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| 1 | The natural history of nonalcoholic fatty liver disease: a clinical histopathological study显示文摘 | Stephen A Harrison Sigurd Torgerson Paul H Hayashi | 2003 | The American Journal of Gastroenterology2003，，9： | 4 |
| 2 | Rapid induction of vascular endothelial growth factor gene expression after transient middle cerebral artery occlusion in rats显示文摘 | Hayashi T Abe K Suzuki H | 1997 | Stroke1997，28，10： | 2 |
| 3 | Stiffness and elastic behavior of human intracranial and extracranial arteries显示文摘 | Hayashi K Handa H Nagasawa S | 1980 | Journal of Biomechanics1980，13，： | 2 |
| 4 | Enzymatic hydrolysis of cellulosic mixture of Aspergillus aculestus and Trichoderma viride, and ethanol production from the hydrolyzate显示文摘 | Hayashi H Arai M | 1983 | Hakkokogaku1983，61，： | 2 |
| 5 | Pre-treatment role of inosine triphosphate pyrophosphatase polymorphism for predicting anemia in Egyptian hepatitis C virus patients显示文摘AIM: To investigate and clarify, for the first time, the role of inosine triphosphate pyrophosphatase (ITPA ) polymorphism in Egyptian chronic hepatitis C virus (HCV) patients.METHODS:The human genomic DNA of all patients was extracted from peripheral blood cells in order to determine the single nucleotide polymorphism (SNP) of ITPA (rs1127354). SNP genotyping was performed by real time polymerase chain reaction (PCR, ABI TaqMan allelic discrimination kit) for 102 treatment-naive Egyptian patients with chronic HCV. All patients had no evidence of cardiovascular or renal diseases. They received a combination treatment of pegylated interferon α (PEG-IFNα) as a weekly subcutaneous dose plus an oral weight-adjusted dose of ribavirin (RBV). The majority received PEG-IFNα2a (70.6%) while 29.4% received PEG-IFNα2b. The planned duration of treatment was 24-48 wk according to the viral kinetics throughout the course of treatment. Pre-treatment liver biopsy was done for each patient for evaluation of fibrosis stage and liver disease activity. The basal viral load level was detected quantitatively by real time PCR while viral load throughout the treatment course was performed qualitatively by COBAS TaqMan assay. RESULTS: Ninety-three patients (91.2%) had ITPA SNP CC genotype and 9 (8.8%) had non-CC genotype (CA and AA). The percentage of hemoglobin (Hb) decline was higher for CC patients than for non-CC patients, particularly at weeks 4 and 8 (P=0.047 and 0.034, respectively). During the first 12 wk of treatment, CC patients had significantly more Hb decline > 3 g/dL than non-CC patients: 64.5% vs 22.2% at weeks 8 and 12, respectively, (P=0.024 and 0.038). Reduction of the amount of the planned RBV dose was significantly higher for CC patients than non-CC patients during the first 12 wk (18% ± 12.1% vs 8.5% ± 10.2%, P=0.021). The percentage of CC patients with RBV dose reduction was significantly greater than that of non-CC patients (77.4% vs 44.4%, P=0.044). Multivariate analysis identified only the percentage of RBV dose as a predictor for Hb decline. Platelet decline was significantly higher in non-CC patients than CC patients at weeks 12, 24 and 48 (P=0.018, 0.009 and 0.026, respectively). CONCLUSION: Rs1127354 ITPA polymorphism plays a decisive role in protecting against treatment-induced anemia and the need for RBV dose reduction in Egyptian HCV patients. | Walaa H Ahmed Norihiro Furusyo Saad Zaky Abeer Sharaf Eldin Hany Aboalam Eiichi Ogawa Masayuki Murata Jun Hayashi | 2013 | World Journal of Gastroenterology2013，19，9： | 2 |
| 6 | Prospective randomized pilot trial of selective biLiary cannulation using pancreatic guide-wire placement 显示文摘 | MAEDA S HAYASHI H HOSOKAWA O | 2003 | Endoscopy2003，35，9： | 1 |
| 7 | Simulation of Transverse Crack Formation on Continuously Cast Periteetie Medium Carbon Steel Slabs 显示文摘 | Suzuki M Hayashi H Shibata H | 1999 | Steel Research1999，70，10： | 1 |
| 8 | Spinal cord repair in neonatal rats:a correlation between axonal regeneration and functional recovery显示文摘 | Hase T Kawaguchi S Hayashi H | 2002 | Eur J Neurosci2002，15，6： | 1 |
| 9 | The correlation between incision size and corneal shape change in sutureless cataract surgery 显示文摘 | Hayashi K Hayashi H Nakao F | 1995 | Ophthalmology1995，102，6： | 1 |
| 10 | Molecular cloning and characterization of isomultiflorenol synthase, a new triterpene synthase from Luffa cylindrica, involved in biosynthesis of bryonolic acid显示文摘 | Huang P Inoue K et al | 2001 | Eur J Biochem2001，268，： | 1 |
| 11 | Reduction of ischemic brain injury by topital application of glial line-derived neurotrophic factor after permanent middle cerebral artery occlusion in rat显示文摘 | Hayashi T Mitsumoto Y | 1998 | Stroke1998，29，7： | 1 |
| 12 | Differential regulation of elevated angiotensin Ⅱ in chronic renal ischemia显示文摘 | Hayashi K Matsuda H | 2002 | Hypertension2002，40，： | 1 |
| 13 | Phylogenetic analysis of the human gut microbiota using 16S rDNA clone libraries and strictly anaerobic culture-based methods显示文摘 | Sakamoto M Benno Y | 2002 | Microbiol Immunol2002，46，： | 1 |
| 14 | Endovascular treatment for cervical carotid artery stenosis presenting with progressing stroke:three case reports显示文摘 | Kitagawa N Takahata H | 2002 | Surg Neurol2002，58，： | 1 |
| 15 | Liquid-phase oxidation of ethyl lactate to pyruvate over suspended oxide catalysts显示文摘 | Sugiyama S Katayama Y | 1993 | J Molecular Catalysis1993，83，12： | 1 |
| 16 | Extremely low-dose ACTH step-up protocol for West syndrome:Maximum therapeutic effect with minimal side effects显示文摘 | Oguni H Yanagaki S Hayashi K | 2006 | Brain Dev2006，28，1： | 1 |
| 17 | J Power Sources显示文摘 | Matsuoka O Hiwara A Omi T Toriida M Hayashi T Tanaka C Saito Y Ishida T Tan H Ono S S Yamamoto S | 2002 | 108:1282002，108，： | 1 |
| 18 | COX-2/VEGF-dependent facilitation of tumor-associated angiogenesis and tumor growth in vivo显示文摘 | YOSHIDA S AMANO H HAYASHI I | 2003 | Lab Invest2003，83，10： | 1 |
| 19 | Prepatation and characterization of silica-polyimide composite membranes coated on porous tubes for CO2 separation显示文摘 | Kusakabe K Ichiki K Hayashi J Macda H Morooka S | 1996 | Journal of Membrane Science1996，115，： | 1 |
| 20 | Rapid and specific genotyping system for Hepatitis B Virus corresponding to six major genotypes by PCR using type specific primers显示文摘 | Naito H Hayashi S Abe K | 2001 | J Clin Micobiol2001，39，1： | 1 |
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