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| 1 | Feasibility and safety of autologous bone marrow mononuclear cell transplantation in patients with advanced chronic liver disease显示文摘AIM: To evaluate the safety and feasibility of bone marrow cell (BMC) transplantation in patients with chronic liver disease on the waiting list for liver transplantation. METHODS: Ten patients (eight males) with chronic liver disease were enrolled to receive infusion of autologous bone marrow-derived cells. Seven patients were classified as Child-Pugh B and three as Child-Pugh C. Baseline assessment included complete clinical and laboratory evaluation and abdominal MRI. Approximately 50 ml of bone marrow aspirate was prepared by centrifugation in a ficoll-hypaque gradient. At least of 100 millions of mononuclear-enriched BMCs were infused into the hepatic artery using the routine technique for arterial chemoembolization for liver tumors. Patients were followed up for adverse events up to 4 mo. RESULTS: The median age of the patients was 52 years (range 24-70 years). All patients were discharged 48 h after BMC infusion. Two patients complained ofmild pain at the bone marrow needle puncture site. No other complications or specific side effects related to the procedure were observed. Bilirubin levels were lower at 1 (2.19 ± 0.9) and 4 mo (2.10 ± 1.0) after cell transplantation that baseline levels (2.78 ± 1.2). Albumin levels 4 mo after BMC infusion (3.73 ± 0.5) were higher than baseline levels (3.47 ± 0.5). International normalized ratio (INR) decreased from 1.48 (SD = 0.23) to 1.43 (SD = 0.23) one month after cell transplantation. CONCLUSION: BMC infusion into hepatic artery of patients with advanced chronic liver disease is safe and feasible. In addition, a decrease in mean serum bilirubin and INR levels and an increase in albumin levels are observed. Our data warrant further studies in order to evaluate the effect of BMC transplantation in patients with advanced chronic liver disease. | Andre Castro lyra Milena Botelho Pereira Soares luiz Flavio Maia da Silva Marcos Fraga Fortes André Goyanna Pinheiro Silva Augusto César de Andrade Mota Sheilla A Oliveira Eduardo lorens Braga Wilson Andrade de Carvalho Bernd Genser Ricardo Ribeiro dos Santos luiz Guilherme Costa lyra | 2007 | World Journal of Gastroenterology2007，13，7： | 21 |
| 2 | 胚胎巨噬细胞和小胶质细胞消融调控小鼠胚胎背根神经节感觉神经元的发育显示文摘众所周知,小胶质细胞可以调节中枢神经系统发育的一些方面。在第11.5天的小鼠胚胎中的小胶质细胞定殖脊髓时,它们与背根神经节感觉神经元(SN)的生长中心轴突相互作用,这表明它们可能在SN发育中发挥一定功能。为了解决这个问题,我们使用缺乏胚胎巨噬细胞(PU.1敲除小鼠)和免疫细胞消融的小鼠胚胎分析胚胎巨噬细胞消融对SNs早期发育的影响。我们发现,除小胶质细胞外,胚胎巨噬细胞还与来自第11.5天的小鼠胚胎的原肌球蛋白受体激酶(Trk)C+感觉神经元,TrkB+感觉神经元和TrkA+感觉神经元外周神经突产生交联。免疫细胞剥夺会导致第11.5天的小鼠胚胎的TrkC+感觉神经元和TrkB+感觉神经元初始数量的减少,这与其发育细胞死亡(DCD)的改变有关联的可能性较小,因为其后在第12.5天的胚胎中的数量有短暂增加。在分析的发育期(第11.5~15.5天),它也导致TrkA+感觉神经元数量减少,尽管我们没有观察到他们的DCD有任何变化。与神经元祖细胞可能存在一致性的脑脂肪酸结合蛋白(BFABP-)阴性细胞的增殖在第11.5天的胚胎中增加,而它们的增殖在第12.5天的胚胎减少,这可部分解释从11.5 d观察到的SN亚型产生的改变。此外,我们观察到在缺乏胚胎巨噬细胞的情况下神经胶质细胞祖细胞(BFABP+细胞)增殖的改变。我们的数据表明,胚胎巨噬细胞和小胶质细胞消融调控SN的发育。 | Angelim MKSC Maia LMSS Mouffle C Ginhoux F Low D Amancio-Dos-Santos A Makhoul J Le Corronc H Mangin JM Legendre P 聂昊(编译) | 2018 | 神经损伤与功能重建2018，13，9： | 2 |
| 3 | Bone mineral density and depression:a community study in women显示文摘 | Coelho R Silva C Maia A | 1999 | J Psychosom Res1999，46，1： | 1 |
| 4 | Environmental behavior and analysis of veterinary and human drugs in soils,sediments and sludge显示文摘 | SILVIA D C MAIA J LOPEZ A | | 0，，06： | 1 |
| 5 | Pichia pastoris:a recombinant microfactory for antibodies and human membrane proteins显示文摘 | GonCalves A M Pedro A Q Maia C | 2013 | J Microbiol Biotechnol2013，23，5： | 1 |
| 6 | Effect of arbuscular mycorrhizal fungi on the acclimatization of micropropagated banana planters 显示文摘 | YANO-MELO A M MAIA L C SAC GIN O J JR | 1999 | Mycorrhiza1999，9，2： | 1 |
| 7 | P roliferat ion prof ile of endometrial polyps inpost-menopausalwomen显示文摘 | Maia H Maltez A At hayde C | 2001 | Maturitas2001，40，2： | 1 |
| 8 | Small- scale distribution of Solea solea and Solea senegalen- sis juveniles in the Tagus estuary (Portugal)显示文摘 | VINAGRE C MAIA A SANTOS P R | 2009 | Es- tuarine Coastal and Shelf Science2009，81，3： | 1 |
| 9 | Use of zirconium in microalloyed steels显示文摘 | Maia A R B Guinancio C R Germano R L | | 0，，： | 1 |
| 10 | C-erbB2 over-expression in endometrial hyperplasia induced by estrogens显示文摘 | Maia H Jr Maltez A Athayde C | 2002 | Maturitas2002，43，1： | 1 |
| 11 | Bioconcentration factor estimates of polycyclic aromatic hydrocarbons in grains of corn plants cultivated in soils treated with sewage sludge显示文摘 | PARAíBA L C QUEIROZ S C N MAIA A H N | 2010 | Science of the Total Environment2010，408，16： | 1 |
| 12 | Small-scale distri- bution of Soleas olea and Soleas enegalensis juveniles in the Tagus estuary (Portugal)显示文摘 | Vinagre C Maia A Reis-Santos P | 2009 | Estuarine Coastal and Shelf Science2009，81，3： | 1 |
| 13 | A condition based maintenance policy and input parameters estima- tion for deteriorating systems under periodic inspection 显示文摘 | NEVES M k SANTIAGO L P MAIA C A | 2011 | Computers & Industrial Engineering2011，61，3： | 1 |
| 14 | A methodology for short-term electric load forecasting based on specialized recursive digital filters显示文摘 | Maia C A Goncalves M M | 2009 | Computers & Industrial Engineering2009，57，： | 1 |
| 15 | Effect of arbuscular mycorrhizal fungi on the acclimatization of micropropagated banana planflets 显示文摘 | Yano - Melo A M Maia L C Saggin 0 J | 1999 | Mycorrhiza1999，9，2： | 1 |
| 16 | Proliferation profile of endome- trial polyps in post - menopausal women 显示文摘 | Maia H Maltez A Athayde C | 2001 | Maturitas2001，40，3： | 1 |
| 17 | Performance of aerobic granular sludge in a sequencing batch bioreactor exposed to ofloxacin, norfloxacin and ciprofloxacin 显示文摘 | Amorim C L Maia A S Mesquita R B R | 2014 | Water Research2014，48，6： | 1 |
| 18 | Optical Investigation of Y2O3∶Sm3+Nanophosphor Prepared by Combustion and Pechini Methods显示文摘 | Kodaira C A Stefani R Maia A S | 2007 | Journal of Luminescence2007，127，： | 1 |
| 19 | Diabetes mellitus as etio- logical factor of hearing loss显示文摘 | MAIA C A CAMPOS C A | 2005 | Braz J Otorhinolar yngol2005，71，： | 1 |
| 20 | Environmental Behavior and Analysis of Veterinary and Human Drugs in Soils, Sediments and Sludge 显示文摘 | SILVIA D C MAIA J LOPEZ A | 2003 | Trends in Analytical Chemistry2003，22，6： | 1 |
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