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| 1 | Effect of vitamin E and human placenta cysteine peptidase inhibitor on expression of cathepsins B and L in implanted hepatoma Morris 5123 tumor model in Wistar rats显示文摘AIM: To examine the effectiveness of human placental inhibitors, by injecting vitamin E to rats with transplanted Norris-5123 hepatoma, on the expression of cathepsins B and L in tumor, liver, lung and blood sera after transplantation of Norris 5123 hepatoma.METHODS: Animals were divided into 10 groups receiving three different concentrations of vitamin E and inhibitors along or in combination and compared with negative control (healthy rats) and positive control (tumor rats). Effectiveness of treatment was evaluated with regard to survival time,tumor response and determination of the activities of proteolytic enzymes and their inhibitors using flurogenic substrates.RESULTS: Cathepsins B and L activities were elevated by 16-fold in comparison with negative control tissues, and their endogenous inhibitor activity decreased by 1.2-fold before treatment. In several cases, tumors completely disappeared following vitamin E plus human placental cyteine protease inhibitor (CPI) compared with controls.The number of complete tumor responses was higher when 20 m/kg vitamin E plus 400 μg of CPI was used, i.e.7/10 rats survived more than two mo. Cathepsins B and L were expressed significantly in tumor, liver, lung tissues and sera in parallel to the increasing of the endogenous inhibitor activity compared with the controls after treatment (P<0.0001).CONCLUSION: The data indicate formation of metastasis significantly reduced in treated rats, which might provide a therapeutic basis for anti-cancer therapy. | Tadeusz Sebzda Piotr Hanczyc Yousif Saleh Bernice F Akinpelumi Maciej Siewinski Jerzy Rudnicki | 2005 | World Journal of Gastroenterology2005，11，4： | 2 |
| 2 | Solubility of pyromorphite Pb5 (P04 )3 Cl-mimetite Pb5 ( As04 )3 Cl solid solution series显示文摘 | Justyna F Maciej M Tomasz B | 2011 | Geochimica et Cosmochimica Acta2011，75，7： | 1 |
| 3 | Inflammatory mediators exert toxic effects of oxjdatire stress on human spermatozoa显示文摘 | Monika F Maciej K | 2007 | J Androl2007，28，： | 1 |
| 4 | How to detect early left atrial remodelling and dysfunction in mild-to-moderate hypertension显示文摘 | Aigul Baltabaeva Maciej Marciniak Bart Bijnens Chirine Parsai James Moggridge Tarek F Antonios Graham A MacGregor George R Sutherland | 2009 | Journal of Hypertension2009，，10： | 1 |
| 5 | Precipitation-stripping processes for heavy metals显示文摘 | STEFAN Z MAREK B MACIEJ F | 1998 | Hydrometallurgy1998，48，： | 1 |
| 6 | Production of large amounts of mouse polyclonal antisera 显示文摘 | Maciej K Satish K G David L F | 1988 | Journal of Immunological Methods1988，115，： | 1 |
| 7 | Mechanical stretch exacerbates the cell death in SH-SY5Y cells exposed to paraquat:mitochon- drial dysfunction and oxidative stress 显示文摘 | Fang W Rodrigo F Maciej S | 2014 | Neurotoxieology2014，41，： | 1 |
| 8 | Influ- enza drift and epidemic size: the race between generating and escaping immunity 显示文摘 | Maciej F Boni Julia R Cog Viggo Andreasen | 2004 | Theoretical Population Biolo- gy2004，65，2： | 1 |
| 9 | Gap junction control of glial glutamate transporter expression 显示文摘 | Maciej F Claudia A Claudia L etal | 2007 | Mol Cell Neurosci2007，35，1： | 1 |
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