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| 1 | Retrospective study on mixed neuroendocrine non-neuroendocrine neoplasms from five European centres显示文摘BACKGROUND Mixed neuroendocrine non-neuroendocrine neoplasm(MiNEN)is a rare diagnosis,mainly encountered in the gastro-entero-pancreatic tract.There is limited knowledge of its epidemiology,prognosis and biology,and the best management for affected patients is still to be defined.AIM To investigate clinical-pathological characteristics,treatment modalities and survival outcomes of a retrospective cohort of patients with a diagnosis of MiNEN.METHODS Consecutive patients with a histologically proven diagnosis of MiNEN were identified at 5 European centres.Patient data were retrospectively collected from medical records.Pathological samples were reviewed to ascertain compliance with the 2017 World Health Organisation definition of MiNEN.Tumour responses to systemic treatment were assessed according to the Response Evaluation Criteria in Solid Tumours 1.1.Kaplan-Meier analysis was applied to estimate survival outcomes.Associations between clinical-pathological characteristics and survival outcomes were explored using Log-rank test for equality of survivors functions(univariate)and Cox-regression analysis(multivariable).RESULTS Sixty-nine consecutive patients identified;Median age at diagnosis:64 years.Males:63.8%.Localised disease(curable):53.6%.Commonest sites of origin:colon-rectum(43.5%)and oesophagus/oesophagogastric junction(15.9%).The neuroendocrine component was;predominant in 58.6%,poorly differentiated in 86.3%,and large cell in 81.25%,of cases analysed.Most distant metastases analysed(73.4%)were occupied only by a poorly differentiated neuroendocrine component.Ninety-four percent of patients with localised disease underwent curative surgery;53%also received perioperative treatment,most often in line with protocols for adenocarcinomas from the same sites of origin.Chemotherapy was offered to most patients(68.1%)with advanced disease,and followed protocols for pure neuroendocrine carcinomas or adenocarcinomas in equal proportion.In localised cases,median recurrence free survival(RFS);14.0 months(95%CI:9.2-24.4),and median overall survival(OS):28.6 months(95%CI:18.3-41.1).On univariate analysis,receipt of perioperative treatment(vs surgery alone)did not improve RFS(P=0.375),or OS(P=0.240).In advanced cases,median progression free survival(PFS);5.6 months(95%CI:4.4-7.4),and median OS;9.0 months(95%CI:5.2-13.4).On univariate analysis,receipt of palliative active treatment(vs best supportive care)prolonged PFS and OS(both,P<0.001).CONCLUSION MiNEN is most commonly driven by a poorly differentiated neuroendocrine component,and has poor prognosis.Advances in its biological understanding are needed to identify effective treatments and improve patient outcomes. | Melissa Frizziero Xin Wang Bipasha Chakrabarty Alexa Childs Tu V Luong Thomas Walter Mohid S Khan Meleri Morgan Adam Christian Mona Elshafie Tahir Shah Annamaria Minicozzi Wasat Mansoor Tim Meyer Angela Lamarca Richard A Hubner Juan W Valle Mairéad G McNamara | 2019 | World Journal of Gastroenterology2019，25，39： | 13 |
| 2 | Catalysis on Pd/WO3 and Pd/WO2 Ⅱ Effect of redox treatments in hexanes and hexenes re-forming reactions显示文摘 | BIGEY C MAIRE G | 2000 | J Catal2000，196，2： | 1 |
| 3 | Molybdenum and tungsten dioxides, XO2(X=Mo,W), as reforming catalysts for hydrocarbon compounds显示文摘 | Katrib A Mey D mAire G | 2001 | Catal Today2001，65，24： | 1 |
| 4 | Growth performance trials of genetically male tilapia (GMT) derived from YY-male in Oreochromis niloticus L: on station comparisons with mixed sex and sex reversed male populations 显示文摘 | Mair G C Abucay J S Beardmore J A | 1995 | Aquaculture1995，137，： | 1 |
| 5 | Leaf area index estimation with MODIS reflectance time series and model inversion during full rotations of Eucalyptus plantations显示文摘 | Maire G Marsden C Verhoef W | 2011 | Remote Sensing of Environment2011，115，2： | 1 |
| 6 | Inflammatory malignant fibrous histiocytomas and dedifferentiated liposarcomas:histological review,genomic profile,and MDM2 and CDK4 status favour a single entity显示文摘 | Coindre JM Hostein I Maire G | 2004 | J Pathol2004，203，3： | 1 |
| 7 | Acoustic impedanceinversion and seismic reflection continuity analysis for delineating gas hydrate near the Mallik research sites, Mackenzie Delta, northwest Territories, Canada 显示文摘 | Riedel M Bellefleur G Mair S | 2009 | Geophysics2009，74，5： | 1 |
| 8 | An evaluation of trip- loidy as a potential solution to the problem of precocious sexual mat- uration in common carp, Cyprinus carpio, in Kamataka, India 显示文摘 | Basavaraju Y Mair G C Kumar H M M | 2002 | Aquaculture2002，204，34： | 1 |
| 9 | Entanglement of the orbital angular momentum states of photons显示文摘 | Mair A Vaziri A Weihs G | 2001 | Nature2001，412，6844： | 1 |
| 10 | Immunoenzy-mometric assay of human glycogen phosphorylase isoenzyme BB in diagnosis of ischemic myocardial injury显示文摘 | Rabilzch G Mair J Lechleither P | 1995 | Clin Chem1995，41，7： | 1 |
| 11 | Catalytic activity of bulk tungsten carbides for alkane reforming ( I ): Characterization and catalytic activity for reforming of hexane isomers in the absence of oxygen 显示文摘 | Keller V Wehrer P Garin F Ducros R Maire G | 1995 | Journal of Catalysis1995，153，1： | 1 |
| 12 | Molybdenum and tungsten dioxides,XO2 (X= Mo,W),as reforming catalysts for hydrocarbon compounds显示文摘 | KATRIB A MEY D MAIRE G | 2001 | Catal Today2001，65，24： | 1 |
| 13 | Monosex male production in finfish as exemplified by tilapia: applications, problems, and prospects 显示文摘 | Beardmore J A Mair G C Lewis R T | 2001 | Aquaculture2001，，197： | 1 |
| 14 | Sulfur: Role in genesis of petroleum显示文摘 | Douglas A G Mair B J | 1965 | Science1965，147，29： | 1 |
| 15 | Biodiversity in aquatic systems in relation to aquaculture 显示文摘 | Beardmore J A Mair G C Lewis R I | 1997 | Aquacuhure Research1997，28，10： | 1 |
| 16 | B-type natriuretic peptide(BNP)is more sensitive to rapid hemodynamic changes in acute heart failure than N-terminal proBNP显示文摘 | Mair J Falkensammer G Poelzl G | | 0，，08： | 1 |
| 17 | COLIAI-PDGFB gene fusion demonstrates a common histogenetic origin for dermatofibrosarcroma protuberans显示文摘 | Maire G Pedeutour F Coiondre JM | 2002 | Am J Surg Pathol2002，26，： | 1 |
| 18 | Calibration and validation of hyperspectral indices for the estimation of broadleaved forest leaf chlorophyll content, leaf mass per area,leaf area index,and leaf canopy biomass显示文摘 | Maire G L Franois C Soudani K | 2008 | Remote Sensing of Environment2008，112，10： | 1 |
| 19 | Immunoenzymometric assay of human glycogen phosphorylase isoenzyme BB in diagnosis of ischemic myocardial injury显示文摘 | Rabitzsch G Mair J Lechleitner P | 2001 | Clin Chem2001，92，4： | 1 |
| 20 | Study of the damage mechanisms in an OSPREYTM Al alloy-SiCp composite by scanning electron microscope in sidu tensile tests显示文摘 | VERDU C LORMAND G | 1995 | Mater Sci Eng1995，196，： | 1 |
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