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| 1 | Role of quorum sensing in bacterial infections显示文摘Quorum sensing(QS) is cell communication that is widely used by bacterial pathogens to coordinate the expression of several collective traits, including the production of multiple virulence factors, biofilm formation, and swarming motility once a population threshold is reached. Several lines of evidence indicate that QS enhances virulence of bacterial pathogens in animal models as well as in human infections; however, its relative importance for bacterial pathogenesis is still incomplete. In this review, we discuss the present evidence from in vitro and in vivo experiments in animal models, as well as from clinical studies, that link QS systems with human infections. We focus on two major QS bacterial models, the opportunistic Gram negative bacteria Pseudomonas aeruginosa and the Gram positive Staphylococcus aureus, which are also two of the main agents responsible of nosocomial and wound infections. In addition, QS communication systems in other bacterial, eukaryotic pathogens, and even immune and cancer cells are also reviewed, and finally, the new approaches proposed to combat bacterial infections by the attenuation of their QS communication systems and virulence are also discussed. | Israel Castillo-Juárez Toshinari Maeda Edna Ayerim Mandujano-Tinoco María Tomás Berenice Pérez-Eretza Silvia Julieta García-Contreras Thomas K Wood Rodolfo García-Contreras | 2015 | World Journal of Clinical Cases2015，3，7： | 15 |
| 2 | Polygenic control of the expression of biological activities of an antitumor polysaccharide, lentinan 显示文摘 | Maeda Y Takahama S Kohara Y | 1997 | Int J Immunopharmacol1997，19，910： | 2 |
| 3 | Prognostic value of vascular endothelial growth factor in gastriccarcinoma显示文摘 | MAEDA K CHUNG Y S OGAWA Y | 1996 | Cancer1996，77，5： | 2 |
| 4 | Respiratory health associated with exposure to automobile exhaust Ⅲ :results of a cross-sectional study in 1987,and repeated pulmonary function tests from 1987 to 1990 显示文摘 | Nakai S Nitta H Maeda K | 1999 | Arch of Environ Health1999，54，： | 2 |
| 5 | Time course alterations of myocardial endothelin - 1 production during the formation of exercise training - induced cardiac hypertrophy 显示文摘 | Iemitsu M Maeda S Otsuki T | 2006 | Exp Biol Med (Maywood)2006，231，6： | 1 |
| 6 | Prospective randomized pilot trial of selective biLiary cannulation using pancreatic guide-wire placement 显示文摘 | MAEDA S HAYASHI H HOSOKAWA O | 2003 | Endoscopy2003，35，9： | 1 |
| 7 | In-plane dynamic interaction between a tower and conductors at lower frequencies 显示文摘 | Ozono S Maeda J | 1992 | Engineering Structures1992，14，： | 1 |
| 8 | Tunnel entrance hoods for reduction of micro-pressure wave显示文摘 | OZAWA S MAEDA T | 1988 | QR of RTRI1988，39，3： | 1 |
| 9 | On the decomposition of a matrix into the sum of stable matrices显示文摘 | Hattori S Maeda H | 1999 | Linear Algebra Appl1999，，297： | 1 |
| 10 | Video-assisted neck surgery for thyroid and parathyroid disease显示文摘 | Shimizu K Minami S | 2002 | Biomed Pharmacother2002，56，1： | 1 |
| 11 | Expression of cdna for batroxobin, a thrombin-like enzyme 显示文摘 | MAEDA M SATOH S SUZUKI S | 1993 | Biochem1993，294，2： | 1 |
| 12 | Development of the automatic system for pneumatic caisson显示文摘 | KODAKI K NAKANO M MAEDA S | 1997 | Automation in Construction1997，6，3： | 1 |
| 13 | A large noncoding RNA is a marker for murine hepatocellular carcinomas and a spectrum of human carcinomas显示文摘 | LIN R MAEDA S LIU C | 2007 | Oncogene2007，26，6： | 1 |
| 14 | An expert system for designing removable partial dentures显示文摘 | Maeda Y Tsutumi S Minoura M | 1985 | J Osaka Univ Dent Sch1985，25，： | 1 |
| 15 | Detection of cancer cells in the peripheral blood of gastric cancer patients显示文摘 | Ikeguchi M Ohro S Maeda Y | 2003 | Int J Mol Med2003，11，： | 1 |
| 16 | Low levels of insulin-like growth factor type 1 receptor expression at cancer cell membrane predict liver metastasis in Dukes' C human colorectal cancers显示文摘 | Nakamura M Miyamoto S Maeda H | 2004 | Clinical cancer research2004，10，24： | 1 |
| 17 | Helicobacter pylori activates the proto-oncogene c-fos through SRE transactivation显示文摘 | Mitsuno Y Maeda S Yoshida H | 2002 | Biochem Biophys Res Commun2002，291，4： | 1 |
| 18 | Detection of cancer cells in the peripheral blood of gastric cancer patients显示文摘 | Ikeguchi M Ohro S Maeda Y | 2003 | Int J Idol Med2003，11，2： | 1 |
| 19 | Exacerbation of heart failure in adiponectin--deficient mice due to impaired regulation of AMPK and glucose metabolism显示文摘 | Liao Y Takashima S Maeda N | 2005 | Cardiovasc Res2005，19，： | 1 |
| 20 | Partial laryngospasms during general anesthesia with a laryngeal mask airway for dental treatment:a report of 5 cases显示文摘 | Jinzenji A Maeda S Higuchi H | | 0，，10： | 1 |
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