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| 1 | Manipulation of a VEGF-Notch signaling circuit drives formation of functional vascular endothelial progenitors from human pluripotent stem cells显示文摘人的 pluripotent 干细胞(hPSC ) 导出 endothelial 系细胞组成有希望的来源因为在这个竞技场的治疗学的 revascularization,而是进步被临床上可伸缩的区别协议和在移植之上与宿主发行量集成的一个功能的容器网络的低效的形成的缺乏妨碍了。在绿的地方,使用一根人的胚胎的干细胞记者房间线荧光灯蛋白质表示被 endothelial 驾驶房间特定的 VE-cadherin (VEC ) 倡导者,我们为 > 屏蔽了;60 bioactive 将支持 endothelial 区别,并且发现 BMP4 和 GSK-3β 的那个政府的小分子;在有 VEGF 的一个早阶段和处理的禁止者 -- 在一个以后的阶段表明小径的槽口的 A 和抑制在六天以内导致了 hPSCs 的有效区别到 endothelial 系。这条顺序的途径产生了 >到 endothelial 房间(EC ) 的 hPSCs 的50%变换,明确地 VEC + CD31 + CD34 + CD14 − KDR 在 endothelial 系房间之中展出了更高的 angiogenic 和 clonogenic 增长潜力的高 endothelial 祖先( EP )。药品的抑制或基因槽口发信号击倒,在有 VEGF 的联合 -- 一个处理,经由 KDR + mesodermal 先锋和对成熟 EC 的 EP 的变换的封锁导致了 EP 的有效形成。当移植了进 immunocompromised 老鼠时,产生 EP 成功地与吻合在 vivo 形成了功能的毛状的容器到主人容器。在我们的协议表明电路的这 VEGF-A-Notch 的操作由 12- 导致导出 hPSC 的 EP 的快速的大规模生产到 20 褶层对当前的方法,它可以与与成熟 EC 相比形成能力的优异容器为再生 vascularization 用作一张吸引人的房间人口。 | Makoto Sahara Emil M Hansson Oliver Wemet Kathy O Lui Daniela Spater Kenneth R Chien | 2014 | Cell Research2014，24，7： | 10 |
| 2 | Human macrophage receptors:Primary structure,expression and localization in atherosclerotic lesions显示文摘 | Akiyo M Makoto N Hiroshige I | 1990 | Proc Natl Acad Sci USA1990，87，9： | 1 |
| 3 | Phenolic glucosides from the root of Pueraria lobata显示文摘 | KAZUHIRO H MAKOTO M KAORU N | 1997 | Phytochemistry1997，46，5： | 1 |
| 4 | Nectrisine is a potent inhibitor of α-glucosidases,demonstrating activities similarly at enzyme and cellular levels显示文摘 | EISAKU T MAKOTO M | 1996 | Biochmical and Biophysical Research Communications1996，200，66： | 1 |
| 5 | Effects on development of the reproductive system in male offspring of rats given butylbenzyl phthalate during late pregnancy显示文摘 | Makoto E Emiko M | 2002 | Reproductive Toxicology2002，16，： | 1 |
| 6 | Selective hydrodesulfurization of FCC gasoline over CoMo/Al2O3 sulfide catalyst 显示文摘 | MAKOTO T YASUO M YUKIO K | 2005 | Catalysis Today2005，104，1： | 1 |
| 7 | Impaired glucose tolerance is a risk factor of cardiovaseular disease, but not impaired fasting glueose:the Funagata diabetes study显示文摘 | Makoto T Hideyuki E Hideo M | 1999 | Diabetes Care1999，22，： | 1 |
| 8 | Dopamine-derived salsolinol derivatives as endogenous monoamine oxidase inhibitors: occurrence, metabolism and function in human brains 显示文摘 | Makoto N Wakako M Georgy M N | 2004 | Neurotoxicology2004，25，12： | 1 |
| 9 | Alteration of Properties of Natural Pigments by Conjugation with Fibroin or Polyethylene Glycol显示文摘 | Asako I Makoto F Ayako M | 1995 | Dyes and Pigments1995，27，3： | 1 |
| 10 | Randomized phase Ⅱ trial of gemcitabine plus S-1 combination therapy versus S-1 in advanced biliary tract cancer: Results of the Japan Clinical Oncology Group study (JCOG0805)显示文摘 | Makoto U Takuji O Junki M | 2010 | JpnJ Clin Oncol2010，40，12： | 1 |
| 11 | Nondestructive measurement of sugar content in apples by millimeter-wave reflectometry显示文摘 | MAKOTO O ATSUSHI M KIICHIRO U | 2012 | J Infrared Milli Terah Waves2012，33，2： | 1 |
| 12 | Continuous regional arterial infusion of protease inhibitor and antibiotics in acute necrotizing pancreatitis 显示文摘 | KAZUNORI T SEIKI M MAKOTO S | 1996 | Am JSurg1996，171，： | 1 |
| 13 | Successful intraperitoneal hyperthermic chemoperfusion for the prevention of postoperative peritoneal recurrence in patients with advanced gastric carcinoma显示文摘 | Shigeru F Makoto T Takaki M | 1999 | Cancer1999，85，3： | 1 |
| 14 | Detection of gp43 of Paracoccidioides brasiliensis by the loop-mediated isothermal amplification (LAMP)method 显示文摘 | Endo S Komori T Ricci G Sano A Yokoyama K Ohori A Kamei K Franco M Makoto Miyaji M and Nishimura K | 2004 | FEMS Microbiology Letters2004，234，1： | 1 |
| 15 | Phylogenetic relationships between toxic and non-toxic strains of the genus Microcystis based on 16S to 23S internal transcribed spacer sequence显示文摘 | Shigeto Otsuka Shoichiro Suda Renhui Li Masayuki Watanabe Hiroshi Oyaizu Satoshi Matsumoto Makoto M Watanabe | 1999 | FEMS Microbiology Letters1999，，1： | 1 |
| 16 | Structural capacities of H-shaped RC core wall subjected to lateral load and torsion显示文摘 | Makoto M | 2000 | 12^th WCEE2000，12，： | 1 |
| 17 | Expression of the rice homeobox gene, OSH 1, causes morphologi-cal changes in transgenic kiwifruit 显示文摘 | KUSABA S YURIKO K M MAKOTO M | 1999 | Journal of the Japanese Society for Hort Sci1999，68，3： | 1 |
| 18 | Effect of lipid-lowering therapy with atorvastatin on atherosclerotie aortic plaques detected by noninvasive magnetic resonance imaging显示文摘 | Atsushi Y Yukihiko M Makoto A | 2005 | Journal of the American College of Cardiology2005，45，5： | 1 |
| 19 | Disposition of Lipid-Based Formulation in the Intestinal Tract Affects the Absorption of Poorly Water-Soluble Drugs显示文摘 | Toshihiro K Makoto M | 2006 | Biol Pharm Bull2006，29，3： | 1 |
| 20 | Potential adverse effects of phthalic acid esters on human health:A review of recent studies on reproduction显示文摘 | Mariko M Mutsuko HK Makoto E | | 0，，： | 1 |
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