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| 1 | The role of Src homology 2 containing protein tyrosine phosphatase 2 in vascular smooth muscle cell migration and proliferation显示文摘脉管的光滑的肌肉房间(VSMC ) 在生理、病理学的条件下面包括移植,区别和增长执行可收缩的必要光滑的肌肉和合成功能。响应病理学的刺激, VMSC 经历 phenotypic 变化导致反常移植和增长,它可以贡献鈥減a 象 thogenesis 一样鈥 ? 动脉粥样硬化。管理这个 phenotypic 开关的细胞内部的发信号机制不仅为动脉粥样硬化患者匾形成的更好的理解而且为为恰当的治疗学的疗法的策略意义大。(SHP2 ) Src 相同 2 包含的蛋白质酷氨酸磷酸酶 2 是包含响应各种各样的生长因素,荷尔蒙或 cytokines 玩主要生物函数的 Src 相同 2 域的无所不在的酷氨酸磷酸酶。特别地, SHP2 在表明控制房间周期前进,生长和移植的小径的房间被含有。在这评论,我们将主要讨论在 VSMC 移植和增长表明 SHP2 的角色的最近的文学。 | Machender R KANDADI Matthew S STRATION Jun REN | 2010 | Acta Pharmacologica Sinica2010，31，10： | 7 |
| 2 | Ablation of Akt2 and AMPKα2 rescues high fat diet-induced obesity and hepatic steatosis through Parkin-mediated mitophagy显示文摘Given the opposing effects of Akt and AMP-activated protein kinase(AMPK)on metabolic homeostasis,this study examined the effects of deletion of Akt2 and AMPKα2 on fat diet-induced hepatic steatosis.Akt2–Ampkα2 double knockout(DKO)mice were placed on high fat diet for 5 months.Glucose metabolism,energy homeostasis,cardiac function,lipid accumulation,and hepatic steatosis were examined.DKO mice were lean without anthropometric defects.High fat intake led to adiposity and decreased respiratory exchange ratio(RER)in wild-type(WT)mice,which were ablated in DKO but not Akt2^(-/-) and Ampkα2^(-/-) mice.High fat intake increased blood and hepatic triglycerides and cholesterol,promoted hepatic steatosis and injury in WT mice.These effects were eliminated in DKO but not Akt2^(-/-) and Ampkα2^(-/-) mice.Fat diet promoted fat accumulation,and enlarged adipocyte size,the effect was negated in DKO mice.Fat intake elevated fatty acid synthase(FAS),carbohydrate-responsive element-binding protein(CHREBP),sterol regulatory element-binding protein 1(SREBP1),peroxisome proliferator-activated receptor gamma coactivator 1-alpha(PGC-1α),peroxisome proliferator-activated receptor-α(PPARα),PPARγ,stearoyl-CoA desaturase 1(SCD-1),phosphoenolpyruvate carboxykinase(PEPCK),glucose 6-phosphatase(G6Pase),and diglyceride O-acyltransferase 1(DGAT1),the effect was absent in DKO but not Akt2^(-/-) and Ampkα2^(-/-) mice.Fat diet dampened mitophagy,promoted inflammation and phosphorylation of forkhead box protein O1(FoxO1)and AMPKα1(Ser^(485)),the effects were eradicated by DKO.Deletion of Parkin effectively nullified DKO-induced metabolic benefits against high fat intake.Liver samples from obese humans displayed lowered microtubule-associated proteins 1A/1B light chain 3B(LC3B),Pink1,Parkin,as well as enhanced phosphorylation of Akt,AMPK(Ser^(485)),and FoxO1,which were consolidated by RNA sequencing(RNAseq)and mass spectrometry analyses from rodent and human livers.These data suggest that concurrent deletion of Akt2 and AMPKα2 offers resilience to fat diet-induced obesity and hepatic steatosis,possibly through preservation of Parkin-mediated mitophagy and lipid metabolism. | Shuyi Wang Jun Tao Huaguo Chen Machender R.Kandadi Mingming Sun Haixia Xu Gary D.Lopaschuk Yan Lu Junmeng Zheng Hu Peng Jun Ren | 2021 | Acta Pharmaceutica Sinica B2021，11，11： | 4 |
| 3 | Assessment of heavy metal contamination in soils around Balanagar industrial area,Hyderabad,India显示文摘 | Machender G Dhakate R Prasanna L | | 0，，： | 1 |
| 4 | Chromium alleviates glucose intolerance,insulin resistance,and hepatic ER stress in obese mice显示文摘 | Nair Sreejayan Feng Dong MAChEnder R.Kandadi | | 0，，06： | 1 |
| 5 | Assess- ment of heavy metal contamination in soils around Balanagar industrial area, Hyderabad,India 显示文摘 | MACHENDER G DHAKATE R PRASANNA L | 2010 | Environment Earth Sci- ences2010，63，5： | 1 |
| 6 | Assessment of heavy metal contamination in soils around Balanagar industrial area Hyder- abad India 显示文摘 | Machender G Dhakate R Prasanna L | 2011 | Environmental Earth Sciences2011，63，5： | 1 |
| 7 | Assessment of heavy metal contamination in soils around Balanagar industrial area, Hyderabad, India 显示文摘 | Machender G Dhakate R Prasanna L | 2010 | Environment Earth Sciences2010，10，： | 1 |
| 8 | Assessment of heavy metal contamination in soils around Balanagar industrial area,Hyderabad,India显示文摘 | Machender G Dhakate R Prasanna L | 2010 | Environment Earth Sciences2010，，10： | 1 |
| 9 | Assessment of heavey metal contamination in soils around Balanagar industrial area,Hyderabad,India显示文摘 | MACHENDER G DHAKATE R PRASANNA L | 2011 | Environ Earth Sci2011，63，5： | 1 |
| 10 | Biochemical,Molecular,and Genetic Mechanisms Chromium(D-phenylalanine)3 Supplementation Alters Glucose Disposal,Insulin Signaling,and Glucose Transporter-4 Membrane Translocationin Insulin-Resistant Mice1-3 J显示文摘 | Feng Dong Machender Reddy Kandadi | | 0，，： | 1 |
| 11 | Assessment of heavy metal contamination in soils around Balanagar industrial area,Hyderabad,India显示文摘 | Machender G Dhakate R Prasanna L | 2011 | Environmental Earth Sciences2011，63，5： | 1 |
| 12 | Assessment of heavy metal contamination in soils around Balanagar industrial area,Hyderabad,India显示文摘 | MACHENDER G DHAKATE R PRASANNA L | 2010 | Environment Earth Sciences2010，63，： | 1 |
| 13 | Assessment of heavy metal contamination in soils around Balanagar industrial area, Hyderabad, India 显示文摘 | Machender G Dhakate R Prasanna L | 2011 | Environmental Earth Sciences2011，63，5： | 1 |
| 14 | Author correction to‘Ablation of Akt2 and AMPKα2 rescues high fat diet-induced obesity and hepatic steatosis through Parkin-mediated mitophagy’[Acta Pharmaceutica Sinica B 11(2021)3508-3526]显示文摘The authors of the above-mentioned paper noticed an error in Fig.5a as reported.H&E staining was shown in wrong color during figure processing and DKO-LF group was accidently copied and pasted twice.Original H&E images have been replaced with the correct color with the accurate grouping information.No text content in figure legend or conclusion is affected by this error.The authors sincerely apologize for any inconvenience caused to the journal and readers. | Shuyi Wang Jun Tao Huaguo Chen Machender R.Kandadi Mingming Sun Haixia Xu Gary D.Lopaschuk Yan Lu Junmeng Zheng Hu Peng Jun Ren | 2023 | Acta Pharmaceutica Sinica B2023，13，2： | 0 |
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