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| 1 | Extracorporeal shock wave lithotripsy for pancreatic and large common bile duct stones显示文摘Extraction of large pancreatic and common bile duct(CBD)calculi has always challenged the therapeutic endoscopist.Extracorporeal shockwave lithotripsy(ESWL)is an excellent tool for patients with large pancreatic and CBD calculi that are not amenable to routine endotherapy.Pancreatic calculi in the head and body are targeted by ESWL,with an aim to fragment them to<3 mm diameter so that they can be extracted by subsequent endoscopic retrograde cholangio-pancreatography(ERCP).In our experience,complete clearance of the pancreatic duct was achieved in 76% and partial clearance in 17%of 1006 patients.Short-term pain relief with reduction in the number of analgesics ingested was seen in 84%of these patients.For large CBD calculi,a nasobiliary tube is placed to help target the calculi,as well as bathe the calculi in salinea simple maneuver which helps to facilitate fragmenta-tion.The aim is to fragment calculi to<5 mm size and clear the same during ERCP.Complete clearance of the CBD was achieved in 84.4%of and partial clearance in 12.3%of 283 patients.More than 90%of the patients with pancreatic and biliary calculi needed three or fewer sessions of ESWL with 5000 shocks being de-livered at each session.The use of epidural anesthesia helped in reducing patient movement.This,together with the better focus achieved with newer third-gen-eration lithotripters,prevents collateral tissue damage and minimizes the complications.Complications in our experience with nearly 1300 patients were minimal,and no extension of hospital stay was required.Similar rates of clearance of pancreatic and biliary calculi with minimal adverse effects have been reported from the centers where ESWL is performed regularly.In view of its high efficiency,non-invasive nature and low complication rates,ESWL can be offered as the first-line therapy for selected patients with large pancreatic and CBD calculi. | Manu Tandan D Nageshwar Reddy | 2011 | World Journal of Gastroenterology2011，17，39： | 36 |
| 2 | Efficacy of low dose peginterferon alpha-2b with ribavirin on chronic hepatitis C显示文摘AIM: To assess the effi cacy of peginterferon alpha 2b at doses of 50 μg weekly and 80 μg weekly (based on body weight) plus ribavirin in HCV genotype 2 and genotype 3 chronic hepatitis C patients. METHODS: During the study period of Jan 2002 to Dec 2003, all patients diagnosed as chronic hepatitis C or HCV related compensated cirrhosis were treated with peginterferon alpha 2b 50 μg S/C weekly (body weight < 60 kg) or 80 μg S/C weekly (body weight > 60 kg) plus ribavirin 800 mg/d for 24 wk. RESULTS: Overall 28 patients, 14 patients in each group (based on body weight) were treated during the period. Out of 28 patients, 75% were genotype 3, 18% were genotype 2 and 7% were genotype 1. The mean dose of peginterferon alpha 2b was 0.91 μg/kg in group 1 and 1.23 μg/kg in group 2 respectively. The end of treatment and sustained virologic response rates were 82% and 78% respectively. Serious adverse effects were seen in 3.5% patients. CONCLUSION: Low dose peginterferon alpha 2b in combination with ribavirin for 24 wk is effective in HCV genotype 2 and 3 chronic hepatitis C patients. | Rajesh Gupta CH Ramakrishna Sandeep Lakhtakia Manu Tandan Rupa Banerjee D Nageshwar Reddy | 2006 | World Journal of Gastroenterology2006，12，34： | 10 |
| 3 | 胆固醇酯转移蛋白基因的蛋白质截断型变异体与冠状动脉性心脏病风险的关系显示文摘随机对照试验结果表明,抑制胆固醇酯转运蛋白(cholesteryl ester transfer protein,CETP)的疗法并不能降低冠状动脉性心脏病(coronary heart disease,CHD)的发生风险。研究失败的可能原因包括靶目标无效、靶目标外小分子的不良反应和随机对照设计因素影响等。在编码药物靶点的基因中具有天然存在的遗传变异,以此为基础,人类研究可以深入了解针对基因产物的治疗的潜在功效和安全性。 | Nomura A Won HH Khera AV Takeuchi F Ito K McCarthy S Emdin CA Klarin D Natarajan P Zekavat SM Gupta N Peloso GM Borecki IB Teslovich TM Asselta R Duga S Merlini PA Correa A Kessler T Wilson JG Bown MJ Hall AS Braund PS Carey DJ Murray MF Kirchner HL Leader JB Lavage DR Manus JN Hartze DN Samani NJ Schunkert H Marrugat J Elosua R McPherson R Farrall M Watkins H Juang JJ Hsiung CA Lin SY Wang JS Tada H Kawashiri MA Inazu A Yamagishi M Katsuya T Nakashima E Nakatochi M Yamamoto K Yokota M Momozawa Y Rotter JI Lander ES Rader DJ Danesh J Ardissino D Gabriel S Willer CJ Abecasis GR Saleheen D Kubo M Kato N Ida Chen YD Dewey FE Kathiresan S 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，9： | 2 |
| 4 | Echinocosis显示文摘 | Mc Manus Zhang D P W Li J | 2005 | Lancet2005，362，： | 1 |
| 5 | Cohen, Jan Olek ,Mechanism of sulfate attack: A fresh look显示文摘 | Manu Santhanam Menashi D | 2002 | Cement and Concrete Research2002，32，： | 1 |
| 6 | Stability and reactivity of thaumasite at different pH levels显示文摘 | KARIM N J MANU S MENASHI D C | 2003 | C C R2003，33，3： | 1 |
| 7 | Efects of gypsum formation on the performance of cement mortars during external sulphate attack 显示文摘 | Manu Santhanam Menashi D Cohen Jan Olek | 2003 | Cem and Concr Res2003，33，： | 1 |
| 8 | NADH dehydrogenase 1 gene sequences compared for species and strains of the genus Echinococcus显示文摘 | BOWLES J MC MANUS D P | 1993 | Int J Parasitol1993，23，7： | 1 |
| 9 | Recent trends in the characteristics and prognosis of patients hospitalized with acute heart failure显示文摘 | ParkD Me Manus D Darling C | 2011 | Clin Epidemiol2011，22，： | 1 |
| 10 | Molecular genetic approaches to parasite identification:their value in diagnostic parasitology and systematics显示文摘 | Endtz H P Ang C W Mc Manus D P | 1996 | Int Paras-itol1996，26，7： | 1 |
| 11 | BAI 3, CDX 2 and VIL 1: a panel of three antibodies to distinguish small cell from large cell neuroendocrine lung carcinomas显示文摘 | Muhammad F Bari Helen Brown Andrew G Nicholson Keith M Kerr John R Gosney William A Wallace Irshad Soomro Salli Muller Danielle Peat Jonathan D Moore Lesley A Ward Maxim B Freidin Eric Lim Manu Vatish David R J Snead | 2014 | Histopathology2014，，： | 1 |
| 12 | Continuation of Long-Term Care for Cervical Dystonia at an Academic Movement Disorders Clinie显示文摘 | CHANDLER E Gill NEIL D Manus Michael W Pelster | 2013 | Toxins2013，5，4： | 1 |
| 13 | Trends in atrial fibrillation complicating acute myocardial infarction显示文摘 | Saczynski JS Mc Manus D Zhou Z | 2009 | Am J Cardiol2009，104，2： | 1 |
| 14 | Sulfate attack research-whither now?显示文摘 | MENASHI D C JAN O | 2001 | Cement and Concrete Research2001，，31： | 1 |
| 15 | Modeling the Effects of Solution Temperature and Concentration During Sulfate Attack on Cement Mortars显示文摘 | Manu S Menashi D C Jan O | 2002 | Cement and Concrete Research2002，32，4： | 1 |
| 16 | The effects of forest fragmentation on species richness on the Obudu Plateau,south-eastern Nigeria显示文摘 | Dami F D Mwansat G S Manu S A | | 0，，01： | 1 |
| 17 | Results of surgical resection in patients with N2 non-small lung cancer 显示文摘 | Millie D L Mc Manus K G Allen M S | 1994 | Ann Thorac Surg1994，57，： | 1 |
| 18 | 查看详情显示文摘 | Grober R D Acimovic J Schuck J Hessman D Kindlemann P J Hespanha J Morse A S Karrai K Tiemann I Manus S | | 0，，： | 1 |
| 19 | Endoscopic botulinum toxin injection for the treatment of diabetic gastropathy in pancreas and islet-cell transplant patients 显示文摘 | Thomas M P Wilson C H Nayar M Manus D M Walker M Shaw J | 2012 | Exp Clin Transplant2012，10，： | 1 |
| 20 | Angiogenesis therapy with human tissue kallikrein For the treatment of ischemic diseases显示文摘 | Manueli C Madeddu P Regoli D | 2004 | Arch Mal Coeur2004，97，： | 1 |
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