|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Genomic variation in the MAP3K5 gene is associated with &bgr;-thalassemia disease severity and hydroxyurea treatment efficacy显示文摘 | Christina Tafrali Arsinoi Paizi Joseph Borg Milena Radmilovic Marina Bartsakoulia Emily Giannopoulou Olga Giannakopoulou Maja Stojiljkovic-Petrovic Branka Zukic Konstantinos Poulas Eleana F Stavrou Polyxeni Lambropoulou Alexandra Kourakli Alexander E Feli | 2013 | Pharmacogenomics2013，，5： | 1 |
| 2 | A theoretical investigation of the geometries and binding energies of molecular tweezer and clip Host-Guest systems 显示文摘 | Maja P Mihajlo E Miljenko P etal | 2005 | J Chem Theory Comput2005，1，： | 1 |
| 3 | Two fruit counting techniques for citrus mechanical harvesting machinery显示文摘 | Ehsani M R Grift T E Maja J M | 2009 | Computers and Electronics in Agriculture2009，65，2： | 1 |
| 4 | Laser--Based People Tracking 显示文摘 | Ajo Fod Andrew Howard Maja J Matari'e | 2002 | ICRA2002，，： | 1 |
| 5 | Glutamine starvation ofmonocytes inhibits the ubiqui-in-proteasome proteolytic path-way显示文摘 | Maria Z Christopher G Maja M E | 2003 | Biochimica et Biophysica Acta2003，1638，： | 1 |
| 6 | Three-dimensional volume- rendered helical CT before laparoscopic adrenalectomy 显示文摘 | MAJA E BRIAN R ERICK M | 2003 | Radiology2003，229，3： | 1 |
| 7 | Vanadium bioavailability in soils amended with blast furnace slag 显示文摘 | Maja A L Baken S Smolders E | 2015 | Journal of hazardous materials2015，296，： | 1 |
| 8 | Enantioselective ring opening of epoxides with cyanide catalysed by halohydrin dehalogenases: A new approach to non racemie β-hydroxy ni- triles 显示文摘 | Maja M E Bernhard H Janssen D B | 2006 | Adv Synth Catal2006，348，： | 1 |
| 9 | An efficient partial power processing DC/DC converter for distributed PV architectures 显示文摘 | Mohammed S Maja H Ahmed E | 2014 | IEEE Transactions on Power Elec- tronics2014，29，2： | 1 |
| 10 | The role of flue gas desulphurisation in mercury speciation and distribution in a lignite burning power plant显示文摘 | Andrej Stergar?ek Milena Horvat Jo?e Kotnik Janja Tratnik Peter Frkal David Kocman Radojko Ja?imovi? Vesna Fajon Maja Ponikvar Iztok Hrastel Jo?e Lenart Branko Debeljak Majda ?uje? | 2008 | Fuel2008，，17： | 1 |
| 11 | finDr:A web server for in silico D-peptide ligand identification显示文摘In the rapidly expanding field of peptide therapeutics,the short in vivo half-life of peptides represents a considerable limitation for drug action.D-peptides,consisting entirely of the dextrorotatory enantiomers of naturally occurring levorotatory amino acids(AAs),do not suffer from these shortcomings as they are intrinsically resistant to proteolytic degradation,resulting in a favourable pharmacokinetic profile.To experimentally identify D-peptide binders to interesting therapeutic targets,so-called mirror-image phage display is typically performed,whereby the target is synthesized in D-form and L-peptide binders are screened as in conventional phage display.This technique is extremely powerful,but it requires the synthesis of the target in D-form,which is challenging for large proteins.Here we present finDr,a novel web server for the computational identification and optimization of D-peptide ligands to any protein structure(http://gffzz4d57a956f0c348acskv06xqwnqvqo696c.ffgz.tsg.suse.edu.cn/).finDr performs molecular docking to virtually screen a library of helical 12-mer peptides extracted from the RCSB Protein Data Bank(PDB)for their ability to bind to the target.In a separate,heuristic approach to search the chemical space of 12-mer peptides,finDr executes a customizable evolutionary algorithm(EA)for the de novo identification or optimization of D-peptide ligands.As a proof of principle,we demonstrate the validity of our approach to predict optimal binders to the pharmacologically relevant target phenol soluble modulin alpha 3(PSMα3),a toxin of methicillin-resistant Staphylococcus aureus(MRSA).We validate the predictions using in vitro binding assays,supporting the success of this approach.Compared to conventional methods,finDr provides a low cost and easy-to-use alternative for the identification of D-peptide ligands against protein targets of choice without size limitation.We believe finDr will facilitate D-peptide discovery with implications in biotechnology and biomedicine. | Helena Engel Felix Guischard Fabian Krause Janina Nandy Paulina Kaas Nico Hofflin Maja Kohn Normann Kilb Karsten Voigt Steffen Wolf Tahira Aslan Fabian Baezner Salom´e Hahne Carolin Ruckes Joshua Weygant Alisa Zinina Emir Bora Akmeriç Enoch B.Antwi Dennis Dombrovskij Philipp Franke Klara L.Lesch Niklas Vesper Daniel Weis Nicole Gensch Barbara Di Ventura Mehmet Ali Oztürk | 2021 | Synthetic and Systems Biotechnology2021，6，4： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员