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| 1 | FK506对实验性卒中疗效的系统评价和Meta分析显示文摘FK506是治疗急性卒中的一种候选用药。决定一种药物是否可以用于临床试验,应当以全面的、无偏倚的动物实验数据的评估为依据,同时还应考虑到这些数据的局限性。这种评估不但应包括药物疗效,而且也应包括药效在体内的特征和局限性。本研究应用系统评价和Meta分析的方法对FK506在卒中动物模型中保护作用的证据进行评价。总共纳入了29个描述了实验步骤的研究,包括1759只动物。结果显示,FK506疗效的点估计值(结局指标的改善)是31.3%[95%CI(0.272-0.354)]。在采用氯胺酮麻醉和短暂性脑缺血的动物实验中,FK506的疗效更高,在使用大鼠,合并其他疾病的动物及仅以梗死面积为疗效指标的实验中,FK506疗效较低。已发表的实验研究质量均接近临床试验标准,但在高质量的研究中,FK506的疗效较低。FK506在实验性脑卒中的研究中,虽然显示出有明显的疗效,但是应注意由于研究质量和可能的发表偏倚等冈素的影响,FK506的疗效可能被过高估计。 | Malcolm R Macleod Tori O’Collins Laura L Horky David W Howells Geoffrey A Donnan 段建钢 | 2006 | 中国循证医学杂志2006，6，6： | 3 |
| 2 | An Intervention to Reduce HIV-Related Stigma in Partnership With African American and Latino Churches显示文摘 | Derose Kathryn Pitkin Bogart Laura M. Kanouse David E. Felton Alexandria Collins Deborah Owens Mata Michael A. Oden Clyde W. Domínguez Blanca X. Flórez Karen R. Hawes-Dawson Jennifer Williams Malcolm V | 2014 | AIDS Education and Prevention2014，，1： | 1 |
| 3 | Predictors of Surgical Margin Status in Breast-Conserving Surgery Within a Breast Screening Program显示文摘 | Emil D. Kurniawan Matthew H. Wong Imogen Windle Allison Rose Arlene Mou Malcolm Buchanan John P. Collins Julie A. Miller Russell L. Gruen G. Bruce Mann | 2008 | Annals of Surgical Oncology2008，，9： | 1 |
| 4 | What makes champions A review of the relative contribution of genes and training to sporting success显示文摘 | ROSS TUCKER MALCOLM COLLINS | 2012 | Br J Sports Med2012，46，8： | 1 |
| 5 | The decision-making process for senior cancer patients: treatment allocation of older women with operable breast cancer in the UK显示文摘Objective: Up to 40% of women over 70 years with primary operable breast cancer in the UK are treated with primary endocrine therapy(PET) as an alternative to surgery. A variety of factors are important in determining treatment for older breast cancer patients. This study aimed to identify the patient and tumor factors associated with treatment allocation in this population.Methods: Prospectively collected data on treatment received(surgery vs. PET) were analysed with multivariable logistic regression using the variables age, modified Charlson Comorbidity Index(CCI), activities of daily living(ADL) score, Mini-Mental State Examination(MMSE) score, HER2 status, tumour size, grade and nodal status. Results: Data were available for 1,122 cancers in 1,098 patients recruited between February 2013 and June 2015 from 51 UK hospitals. About 78% of the population were treated surgically, with the remainder being treated with PET. Increasing patient age at diagnosis, increasing CCI score, large tumor size(5 cm or more) and dependence in one or more ADL categories were all strongly associated with non-surgical treatment(P<0.05).Conclusion: Increasing comorbidity, large tumor size and reduced functional ability are associated with reduced likelihood of surgical treatment of breast cancer in older patients. However, age itself remains a significant factor for non-surgical treatment; reinforcing the need for evidence-based guidelines. | Jenna L.Morgan Paul Richards Osama Zaman Sue Ward Karen Collins Thompson Robinson Kwok-Leung Cheung Riccardo A.Audisio Malcolm W.Reed Lynda Wyld on behalf of the Bridging the Age Gap in Breast Cancer Trial Management Team | 2015 | Cancer Biology & Medicine2015，12，4： | 0 |
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