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| 1 | Retrospective study on mixed neuroendocrine non-neuroendocrine neoplasms from five European centres显示文摘BACKGROUND Mixed neuroendocrine non-neuroendocrine neoplasm(MiNEN)is a rare diagnosis,mainly encountered in the gastro-entero-pancreatic tract.There is limited knowledge of its epidemiology,prognosis and biology,and the best management for affected patients is still to be defined.AIM To investigate clinical-pathological characteristics,treatment modalities and survival outcomes of a retrospective cohort of patients with a diagnosis of MiNEN.METHODS Consecutive patients with a histologically proven diagnosis of MiNEN were identified at 5 European centres.Patient data were retrospectively collected from medical records.Pathological samples were reviewed to ascertain compliance with the 2017 World Health Organisation definition of MiNEN.Tumour responses to systemic treatment were assessed according to the Response Evaluation Criteria in Solid Tumours 1.1.Kaplan-Meier analysis was applied to estimate survival outcomes.Associations between clinical-pathological characteristics and survival outcomes were explored using Log-rank test for equality of survivors functions(univariate)and Cox-regression analysis(multivariable).RESULTS Sixty-nine consecutive patients identified;Median age at diagnosis:64 years.Males:63.8%.Localised disease(curable):53.6%.Commonest sites of origin:colon-rectum(43.5%)and oesophagus/oesophagogastric junction(15.9%).The neuroendocrine component was;predominant in 58.6%,poorly differentiated in 86.3%,and large cell in 81.25%,of cases analysed.Most distant metastases analysed(73.4%)were occupied only by a poorly differentiated neuroendocrine component.Ninety-four percent of patients with localised disease underwent curative surgery;53%also received perioperative treatment,most often in line with protocols for adenocarcinomas from the same sites of origin.Chemotherapy was offered to most patients(68.1%)with advanced disease,and followed protocols for pure neuroendocrine carcinomas or adenocarcinomas in equal proportion.In localised cases,median recurrence free survival(RFS);14.0 months(95%CI:9.2-24.4),and median overall survival(OS):28.6 months(95%CI:18.3-41.1).On univariate analysis,receipt of perioperative treatment(vs surgery alone)did not improve RFS(P=0.375),or OS(P=0.240).In advanced cases,median progression free survival(PFS);5.6 months(95%CI:4.4-7.4),and median OS;9.0 months(95%CI:5.2-13.4).On univariate analysis,receipt of palliative active treatment(vs best supportive care)prolonged PFS and OS(both,P<0.001).CONCLUSION MiNEN is most commonly driven by a poorly differentiated neuroendocrine component,and has poor prognosis.Advances in its biological understanding are needed to identify effective treatments and improve patient outcomes. | Melissa Frizziero Xin Wang Bipasha Chakrabarty Alexa Childs Tu V Luong Thomas Walter Mohid S Khan Meleri Morgan Adam Christian Mona Elshafie Tahir Shah Annamaria Minicozzi Wasat Mansoor Tim Meyer Angela Lamarca Richard A Hubner Juan W Valle Mairéad G McNamara | 2019 | World Journal of Gastroenterology2019，25，39： | 13 |
| 2 | Fractionated radia tion therapy in the treatment of stage IlI and IV cerebel- lopontine angle neurinonas: Preliminary results in 20 cases显示文摘 | Maire J Floquet A Darrouzet V | 1992 | Int J Radiat Oncol Biol Phys1992，23，1： | 1 |
| 3 | Oxygen evolution loss and structural transitions in photosystem II induced by low intensity UV-B radiation of 280 nm wavelength显示文摘 | Ségui J A Maire V Gabashvili I S | 2000 | Journal of Photochemistry and Photobiology B: Biology2000，56，： | 1 |
| 4 | Frequent PTEN genomic alterations and activated phosphatidylinositol 3-kinase pathway in basal-like breast cancer cells显示文摘 | Marty B Maire V Gravier E | | 0，，06： | 1 |
| 5 | Close relation of endothelial function in the human coronary and peripheral circulations显示文摘 | Akimi V Maire D | 1995 | J Am Coll Cardiol1995，26，5： | 1 |
| 6 | Catalytic activity of bulk tungsten carbides for alkane reforming ( I ): Characterization and catalytic activity for reforming of hexane isomers in the absence of oxygen 显示文摘 | Keller V Wehrer P Garin F Ducros R Maire G | 1995 | Journal of Catalysis1995，153，1： | 1 |
| 7 | Total Nasopharyngeal Stenosis: Treatment With Laser Excision, Nasopharyngeal Obturators, and Topical Mitomycin-C显示文摘 | Jones L M Guillory V L Mair E A | 2005 | Otolaryngol Head Neck Surg2005，133，： | 1 |
| 8 | Frequent PTEN genomic alterations and activated phosphatidylinositol 3-kinase pathway in basal-like breast cancer cells显示文摘 | Marty B Maire V Gravier E | | 0，，06： | 1 |
| 9 | Exhaled nitric oxide in relation to the clinical features of childhood asthma 显示文摘 | Warke TJ Mairs V Fitch PS | 2004 | J Asthma2004，41，： | 1 |
| 10 | Cyclosporin A up-regulates angiotension II receptors and calcium responses in human vascular smooth muscle cells显示文摘 | Avdonin P V Maire F C Afanasjeve | 1999 | Kidney Int1999，55，6： | 1 |
| 11 | Exhaled nitric oxide in relation to the clinical features of childhood asthma 显示文摘 | Warke TJ Mairs V Fitch PS | 2004 | J Asthma2004，41，7： | 1 |
| 12 | Rijndael FPGA implementations utilising look-up tables 显示文摘 | Maire McLoone McCanny J V | 2003 | Journal of VLSI Signal Processing2003，3，4： | 1 |
| 13 | Frequent PTEN genomic al-terations and activated phosphatidylinositol 3-kinase pathway inbasal-like breast cancer cells显示文摘 | Marty B Maire V Gravier F | 2008 | Breast Cancer Res2008，10，6： | 1 |
| 14 | Exhaled nitric oxide in relation to the clinical features of childhood asthma显示文摘 | WARKE T J MAIRS V FITCH P S | 2004 | Asthma2004，41，7： | 1 |
| 15 | Fungi mediate long term sequestration of carbon and nitrogen in soil through their priming effect显示文摘 | Fontaine S Henault C Aamor A Bdioui N Bloor JMG Maire V Mary B Revaillot S Maron PA | | 0，，： | 1 |
| 16 | Unexpected response of high alpine lake waters to climate change显示文摘 | THIES H NICKUS U MAIR V | 2007 | Environmental Science & Technology2007，41，： | 1 |
| 17 | Characterization of three optional promoters in the 5' -region of the human aldolase A gene显示文摘 | Maire P Gauttrons S Hakim V et at | 1987 | J Mol BioI1987，197，： | 1 |
| 18 | Habitat filtering and niche differentiation jointly explain species relative abundance within grassland communities along fertility and disturbance gradients显示文摘 | Maire V Gross N B6rger L Proulx R Wirth C da Silveira Pontes L Soussana J F Louault F | 2012 | New Phytologist2012，196，： | 1 |
| 19 | Fractionated radiation therapy in the treatment of stage Ⅲ and Ⅳ cerebellopontine angle neurinomas: Preliminary results in 20 cases 显示文摘 | Maire JP Floquet A Darrouzet V | 1992 | Int J Radiat Oncol Bio Phys1992，23，： | 1 |
| 20 | Interaction of membrane proteins and lipids with solubilizing detergents显示文摘 | MAIRE M l CHAMPEIL P MOLLER J V | 2000 | Biochim Biophys Acta2000，1508，： | 1 |
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