu WANG Shuyun WANG Hongyun MA Jijie JIANG Yonghua | 2015 | Chinese Journal of Mechanical Engineering2015，28，5： | 3 |
| 5 | Magnetic resonance imaging for non-invasive clinical evaluation of normal and regenerated cartilage显示文摘With the development of tissue engineering and regenerative medicine,it is much desired to establish bioimaging techniques to monitor the real-time regeneration efficacy in vivo in a non-invasive way.Herein,we tried magnetic resonance imaging(MRI)to evaluate knee cartilage regeneration after implanting a biomaterial scaffold seeded with chondrocytes,namely,matrix-induced autologous chondrocyte implantation(MACI).After summary of the T2 mapping and the T1-related delayed gadolinium-enhanced MRI imaging of cartilage(dGEMRIC)in vitro and in vivo in the literature,these two MRI techniques were tried clinically.In this study,18 patients were followed up for 1 year.It was found that there was a significant difference between the regeneration site and the neighboring normal site(control),and the difference gradually diminished with regeneration time up to 1 year according to both the quantitative T1 and T2 MRI methods.We further established the correlation between the quantitative evaluation of MRI and the clinical Lysholm scores for the first time.Hence,the MRI technique was confirmed to be a feasible semiquantitative yet non-invasive way to evaluate the in vivo regeneration of knee articular cartilage. | Xian Xu Jingming Gao Shuyun Liu Liang Chen Min Chen Xiaoye Yu Ning Ma Jun Zhang Xiaobin Chen Lisen Zhong Lin Yu Liming Xu Quanyi Guo Jiandong Ding | 2021 | Regenerative Biomaterials2021，8，5： | 2 |
| 6 | On Continuous Mappings and Closed Mappings Between Depdndence Systems显示文摘 | Ma Shuyun Wang Shoufeng | 2010 | Southeast Asian Bulletin of Mathematics2010，34，2： | 1 |
| 7 | Electrochemical synthesis of silver nanoparticles under protection of poly(N- vinylpyrrolidone)显示文摘 | YIN Bingsheng MA Houyi WANG Shuyun | 2003 | J Phys Chem B2003，107，34： | 1 |
| 8 | Effects of sweeping frequency ultrasound treatment on enzymatic preparations of ACE-inhibitory peptides from zein显示文摘 | Ren Xiaofeng Ma Haile Mao Shuyun | 2014 | European Food Research and Technology2014，238，： | 1 |
| 9 | On Continuous Mappingsand Closed Mappings Between Dependence Systems显示文摘 | Ma Shuyun Wang Shoufeng | 2010 | Southeast Asian Bulletin of Mathematics2010，34，2： | 1 |
| 10 | On Continuous Mappings and Closed Mappings Between Dependence Systems显示文摘 | Ma Shuyun Wang Shoufeng | 2010 | Southeast Asian Bulletin of Mathematics2010，34，2： | 1 |
| 11 | Characterization of ZnO: Al films deposited by r.f. magnetron-sputtering at low temperature显示文摘 | Hao Xiaotao Ma Jin Ma Honglei Tian Maohua Cao Baocheng Ye Lina Cheng Chuanfu Teng Shuyun | 2002 | Science in China Series A: Mathematics2002，，3： | 1 |
| 12 | Comprehensive view on genetic features, therapeutic modalities and prognostic models in adult T-cell lymphoblastic lymphoma显示文摘Adult T-cell lymphoblastic lymphoma(T-LBL)is a rare and aggressive subtype of non-Hodgkin’s lymphoma that differs from pediatric T-LBL and has a worse prognosis.Due to its rarity,little is known about the genetic and molecular characteristics,optimal treatment modalities,and prognostic factors of adult T-LBL.Therefore,we summarized the existing studies to comprehensively discuss the above issues in this review.Genetic mutations of NOTCH1/FBXW7,PTEN,RAS,and KMT2D,together with abnormal activation of signaling pathways,such as the JAK-STAT signaling pathway were described.We also discussed the therapeutic modalities.Once diagnosed,adult T-LBL patients should receive intensive or pediatric acute lymphoblastic leukemia regimen and central nervous system prophylaxis as soon as possible,and cranial radiation-free protocols are appropriate.Mediastinal radiotherapy improves clinical outcomes,but adverse events are of concern.Hematopoietic stem cell transplantation may be considered for adult T-LBL patients with high-risk factors or those with relapsed/refractory disease.Besides,several novel prognostic models have been constructed,such as the 5-miRNAs-based classifier,11-gene-based classifier,and 4-CpG-based classifier,which have presented significant prognostic value in adult T-LBL. | Qihua Zou Shuyun Ma Xiaopeng Tian Qingqing Cai | 2022 | Blood Science2022，4，3： | 0 |
| 13 | Advances in Research on the ITCZ:Mean Position,Model Bias,and Anthropogenic Aerosol Influences显示文摘The zonal-mean position of the intertropical convergence zone(ITCZ)and its shift in the meridional direction significantly influence both the tropical and even global climate.This work reviews three aspects of the progress in ITCZ-relevant research:1)the mechanism behind the asymmetry of the ITCZ annual-and zonal-mean positions relative to the equator;2)causes of the double-ITCZ problem(pervasive in climate models)and the efforts to solve it;and 3)the physical mechanisms by which anthropogenic aerosols affect the location of the zonal-mean ITCZ.According to recent studies,the north-of-the-equator location of the annual-and zonal-mean ITCZ is mainly driven by the cross-equatorial energy transports in the ocean,induced by the Atlantic overturning circulation.A quantitative relationship between the ITCZ shift and the anomalous cross-equatorial energy transport in the atmosphere has been found.Presently,the double-ITCZ problem is still the most common and pronounced bias in tropical precipitation simulations with climate models.Recently,some studies have found that simply correcting the biases in hemispheric energy contrast does not improve the simulation of the ITCZ with climate models;whereas others have found that improving model resolutions and convective parameterizations in climate models,such as entrainment rate,raindroplet re-evaporation,and convection triggering function,can alleviate the double-ITCZ bias.Therefore,it seems that the double-ITCZ problem in climate models is rooted in the complex physics of the models,which is not yet well-understood.In addition,anthropogenic aerosols are suggested to be able to induce meridional shifts of the ITCZ,but through various physical mechanisms.Absorbing aerosols like black carbon influence the ITCZ position basically via instantaneous absorption of shortwave radiation in the atmosphere,whereas scattering aerosols like sulfate affect the location of the ITCZ through the cloud lifetime effect and the subsequent response of surface evaporation. | Hua ZHANG Xinyu MA Shuyun ZHAO Linghan KONG | 2021 | Journal of Meteorological Research2021，35，5： | 0 |
| 14 | Engineering of electrospun nanofiber scaffolds for repairing brain injury显示文摘Patients with brain injury can suffer disability and accompanying complications.Current clinical treatments have significant limitations to successful repair due to the complexity of the pathological processes and the inhibitory microenvironment that follows brain injury.Here,we conclude recent research progresses in engineering strate-gies based on electrospun nanofibers for promoting neural repair and functional recovery after brain injury.Firstly,we introduce the main pathological mechanisms of current brain injuries,pointing out the prospect of the application of electrospun nanofiber scaffolds compared to current clinical treatment strategies.We then discuss the repair strategies combining the structure and the morphology of nanofiber scaffolds with load therapeutic factors such as cells,drugs and growth factors.All of these strategies show potential for improving the repair of brain injury.Finally,we point out the challenges facing the effective treatment of brain injury,aiming to provide insights into the development of repairing scaffolds for brain function recovery from the perspective of clinical treatment. | Wenzhe Du Tong Wang Shuyun Hu Jixin Luan Feng Tian Guolin Ma Jiajia Xue | 2023 | Engineered Regeneration2023，4，3： | 0 |
| 15 | Inducing Fe 3d Electron Delocalization and Spin‑State Transition of FeN_(4) Species Boosts Oxygen Reduction Reaction for Wearable Zinc–Air Battery显示文摘Transition metal-nitrogen-carbon materials(M-N-Cs),particularly Fe-N-Cs,have been found to be electroactive for accelerating oxygen reduction reaction(ORR)kinetics.Although substantial efforts have been devoted to design Fe-N-Cs with increased active species content,surface area,and electronic conductivity,their performance is still far from satisfactory.Hitherto,there is limited research about regulation on the electronic spin states of Fe centers for Fe-N-Cs electrocatalysts to improve their catalytic performance.Here,we introduce Ti_(3)C_(2) MXene with sulfur terminals to regulate the electronic configuration of FeN_(4) species and dramatically enhance catalytic activity toward ORR.The MXene with sulfur terminals induce the spin-state transition of FeN_(4) species and Fe 3d electron delocalization with d band center upshift,enabling the Fe(II)ions to bind oxygen in the end-on adsorption mode favorable to initiate the reduction of oxygen and boosting oxygen-containing groups adsorption on FeN_(4) species and ORR kinetics.The resulting FeN_(4)-Ti_(3)C_(2)Sx exhibits comparable catalytic performance to those of commercial Pt-C.The developed wearable ZABs using FeN_(4)-Ti_(3)C_(2)Sx also exhibit fast kinetics and excellent stability.This study confirms that regulation of the electronic structure of active species via coupling with their support can be a major contributor to enhance their catalytic activity. | Shengmei Chen Xiongyi Liang Sixia Hu Xinliang Li Guobin Zhang Shuyun Wang Longtao Ma Chi‑Man Lawrence Wu Chunyi Zhi Juan Antonio Zapien | 2023 | Nano-Micro Letters2023，15，4： | 0 |
| 16 | Willingness of Caregivers to Have Their Children Vaccinated with Pneumococcal Vaccines in the Context of an Innovative Immunization Strategy—Weifang City,Shandong Province,2021显示文摘Summary What is already known about this topic?Pneumococcal diseases(PDs)pose a serious health threat to children.Vaccination is the most costeffective intervention to prevent PDs,but pneumococcal vaccines coverage among children is low in China.What is added by this report?This study investigated the willingness of children’s caregivers to have their children vaccinated with pneumococcal vaccines under an innovative policy to offer 1-dose of the 13-valent pneumococcal conjugate vaccines at no charge to families.The research found that 70.51%of caregivers were willing to have their infants receive pneumococcal vaccines and that reducing the cost of vaccines may increase caregivers’willingness.What are the implications for public health practice?This is the first evaluation in China of acceptance of pneumococcal vaccines among children under a 1-dose,cost-free policy.The results provide scientific evidence for updating local and national pneumococcal immunization strategies to promote the use of the pneumococcal vaccine. | Yuan Yang Ting Zhang Yan Wang Libing Ma Shuyun Xie Jian Zhou Weiran Qi Qing Wang Peixi Dai Yuanze Du Luzhao Feng Chunping Wang Weizhong Yang | 2022 | China CDC weekly2022，4，20： | 0 |
| 17 | Combination of anti-PD-1 antibody with P-GEMOX as apotentially effective immunochemotherapy for advancednatural killer/T cell lymphoma显示文摘Advanced natural killer/T cell lymphoma(NKTL)has demonstrated poor prognosis with currently available therapies.Here,we report the efficacy of anti-programmed death 1(PD-1)antibody with the P-GEMOX(pegaspargase,gemcitabine,and oxaliplatin)regimen in advanced NKTL.Nine patients underwent six 21-day cycles of anti-PD-1 antibody(day 1),pegaspargase 2000 U/m^(2)(day 1),gemcitabine 1 g/m^(2)(days 1 and 8)and oxaliplatin 130 mg/m^(2)(day 1),followed by anti-PD-1 antibody maintenance every 3 weeks.Programmed death-ligand 1(PD-L1)expression and genetic alterations were determined in paraffin-embedded pretreatment tissue samples using immunohistochemistry and next-generation sequencing(NGS)analysis.Responses were assessed using ^(18)F-fluorodeoxyglucose positron emission tomography(^(18)FDG-PET)and computed tomography or magnetic resonance imaging.Eight patients exhibited significant responses,comprising of seven complete remissions and one partial remission(overall response rate:88.9%).After a median follow-up of 10.6 months,6/9 patients(66.7%)remained in complete remission.The most common grade 3/4 adverse events were anemia(33.3%),neutropenia(33.3%),and thrombocytopenia(33.3%);all of which were manageable and resolved.Immunochemotherapy produced a high response rate in patients with positive PD-L1 expression(5/6,83.3%).NGS analysis suggested that STAT3/JAK3/PD-L1 alterations and ARID1A mutation were associated with immunochemotherapy efficacy.Mutation in DDX3X and alteration in epigenetic modifiers of KMT2D,TET2,and BCORL1 might indicate a poor response to immunochemotherapy.In conclusion,the anti-PD-1 antibody plus P-GEMOX regimen demonstrated promising efficacy in advanced NKTL.PD-L1 expression combined with specific genetic alterations could be used as potential biomarkers to predict therapeutic responses to immunochemotherapy. | Jun Cai Panpan Liu Huiqiang Huang Yajun Li Shuyun Ma Hui Zhou Xiaopeng Tian Yuchen Zhang Yan Gao Yi Xia Xuanye Zhang Hang Yang Lirong Li Qingqing Cai | 2021 | Signal Transduction and Targeted Therapy2021，6，1： | 0 |
| 18 | Application of Student Standardized Patient in the Clinical Teaching of Acute Abdomen显示文摘Background:In recent years,with the gradual expansion of the scale of medical education,the shortage of medical teaching resources and the reluctance of patients to cooperate with teaching have become increasingly prominent.Objective:To explore the application effect of student standardized patient(SSP)in the clinical teaching of acute abdomen.Methods:Fifty-four fifth-year general medical students from class 1826 of the general department of The First Affiliated Hospital of Xi’an Medical University were selected as the research subjects and randomly divided into two groups,with 27 students in the experimental teaching group,and the remaining 27 students in the conventional teaching group.The experimental teaching group adopted the SSP teaching approach.The SSPs were generated from the training students of the hospital through the recruitment and training process of SSP.In this study,seven qualified SSPs were selected for the clinical teaching of acute abdomen.At the end of the course,a periodic assessment was held.The rank sum test was used to compare the excellent and good rates between the two groups,while t-test was used to compare the difference between the two groups.Results:The results showed that the excellent and good rate of the experimental teaching group was significantly higher than that of the conventional group,in which the difference between the two groups was statistically significant(p<0.05).In terms of the assessment results,the theoretical scores and skills scores of the experimental teaching group were better than those of the conventional teaching group,in which the differences between the two groups were statistically significant(p<0.05).Conclusion:Through the training of SSP for acute abdomen and its application in surgical teaching and examination,the superiority of SSP is emphasized.Although there are still some shortcomings in the application of SSP in clinical teaching,it is a relatively new and effective teaching method,and it will play an increasingly critical role in clinical skills training pertaining to the medical specialty. | Xiaowei Chang Yu Cai Yuanyuan Jia Pu Yan Shuyun Ma | 2022 | Journal of Contemporary Educational Research2022，6，8： | 0 |
| 19 | Petrophysical Texture Heterogeneity of Vesicles in Andesite Reservoir on Micro-Scales显示文摘It is of great significance to study the spatial distribution patterns and petrophysical complexity of volcanic vesicles which determine whether the reservoir spaces of the volcanic rocks can accumulate oil and gas and enrich high yields or not.In this paper,the digital images of three different textures of vesicular andesite samples,including spherical vesicular andesite,shear deformation vesicular andesite,and secondary filling vesicular andesite,are obtained by microscopic morphology X-CT imaging technology.The spatial micro-vesicle heterogeneity of vesicular andesite samples with different textures is quantitatively analyzed by fractal and multifractal methods such as box-counting dimension and the moment method.It is found that the shear stress weakens the spatial homogeneity since vesicles rupture are accelerated,elongated directionally,and connected with one another under the strain;the secondary filling breaks the vesicles,which significantly enhances the spatial heterogeneity.In addition,shear stress and secondary filling increase the complexity of vesicle microstructures characterized by different fractal and multifractal parameters.These conclusions will provide important theoretical and practical insights into understanding the degassing of volcanic rocks and prediction of high-quality volcanic reservoirs. | Mutian Qin Shuyun Xie Jianbo Zhang Tianfu Zhang Emmanuel John M.Carranza Hongjun Li Jiayi Ma | 2021 | Journal of Earth Science2021，32，4： | 0 |
| 20 | Factors Associated with PCV13 Vaccine Hesitancy in Parents under an Innovative Immunization Strategy:a Cross-Sectional Study—Weifang City,Shandong Province,China,2021显示文摘Summary What is already known on this topic?Pneumococcal diseases(PDs)are serious threats to child health.Although vaccination is one of the most effective ways to prevent these diseases,the pneumococcal vaccination coverage rate is still relatively low in China.What is added by this report?This study investigated the factors associated with 13-valent pneumococcal conjugate vaccine(PCV13)vaccine hesitancy in parents under an innovative immunization strategy. | Yuanze Du Yan Wang Ting Zhang Libing Ma Shuyun Xie Yi Wang Yuan Yang Juanjuan Li Yushu Feng Yujue Wang Weiran Qi Weizhong Yang Jian Zhou Chunping Wang Luzhao Feng | 2023 | China CDC weekly2023，5，12： | 0 |
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