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| 1 | 世界胃肠病学组织全球指南——发展中国家幽门螺杆菌感染显示文摘世界上有一半人口感染幽门螺杆菌(H.pylori),其感染率因地理位置、种族、年龄和社会经济状况不同而存在很大差异.在发展中国家较高.发达国家较低。但总体而言,近年世界许多地区的H.pylori感染率均呈下降趋势。 | Hunt RH Xiao SD Megraud F Leon-Barua R Bazzoli F van der Merwe S Vaz Coelho LG Fock M Fedail S Cohen H Malfertheiner P Vakil N Hamid S Goh KL Wong BCY Krabshuis J Le Mair A 杜颖 戴宁 | 2011 | 胃肠病学2011，16，7： | 27 |
| 2 | Retrospective study on mixed neuroendocrine non-neuroendocrine neoplasms from five European centres显示文摘BACKGROUND Mixed neuroendocrine non-neuroendocrine neoplasm(MiNEN)is a rare diagnosis,mainly encountered in the gastro-entero-pancreatic tract.There is limited knowledge of its epidemiology,prognosis and biology,and the best management for affected patients is still to be defined.AIM To investigate clinical-pathological characteristics,treatment modalities and survival outcomes of a retrospective cohort of patients with a diagnosis of MiNEN.METHODS Consecutive patients with a histologically proven diagnosis of MiNEN were identified at 5 European centres.Patient data were retrospectively collected from medical records.Pathological samples were reviewed to ascertain compliance with the 2017 World Health Organisation definition of MiNEN.Tumour responses to systemic treatment were assessed according to the Response Evaluation Criteria in Solid Tumours 1.1.Kaplan-Meier analysis was applied to estimate survival outcomes.Associations between clinical-pathological characteristics and survival outcomes were explored using Log-rank test for equality of survivors functions(univariate)and Cox-regression analysis(multivariable).RESULTS Sixty-nine consecutive patients identified;Median age at diagnosis:64 years.Males:63.8%.Localised disease(curable):53.6%.Commonest sites of origin:colon-rectum(43.5%)and oesophagus/oesophagogastric junction(15.9%).The neuroendocrine component was;predominant in 58.6%,poorly differentiated in 86.3%,and large cell in 81.25%,of cases analysed.Most distant metastases analysed(73.4%)were occupied only by a poorly differentiated neuroendocrine component.Ninety-four percent of patients with localised disease underwent curative surgery;53%also received perioperative treatment,most often in line with protocols for adenocarcinomas from the same sites of origin.Chemotherapy was offered to most patients(68.1%)with advanced disease,and followed protocols for pure neuroendocrine carcinomas or adenocarcinomas in equal proportion.In localised cases,median recurrence free survival(RFS);14.0 months(95%CI:9.2-24.4),and median overall survival(OS):28.6 months(95%CI:18.3-41.1).On univariate analysis,receipt of perioperative treatment(vs surgery alone)did not improve RFS(P=0.375),or OS(P=0.240).In advanced cases,median progression free survival(PFS);5.6 months(95%CI:4.4-7.4),and median OS;9.0 months(95%CI:5.2-13.4).On univariate analysis,receipt of palliative active treatment(vs best supportive care)prolonged PFS and OS(both,P<0.001).CONCLUSION MiNEN is most commonly driven by a poorly differentiated neuroendocrine component,and has poor prognosis.Advances in its biological understanding are needed to identify effective treatments and improve patient outcomes. | Melissa Frizziero Xin Wang Bipasha Chakrabarty Alexa Childs Tu V Luong Thomas Walter Mohid S Khan Meleri Morgan Adam Christian Mona Elshafie Tahir Shah Annamaria Minicozzi Wasat Mansoor Tim Meyer Angela Lamarca Richard A Hubner Juan W Valle Mairéad G McNamara | 2019 | World Journal of Gastroenterology2019，25，39： | 13 |
| 3 | Future biomarkers for detection of ischemia and risk stratification in acute coronary syndrome 显示文摘 | Apple F S Wu A H Mair J | 2005 | Clin Chem2005，51，： | 1 |
| 4 | The impact of cardiac natriuretic peptide determination on the dioagnosis and management of heart failure显示文摘 | Mair J Lercher A H Puschendort B | 2009 | Clin Chem Lab Med2009，39，7： | 1 |
| 5 | Pediatric functional endoscopic sinus surgery:postoperative care显示文摘 | MAIR E A | 1996 | Otolaryngol Clin North Am1996，29，3： | 1 |
| 6 | Storage of Light in Atomic Vapor显示文摘 | Philips D F Fleischhauer A Mair A | 2001 | Phys Rev Lett2001，86，5： | 1 |
| 7 | Storage of light in atomic vapor显示文摘 | PHILLIPS D F FLEISCHHAUER A MAIR A ct al | 2001 | PHYS REV LETT2001，86，： | 1 |
| 8 | Molybdenum and tungsten dioxides, XO2(X=Mo,W), as reforming catalysts for hydrocarbon compounds显示文摘 | Katrib A Mey D mAire G | 2001 | Catal Today2001，65，24： | 1 |
| 9 | Growth performance trials of genetically male tilapia (GMT) derived from YY-male in Oreochromis niloticus L: on station comparisons with mixed sex and sex reversed male populations 显示文摘 | Mair G C Abucay J S Beardmore J A | 1995 | Aquaculture1995，137，： | 1 |
| 10 | Cytologic and histologic diagnosis and significance of controversial squamous lesions of the uterine cervix 显示文摘 | Maire A Duggan M A | 2000 | Mod Pathol2000，13，3： | 1 |
| 11 | ~chanics of tunnelling machine screw conveyors : A theoretical model 显示文摘 | A S Merritt R J Mair | 2008 | Geotechnique2008，58，2： | 1 |
| 12 | Arginine-vasopressinin neonates with vasodilatory shock after cardiopulmonary bypass显示文摘 | Lechner E Hofer A Mair R | 2007 | Eur J Pediatr2007，166，12： | 1 |
| 13 | Storage of Light in Atomic Vapor显示文摘 | Phillips D F Fleischhauer A Mair A Walsworth R L Lukin M D | 2001 | Phys Rev Lett2001，86，78： | 1 |
| 14 | Fractionated radia tion therapy in the treatment of stage IlI and IV cerebel- lopontine angle neurinonas: Preliminary results in 20 cases显示文摘 | Maire J Floquet A Darrouzet V | 1992 | Int J Radiat Oncol Biol Phys1992，23，1： | 1 |
| 15 | Mechanics of tunnelling machine screw conveyor: model tests显示文摘 | MERRITT A MAIR R J | 2006 | Geotechnique2006，56，9： | 1 |
| 16 | Entanglement of the orbital angular momentum states of photons显示文摘 | Mair A Vaziri A Weihs G | 2001 | Nature2001，412，6844： | 1 |
| 17 | The impact of cardiac natriuretic peptide determination on the diagnosis and management of heart failure显示文摘 | Mair J Hammerer-Lercher A Puschendorf B | 2001 | Clin Chem Lab Med2001，39，7： | 1 |
| 18 | Oxygen evolution loss and structural transitions in photosystem II induced by low intensity UV-B radiation of 280 nm wavelength显示文摘 | Ségui J A Maire V Gabashvili I S | 2000 | Journal of Photochemistry and Photobiology B: Biology2000，56，： | 1 |
| 19 | Cardiac natriuretic peptides: new laboratory parameters in heart failure patients显示文摘 | Hammerer-Lercher A Puschendorf B Mair J | 2001 | Clin Lab2001，47，56： | 1 |
| 20 | Predictive value of NT-pro BNP after acute myocardial infarction: relation with acute and chronic infarct size and myocardial function 显示文摘 | Mayr A Mair J Schocke M | 2011 | IntJCardiol2011，147，1： | 1 |
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