| 10 | Comparative study on ghrelin level change and its related factors in hypertensive elders with psychological distress显示文摘Objective To investigate the change of plasma ghrelin level and explore the related factors of ghrelin alteration in elderly hypertensive patients with psychological distress.Methods A total of 300 elders,who were screened with Hamilton Anxiety Scale(HAMA),Hamilton Rating Scale for Depression(HAMD),and the Symptom Checklist-90(SCL-90)for psychological stress and somato-psychological manifestations respectively,were divided into hypertension group(n=148)and non-hypertension group(n=152).Their blood samples were collected to measure the plasma level of ghrelin and total cortisol on the same day.Results The incidences of anxiety and depression were 27.7% and 11.7%,respectively,in all the enrolled elders.However,the rates of psychological distress,particularly anxiety,were significantly higher in the hypertensive elders than in the non-hypertensive ones(43.2% vs.12.5%).Anxiety was positively related to the cortisol level but negatively related to the plasma ghrelin level,and the latter two were negatively correlated with each other.Conclusion Chronic increase of plasma cortisol induced by long-term anxiety can lead to the reduction of ghrelin level,which then adversely affects blood pressure in elders with psychological distress.Therefore,ghrelin might be a selective antihypertensive medicine for hypertensive elders with anxiety. | Fen-Ling Fan1,Yu-Liang Zou2,Ai-Qun Ma1,Hong-Yan Tian1,Jun-Bo Zhang1,Xian-Cang Ma3,Ya-Min Liu1,Zhi Hu1,Hong-Mei Wan1,Yu-Shun Zhang1 1.Department of Cardiovascular Medicine 2.Department of Gynecology and Obstetrics 3.Department of Psychology and Psychiatry,the First Affiliated Hospital,Medical School of Xi’an Jiaotong University,Xi’an 710061,China | 2010 | Journal of Pharmaceutical Analysis2010，22，3： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员