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| 1 | Adaptive broadband beamformer for nonuniform linear array based on second order cone programming显示文摘Adaptive broadband beamforming is a key issue in array applications. The adaptive broadband beamformer with tapped delay line (TDL) structure for nonuniform linear array (NLA) is designed according to the rule of minimizing the beamformer’s output power while keeping the distortionless response (DR) in the direction of desired signal and keeping the constant beamwidth (CB) with the prescribed sidelobe level over the whole operating band. This kind of beamforming problem can be solved with the interior-point method after being converted to the form of standard second order cone programming (SOCP). The computer simulations are presented which illustrate the effectiveness of our beamformer. | Chen Peng Hou Chaohuan Ma Xiaochuan Cao Zhiqian Liang Yicong Yan Sheng | 2009 | Journal of Systems Engineering and Electronics2009，20，2： | 3 |
| 2 | Medroxyprogestogen enhances apoptosis of SKOV-3 cells via inhibition of the PI3K/Akt signaling pathway显示文摘We sought to assess the effect of progestin on the apoptosis of epithelial ovarian cancer cell line SKOV-3 and via regulation of phosphorylation signaling in.Epithelial ovarian cancer cell line SKOV-3 was treated with medroxyprogestogen,phosphatidylinositol 3-kinase inhibitor LY294002 and vehicle control.Akt,phospho-Akt,Bcl-2 and phospho-Bad proteins were examined by immunoblotting assays.Medroxyprogestogen-induced apoptosis was assessed by MTT assays and Annexin V apoptosis assay.We found no significant difference in Akt and Bad expression in both the medroxyprogestogen groups and the control group.The levels of phospho-Akt,Bcl-2 and phospho-Bad were decreased in all the medroxyprogestogen groups and significantly decreased in the high dose mitogen-activated protein (MAP) group (10 μmol/L).Viability of SKOV-3 was reduced and apparent apoptosis of SKOV-3 cells was observed with increased doses of MAP.The findings suggest that medroxyprogestogen can induce SKOV-3 cell apoptosis by inhibiting Akt phosphorylation. | Yan Li Yi Jiang Yicong Wan Lin Zhang Weiwei Tang Jingjing Ma Shan Wu Wenjun Cheng | 2013 | The Journal of Biomedical Research2013，27，1： | 2 |
| 3 | Interaction of five anthraquinones from rhubarb with human organic anion transporter 1 (SLC22A6) and 3 (SLC22A8) and drug–drug interaction in rats显示文摘 | Liping Ma Lei Zhao Haihong Hu Yahong Qin Yicong Bian Huidi Jiang Hui Zhou Lushan Yu Su Zeng | 2014 | Journal of Ethnopharmacology2014，，3： | 1 |
| 4 | From wound response to repair-lessons from C.elegans显示文摘As a result of evolution,the ability to repair wounds allows organisms to combat environment insults.Although the general process of wound healing at the tissue level has been described for decades,the detailed molecular mechanisms regarding the early wound response and rapid wound repair at the cellular level remain little understood.Caenorhabditis elegans is a model organism widely used in the field of development,neuroscience,programmed cell death etc.The nematode skin is composed of a large epidermis associated with a transparent extracellular cuticle,which likely has a robust capacity for epidermal repair.Yet,until the last decades,relatively few studies had directly analyzed the wound response and repair process.Here we review recent findings in how C.elegans epidermis responds to wounding and initiates early actin-polymerization-based wound closure as well as later membrane repair.We also discussed some remained outstanding questions for future study. | Yicong Ma Jing Xie Chandra Sugiarto Wijaya Suhong Xu | 2021 | Cell Regeneration2021，10，1： | 0 |
| 5 | Mechanisms of imperatorin on regulating Pglycoprotein in blood-brain barrier based on network pharmacology and in vitro experiment显示文摘OBJECTIVE To explore mecha⁃nisms of imperatorin on regulating P-glycoprotein(P-gp)in blood-brain barrier(BBB)based on net⁃work pharmacology combined with in vitro experi⁃ment.METHODS Drug targets were predicted using the Pharmapper and Swiss targets data⁃bases;disease targets were obtained through the Genecards database;intersections between drugs and disease targets were screened by Cytoscape software;the obtained core targets were used to construct protein-protein interaction(PPI)network,gene ontology(GO)functions,and Kyoto encyclopedia of genes and genomes(KEGG)pathway enrichment analysis.The effects of imperatorin(20,50,100μmol·L^(-1))on P-gp activity were monitored in hCMEC/D3 in vitro BBB model,and the effects of imperatorin on the expression of target proteins were verified using Western blot method.RESULTS 55 drug targets and 3102 disease targets were obtained from the network pharmacology screening,and 37 core targets were obtained after the combination.Enrichment analysis showed that core targets were closely related to chemical synaptic trans⁃mission regulation,neurotransmitter receptor activity,protein kinase regulation activity,G proteincoupled receptor signaling pathway,neural active ligand receptor interaction pathway,PI3K-Akt sig⁃naling pathway,VEGF signaling pathway,etc..In vitro experimental validation suggested that all tested concentration groups of imperatorin signifi⁃cantly reduced the activity and expression of P-gp,which were achieved by significantly downregu⁃lating the phosphorylation levels of PI3K and Akt,and repressing the expression of VEGFR2 pro⁃tein.CONCLUSION Network pharmacology was used to predict the core targets and signaling pathways of imperatorin on regulating P-gp in BBB and relevant validation was conducted through in vitro experiments,providing a refer⁃ence basis for further exploration of the mecha⁃nisms of imperatorin on regulating P-gp in BBB. | SONG Yizhen YIN Wanxin MA Yicong AN Yufan HUANG Jiaqi YAN Zhongjie WU Xiuwen WANG Yuanyu | 2023 | 中国药理学与毒理学杂志2023，37，S01： | 0 |
| 6 | Adenosine triphosphate-based tumor chemosensitivity assay may predict the clinical outcomes of gastric cancer patients receiving taxane-based post-operative adjuvant chemotherapy显示文摘To the Editor:Gastric cancer is one of the most commonly diagnosed cancers in the world.For patients with a pathological tumor-node-metastasis stage of II or III,postoperative adjuvant chemotherapy is generally required to reduce recurrence risk by controlling residual tumor cells following curative resection.[1]Although taxanes have recently shown promising activity in gastric cancer,[2,3]non-responders may incur costs and experience adverse reactions without clinical benefit,and efforts to select effective regimens for individuals are very important.The application of in vitro chemosensitivity assays as predictive markers in personalized cancer treatment has been investigated in several studies.[4]However,the heterogeneity of the gastric cancer response to taxane-based chemotherapy and the correlation between in vitro chemosensitivity and clinical outcomes remain unclear. | Yicong Bian Minzhou Huang Sheng Ma Linsheng Liu Fan Xia Zhiyao Chen Di Yu Chenrong Huang Liyan Miao | 2022 | Chinese Medical Journal2022，，11： | 0 |
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