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| 1 | The effects of 1 month antihypertensive treatment with perindopril,bisoprolol or both on the ex vivo ability of monocytes to secrete inflammatory cytokines显示文摘 | Madej A Buldak L Basiak M | 2009 | Int J Clin Pharmacol Ther2009，47，11： | 1 |
| 2 | Agricultural use of three organic residues: effect on orange production and on properties of a soil of the ‘Comarca Costa de Huelva’ (SW Spain)显示文摘 | Engracia Madejón Pilar Burgos Rafael López Francisco Cabrera | 2003 | Nutrient Cycling in Agroecosystems2003，，3： | 1 |
| 3 | Agricultural use of three (sugar-beet) vinasse composts: effect on crops and chemical properties of a Cambisol soil in the Guadalquivir river valley (SW Spain)显示文摘 | Engracia Madejón Rafael López José M Murillo Francisco Cabrera | 2001 | Agriculture Ecosystems and Environment2001，，1： | 1 |
| 4 | Bile bacterial flora and its in vitro resistance pattern in patients with acute eholangitis resulting from choledocholithiasis 显示文摘 | Karpel E Madej A Buldak L | 2012 | Scand J Gastroentero2012，46，7： | 1 |
| 5 | Bile bacterial flora and its in vitro resistance pattern in patients with acute cholangitis resulting from choledocholithiasis显示文摘 | Karpel E Madej A Buldak L | | 0，，7： | 1 |
| 6 | The genetic diversity of components of rye hybrids 显示文摘 | Rafalsk A Madej L Wiceniewska I and Gawe M | 2002 | Cellular & Molecular Biology Letters2002，，7： | 1 |
| 7 | Prevalence of hepatocarcinoma-related hepatitis B virus mutants in patients in grey zone of treatment显示文摘BACKGROUND Antiviral treatment of patients with chronic hepatitis B(CHB)in the grey zone of treatment comands risk management in order to optimize the health outcome.In this sense,the identification of HBV mutants related with an increased risk of hepatocellular carcinoma(HCC)could be useful to identify subpopulations with potential indication of antiviral treatment.AIM To analyze the prevalence/persistence of hepatitis B virus(HBV)preS and basal core promoter(BCP)/precore/core variants associated to HCC development in CHB patients in the grey zone.METHODS Work was designed as a longitudinal retrospective study,including 106 plasma samples from 31 patients with CHB in the grey zone of treatment:Hepatitis B e antigen negative,HBV-DNA levels between 12-20000 IU/mL,normal or discordant transaminase levels during follow up and mild/moderate necroinflammatory activity in liver biopsy or Fibroscan(up to 9.5 kPa).Serum HBVDNA was tested using the Abbott Real Time HBV Assay and the BCP/precore/core and the hepatitis B surface antigen(HBsAg)coding regions were analyzed in positive samples by PCR/bulk-sequencing to identify the HCCrelated HBV mutants.RESULTS High-risk HCC related mutants were detected in 24(77%)patients:19(61%)in the BCP/precore/core,and 7(23%)in the HBsAg coding region(2 preS1 and 5 preS2 deletions).The prevalence of preS deletions was genotype-dependent:3/5(60%)patients with preS2 deletions and 1/2 with preS1 deletions were infected with the HBV-E genotype.Since HBV-E was the most prevalent in sub-Saharan patients,a correlation between preS deletions and ethnicity was also found:6/8(75%)sub-Saharan vs 1/19(5%)Caucasian patients had preS deletions(P=0.00016).Remarkably,this correlation was maintained in those patients infected with HBV-A,a minor genotype in sub-Saharan patients:2/2 patients infected with HBV-A from West Africa vs 0/6 of Caucasian origin had preS deletions.The HCC related variants were the major strains and persisted over time(up to 48 mo).Patients with preS deletions had a significant higher prevalence of F2 fibrosis stage than the negatives(57%vs 10%,P=0.0078).CONCLUSION HBV genetic analysis of selected populations,like sub-Saharans infected with HBV-E/A genotypes,will allow identification of subpopulations with risk of HCC development due to accumulation of high-risk HBV variants,thus commanding their increased clinical surveillance. | Ana Isabel Gil-García Antonio Madejón Irene Francisco-Recuero Ana López-López Emiliana Villafranca Miriam Romero Araceli García Antonio Olveira Rocío Mena Juan Ramón Larrubia Javier García-Samaniego | 2019 | World Journal of Gastroenterology2019，25，38： | 1 |
| 8 | Hydration products at the blast furnace slag aggregate cement paste interface显示文摘 | STEVULA L MADEJ J KOZANKOVA J | 1993 | Cement and Concrete Research1993，24，3： | 1 |
| 9 | The effects of 1 month antihypertensive treatment with perindopril, bisoprolol or both on the ex vivo ability ofmono- cytes to secrete inflammatory cytokines显示文摘 | Madej A Buldak L Basiak M | 2009 | Int J Clin Pharmacol Ther2009，47，11： | 1 |
| 10 | Effect of aeration rate and moisture content on the emissions of selected VOCs during municipal solid waste composting显示文摘 | M. Delgado-Rodríguez M. Ruiz-Montoya I. Giraldez R. López E. Madejón M. J. Díaz | 2012 | Journal of Material Cycles and Waste Management2012，，4： | 1 |
| 11 | Recent development in orbital forging technology 显示文摘 | NOWAK J MADEJ L ZIOLKIEWICZ S PLEWINSKI A GROSMAN F PIETRZYK M | 2008 | International Journal of Materials Forming2008，，1： | 1 |
| 12 | Oxidative metabolism of combretastatin A-1poroduces quinone interme-diates with the potential to bind to nucleophiles and to en-hance oxidative stress via free radicals显示文摘 | Folkes L K Christlieb M Madej E | 2007 | Chem Res Toxi-col2007，20，12： | 1 |
| 13 | Optimization of the rate vinasse/grape marc for co-composting process显示文摘 | M.J Diaz E Madejón F López R López F Cabrera | 2002 | Process Biochemistry2002，，10： | 1 |
| 14 | Long-term effects of conservation tillage on organic fractions in two soils in southwest of Spain显示文摘 | MELERO S LóPEZ-GARRIDO R MADEJóN E | 2009 | Agriculture Ecosystems and Environment2009，133，： | 1 |
| 15 | The effects of 1 month antihypertensive treatment with perindopril, bisoprolol or both on the vivo ability of monocytes to secrete inflammatory cytokines 显示文摘 | Madej A Buldak L Basiak M | 2009 | Int J Clin Pharmacol Ther2009，4701，： | 1 |
| 16 | The effects of 1 month antihypertensive treatment with perindopril,bisoprolol or both on the ex vivo ability of monocytes to secrete inflammatory cytokines显示文摘 | Madej A Buldak L Basiak M | 2009 | Int J Clin Pharmacol Ther2009，47，11： | 1 |
| 17 | The genetic diversity of components of rye hybrids 显示文摘 | Rafalsk A Madej L Wiceniewska I and Gawe M | 2002 | Cellular & Molecular Biology Letters2002，，7： | 1 |
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