|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | ALDH2 contributes to melatonin-induced protection against APP/PS1 mutation-prompted cardiac anomalies through cGAS-STING-TBK1-mediated regulation of mitophagy显示文摘Ample clinical evidence suggests a high incidence of cardiovascular events in Alzheimer’s disease(AD),although neither precise etiology nor effective treatment is available.This study was designed to evaluate cardiac function in AD patients and APP/PS1 mutant mice,along with circulating levels of melatonin,mitochondrial aldehyde dehydrogenase(ALDH2)and autophagy.AD patients and APP/PS1 mice displayed cognitive and myocardial deficits,low levels of circulating melatonin,ALDH2 activity,and autophagy,ultrastructural,geometric(cardiac atrophy and interstitial fibrosis)and functional(reduced fractional shortening and cardiomyocyte contraction)anomalies,mitochondrial injury,cytosolic mtDNA buildup,apoptosis,and suppressed autophagy and mitophagy.APP/PS1 mutation downregulated cyclic GMP-AMP synthase(cGAS)and stimulator of interferon genes(STING)levels and TBK1 phosphorylation,while promoting Aβaccumulation.Treatment with melatonin overtly ameliorated unfavorable APP/PS1-induced changes in cardiac geometry and function,apoptosis,mitochondrial integrity,cytosolic mtDNA accumulation(using both immunocytochemistry and qPCR),mitophagy,and cGAS-STING-TBK1 signaling,although these benefits were absent in APP/PS1/ALDH2−/−mice.In vitro evidence indicated that melatonin attenuated APP/PS1-induced suppression of mitophagy and cardiomyocyte function,and the effect was negated by the nonselective melatonin receptor blocker luzindole,inhibitors or RNA interference of cGAS,STING,TBK1,and autophagy.Our data collectively established a correlation among cardiac dysfunction,low levels of melatonin,ALDH2 activity,and autophagy in AD patients,with compelling support in APP/PS1 mice,in which melatonin rescued myopathic changes by promoting cGAS-STING-TBK1 signaling and mitophagy via an ALDH2-dependent mechanism. | Shuyi Wang Lin Wang Xing Qin Subat Turdi Dongdong Sun Bruce Culver Russel JReiter Xiaoming Wang Hao Zhou Jun Ren | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 9 |
| 2 | Synthesis of ordered mesoporous carbonaceous materials and their highly efficient capture of uranium from solutions显示文摘An extremely effortless method was applied for successful synthesis of mesoporous carbonaceous materials(MCMs) using well-ordered mesoporous silica as template. Various characterizations(scanning electron microscopy(SEM), transmission electron microscopy(TEM), X-ray diffraction(XRD), Fourier transform infrared spectroscopy(FT-IR), Raman, X-ray photoelectron spectroscopy(XPS), Brunner-Emmet-Teller(BET) and Zeta potential) confirmed that MCMs had large surface area, uniform pore size distribution, and abundant oxygen-containing functional groups. The batch techniques were employed to study U(VI) adsorption on MCMs under a wide range of experiment conditions. The adsorption kinetics of U(VI) onto MCMs were well-fitted by pseudo-second-order kinetic model, indicating a chemisorption process. The excellent adsorption capacity of MCMs calculated from the Langmuir model was 293.95 mg g^(-1) at pH 4.0. The FT-IR and XPS analyses further evidenced that the binding of U(VI) onto MCMs was ascribed to the plentiful adsorption sites(–OH and –COOH groups) in the internal mesoporous structure, which could efficiently trap guest U(VI) ions. The results presented herein revealed that MCMs were ideal adsorbents in the efficient elimination of uranium or other lanthanides/actinides from aqueous solutions, which would play an important role in environmental pollution management application. | Chenlu Zhang Xing Li Zhongshan Chen Tao Wen Shuyi Huang Tasawar Hayat Ahmed Alsaedi Xiangke Wang | 2018 | Science China Chemistry2018，61，3： | 8 |
| 3 | Radial acceleration estimation within one pulse echo based on Hough-ambiguity transformation显示文摘The information of acceleration of a highly maneuverable target can be helpful to enhancing the performance of the tracker and facilitating the classification of targets.However,the current radars cannot provide information on the acceleration of the target in signal processing.Conventionally,acceleration is estimated by using Kalman filtering in several pulse echoes.There are limitations and shortcomings in this method because of its low precision.This paper proposes a Hough-ambiguity transformation(HAT) method for estimating the acceleration within one pulse.Simulations results validate the effectiveness of the proposed algorithm under several conditions with different pulse durations,signal to noise ratios(SNR),searching steps and searching radii respectively.Simulation results also show that the performance of the proposed method is superior to that of other methods. | WANG GuoHong JIA ShuYi DU WenChao | 2010 | Science China(Information Sciences)2010，53，9： | 7 |
| 4 | FGF1^(△HBS) prevents diabetic cardiomyopathy by maintaining mitochondrial homeostasis and reducing oxidative stress via AMPK/Nur77 suppression显示文摘As a classically known mitogen,fibroblast growth factor 1(FGF1)has been found to exert other pleiotropic functions such as metabolic regulation and myocardial protection.Here,we show that serum levels of FGF1 were decreased and positively correlated with fraction shortening in diabetic cardiomyopathy(DCM)patients,indicating that FGF1 is a potential therapeutic target for DCM.We found that treatment with a FGF1 variant(FGF1^(△HBS))with reduced proliferative potency prevented diabetes-induced cardiac injury and remodeling and restored cardiac function.RNA-Seq results obtained from the cardiac tissues of db/db mice showed significant increase in the expression levels of anti-oxidative genes and decrease of Nur77 by FGF1AHBS treatment.Both in vivo and in vitro studies indicate that FGF1^(△HBS) exerted these beneficial effects by markedly reducing mitochondrial fragmentation,reactive oxygen species(ROS)generation and cytochrome c leakage and enhancing mitochondrial respiration rate and β-oxidation in a 5;AMP-activated protein kinase(AMPK)/Nur77-dependent manner,all of which were not observed in the AMPK null mice.The favorable metabolic activity and reduced proliferative properties of FGF1^(△HBS) testify to its promising potential for use in the treatment of DCM and other metabolic disorders. | Dezhong Wang Yuan Yin Shuyi Wang Tianyang Zhao Fanghua Gong Yushuo Zhao Beibei Wang Yuli Huang Zizhao Cheng Guanghui Zhu Zengshou Wang Yang Wang Jun Ren Guang Liang Xiaokun Li Zhifeng Huang | 2021 | Signal Transduction and Targeted Therapy2021，6，4： | 6 |
| 5 | Fouling community characteristics in subtropical coastal waters of the southwestern East China Sea显示文摘A fouling study was conducted in coastal waters southwest of the East China Sea between December 2013 and November 2014. A total of 84 species of fouling organisms belonging to 69 genera, 49 families, and 10 phyla were recorded over the entire year. The community composition was dominated by coastal warm-water species belonging to typical subtropical inner bay communities. The prosperous stage of settlement lasted from April to September, and the adhesion strength of the fouling organisms was the highest in summer. Sessile suspension feeders constituted the main core of settlement for the fouling community. Amphibalanus reticulatus was the most dominant and representative species of fouling organism, and other dominant species included Caprella equilibra, Ectopleura crocea, Anthopleura nigrescens, Stylochus ijimai, Spirobranchus kraussii, Crassostrea angulata, Perna viridis, Jassa falcata, Stenothoe valida, Sphaerozius nitidus, and Biflustra grandicella. The individuals in the fouling community showed a mutual dependence or constraint relationship due to competition for settlement space and food, and they exhibited a particular spatiotemporal distribution in accordance with adaptation to environmental factors. Temperature was the most important environmental factor determining the geographic distribution of fouling organisms. The temperature characteristics of species essentially reflect the differences in the fouling community composition in various climate zones. The species number, settlement stage, and settlement rate of fouling organisms are closely related to water temperature. Local natural environmental conditions(salinity, water currents, light, etc.) as well as human activity(such as aquaculture production) are all important factors affecting the settlement of fouling organisms. | LIN Heshan WANG Jianjun LIU Wei LIU Kun ZHANG Shuyi HE Xuebao HUANG Yaqin LIN Junhui MOU Jianfeng ZHENG Chengxing YAN Tao | 2017 | Acta Oceanologica Sinica2017，36，10： | 6 |
| 6 | Ablation of Akt2 and AMPKα2 rescues high fat diet-induced obesity and hepatic steatosis through Parkin-mediated mitophagy显示文摘Given the opposing effects of Akt and AMP-activated protein kinase(AMPK)on metabolic homeostasis,this study examined the effects of deletion of Akt2 and AMPKα2 on fat diet-induced hepatic steatosis.Akt2–Ampkα2 double knockout(DKO)mice were placed on high fat diet for 5 months.Glucose metabolism,energy homeostasis,cardiac function,lipid accumulation,and hepatic steatosis were examined.DKO mice were lean without anthropometric defects.High fat intake led to adiposity and decreased respiratory exchange ratio(RER)in wild-type(WT)mice,which were ablated in DKO but not Akt2^(-/-) and Ampkα2^(-/-) mice.High fat intake increased blood and hepatic triglycerides and cholesterol,promoted hepatic steatosis and injury in WT mice.These effects were eliminated in DKO but not Akt2^(-/-) and Ampkα2^(-/-) mice.Fat diet promoted fat accumulation,and enlarged adipocyte size,the effect was negated in DKO mice.Fat intake elevated fatty acid synthase(FAS),carbohydrate-responsive element-binding protein(CHREBP),sterol regulatory element-binding protein 1(SREBP1),peroxisome proliferator-activated receptor gamma coactivator 1-alpha(PGC-1α),peroxisome proliferator-activated receptor-α(PPARα),PPARγ,stearoyl-CoA desaturase 1(SCD-1),phosphoenolpyruvate carboxykinase(PEPCK),glucose 6-phosphatase(G6Pase),and diglyceride O-acyltransferase 1(DGAT1),the effect was absent in DKO but not Akt2^(-/-) and Ampkα2^(-/-) mice.Fat diet dampened mitophagy,promoted inflammation and phosphorylation of forkhead box protein O1(FoxO1)and AMPKα1(Ser^(485)),the effects were eradicated by DKO.Deletion of Parkin effectively nullified DKO-induced metabolic benefits against high fat intake.Liver samples from obese humans displayed lowered microtubule-associated proteins 1A/1B light chain 3B(LC3B),Pink1,Parkin,as well as enhanced phosphorylation of Akt,AMPK(Ser^(485)),and FoxO1,which were consolidated by RNA sequencing(RNAseq)and mass spectrometry analyses from rodent and human livers.These data suggest that concurrent deletion of Akt2 and AMPKα2 offers resilience to fat diet-induced obesity and hepatic steatosis,possibly through preservation of Parkin-mediated mitophagy and lipid metabolism. | Shuyi Wang Jun Tao Huaguo Chen Machender R.Kandadi Mingming Sun Haixia Xu Gary D.Lopaschuk Yan Lu Junmeng Zheng Hu Peng Jun Ren | 2021 | Acta Pharmaceutica Sinica B2021，11，11： | 4 |
| 7 | Effects on Growth Performance and Feed Digestibility of Hainan Black Pigs by Adding Lysine in Low Protein Diet显示文摘[Objective] The paper was to study the effects on growth performance and feed digestibility of Hainan black pigs by adding lysine in low protein diet.[Method] A total of 36 Hainan black pigs with the body weight of(46.34 ±3.06) kg were randomly divided into three groups:control group(protein level 15%,lysine level 0.83%),experimental group I(protein level 13%,0.83%),and experimental group II(protein level 13%,lysine level 1.03),each group had three replicates of four pigs.The trial lasted 35 d.[Result] The growth performance of Hainan black pig in group II had no significant difference with that in control group(P>0.05).The apparent digestibility of crude protein and phosphorus of Hainan black pigs in Group II increased significantly(P<0.05),which were increased by 10.08% and 11.85% respectively compared to the control group;the apparent digestibility of calcium was increased,but the difference was not significant(P>0.05).[Conclusion] It will not reduce the growth performance of Hainan black pig when the protein level of diet is reduced by 2% and the lysine level is increased to 1.03%.It is recommended that the diet can be used in the production of Hainan black pig. | Wei Limin Liu Quanwei Sun Ruiping Zheng Xinli Wang Feng Tan Shuyi Huang Lili Xing Manping | 2018 | Animal Husbandry and Feed Science2018，10，2： | 4 |
| 8 | Resolution and parameters estimations for multiple maneuvering targets显示文摘Resolution and parameters estimations for multiple maneuvering targets in the same range cell is addressed in this work.The low-resolution radar cannot distinguish multiple targets in both distance and angle,but the detection of Doppler frequency variation of the multiple maneuvering targets can be used to resolve this problem.At present,most of researches on detection of Doppler frequency variation are carried out with time-frequency analysis methods,such as Fractional Fourier transformation(FRFT),Adaptive Chirplet transformation(ACT),and Wigner-Ville distribution(WVD)and so on,which need satisfy enough time duration and sampling theorem.This paper proposes a new method of resolution and parameters estimation for multiple maneuvering targets based on Compressive Sensing(CS)and clustering technique,which samples at low rate and short time duration without sacrificing estimation performance.Simulation results validate the effectiveness of the proposed algorithm,and also show that the performance of the proposed method is superior to that of FRFT in the condition of multiple targets. | JIA ShuYi WANG GuoHong ZHANG Yun ZHANG Lei | 2014 | Science China(Information Sciences)2014，57，8： | 4 |
| 9 | An ecological survey of the abundance and diversity of benthic macrofauna in Indonesian multispecific seagrass beds显示文摘Seagrasses are one of the most productive ecosystems in coastal areas and support a wide variety of associated fauna. The tropical Indo-Pacific region is considered to have the highest diversity of seagrass plant species and the largest distribution areas of seagrass, yet the seagrass macrofauna in this region are poorly understood. To help fill this gap in our knowledge, an ecological survey was conducted to describe the abundance and diversity of benthic macrofauna from tropical seagrass beds and to determine between-station variations within a transect and between-site variations in macrofaunal abundance, taxa richness and community structure. Benthic macrofaunal samples associated with seagrass beds were collected with a core sampler on the east coast of North Sulawesi in May 2014 and on the west coast in October 2015. A total of 149 species from 14 higher taxa was collected. The most species-rich groups were polychaetes(56 species, 26% of total individual numbers), decapods(20 species, 9% of total numbers) and amphipods(18 species, 35% of total numbers). Between-station variations within a transect displayed different patterns between the east coast and the west coast. On the east coast, there were marked variations in abundance between stations within a transect for the macrofauna and amphipod assemblages. Both taxa richness and abundance varied with station for the macrofauna and polychaete assemblages on the west coast, resulting from the heterogeneity of the substrate along a transect. One-way ANOSIM together with MDS ordination indicated that macrofaunal community structure in seagrasses differed significantly between the east coast and the west coast, corresponding with the division of seagrasses into two broad categories of habitats, i.e.,mangrove-seagrass-reef continuum and seagrass-reef continuum. Compared with other studies in tropical areas,the abundance and diversity of benthic macrofauna in the present study were moderate. The reason for the two markedly distinct macrofaunal communities might be attributed to multiple factors, including sediment pattern,seagrass structure and temporal changes. | LIN Junhui HUANG Yaqin ARBI Ucu Yanu LIN Heshan AZKAB Muhammad Husni WANG Jianjun HE Xuebao MOU Jianfeng LIU Kun ZHANG Shuyi | 2018 | Acta Oceanologica Sinica2018，37，6： | 3 |
| 10 | 雷公藤红素通过靶向核受体Nur77促进损伤线粒体自噬而抑制炎症反应显示文摘文章简介线粒体在细胞死亡、自噬、免疫和炎症中起着不可或缺的作用。前期研究发现,孤儿核受体Nur77通过靶向线粒体诱导细胞凋亡。本文报道了Nur77作为具有抗炎作用的雷公藤红素的直接靶点,介导雷公藤红素通过自噬清除损伤线粒体,抑制炎症反应而达到治疗炎症疾病包括肥胖症的功能。 | Mengjie Hu Qiang Luo Gulimiran Alitongbieke Shuyi Chong Chenting Xu Lei Xie Xiaohui Chen Duo Zhang Yuqi Zhou Zhaokai Wang Xiaohong Ye Lijun Cai Fang Zhang Huibin Chen Fuquan Jiang Hui Fang Shanjun Yang Jie Liu Maria T.Diaz-Meco Ying Su Hu Zhou Jorge Moscat Xiangzhi Lin 张晓坤 | 2018 | 科学新闻2018，0，4： | 3 |
| 11 | Elliptical model for surface topography prediction in five-axis flank milling显示文摘In five-axis flank milling operations,the intersecting surfaces of different cutting edges create roughness on the milled surfaces that cannot be ignored in situations with strict requirements,especially in aeronautical manufacturing.To focus on motion problems in milling operations,this paper presents a new model that utilizes elliptical paths as cutting edge trajectories on 3D surface topography machined by peripheral milling.First,the cutter parallel axis offset and location angle are considered,which change the location of the ellipse center and intersection point of the cutting edges.Then,through the proposed model,the predicted surface topography is obtained,and the factors that affect the development tendency of roughness are analyzed.Next,the effects of the cutter location position(CLP)geometric parameters,cutter parallel axis offset and curvature on the roughness are evaluated by a numerical simulation.Finally,machining tests are carried out to validate the model predictions,and the results show that the surface topography predictions correspond well with the experimental results. | Liping WANG Shuyi GE Hao SIa Liwen GUAN Feiyu DUAN Yuzhe LIU | 2020 | Chinese Journal of Aeronautics2020，33，4： | 3 |
| 12 | E17110 promotes reverse cholesterol transport with liver X receptor β agonist activity in vitro显示文摘Liver X receptor(LXR) plays an important role in reverse cholesterol transport(RCT), and activation of LXR could reduce atherosclerosis. In the present study we used a cell-based screening method to identify new potential LXRβ agonists. A novel benzofuran-2-carboxylate derivative was identified with LXRβ agonist activity: E17110 showed a significant activation effect on LXRβ with an EC50 value of 0.72 μmol/L. E17110 also increased the expression of ATP-binding cassette transporter A1(ABCA1) and G1(ABCG1) in RAW264.7 macrophages. Moreover, E17110 significantly reduced cellular lipid accumulation and promoted cholesterol efflux in RAW264.7 macrophages. Interestingly, we found that the key amino acids in the LXRβ ligand-binding domain had distinct interactions with E17110 as compared to TO901317. These results suggest that E17110 was identified as a novel compound with LXRβ agonist activity in vitro via screening, and could be developed as a potential anti-atherosclerotic lead compound. | Ni Li Xiao Wang Peng Liu Duo Lu Wei Jiang Yanni Xu Shuyi Si | 2016 | Acta Pharmaceutica Sinica B2016，6，3： | 3 |
| 13 | CPTA treatment reveals potential transcription factors associated with carotenoid metabolism in flowers of Osmanthus fragrans显示文摘Osmanthus fragrans is one of the top ten traditional flowers in China.It is divided into three different groups according to its color.α-Carotene and β-carotene are the main determinants to distinguish the color differences between three groups.However,the dominant genes and transcription factors involved in carotenoid metabolism remain unclear.CPTA treatment(0.7mmol·L−1)remarkably promoted lycopene,α-carotene and β-carotene contents in flowers.Transcriptome sequencing analysis revealed that CPTA treatment could trigger chain reactions in carotenoid metabolism pathway genes.Four up-regulated and 10 down-regulated transcription factors which have close association with carotenoid variation were significantly induced by CPTA treatment.The up-regulated TFs such as MYB43,MYB123,HSF,were further subjected to transcript expression determination in different cultivars with drastic colors.Among them,transcript expression of four up-regulated TFs coincided with the carotenoid accumulation in different cultivars.We selected up-regulated OfMYB43 to verify its function,which is related to stress tolerance and transcriptional regulation.Transient overexpression of OfMYB43 in O.fragrans flowers showed that it could remarkably promote the expression of PDS,ZISO,LCYE and CCD4,leading to increased accumulation of β-branch carotenoids.OfMYB43 was a potential positive regulator of carotenoid biosynthesis in O.fragrans flowers.This study provides insight into the molecular mechanism of carotenoid metabolism in O.fragrans. | Wan Xi Yanhong He Linlin Zhu Shiyang Hu Shuyi Xiong Yi Zhang Jingjing Zou Hongguo Chen Caiyun Wang Riru Zheng | 2021 | Horticultural Plant Journal2021，7，5： | 3 |
| 14 | Identification of anti-Gram-negative bacteria agents targeting the interaction between ribosomal proteins L12 and L10显示文摘Gram-negative bacteria have become the main pathogens and cause serious clinical problems with increased morbidity and mortality. However, the slow discovery of new antimicrobial agents is unable to meet the need for the treatment of bacterial infections caused by drug-resistant strains. The interaction of L12 and L10 is essential for ribosomal function and protein synthesis. In this study, a yeast two-hybrid system was established to successfully detect the interaction between L12 and L10 proteins from gram-negative bacteria Escherichia coli, which allows us to screen compounds that specifically disrupt this interaction. With this system, we identified two compounds IMB-84 and IMB-87 that block L12-L10 interaction and show bactericidal activity against E. coli. We used glutathione-S-transferase(GST) pull-down and surface plasmon resonance(SPR) assays to demonstrate that these compounds disrupt L12-L10 interaction in vitro and the target of compounds was further confirmed by the overexpression of target proteins. Moreover, protein synthesis and elongation factor G-dependent GTPase activities are inhibited by two compounds. Therefore, we have identified two antibacterial agents that disrupt L12-L10 interaction by using yeast two-hybrid system. | Weiwei Wang Chao Liu Ningyu Zhu Yuan Lin JiANDong Jiang Yanchang Wang Yan Li Shuyi Si | 2018 | Acta Pharmaceutica Sinica B2018，8，5： | 3 |
| 15 | Effects of Ginsenoside Rg1 on nuclear factor-kappa B activity in beta amyloid protein-treated neural cells显示文摘BACKGROUND:Modern pharmacological studies have shown that Ginsenoside Rg1 is one of the active components of ginseng that promote intelligence in the nervous system.Ginsenoside Rg1 can improve memory and learning in mouse models ofβ-amyloid protein(Aβ)-induced dementia. OBJECTIVE:To investigate whether effects of Ginsenoside Rg1 against Aβare associated with activity of nuclear factor-kappa B(NF-κB). DESIGN,TIME AND SETTING:The randomized,controlled,cell biological experiment was performed at the DME Center,Institute of Clinical Pharmacology,Guangzhou University of Chinese Medicine,China from July 2005 to May 2006. MATERIALS:Beta-amyloid fragment 25-35(Aβ_(25-35)) was supplied by the Neural Biochemical Laboratory,Xuanwu Hospital,Capital Medical University,China.Ginsenoside Rg1 was obtained from National Institute for the Control of Pharmaceutical and Biological Products,China.Rabbit anti-rat NF-κB p65 antibody was purchased from Santa Cruz Biotechnology,USA. METHODS:Hippocampal neurons and cortical astrocytes of neonatal Sprague Dawley rats were harvested and treated with various concentrations(0,5,10,20,and 40μmol/L) of Aβfor 6,12,and 24 hours to establish cellular models of Alzheimer's disease.Cellular models were pretreated with various concentrations of Ginsenoside Rg1(1,2,4,8,and 16μmol/L).According to cell morphology and activity,the following conditions were selected:40μmol/L Aβfor 24 hours,as well as 2,4,and 8μmol/L Ginsenoside Rg1.NF-κB activity was observed using immunofluorescence and cytochemical staining. MAIN OUTCOME MEASURES:Morphology and viability of hippocampal neurons and cortical astrocytes,and activities of NF-κB were measured. RESULTS:Hippocampal neuron activity was significantly greater in the normal and 2 and 4μmol/L Ginsenoside Rg1 groups compared with the model group(P<0.05).Astrocyte activity was significantly greater in the normal,1,2,4,8,and 16μmol/L Ginsenoside Rg1 groups compared with the model group(P<0.05).NF-κB activity of hippocampal neurons was significantly greater in the normal,2,4,and 8μmol/L Ginsenoside Rg1 groups compared with the model group(P<0.01). NF-κB activity of astrocytes was significantly less in the normal,2,4,and 8μmol/L Ginsenoside Rg1 groups compared with the model group(P<0.01 or P<0.05).No significant difference in NF-κB activity was determined between the 2μmol/L Ginsenoside Rg1 and normal groups(P>0.05). CONCLUSION:Ginsenoside Rg1 protected neural cells by upregulating NF-κB activity in neurons and downregulating NF-κB activity in astrocytes.Ginsenoside Rg1(2μmol/L) maintained cell activity and NF-κB activity at normal levels. | Yunbo Chen Dapeng Zhang Mei Feng Qi Wang Shuyi Cheng Weixiong Liang Zehuai Wen | 2009 | Neural Regeneration Research2009，4，8： | 2 |
| 16 | Flotation performance of a novel Gemini collector for kaolinite at low temperature显示文摘How to sustainably produce bauxite by effective reverse froth flotation of kaolinite at low temperature is an urgent problem to be solved in the field of mineral processing.In this work,a novel amino-based Gemini surfactant butadiyl-1,4-bis(dimethyl dodecylammonium bromide)(BBDB) was prepared and first utilized as a novel collector for kaolinite flotation.Its flotation performance for kaolinite was compared with that of the common monomolecular surfactant 1-dodecylamine(DDA) by micro-flotation tests.The tests results indicated that 95% kaolinite recovery was obtained using 2.0×10^(-4) mol/L BBDB at 25℃ which was half of the dosage when DDA obtained the maximum kaolinite recovery of81%.At extremely low temperature(0℃),3.0×10^(-4) mol/L BBDB could still collect 91% kaolinite,while DDA showed a frustrating ability.The contact angle tests indicated that BBDB could still significantly improve the hydrophobicity of the kaolinite surface(contact angle 71.7°) than DDA(contact angle only25.8°) at 0℃.The Krafft point comparison tests indicated that BBDB had a much lower Krafft point(below0℃) than DDA.Fourier transform infrared spectroscopy(FTIR)-spectrum analysis and zeta potential measurements showed that BBDB was physically adsorbed on the surface of kaolinite through electrostatic interaction. | Shiyong Zhang Zhiqiang Huang Hongling Wang Rukuan Liu Chen Cheng Shuyi Shuai Yajing Hu Zhiqun Guo Xinyang Yu Guichun He Weng Fu | 2021 | International Journal of Mining Science and Technology2021，31，6： | 2 |
| 17 | Radial acceleration estimation of multiple high maneuvering targets显示文摘The acceleration of a high maneuvering target in signal processing is helpful to enhance the performance of the tracker and facilitate the classification of targets. At present, most of the research on acceleration estimation is carried out in cases of a single target with time-frequency analysis methods such as fractional Fourier transform(FRFT), Hough-ambiguity transform(HAT), and Wigner-Ville distribution(WVD), which need to satisfy enough time duration and sampling theorem. Only one reference proposed a method of acceleration estimation for multiple targets based on modified polynomial phase transform(MPPT) in the linear frequency modulation(LFM) continuous-wave(CW) radar. The method of acceleration estimation for multiple targets in the pulse Doppler(PD) radar has not been reported so far. Compressive sensing(CS) has the advantage of sampling at a low rate and short duration without sacrificing estimation performance. Therefore, this paper proposes a new method of acceleration estimation for multiple maneuvering targets with the unknown number based on CS with pulse Doppler signals. Simulation results validate the effectiveness of the proposed method under several conditions with different duration, measurement numbers, signal to noise ratios(SNR), and regularization parameters, respectively. Simulation results also show that the performance of the proposed method is superior to that of FRFT and HAT in the condition of multiple targets. | Shuyi Jia Guohong Wang Shuncheng Tan | 2014 | Journal of Systems Engineering and Electronics2014，25，2： | 2 |
| 18 | Recombinant Clostridium difficile toxin B induces endoplasmic reticulum stress in mouse colonal carcinoma cells显示文摘Clostridium 顽固在人和动物是联系抗菌素的腹泻和 pseudomembranous 大肠炎的主要原因。它的致病力首先被连接到二外毒素(TcdA 和 TcdB ) 的分泌物。尽管在 TcdA 和 TcdB 的有毒的机制的大进步被获得了,关于 apoptotic 机制有许多冲突报告。更重要地, apoptotic endoplasmic 蜂窝胃(嗯) 应力在与能引起腹泻和大肠炎的细胞毒素客气的 Shiga toxinsanother 对待的房间被报导了。此处,我们检查了 TcdB 是否能导致嗯应力。结果证明 recombinant TcdB (rTcdB ) 激活展开的蛋白质反应的分子的标记,建议导致的那 rTcdB 嗯在 CT26 房间的应力。然而, rTcdB 没导致 C/EBP 相应蛋白质(砍) 的起来规定, apoptotic 的一个经典调停人嗯应力,而是它激活半胱氨酸丁氨二酸的先锋酸特定的朊酶 12 (caspase-12 ) , apoptotic 的一个争论调停人嗯应力。而且,活动缺乏的变异的 recombinant TcdB 导致了的 glucosyltransferase 嗯应力,不过,它有不细胞毒素或 CT26 房间上的 cytopathic 效果。总的来说,这些数据表明了那嗯 rTcdB 导致的应力是 glucosyltransferase 独立的,显示那嗯 rTcdB 导致的应力是 non-apoptotic。这个工作也为我们提供新卓见进砍蛋白质表示规定和砍表示的角色的分子的机制在嗯应力。 | Chunli Sun Haiying Wang Shuyi Chen Zhendong Li Shan Li Jufang Wang | 2014 | Acta Biochimica et Biophysica Sinica2014，46，11： | 2 |
| 19 | The novel ER stress inducer Sec C triggers apoptosis by sulfating ER cysteine residues and degrading YAP via ER stress in pancreatic cancer cells显示文摘Pancreatic adenocarcinoma(PAAD) is one of the most lethal malignancies. Although gemcitabine(GEM) is a standard treatment for PAAD, resistance limits its application and therapy. Secoemestrin C(Sec C) is a natural compound from the endophytic fungus Emericella, and its anticancer activity has not been investigated since it was isolated. Our research is the first to indicate that Sec C is a broad-spectrum anticancer agent and could exhibit potently similar anticancer activity both in GEM-resistant and GEM-sensitive PAAD cells. Interestingly, Sec C exerted a rapid growth-inhibiting effect(80% death at 6 h), which might be beneficial for patients who need rapid tumor shrinkage before surgery. Liquid chromatography/mass spectrometry and N-acetyl-L-cysteine(NAC) reverse assays show that Sec C sulfates cysteines to disrupt disulfide-bonds formation in endoplasmic reticulum(ER) proteins to cause protein misfolding, leading to ER stress and disorder of lipid biosynthesis. Microarray data and subsequent assays show that ER stress-mediated ER-associated degradation(ERAD) ubiquitinates anddownregulates YAP to enhance ER stress via destruction complex(YAP-Axin-GSK-βTr CP), which also elucidates a unique degrading style for YAP. Potent anticancer activity in GEM-resistant cells and low toxicity make Sec C a promising anti-PAAD candidate. | Junxia Wang Minghua Chen Mengyan Wang Wenxia Zhao Conghui Zhang Xiujun Liu Meilian Cai Yuhan Qiu Tianshu Zhang Huimin Zhou Wuli Zhao Shuyi Si Rongguang Shao | 2022 | Acta Pharmaceutica Sinica B2022，12，1： | 2 |
| 20 | Highly maneuvering target tracking using multi-parameter fusion Singer model显示文摘An algorithm of highly maneuvering target tracking is proposed to solve the problem of large tracking error caused by strong maneuver. In this algorithm, a new estimator, named as multi-parameter fusion Singer(MF-Singer) model is derived based on the Singer model and the fuzzy reasoning method by using radial acceleration and velocity of the target, and applied to the problem of maneuvering target tracking in strong maneuvering environment and operating environment. The tracking performance of the MF-Singer model is evaluated and compared with other manuevering tracking models. It is shown that the MF-Singer model outperforms these algorithms in several examples. | Shuyi Jia Yun Zhang Guohong Wang | 2017 | Journal of Systems Engineering and Electronics2017，28，5： | 2 |
您所在的机构暂未开通此部分的功能，请联系管理员