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| 1 | Impact of Helicobacter pylori on the healing process of the gastric barrier显示文摘AIM To determine the impact of selected well defined Helicobacter pylori(H. pylori) antigens on gastric barrier cell turnover.METHODS In this study,using two cellular models of gastric epithelial cells and fibroblasts,we have focused on exploring the effects of well defined H. pylori soluble components such as glycine acid extract antigenic complex(GE),subunit A of urease(Ure A),cytotoxin associated gene A protein(Cag A) and lipopolysaccharide(LPS) on cell turnover by comparing the wound healing capacity of the cells in terms of their proliferative and metabolic activity as well as cell cycle distribution. Toxic effects of H. pylori components have been assessed in an association with damage to cell nuclei and inhibition of signal transducer and activator of transcription 3(STAT3) phosphorylation. RESULTS We showed that H. pylori GE,Cag A and Ure A promoted regeneration of epithelial cells and fibroblasts,which is necessary for effective tissue healing. However,in vivo increased proliferative activity of these cells may constitute an increased risk of gastric neoplasia. In contrast,H. pylori LPS showed a dose-dependent influence on the process of wound healing. At a low concentration(1 ng/m L) H. pylori LPS accelerated of healing epithelial cells,which was linked to significantly enhanced cell proliferation and MTT reduction as well as lack of alterations in cell cycle and downregulation of epidermal growth factor(EGF) production as well as cell nuclei destruction. By comparison,H. pylori LPS at a high concentration(25 ng/m L) inhibited the process of wound repair,which was related to diminished proliferative activity of the cells,cell cycle arrest,destruction of cell nuclei and downregulation of the EGF/STAT3 signalling pathway.CONCLUSION In vivo H. pylori LPS driven effects might lead to the maintenance of chronic inflammatory response and pathological disorders on the level of the gastric mucosal barrier. | Eliza Mnich Magdalena Kowalewicz-Kulbat Paulina Sicińska Krzysztof Hinc Michal Obuchowski Adrian Gajewski Anthony P Moran Magdalena Chmiela | 2016 | World Journal of Gastroenterology2016，22，33： | 4 |
| 2 | IL-6 trans-signaling promotes pancreatitis-associated lung injury and lethality显示文摘 | Zhang Hong Neuh?fer Patrick Song Liang Rabe Bj?rn Lesina Marina Kurkowski Magdalena U Treiber Matthias Wartmann Thomas Regnér Sara Thorlacius Henrik Saur Dieter Weirich Gregor Yoshimura Akihiko Halangk Walter Mizgerd Joseph P Schmid Roland | 2013 | Journal of Clinical Investigation2013，，3： | 2 |
| 3 | Phage display: Concept, innovations, applications and future 显示文摘 | JYOTI P MAGDALENA M SZENWCZYK | 2010 | Biotechnol Adv2010，28，： | 1 |
| 4 | Identification of novel intergenic repetitive units in a mycobacterial two-component system operon显示文摘 | Supply P Magdalena J Himpens S | 1997 | Mol Microbiol1997，26，5： | 1 |
| 5 | Combined genotypes of CCR5, CCR2, SDF1, and HLA genes can predict the long-term nonprogressor status in HIV-1 infected individuals显示文摘 | Magdalena M Theodorou L Debre P | 1999 | Blood1999，93，3： | 1 |
| 6 | Anastomoticleakage after lower gastrointestinal anastomosis : men are at a higherrisk 显示文摘 | Magdalena A Lipska Ian P Bissett Bryan R Parry | 2006 | ANZ Journal of Suigeiy2006，76，57： | 1 |
| 7 | Androgen, progesterone, and FSH receptor polymorphisms in ovarian cancer risk and outcome 显示文摘 | Agnieszka H L Magdalena M Grzegorz P | 2009 | Endocr Relat Cancer2009，16，3： | 1 |
| 8 | Expression analysis of phenylketonuria mutation:effect on foiding and stability of the phenylalanine hydroxylase protein 显示文摘 | Aleijadra G Belen P Magdalena U | 2000 | J Bio Chem2000，275，29： | 1 |
| 9 | Highly selective synthesis of 1 - (silyl) -1 -(boryl) ethenes via a ruthenium-catalyzed silylative coupling reaction 显示文摘 | Magdalena J Bogdan M Cezary P Joanna C | 2004 | Tetrahedron Lett2004，45，25： | 1 |
| 10 | The p53-induced WIG-1 protein binds double-stranded RNAs with structural characteristics of siRNAs and miRNAs显示文摘 | Cristina MV Magdalena P Klas G | 2006 | FEBS Letters2006，580，18： | 1 |
| 11 | Inactivation of Bacillus stearothermophilus spores during thermal pro- cessing显示文摘 | JAN I AGNIESZKA P MAGDALENA M | 2006 | Journal of Food Engineering2006，77，： | 1 |
| 12 | Identification of novelintergenic repetitive units in a mycobacterial two-component sys-tem operon显示文摘 | Supply P Magdalena J Himpens S | 1997 | Mol Microbiol1997，26，： | 1 |
| 13 | Rapid analytical procedure for determination of mineral oils in edible oil by GC-FID显示文摘 | MAGDALENA W DAVINSON P Cristina Nerin | 2013 | Food Chemistry2013，141，4： | 1 |
| 14 | A taxonomic study of some Anystidae (Acari:Prostigmata)显示文摘 | Magdalena K P Smith meyer E A Ueckerman N | 1987 | Entomology Memoir Department of Agriculture and Water supply1987，，68： | 1 |
| 15 | Toxicity of ionic liquid cations and anions towards activated sewage sludge organisms from different sources: Consequences for biodegradation testing and wastewater treatment plant operation显示文摘 | Maria M Magdalena P Nelson C | 2013 | Water Research2013，47，9： | 1 |
| 16 | The Plackett-Burman design in optimization of media components for biomass production of Lactobacillus rhamnosus OXY 显示文摘 | WASKO MONIKA K W PODLESNY M MAGDALENA P B TARGONSKI Z AGNIESZKA K K | 2010 | Acta Biologica Hungarica2010，61，3： | 1 |
| 17 | Analysis of new po- tential anticonvulsant compounds in mice brain tissue by SPE/HPLC/DAD显示文摘 | Jolanta F Magdalena P Tomasz P | 2012 | J Chromatogr B2012，909，： | 1 |
| 18 | Identification of a new DNA region specific for members of mycobacterium tuberculosis complex显示文摘 | Magdalena J Vachee A Supply P | 1998 | Journal of Clinical Microbiology1998，36，： | 1 |
| 19 | Species identification of meat by electrophoretic methods 显示文摘 | Magdalena M Edward P | 2007 | Acta Sc Pol Technol Aliment2007，6，1： | 1 |
| 20 | Detection of Specific Helicobacter pylori DNA and Antigens in Stool Samples in Dyspeptic Patients and Healthy Subjects显示文摘 | Monika Wi?niewska Hans Olof Nilsson Leokadia B?lk‐Romaniszyn Tomasz Rechciński W?adys?aw Bielański Izabela P?aneta‐Ma?ecka Ma?gorzata P?onka Stanis?aw Konturek Torkel Wadstr?m Wies?awa Rudnicka Magdalena Chmiela | 2002 | Microbiology and Immunology2002，，10： | 1 |
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